BR112017017927A2 - chimeric anti-dll3 antigen receptors and methods of use - Google Patents
chimeric anti-dll3 antigen receptors and methods of useInfo
- Publication number
- BR112017017927A2 BR112017017927A2 BR112017017927A BR112017017927A BR112017017927A2 BR 112017017927 A2 BR112017017927 A2 BR 112017017927A2 BR 112017017927 A BR112017017927 A BR 112017017927A BR 112017017927 A BR112017017927 A BR 112017017927A BR 112017017927 A2 BR112017017927 A2 BR 112017017927A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- chimeric anti
- antigen receptors
- dll3 antigen
- dll3
- Prior art date
Links
- 102000006306 Antigen Receptors Human genes 0.000 title abstract 2
- 108010083359 Antigen Receptors Proteins 0.000 title abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
a presente invenção refere-se a receptores quiméricos de antígenos anti-dll3 e a métodos de uso dos mesmos para tratar distúrbios proliferativos.The present invention relates to chimeric anti-dll3 antigen receptors and methods of using them to treat proliferative disorders.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562119793P | 2015-02-23 | 2015-02-23 | |
US201562241662P | 2015-10-14 | 2015-10-14 | |
US201662296560P | 2016-02-17 | 2016-02-17 | |
PCT/US2016/019192 WO2016138038A1 (en) | 2015-02-23 | 2016-02-23 | Anti-dll3 chimeric antigen receptors and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017017927A2 true BR112017017927A2 (en) | 2018-04-10 |
Family
ID=56789774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017017927A BR112017017927A2 (en) | 2015-02-23 | 2016-02-23 | chimeric anti-dll3 antigen receptors and methods of use |
Country Status (23)
Country | Link |
---|---|
US (1) | US20180044415A1 (en) |
EP (1) | EP3261650A4 (en) |
JP (1) | JP2018506981A (en) |
KR (1) | KR20170120158A (en) |
CN (1) | CN107405362A (en) |
BR (1) | BR112017017927A2 (en) |
CA (1) | CA2977502A1 (en) |
CL (1) | CL2017002150A1 (en) |
CO (1) | CO2017008804A2 (en) |
CR (1) | CR20170436A (en) |
DO (1) | DOP2017000199A (en) |
EA (1) | EA201791884A1 (en) |
EC (1) | ECSP17063327A (en) |
HK (1) | HK1249405A1 (en) |
IL (1) | IL254068A0 (en) |
MA (1) | MA41613A (en) |
MX (1) | MX2017010845A (en) |
PE (1) | PE20171383A1 (en) |
PH (1) | PH12017501521A1 (en) |
SG (1) | SG11201706804SA (en) |
TW (1) | TW201639887A (en) |
WO (1) | WO2016138038A1 (en) |
ZA (1) | ZA201705720B (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
US11885806B2 (en) | 2014-03-05 | 2024-01-30 | Autolus Limited | Method for depleting malignant T-cells |
GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
AU2018219887A1 (en) | 2017-02-08 | 2019-08-22 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
CN108395482B (en) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | Construction of targeting CD20 antigen chimeric antigen receptor and activity identification of engineered T cell thereof |
AU2018220736A1 (en) | 2017-02-20 | 2019-09-05 | Dragonfly Therapeutics, Inc. | Proteins binding HER2, NKG2D and CD16 |
WO2019018828A1 (en) * | 2017-07-20 | 2019-01-24 | Cytomx Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
KR102172092B1 (en) | 2017-09-19 | 2020-10-30 | 주식회사 엘지화학 | Thermoplastic resin composition, method for preparing the theremoplastic resin and molding products |
AU2018346955A1 (en) | 2017-10-13 | 2020-04-30 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
CA3078689A1 (en) * | 2017-10-20 | 2019-04-25 | Nantbio, Inc. | Methods for monitoring bladder cancer immunotherapy |
MX2020008336A (en) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Antibody variable domains targeting the nkg2d receptor. |
JP2021518747A (en) * | 2018-02-13 | 2021-08-05 | キメラ・バイオエンジニアリング,インコーポレーテッド | Regulation of gene expression using RNA destabilizing elements |
WO2019195408A1 (en) * | 2018-04-03 | 2019-10-10 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting dll3, and use thereof |
UY38182A (en) * | 2018-04-10 | 2019-10-31 | Amgen Inc | DLL3 CHEMERIC RECEPTORS AND METHODS FOR THEIR USE |
US20210047399A1 (en) * | 2018-05-08 | 2021-02-18 | Phanes Therapeutics, Inc. | Anti-dll3 antibodies and uses thereof |
WO2020114518A1 (en) * | 2018-12-07 | 2020-06-11 | 科济生物医药(上海)有限公司 | Tumor combined immunotherapy |
CA3131908A1 (en) | 2019-03-01 | 2020-09-10 | Allogene Therapeutics, Inc. | Dll3 targeting chimeric antigen receptors and binding agents |
CN113874526A (en) * | 2019-03-08 | 2021-12-31 | 肿瘤实验室诊断有限公司 | Diagnosis and prognosis of cancer |
EP3952888A1 (en) * | 2019-04-08 | 2022-02-16 | Phanes Therapeutics, Inc. | Humanized anti-dll3 chimeric antigen receptors and uses thereof |
CA3146019A1 (en) * | 2019-07-17 | 2021-01-21 | Nanjing Legend Biotech Co., Ltd. | Anti-dll3 chimeric antigen receptors and uses thereof |
EP4013431A4 (en) * | 2019-08-18 | 2024-05-01 | Chimera Bioengineering Inc | Combination therapy with gold controlled transgenes |
WO2021155380A1 (en) * | 2020-01-31 | 2021-08-05 | Gensun Biopharma Inc. | Bispecific t cell engagers |
WO2022206994A1 (en) * | 2021-04-02 | 2022-10-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells and uses thereof |
CN117169518B (en) * | 2023-11-03 | 2024-01-19 | 赛德特(北京)生物工程有限公司 | Method and kit for detecting CD3 antibody residues in T lymphocyte preparation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2530091T3 (en) * | 2010-01-29 | 2018-05-28 | Chugai Pharmaceutical Co Ltd | ANTI-DLL3 ANTIBODY |
EP3305798A1 (en) * | 2010-12-09 | 2018-04-11 | The Trustees of The University of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
EP3093294A1 (en) * | 2012-02-24 | 2016-11-16 | Stemcentrx, Inc. | Dll3 modulators and methods of use |
PE20150643A1 (en) * | 2012-06-22 | 2015-05-29 | Cytomx Therapeutics Inc | ANTI-JAGGED 1 / JAGGED 2 CROSS-REACTIVE ANTIBODIES ACTIVABLE ANTI-JAGGED ANTIBODIES AND METHODS OF USE OF THEM |
GB201302447D0 (en) * | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
RS58873B1 (en) * | 2013-02-22 | 2019-08-30 | Abbvie Stemcentrx Llc | Antidll3-antibody-pbd conjugates and uses thereof |
WO2016179319A1 (en) * | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
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2016
- 2016-02-22 MA MA041613A patent/MA41613A/en unknown
- 2016-02-23 JP JP2017544615A patent/JP2018506981A/en active Pending
- 2016-02-23 CR CR20170436A patent/CR20170436A/en unknown
- 2016-02-23 PE PE2017001455A patent/PE20171383A1/en unknown
- 2016-02-23 KR KR1020177026963A patent/KR20170120158A/en unknown
- 2016-02-23 TW TW105105289A patent/TW201639887A/en unknown
- 2016-02-23 MX MX2017010845A patent/MX2017010845A/en unknown
- 2016-02-23 WO PCT/US2016/019192 patent/WO2016138038A1/en active Application Filing
- 2016-02-23 SG SG11201706804SA patent/SG11201706804SA/en unknown
- 2016-02-23 CN CN201680019227.8A patent/CN107405362A/en active Pending
- 2016-02-23 EA EA201791884A patent/EA201791884A1/en unknown
- 2016-02-23 EP EP16756219.8A patent/EP3261650A4/en not_active Withdrawn
- 2016-02-23 US US15/553,102 patent/US20180044415A1/en not_active Abandoned
- 2016-02-23 BR BR112017017927A patent/BR112017017927A2/en not_active IP Right Cessation
- 2016-02-23 CA CA2977502A patent/CA2977502A1/en not_active Abandoned
-
2017
- 2017-08-20 IL IL254068A patent/IL254068A0/en unknown
- 2017-08-22 ZA ZA2017/05720A patent/ZA201705720B/en unknown
- 2017-08-23 CL CL2017002150A patent/CL2017002150A1/en unknown
- 2017-08-23 DO DO2017000199A patent/DOP2017000199A/en unknown
- 2017-08-23 PH PH12017501521A patent/PH12017501521A1/en unknown
- 2017-08-29 CO CONC2017/0008804A patent/CO2017008804A2/en unknown
- 2017-09-22 EC ECIEPI201763327A patent/ECSP17063327A/en unknown
-
2018
- 2018-06-22 HK HK18108019.0A patent/HK1249405A1/en unknown
Also Published As
Publication number | Publication date |
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KR20170120158A (en) | 2017-10-30 |
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