BR112017009263A2 - antibody or fragment thereof that binds to a human cd38, bispecific antibody, antibody or fragment thereof that binds to human and cinomolgous cd38, soluble human cd38 epitope, composition and immunoconjugate - Google Patents
antibody or fragment thereof that binds to a human cd38, bispecific antibody, antibody or fragment thereof that binds to human and cinomolgous cd38, soluble human cd38 epitope, composition and immunoconjugateInfo
- Publication number
- BR112017009263A2 BR112017009263A2 BR112017009263-8A BR112017009263A BR112017009263A2 BR 112017009263 A2 BR112017009263 A2 BR 112017009263A2 BR 112017009263 A BR112017009263 A BR 112017009263A BR 112017009263 A2 BR112017009263 A2 BR 112017009263A2
- Authority
- BR
- Brazil
- Prior art keywords
- human
- antibody
- binds
- fragment
- cinomolgous
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title 2
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
a presente invenção refere-se às imunoglobulinas hetero-diméricas que marcam ambos, um componente do antígeno cd3 humano e um componente do antígeno cd38 humano e métodos para preparar os mesmos. a presente invenção também se refere aos anticorpos que se ligam ao antígeno cd38 humano e aos derivados dos mesmos para uso como terapêutico ou reagente de diagnóstico e métodos para preparar o mesmo.The present invention relates to hetero-dimeric immunoglobulins which both mark a component of human cd3 antigen and a component of human cd38 antigen and methods for preparing them. The present invention also relates to antibodies which bind to human cd38 antigen and derivatives thereof for use as a therapeutic or diagnostic reagent and methods for preparing the same.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EPPCT/EP2014/073738 | 2014-11-04 | ||
PCT/EP2014/073738 WO2015063339A1 (en) | 2013-11-04 | 2014-11-04 | Production of t cell retargeting hetero-dimeric immunoglobulins |
EP15167034 | 2015-05-08 | ||
EP15167034.6 | 2015-05-08 | ||
PCT/EP2015/075628 WO2016071355A1 (en) | 2014-11-04 | 2015-11-03 | Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017009263A2 true BR112017009263A2 (en) | 2018-01-30 |
Family
ID=53059011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017009263-8A BR112017009263A2 (en) | 2014-11-04 | 2015-11-03 | antibody or fragment thereof that binds to a human cd38, bispecific antibody, antibody or fragment thereof that binds to human and cinomolgous cd38, soluble human cd38 epitope, composition and immunoconjugate |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP3215541A1 (en) |
JP (3) | JP2018501297A (en) |
KR (1) | KR20170078831A (en) |
CN (1) | CN107207596A (en) |
AU (1) | AU2015341884B2 (en) |
BR (1) | BR112017009263A2 (en) |
CA (1) | CA2965745C (en) |
CL (1) | CL2017001090A1 (en) |
CO (1) | CO2017005240A2 (en) |
EA (1) | EA039658B1 (en) |
HK (1) | HK1244014A1 (en) |
IL (1) | IL251848A0 (en) |
MA (1) | MA40894A (en) |
MX (1) | MX2017005814A (en) |
MY (1) | MY186929A (en) |
NZ (1) | NZ732019A (en) |
PE (1) | PE20171041A1 (en) |
PH (1) | PH12017500819A1 (en) |
SG (1) | SG11201703313SA (en) |
WO (1) | WO2016071355A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
CA3211863A1 (en) | 2013-01-14 | 2014-07-17 | Xencor, Inc. | Novel heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
PT3406633T (en) | 2013-07-25 | 2022-05-04 | Cytomx Therapeutics Inc | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
EA036577B1 (en) | 2013-11-04 | 2020-11-25 | Икнос Сайенсиз Са | Production of t cell retargeting hetero-dimeric immunoglobulins |
AP2016009475A0 (en) | 2014-03-28 | 2016-09-30 | Xencor Inc | Bispecific antibodies that bind to cd38 and cd3 |
EP3172235A2 (en) * | 2014-07-25 | 2017-05-31 | Cytomx Therapeutics Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
RS62332B1 (en) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimeric antibodies that bind cd3 and cd20 |
BR112017011166A2 (en) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | heterodimeric antibodies that bind to cd3 and cd38 |
TWI796283B (en) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Antibody constructs for msln and cd3 |
JO3792B1 (en) | 2015-07-31 | 2021-01-31 | Amgen Res Munich Gmbh | Antibody constructs for flt3 and cd3 |
US11623957B2 (en) | 2015-12-07 | 2023-04-11 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and PSMA |
EA039859B1 (en) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Bispecific antibody constructs binding egfrviii and cd3 |
CN110352070A (en) | 2016-06-14 | 2019-10-18 | Xencor股份有限公司 | Bispecific checkpoint inhibitor antibody |
US20230159661A1 (en) * | 2017-04-24 | 2023-05-25 | Ichnos Sciences SA | T cell redirecting bispecific antibodies for the treatment of egfr positive cancers |
CA3064163A1 (en) | 2017-06-05 | 2018-12-13 | Numab Therapeutics AG | Novel anti-cd3 antibodies |
WO2018224441A1 (en) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
CN110997722B (en) * | 2017-06-08 | 2023-09-26 | 黑带医疗有限公司 | CD38 modulating antibodies |
JP2020523038A (en) | 2017-06-08 | 2020-08-06 | ブラック ベルト セラピューティクス リミテッド | CD38 regulatory antibody |
BR112020002636A2 (en) | 2017-08-10 | 2020-07-28 | Grifols Diagnostic Solutions Inc. | compositions, methods and / or kits comprising a recombinant extracellular domain of human cd38 |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to bcma and uses thereof |
US11542338B2 (en) | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
CN111032086B (en) | 2017-08-16 | 2023-09-26 | 黑带医疗有限公司 | CD38 antibodies |
WO2019075405A1 (en) | 2017-10-14 | 2019-04-18 | Cytomx Therapeutics, Inc. | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
US20220034899A1 (en) * | 2018-09-25 | 2022-02-03 | Ichnos Sciences S.A. | Antibody quantification in biological samples |
KR102353568B1 (en) * | 2018-11-14 | 2022-01-20 | 주식회사 헬릭스미스 | Anti c-Met Antibody or Antigen binding fragment thereof with Improved Stability |
SG11202107941TA (en) * | 2019-01-23 | 2021-08-30 | Encefa | Cd31 competitors and uses thereof |
EP3938398A2 (en) * | 2019-03-13 | 2022-01-19 | Ichnos Sciences S.A. | Non-consensus glycosylation of bispecific antibodies |
US20220227887A1 (en) * | 2019-06-11 | 2022-07-21 | Ono Pharmaceutical Co., Ltd. | Immunosuppressant |
CN110551222B (en) * | 2019-08-27 | 2023-06-06 | 重庆市畜牧科学院 | Novel bifunctional antibody and application thereof |
WO2021063330A1 (en) * | 2019-09-30 | 2021-04-08 | 和铂医药(苏州)有限公司 | Cd3-targeting antibody, bispecific antibody and use thereof |
CN113493519B (en) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | Fusion protein with remarkably prolonged half-life for treating ocular angiogenesis diseases |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
CN115916824A (en) * | 2020-06-17 | 2023-04-04 | Y-单克隆抗体制药有限公司 | CD38 antibodies for the treatment of human diseases |
IL300666A (en) | 2020-08-19 | 2023-04-01 | Xencor Inc | Anti-cd28 compositions |
EP4305065A1 (en) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE025369T2 (en) * | 2004-02-06 | 2016-02-29 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
ZA200709003B (en) * | 2005-03-23 | 2009-05-27 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
CN103554259B (en) * | 2005-10-12 | 2016-05-18 | 莫佛塞斯公司 | Specificity is for generation and the qualification of the derivative treatment of the complete people HuCAL GOLD-antibody of people CD38 |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
MX368932B (en) * | 2009-06-26 | 2019-10-22 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format. |
EP2522724B1 (en) * | 2009-12-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide modification method for purifying polypeptide multimers |
PT2580243T (en) * | 2010-06-09 | 2020-01-22 | Genmab As | Antibodies against human cd38 |
JOP20210044A1 (en) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | Anti-cd38 antibodies |
KR20200052383A (en) * | 2011-03-25 | 2020-05-14 | 아이크노스 사이언스 에스. 아. | Hetero-dimeric Immunoglobulins |
KR20150076172A (en) * | 2012-09-25 | 2015-07-06 | 그렌마크 파머수티칼스 에스. 아. | Purification of Hetero-dimeric Immunoglobulins |
EP2914302B1 (en) * | 2012-11-05 | 2017-01-04 | MorphoSys AG | Radiolabelled antibody and uses thereof |
EA036577B1 (en) * | 2013-11-04 | 2020-11-25 | Икнос Сайенсиз Са | Production of t cell retargeting hetero-dimeric immunoglobulins |
-
2015
- 2015-11-02 MA MA040894A patent/MA40894A/en unknown
- 2015-11-03 KR KR1020177015252A patent/KR20170078831A/en not_active Application Discontinuation
- 2015-11-03 SG SG11201703313SA patent/SG11201703313SA/en unknown
- 2015-11-03 JP JP2017542319A patent/JP2018501297A/en active Pending
- 2015-11-03 PE PE2017000802A patent/PE20171041A1/en unknown
- 2015-11-03 EP EP15790129.9A patent/EP3215541A1/en not_active Withdrawn
- 2015-11-03 BR BR112017009263-8A patent/BR112017009263A2/en active Search and Examination
- 2015-11-03 NZ NZ732019A patent/NZ732019A/en unknown
- 2015-11-03 EA EA201790961A patent/EA039658B1/en unknown
- 2015-11-03 MY MYPI2017701499A patent/MY186929A/en unknown
- 2015-11-03 WO PCT/EP2015/075628 patent/WO2016071355A1/en active Application Filing
- 2015-11-03 CN CN201580072196.8A patent/CN107207596A/en active Pending
- 2015-11-03 AU AU2015341884A patent/AU2015341884B2/en active Active
- 2015-11-03 CA CA2965745A patent/CA2965745C/en active Active
- 2015-11-03 MX MX2017005814A patent/MX2017005814A/en unknown
-
2017
- 2017-04-23 IL IL251848A patent/IL251848A0/en unknown
- 2017-05-02 CL CL2017001090A patent/CL2017001090A1/en unknown
- 2017-05-03 PH PH12017500819A patent/PH12017500819A1/en unknown
- 2017-05-26 CO CONC2017/0005240A patent/CO2017005240A2/en unknown
-
2018
- 2018-03-12 HK HK18103440.0A patent/HK1244014A1/en unknown
-
2019
- 2019-07-23 JP JP2019135318A patent/JP2019214582A/en active Pending
-
2021
- 2021-08-02 JP JP2021126392A patent/JP7403505B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2016071355A1 (en) | 2016-05-12 |
MA40894A (en) | 2017-09-12 |
CL2017001090A1 (en) | 2018-01-05 |
EA039658B1 (en) | 2022-02-22 |
SG11201703313SA (en) | 2017-05-30 |
AU2015341884B2 (en) | 2020-09-17 |
CN107207596A (en) | 2017-09-26 |
CO2017005240A2 (en) | 2017-10-31 |
PE20171041A1 (en) | 2017-07-19 |
IL251848A0 (en) | 2017-06-29 |
JP7403505B2 (en) | 2023-12-22 |
NZ732019A (en) | 2022-07-29 |
HK1244014A1 (en) | 2018-07-27 |
JP2019214582A (en) | 2019-12-19 |
MX2017005814A (en) | 2017-08-02 |
AU2015341884A1 (en) | 2017-06-08 |
CA2965745A1 (en) | 2016-05-12 |
CA2965745C (en) | 2023-12-05 |
JP2021184722A (en) | 2021-12-09 |
EP3215541A1 (en) | 2017-09-13 |
EA201790961A1 (en) | 2017-10-31 |
JP2018501297A (en) | 2018-01-18 |
KR20170078831A (en) | 2017-07-07 |
MY186929A (en) | 2021-08-26 |
PH12017500819A1 (en) | 2017-10-02 |
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