BR112017000305A2 - analyte concentration measurement - Google Patents
analyte concentration measurementInfo
- Publication number
- BR112017000305A2 BR112017000305A2 BR112017000305A BR112017000305A BR112017000305A2 BR 112017000305 A2 BR112017000305 A2 BR 112017000305A2 BR 112017000305 A BR112017000305 A BR 112017000305A BR 112017000305 A BR112017000305 A BR 112017000305A BR 112017000305 A2 BR112017000305 A2 BR 112017000305A2
- Authority
- BR
- Brazil
- Prior art keywords
- potential
- mediator
- electrode
- analyte concentration
- cycle
- Prior art date
Links
- 239000012491 analyte Substances 0.000 title abstract 3
- 238000005259 measurement Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 238000009825 accumulation Methods 0.000 abstract 2
- 230000007423 decrease Effects 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000005534 hematocrit Methods 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
a presente invenção refere-se a um método de determinação de concentração de analito que utiliza uma reação de oxirredução em uma célula eletroquímica que tem pelo menos dois eletrodos, um dos quais é um eletrodo de trabalho, pelo menos um eletrodo sendo exposto a pelo menos um mediador de oxirredução. o método usa pelo menos um ciclo de pulsos, cada ciclo tendo pelo menos um primeiro e um segundo potencial. o método compreende a aplicação de um primeiro potencial para iniciar uma fase de acumulação que força a acumulação de um gradiente de concentração de mediador no ou próximo ao eletrodo de trabalho com uma concentração que diminui em direção ao volume da solução, aplicação de um segundo potencial para iniciar uma fase de medição e esgotar o gradiente de concentração de mediador estabelecido no eletrodo de trabalho, a medição da corrente associada ao segundo potencial de cada ciclo, e o uso da corrente medida para determinar a concentração de analito. desta forma, os efeitos de fatores que interferem na difusão (dif - diffusion interfering factors), especialmente hematócrito (hct), podem ser mitigados.The present invention relates to an analyte concentration determination method utilizing an oxeduction reaction in an electrochemical cell having at least two electrodes, one of which is a working electrode, at least one electrode being exposed to at least one electrode. an oxireduction mediator. The method uses at least one pulse cycle, each cycle having at least one first and a second potential. The method comprises applying a first potential to initiate an accumulation phase that forces the accumulation of a mediator concentration gradient at or near the working electrode with a concentration that decreases toward the solution volume, applying a second potential. to initiate a measurement phase and exhaust the mediator concentration gradient established on the working electrode, the measurement of the current associated with the second potential of each cycle, and the use of the measured current to determine the analyte concentration. In this way, the effects of diff - diffusion interfering factors, especially hematocrit (hct), can be mitigated.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1412156.0A GB201412156D0 (en) | 2014-07-08 | 2014-07-08 | Analyte concentration measurement |
PCT/GB2015/051973 WO2016005743A1 (en) | 2014-07-08 | 2015-07-08 | Analyte concentration measurement |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017000305A2 true BR112017000305A2 (en) | 2017-10-31 |
Family
ID=51410820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017000305A BR112017000305A2 (en) | 2014-07-08 | 2015-07-08 | analyte concentration measurement |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP3167282A1 (en) |
JP (1) | JP6619367B2 (en) |
KR (1) | KR20170028408A (en) |
CN (1) | CN106687803A (en) |
AU (1) | AU2015287447A1 (en) |
BR (1) | BR112017000305A2 (en) |
CA (1) | CA2953452A1 (en) |
GB (1) | GB201412156D0 (en) |
RU (1) | RU2680266C2 (en) |
WO (1) | WO2016005743A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4368991A2 (en) | 2015-08-25 | 2024-05-15 | Avails Medical, Inc. | Devices, systems and methods for detecting viable microorganisms in a fluid sample |
WO2017209839A1 (en) | 2016-05-31 | 2017-12-07 | Avails Medical, Inc. | Detecting viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives |
US20180306744A1 (en) * | 2017-04-20 | 2018-10-25 | Lifescan Scotland Limited | Analyte measurement system and method |
WO2019005296A1 (en) | 2017-06-27 | 2019-01-03 | Avails Medical, Inc. | Apparatus, systems, and methods for determining susceptibility of microorganisms to anti-infectives |
JP7209701B2 (en) | 2017-10-03 | 2023-01-20 | アベイルズ メディカル,インコーポレイテッド | Apparatus, system, and method for determining microbial concentration and susceptibility to anti-infectives based on redox reactions |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7455975B2 (en) * | 2000-04-14 | 2008-11-25 | Esa Biosciences, Inc. | Electrochemical detection of nucleic acid sequences |
RU2267120C2 (en) * | 2000-07-14 | 2005-12-27 | Лайфскен, Инк. | Electrochemical mode of measuring of speed of chemical reactions |
GB0211449D0 (en) * | 2002-05-17 | 2002-06-26 | Oxford Biosensors Ltd | Analyte measurement |
US8105478B2 (en) * | 2004-01-29 | 2012-01-31 | Siemens Aktiengesellschaft | Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device |
MXPA06013232A (en) * | 2004-05-14 | 2007-02-28 | Bayer Healthcare Llc | Voltammetric systems for assaying biological analytes. |
US7749371B2 (en) * | 2005-09-30 | 2010-07-06 | Lifescan, Inc. | Method and apparatus for rapid electrochemical analysis |
EP2437056B1 (en) * | 2006-10-05 | 2013-11-20 | Lifescan Scotland Ltd | Methods for determining the presence of a sufficient quantity of fluid sample on a test strip |
US8603768B2 (en) * | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
AU2011279872B2 (en) * | 2010-07-19 | 2015-10-08 | Cilag Gmbh International | System and method for measuring an analyte in a sample |
US9201038B2 (en) * | 2012-07-24 | 2015-12-01 | Lifescan Scotland Limited | System and methods to account for interferents in a glucose biosensor |
US9005426B2 (en) * | 2012-09-28 | 2015-04-14 | Cilag Gmbh International | System and method for determining hematocrit insensitive glucose concentration |
GB2515299B (en) * | 2013-06-18 | 2015-12-30 | Suresensors Ltd | Methods and apparatus for determining analyte in a sample |
-
2014
- 2014-07-08 GB GBGB1412156.0A patent/GB201412156D0/en not_active Ceased
-
2015
- 2015-07-08 EP EP15747510.4A patent/EP3167282A1/en not_active Withdrawn
- 2015-07-08 BR BR112017000305A patent/BR112017000305A2/en not_active Application Discontinuation
- 2015-07-08 CN CN201580037065.6A patent/CN106687803A/en active Pending
- 2015-07-08 RU RU2017103730A patent/RU2680266C2/en not_active IP Right Cessation
- 2015-07-08 CA CA2953452A patent/CA2953452A1/en not_active Abandoned
- 2015-07-08 JP JP2016573879A patent/JP6619367B2/en not_active Expired - Fee Related
- 2015-07-08 KR KR1020177003207A patent/KR20170028408A/en unknown
- 2015-07-08 AU AU2015287447A patent/AU2015287447A1/en not_active Abandoned
- 2015-07-08 WO PCT/GB2015/051973 patent/WO2016005743A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP6619367B2 (en) | 2019-12-11 |
AU2015287447A1 (en) | 2016-12-22 |
RU2017103730A (en) | 2018-08-08 |
EP3167282A1 (en) | 2017-05-17 |
GB201412156D0 (en) | 2014-08-20 |
CA2953452A1 (en) | 2016-01-14 |
JP2017519990A (en) | 2017-07-20 |
RU2017103730A3 (en) | 2019-01-14 |
KR20170028408A (en) | 2017-03-13 |
CN106687803A (en) | 2017-05-17 |
RU2680266C2 (en) | 2019-02-19 |
WO2016005743A1 (en) | 2016-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |