BR112017000305A2 - analyte concentration measurement - Google Patents

analyte concentration measurement

Info

Publication number
BR112017000305A2
BR112017000305A2 BR112017000305A BR112017000305A BR112017000305A2 BR 112017000305 A2 BR112017000305 A2 BR 112017000305A2 BR 112017000305 A BR112017000305 A BR 112017000305A BR 112017000305 A BR112017000305 A BR 112017000305A BR 112017000305 A2 BR112017000305 A2 BR 112017000305A2
Authority
BR
Brazil
Prior art keywords
potential
mediator
electrode
analyte concentration
cycle
Prior art date
Application number
BR112017000305A
Other languages
Portuguese (pt)
Inventor
Liu Zuifang
Original Assignee
Cilag Gmbh Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Gmbh Int filed Critical Cilag Gmbh Int
Publication of BR112017000305A2 publication Critical patent/BR112017000305A2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements

Abstract

a presente invenção refere-se a um método de determinação de concentração de analito que utiliza uma reação de oxirredução em uma célula eletroquímica que tem pelo menos dois eletrodos, um dos quais é um eletrodo de trabalho, pelo menos um eletrodo sendo exposto a pelo menos um mediador de oxirredução. o método usa pelo menos um ciclo de pulsos, cada ciclo tendo pelo menos um primeiro e um segundo potencial. o método compreende a aplicação de um primeiro potencial para iniciar uma fase de acumulação que força a acumulação de um gradiente de concentração de mediador no ou próximo ao eletrodo de trabalho com uma concentração que diminui em direção ao volume da solução, aplicação de um segundo potencial para iniciar uma fase de medição e esgotar o gradiente de concentração de mediador estabelecido no eletrodo de trabalho, a medição da corrente associada ao segundo potencial de cada ciclo, e o uso da corrente medida para determinar a concentração de analito. desta forma, os efeitos de fatores que interferem na difusão (dif - diffusion interfering factors), especialmente hematócrito (hct), podem ser mitigados.The present invention relates to an analyte concentration determination method utilizing an oxeduction reaction in an electrochemical cell having at least two electrodes, one of which is a working electrode, at least one electrode being exposed to at least one electrode. an oxireduction mediator. The method uses at least one pulse cycle, each cycle having at least one first and a second potential. The method comprises applying a first potential to initiate an accumulation phase that forces the accumulation of a mediator concentration gradient at or near the working electrode with a concentration that decreases toward the solution volume, applying a second potential. to initiate a measurement phase and exhaust the mediator concentration gradient established on the working electrode, the measurement of the current associated with the second potential of each cycle, and the use of the measured current to determine the analyte concentration. In this way, the effects of diff - diffusion interfering factors, especially hematocrit (hct), can be mitigated.

BR112017000305A 2014-07-08 2015-07-08 analyte concentration measurement BR112017000305A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1412156.0A GB201412156D0 (en) 2014-07-08 2014-07-08 Analyte concentration measurement
PCT/GB2015/051973 WO2016005743A1 (en) 2014-07-08 2015-07-08 Analyte concentration measurement

Publications (1)

Publication Number Publication Date
BR112017000305A2 true BR112017000305A2 (en) 2017-10-31

Family

ID=51410820

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017000305A BR112017000305A2 (en) 2014-07-08 2015-07-08 analyte concentration measurement

Country Status (10)

Country Link
EP (1) EP3167282A1 (en)
JP (1) JP6619367B2 (en)
KR (1) KR20170028408A (en)
CN (1) CN106687803A (en)
AU (1) AU2015287447A1 (en)
BR (1) BR112017000305A2 (en)
CA (1) CA2953452A1 (en)
GB (1) GB201412156D0 (en)
RU (1) RU2680266C2 (en)
WO (1) WO2016005743A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6978408B2 (en) 2015-08-25 2021-12-08 アバイルズ メディカル，インコーポレイテッド Devices, systems and methods for detecting live microorganisms in fluid samples
EP3464551A4 (en) 2016-05-31 2020-04-15 Avails Medical, Inc. Detecting viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
US20180306744A1 (en) * 2017-04-20 2018-10-25 Lifescan Scotland Limited Analyte measurement system and method
WO2019005296A1 (en) 2017-06-27 2019-01-03 Avails Medical, Inc. Apparatus, systems, and methods for determining susceptibility of microorganisms to anti-infectives
WO2019070739A1 (en) * 2017-10-03 2019-04-11 Avails Medical, Inc. Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to anti-infectives based on redox reactions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7455975B2 (en) * 2000-04-14 2008-11-25 Esa Biosciences, Inc. Electrochemical detection of nucleic acid sequences
RU2267120C2 (en) * 2000-07-14 2005-12-27 Лайфскен, Инк. Electrochemical mode of measuring of speed of chemical reactions
GB0211449D0 (en) * 2002-05-17 2002-06-26 Oxford Biosensors Ltd Analyte measurement
WO2005073708A2 (en) * 2004-01-29 2005-08-11 Siemens Aktiengesellschaft Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device
WO2005114164A2 (en) * 2004-05-14 2005-12-01 Bayer Healthcare Llc Voltammetric systems for assaying biological analytes
US7749371B2 (en) * 2005-09-30 2010-07-06 Lifescan, Inc. Method and apparatus for rapid electrochemical analysis
EP2437056B1 (en) * 2006-10-05 2013-11-20 Lifescan Scotland Ltd Methods for determining the presence of a sufficient quantity of fluid sample on a test strip
US8603768B2 (en) * 2008-01-17 2013-12-10 Lifescan, Inc. System and method for measuring an analyte in a sample
KR101899307B1 (en) * 2010-07-19 2018-09-18 시락 게엠베하 인터내셔날 System and method for measuring an analyte in a sample
US9201038B2 (en) * 2012-07-24 2015-12-01 Lifescan Scotland Limited System and methods to account for interferents in a glucose biosensor
US9005426B2 (en) * 2012-09-28 2015-04-14 Cilag Gmbh International System and method for determining hematocrit insensitive glucose concentration
GB2515299B (en) * 2013-06-18 2015-12-30 Suresensors Ltd Methods and apparatus for determining analyte in a sample

Also Published As

Publication number Publication date
JP2017519990A (en) 2017-07-20
CN106687803A (en) 2017-05-17
CA2953452A1 (en) 2016-01-14
RU2017103730A3 (en) 2019-01-14
RU2017103730A (en) 2018-08-08
GB201412156D0 (en) 2014-08-20
EP3167282A1 (en) 2017-05-17
KR20170028408A (en) 2017-03-13
JP6619367B2 (en) 2019-12-11
WO2016005743A1 (en) 2016-01-14
RU2680266C2 (en) 2019-02-19
AU2015287447A1 (en) 2016-12-22

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements