BR112018001425A2 - new serogroup y oligomers of neisseria meningitidis and their synthesis processes - Google Patents

new serogroup y oligomers of neisseria meningitidis and their synthesis processes

Info

Publication number
BR112018001425A2
BR112018001425A2 BR112018001425A BR112018001425A BR112018001425A2 BR 112018001425 A2 BR112018001425 A2 BR 112018001425A2 BR 112018001425 A BR112018001425 A BR 112018001425A BR 112018001425 A BR112018001425 A BR 112018001425A BR 112018001425 A2 BR112018001425 A2 BR 112018001425A2
Authority
BR
Brazil
Prior art keywords
oligomers
neisseria meningitidis
men
serogroup
synthesis processes
Prior art date
Application number
BR112018001425A
Other languages
Portuguese (pt)
Inventor
Manoj Kumar Chhikara
Davinder Gill
Kishore Harale
Original Assignee
Msd Wellcome Trust Hilleman Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msd Wellcome Trust Hilleman Laboratories Pvt Ltd filed Critical Msd Wellcome Trust Hilleman Laboratories Pvt Ltd
Publication of BR112018001425A2 publication Critical patent/BR112018001425A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Abstract

a presente invenção se refere a novos oligômeros de unidade de repetição de polissacarídeo capsular de sorogrupo y de neisseria meningitidis (oligômeros men-y) e processo para sintetização de novos oligômeros men-y. particularmente, a presente invenção se refere à síntese química do tetrâmero de unidade de repetição de polissacarídeo capsular men-y podendo ser usado como um candidato no desenvolvimento de vacinas conjugadas semissintéticas ou totalmente sintéticas contra a infecção bacteriana de sorogrupo y meningocócica.The present invention relates to novel neisseria meningitidis serogroup y capsular polysaccharide repeat unit oligomers (men-y oligomers) and process for synthesizing new men-y oligomers. particularly, the present invention relates to the chemical synthesis of the men-y capsular polysaccharide repeat unit tetramer which may be used as a candidate in the development of semisynthetic or fully synthetic conjugate vaccines against bacterial meningococcal serogroup y infection.

BR112018001425A 2015-07-28 2015-10-08 new serogroup y oligomers of neisseria meningitidis and their synthesis processes BR112018001425A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2281DE2015 2015-07-28
PCT/IB2015/057685 WO2017017509A1 (en) 2015-07-28 2015-10-08 Novel neisseria meningitidis serogroup y oligomer and process for synthesizing thereof

Publications (1)

Publication Number Publication Date
BR112018001425A2 true BR112018001425A2 (en) 2018-09-11

Family

ID=61168992

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018001425A BR112018001425A2 (en) 2015-07-28 2015-10-08 new serogroup y oligomers of neisseria meningitidis and their synthesis processes

Country Status (4)

Country Link
KR (1) KR20180040567A (en)
CN (1) CN107709341A (en)
BR (1) BR112018001425A2 (en)
WO (1) WO2017017509A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022197990A1 (en) * 2021-03-19 2022-09-22 Brandeis University Sulfur-substituted sugar to stabilize oligosaccharide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122017002991B1 (en) * 2003-10-02 2023-01-10 Novartis Vaccines And Diagnostics S.R.L. AQUEOUS IMMUNOGENIC COMPOSITIONS FOR MULTIPLE MENINGOCOCCAL SEROGROUPS
WO2011149778A1 (en) * 2010-05-26 2011-12-01 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for neisseria meningitis vaccine
WO2014210564A1 (en) * 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US10105438B2 (en) * 2014-10-09 2018-10-23 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Process of conjugation and novel synthetic oligosaccharide-protein conjugates obtained thereof

Also Published As

Publication number Publication date
KR20180040567A (en) 2018-04-20
WO2017017509A1 (en) 2017-02-02
CN107709341A (en) 2018-02-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2599 DE 27-10-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.