BR112017028318A2 - antibacterial compounds - Google Patents
antibacterial compoundsInfo
- Publication number
- BR112017028318A2 BR112017028318A2 BR112017028318A BR112017028318A BR112017028318A2 BR 112017028318 A2 BR112017028318 A2 BR 112017028318A2 BR 112017028318 A BR112017028318 A BR 112017028318A BR 112017028318 A BR112017028318 A BR 112017028318A BR 112017028318 A2 BR112017028318 A2 BR 112017028318A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibacterial compounds
- compounds
- tuberculosis
- medicaments
- integers
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
a presente invenção refere-se aos seguintes compostos, em que os números inteiros são como definidos na descrição, e onde os compostos podem ser úteis como medicamentos, por exemplo, para uso no tratamento da tuberculose.The present invention relates to the following compounds, wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for example for use in the treatment of tuberculosis.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15174936.3 | 2015-07-02 | ||
EP15174936 | 2015-07-02 | ||
EP16174718.3 | 2016-06-16 | ||
EP16174718 | 2016-06-16 | ||
EP16174713 | 2016-06-16 | ||
EP16174713.4 | 2016-06-16 | ||
PCT/EP2016/065499 WO2017001660A1 (en) | 2015-07-02 | 2016-07-01 | Antibacterial compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017028318A2 true BR112017028318A2 (en) | 2018-09-04 |
BR112017028318B1 BR112017028318B1 (en) | 2024-02-20 |
Family
ID=56289523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017028318-2A BR112017028318B1 (en) | 2015-07-02 | 2016-07-01 | ANTIBACTERIAL COMPOUND, ITS USE, PROCESS FOR ITS PREPARATION, PRODUCT CONTAINING IT, PHARMACEUTICAL COMPOSITION AND COMBINATION |
Country Status (27)
Country | Link |
---|---|
US (5) | US20180155341A1 (en) |
EP (3) | EP3316968A1 (en) |
JP (3) | JP7099824B2 (en) |
KR (2) | KR20180022833A (en) |
CN (3) | CN107708809A (en) |
AU (3) | AU2016287477B2 (en) |
BR (1) | BR112017028318B1 (en) |
CA (2) | CA2986326A1 (en) |
CL (1) | CL2017003404A1 (en) |
CO (1) | CO2017013408A2 (en) |
DK (1) | DK3316969T3 (en) |
EA (2) | EA201890204A1 (en) |
ES (1) | ES2914681T3 (en) |
HK (2) | HK1249468A1 (en) |
HR (1) | HRP20220339T1 (en) |
IL (2) | IL256391B (en) |
LT (1) | LT3316969T (en) |
MA (1) | MA42293A (en) |
MD (1) | MD3316969T2 (en) |
MX (2) | MX2017016789A (en) |
PE (1) | PE20180520A1 (en) |
PH (2) | PH12017502297A1 (en) |
PL (1) | PL3316969T3 (en) |
RS (1) | RS63201B1 (en) |
SI (1) | SI3316969T1 (en) |
UA (1) | UA125171C2 (en) |
WO (2) | WO2017001660A1 (en) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6563017B2 (en) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | Glycosidase inhibitor |
NZ737297A (en) | 2015-07-02 | 2024-03-22 | Hoffmann La Roche | Bicyclic lactams and methods of use thereof |
MA42293A (en) * | 2015-07-02 | 2018-05-09 | Janssen Sciences Ireland Uc | ANTIBACTERIAL COMPOUNDS |
AU2016324598A1 (en) | 2015-09-17 | 2018-03-15 | Marvin J. Miller | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
WO2017144633A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S. A. | Glycosidase inhibitors |
EA201891438A1 (en) | 2016-02-25 | 2019-01-31 | Асенейрон С. А. | ACID ADDITIVE SALTS DERIVATIVES OF PIPERAZINE |
CN108884078A (en) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | Glycosidase inhibitor |
US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
EP3429591B1 (en) | 2016-03-16 | 2023-03-15 | Kura Oncology, Inc. | Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use |
CA3026010A1 (en) | 2016-06-16 | 2017-12-21 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacterials |
JP7349359B2 (en) | 2016-10-17 | 2023-09-22 | エフ. ホフマン-ラ ロシュ アーゲー | Bicyclic pyridone lactams and methods of using them. |
US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
EP3577121A1 (en) * | 2017-02-06 | 2019-12-11 | Janssen Pharmaceutica NV | Oga inhibitor compounds |
EA201991997A1 (en) | 2017-03-01 | 2020-01-22 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | COMBINED THERAPY |
US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
TW201920170A (en) * | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | Substituted inhibitors of MENIN-MLL and methods of use |
US11149022B2 (en) | 2017-10-17 | 2021-10-19 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
US11325896B2 (en) | 2017-12-20 | 2022-05-10 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
RU2680972C1 (en) * | 2018-02-13 | 2019-03-01 | Федеральное государственное бюджетное научное учреждение "Центральный научно-исследовательский институт туберкулеза" | Method for determining duration of chemotherapy of respiratory tuberculosis with multiple and wide mtb drug resistance in children and teenagers |
US20210009583A1 (en) * | 2018-03-12 | 2021-01-14 | University Of Notre Dame Du Lac | Deuterated imidazopyridines |
CN112074519A (en) | 2018-04-20 | 2020-12-11 | 豪夫迈·罗氏有限公司 | N- [ 4-oxo-2, 3-dihydro-1, 5-benzoxazepin-3-yl ] -5, 6-dihydro-4H-pyrrolo [1,2-B ] pyrazole-2-carboxamide derivatives and related compounds as RIP1 kinase inhibitors for the treatment of e.g. Irritable Bowel Syndrome (IBS) |
US11795165B2 (en) | 2018-08-22 | 2023-10-24 | Asceneuron Sa | Tetrahydro-benzoazepine glycosidase inhibitors |
WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
CN109503631A (en) * | 2018-12-29 | 2019-03-22 | 中国医学科学院医药生物技术研究所 | Imidazo [1,2-a] pyridine -3- amides compound containing diazaspiracyclic segment and its preparation method and application |
US20220235047A1 (en) * | 2019-05-28 | 2022-07-28 | Shionogi & Co., Ltd. | A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE |
KR102076958B1 (en) | 2019-06-24 | 2020-02-13 | 엘티소재주식회사 | Hetero-cyclic compound and organic light emitting device using same |
TW202124379A (en) | 2019-09-10 | 2021-07-01 | 日商鹽野義製藥股份有限公司 | Benzyl amine-containing 5,6-heteroaromatic compounds useful against mycobacterial infection |
WO2021048342A1 (en) | 2019-09-13 | 2021-03-18 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
US20220389008A1 (en) | 2019-09-30 | 2022-12-08 | Janssen Sciences Ireland Unlimited Company | 4-quinolinone antibacterial compounds |
MX2022003816A (en) | 2019-09-30 | 2022-05-06 | Janssen Sciences Ireland Unlimited Co | Antibacterial compounds. |
KR20220122649A (en) | 2019-12-27 | 2022-09-02 | 테크니메데 소시에다데 테크니코-메디시날 에스.에이. | NEW PHARMACEUTICAL COMPOUNDS |
EP4308239A1 (en) | 2021-03-16 | 2024-01-24 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
EP4308579A1 (en) | 2021-03-17 | 2024-01-24 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
JP2024509997A (en) | 2021-03-17 | 2024-03-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | antibacterial compounds |
WO2022214520A1 (en) | 2021-04-07 | 2022-10-13 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
WO2022214519A1 (en) | 2021-04-07 | 2022-10-13 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
CA3223626A1 (en) | 2021-06-29 | 2023-01-05 | Augusto Eugenio Pardal Filipe | Heterocyclic compounds for the treatment of tuberculosis |
TW202325274A (en) | 2021-10-28 | 2023-07-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | Antibacterial compounds |
WO2023244764A1 (en) * | 2022-06-15 | 2023-12-21 | C4 Therapeutics, Inc. | Compounds for the targeted degradation of smarca2 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU702733B2 (en) | 1994-11-15 | 1999-03-04 | Pharmacia & Upjohn Company | Bicyclic oxazine and thiazine oxazolidinone antibacterials |
ES2162047T3 (en) | 1995-05-11 | 2001-12-16 | Upjohn Co | OXAZOLIDINONES WITH REST DIAZINYL AND CARBAZINYL SPIROCICLICAL AND BICYCLE. |
ES2395237T3 (en) | 2002-07-25 | 2013-02-11 | Janssen Pharmaceutica N.V. | Quinoline derivatives as intermediates for mycobacterial inhibitors |
AR042956A1 (en) | 2003-01-31 | 2005-07-13 | Vertex Pharma | GIRASA INHIBITORS AND USES OF THE SAME |
MA27360A1 (en) | 2004-11-23 | 2005-06-01 | Brahim Bennani | SYNTHESIS AND APPLICATION OF SPIRO-ISOXAZOLINES AS ANTI-TUBERCULAR AGENTS |
CN101631786A (en) | 2006-12-20 | 2010-01-20 | 先灵公司 | Novel jnk inhibitor |
TW200901969A (en) * | 2007-06-06 | 2009-01-16 | Smithkline Beecham Corp | Chemical compounds |
TWI498115B (en) | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | Imidazole carbonyl compounds |
JP5613656B2 (en) | 2008-03-26 | 2014-10-29 | グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント | Bicyclic nitroimidazoles covalently linked to substituted phenyloxazolidinones |
US8658350B2 (en) | 2008-09-22 | 2014-02-25 | Oregon Health & Science University | Methods for detecting Mycobacterium tuberculosis disease |
US20120040951A1 (en) | 2008-12-30 | 2012-02-16 | Claudio Chuaqui | Heteroaryl compounds useful as raf kinase inhibitors |
BR112012010752B1 (en) | 2009-11-05 | 2021-07-20 | University Of Notre Dame Du Lac | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS |
SG184073A1 (en) * | 2010-03-18 | 2012-10-30 | Pasteur Institut Korea | Anti-infective compounds |
US9029389B2 (en) | 2011-04-21 | 2015-05-12 | Institut Pasteur Korea | Anti-inflammation compounds |
CA2845785A1 (en) | 2011-09-01 | 2013-03-07 | Irm Llc | Compounds and compositions as c-kit kinase inhibitors |
US9199981B2 (en) | 2011-09-01 | 2015-12-01 | Novartis Ag | Compounds and compositions as C-kit kinase inhibitors |
WO2013033167A1 (en) | 2011-09-01 | 2013-03-07 | Irm Llc | Compounds and compositions as c-kit kinase inhibitors |
WO2013127269A1 (en) * | 2012-03-02 | 2013-09-06 | Genentech,Inc. | Amido spirocyclic amide and sulfonamide derivatives |
KR101918469B1 (en) | 2012-06-04 | 2018-11-15 | 한국화학연구원 | Bicyclic nitroimidazole derivatives or their optical isomers, pharmaceutical composition containing the same as an active ingredient |
JP6483610B2 (en) * | 2012-07-18 | 2019-03-13 | ユニバーシティ オブ ノートルダム デュ ラック | 5,5-heteroaromatic anti-infective compound |
KR101650716B1 (en) | 2012-11-22 | 2016-08-24 | 한국화학연구원 | Bicyclic nitroimidazole derivatives, preparation method thereof and pharmaceutical composition for prevention or treatment of tuberculosis containing the same as an active ingredient |
ES2883565T3 (en) * | 2013-08-02 | 2021-12-09 | Pasteur Institut Korea | Anti-infective compounds |
KR101564425B1 (en) | 2013-11-26 | 2015-10-30 | 한국화학연구원 | Novel bicyclic nitroimidazole carbamate compounds, process for preparation thereof and pharmaceutical composition for preventing or treating tuberculosis containing the same as an active ingredient |
CN105524058B (en) | 2014-10-21 | 2018-03-27 | 广州艾格生物科技有限公司 | Pyrazolo [1,5 a] pyridine compounds and their and its application |
EP3215225B1 (en) | 2014-11-03 | 2020-01-08 | The Regents of the University of California | Multi-drug therapies for tuberculosis treatment |
MA42293A (en) * | 2015-07-02 | 2018-05-09 | Janssen Sciences Ireland Uc | ANTIBACTERIAL COMPOUNDS |
CA3026010A1 (en) | 2016-06-16 | 2017-12-21 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacterials |
CA3025727A1 (en) | 2016-06-16 | 2017-12-21 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacterials |
EA201991997A1 (en) | 2017-03-01 | 2020-01-22 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | COMBINED THERAPY |
-
2016
- 2016-07-01 MA MA042293A patent/MA42293A/en unknown
- 2016-07-01 PL PL16734637T patent/PL3316969T3/en unknown
- 2016-07-01 JP JP2017567655A patent/JP7099824B2/en active Active
- 2016-07-01 UA UAA201800904A patent/UA125171C2/en unknown
- 2016-07-01 AU AU2016287477A patent/AU2016287477B2/en active Active
- 2016-07-01 CN CN201680038659.3A patent/CN107708809A/en active Pending
- 2016-07-01 EA EA201890204A patent/EA201890204A1/en unknown
- 2016-07-01 MX MX2017016789A patent/MX2017016789A/en unknown
- 2016-07-01 US US15/736,524 patent/US20180155341A1/en not_active Abandoned
- 2016-07-01 MD MDE20180478T patent/MD3316969T2/en unknown
- 2016-07-01 HR HRP20220339TT patent/HRP20220339T1/en unknown
- 2016-07-01 WO PCT/EP2016/065499 patent/WO2017001660A1/en active Application Filing
- 2016-07-01 BR BR112017028318-2A patent/BR112017028318B1/en active IP Right Grant
- 2016-07-01 CA CA2986326A patent/CA2986326A1/en active Pending
- 2016-07-01 US US15/736,375 patent/US10364232B2/en active Active
- 2016-07-01 EA EA201890201A patent/EA201890201A1/en unknown
- 2016-07-01 LT LTEPPCT/EP2016/065499T patent/LT3316969T/en unknown
- 2016-07-01 SI SI201631501T patent/SI3316969T1/en unknown
- 2016-07-01 CN CN201680038644.7A patent/CN108235704B/en active Active
- 2016-07-01 MX MX2017016788A patent/MX2017016788A/en unknown
- 2016-07-01 EP EP16733105.7A patent/EP3316968A1/en not_active Ceased
- 2016-07-01 DK DK16734637.8T patent/DK3316969T3/en active
- 2016-07-01 CN CN202111173668.2A patent/CN113980015A/en active Pending
- 2016-07-01 AU AU2016287478A patent/AU2016287478B2/en not_active Expired - Fee Related
- 2016-07-01 EP EP22158386.7A patent/EP4074378A1/en active Pending
- 2016-07-01 JP JP2017567289A patent/JP2018519302A/en active Pending
- 2016-07-01 EP EP16734637.8A patent/EP3316969B1/en active Active
- 2016-07-01 RS RS20220464A patent/RS63201B1/en unknown
- 2016-07-01 PE PE2017002738A patent/PE20180520A1/en unknown
- 2016-07-01 KR KR1020187002072A patent/KR20180022833A/en not_active Application Discontinuation
- 2016-07-01 ES ES16734637T patent/ES2914681T3/en active Active
- 2016-07-01 CA CA2986331A patent/CA2986331A1/en not_active Abandoned
- 2016-07-01 WO PCT/EP2016/065503 patent/WO2017001661A1/en active Application Filing
- 2016-07-01 KR KR1020187001923A patent/KR20180022826A/en not_active Application Discontinuation
-
2017
- 2017-12-13 PH PH12017502297A patent/PH12017502297A1/en unknown
- 2017-12-13 PH PH12017502298A patent/PH12017502298B1/en unknown
- 2017-12-18 IL IL256391A patent/IL256391B/en active IP Right Grant
- 2017-12-18 IL IL256379A patent/IL256379A/en unknown
- 2017-12-26 CO CONC2017/0013408A patent/CO2017013408A2/en unknown
- 2017-12-27 CL CL2017003404A patent/CL2017003404A1/en unknown
-
2018
- 2018-07-13 HK HK18109081.1A patent/HK1249468A1/en unknown
- 2018-10-25 HK HK18113658.6A patent/HK1254677A1/en unknown
-
2019
- 2019-07-02 US US16/460,334 patent/US20190330189A1/en not_active Abandoned
-
2020
- 2020-04-14 US US16/848,337 patent/US11180472B2/en active Active
-
2021
- 2021-09-17 US US17/477,970 patent/US11866419B2/en active Active
- 2021-11-30 JP JP2021194493A patent/JP2022043078A/en active Pending
-
2022
- 2022-01-20 AU AU2022200385A patent/AU2022200385A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017028318A2 (en) | antibacterial compounds | |
BR112018076126A2 (en) | heterocyclic compounds as antibacterials | |
BR112018075939A2 (en) | heterocyclic compounds as antibacterials | |
CL2016000839A1 (en) | Compositions to modulate the expression of c9orf72. | |
BR112017007636A2 (en) | methods for preparing ribosides | |
BR112017007123A2 (en) | tetrahydroisoquinoline derivatives | |
CR20170478A (en) | NEW COMPOUNDS | |
NI201600071A (en) | AUTOTAXIN INHIBITOR COMPOUNDS | |
CL2015002891A1 (en) | Deaza-macrocyclic purinones for the treatment of viral infections. | |
CR20150326A (en) | AUTOTAXIN INHIBITORS | |
BR112022003799A2 (en) | antibacterial compounds | |
BR112018008441A2 (en) | polypropylene composition, use of a polypropylene composition, layer element, article, and photovoltaic module. | |
BR112017013498A2 (en) | nitrification inhibitor compositions and methods for preparing them | |
NI201600070A (en) | AUTOTAXIN TETRAYCLIC INHIBITORS | |
BR112017000821A2 (en) | new substituted pyrimidine compounds. | |
UY37193A (en) | NEW ANTIVÍRICOS COMPOUNDS | |
GT201600066A (en) | COMPOSITIONS AND METHODS TO INHIBIT THE EXPRESSION OF GEN ALAS1 | |
CL2016000038A1 (en) | Pyroxolo-substituted pyridinamines | |
BR112017008496A2 (en) | compounds for use in anthelmintic treatment | |
BR112017019750A2 (en) | process for preparing a crystalline form of menaquinol, crystalline form of menaquinol, process for preparing a solid form of menaquinol, pharmaceutical or nutraceutical composition and use of the crystalline form of menaquinol | |
UY36217A (en) | PIRIDONA SUBSTITUTE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE. | |
BR112017005272A2 (en) | cysteamine to treat yeast / mold infections | |
UY36292A (en) | TETRAHYDROQUINOLINE COMPOUNDS FOR USE AS BROMODOMINIUM INHIBITORS | |
DOP2018000049A (en) | COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS | |
BR112016013946A8 (en) | quinazolin-thf-amines as pde1 inhibitors, pharmaceutical composition comprising them, process for preparing said pharmaceutical composition as well as use of the compounds and kit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/07/2016, OBSERVADAS AS CONDICOES LEGAIS |