BR112016021298A2 - COMPOSITIONS AND METHODS FOR PRODUCING CHEMICAL PRODUCTS AND DERIVATIVES THEREOF - Google Patents

COMPOSITIONS AND METHODS FOR PRODUCING CHEMICAL PRODUCTS AND DERIVATIVES THEREOF

Info

Publication number
BR112016021298A2
BR112016021298A2 BR112016021298A BR112016021298A BR112016021298A2 BR 112016021298 A2 BR112016021298 A2 BR 112016021298A2 BR 112016021298 A BR112016021298 A BR 112016021298A BR 112016021298 A BR112016021298 A BR 112016021298A BR 112016021298 A2 BR112016021298 A2 BR 112016021298A2
Authority
BR
Brazil
Prior art keywords
methods
acid
enzymatic
enzymatic conversion
conversion
Prior art date
Application number
BR112016021298A
Other languages
Portuguese (pt)
Inventor
Kambourakis Spiros
M Griffin Benjamin
V Martin Kevin
Original Assignee
Synthetic Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/222,453 external-priority patent/US9528133B2/en
Application filed by Synthetic Genomics Inc filed Critical Synthetic Genomics Inc
Publication of BR112016021298A2 publication Critical patent/BR112016021298A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPOSIÇÕES E MÉTODOS PARA PRODUZIR PRODUTOS QUÍMICOS E DERIVADOS DOS MESMOS. A presente invenção fornece métodos para produzir um produto de uma ou mais vias enzimáticas. As vias usadas nos métodos da invenção envolvem uma ou mais etapas de conversão, tais como, por exemplo, uma conversão enzimática de ácido gulurônico em D-glucarato (Etapa 7); uma conversão enzimática de 5-cetogluconato (5-KGA) em ácido L-idurônico (Etapa 15); uma conversão enzimática de ácido L-idurônico em ácido idárico (Etapa 7b); e uma conversão enzimática de 5-cetogluconato em 4,6-di-hidróxi 2,5-diceto hexanoato (2,5-DDH) (Etapa 16). Em algumas modalidades, os métodos da invenção produzem ácido 2,5-furandicarboxílico (FDCA) como um produto. Os métodos incluem tanto conversões enzimáticas como químicas como etapas. Várias vias também são fornecidas para converter glicose em 5-desidro-4-desoxi-glucarato (DDG), e para converter glicose em ácido 2,5-furandicarboxílico (FDCA). Os métodos também envolvem o uso de enzimas geneticamente modificadas que realizam reações com alta especificidade e eficiência. Os produtos adicionais que podem ser produzidos incluem produtos metabólicos, tais como, porém, sem limitação, ácido gulurônico, ácido L-idurônico, ácido idárico, ácido glucárico. Qualquer um dos produtos pode ser produzido com o uso de glicose como um substrato ou com o uso de qualquer intermediário em qualquer um dos métodos ou vias da invenção.COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF. The present invention provides methods for producing a product from one or more enzymatic pathways. Routes used in the methods of the invention involve one or more conversion steps, such as, for example, an enzymatic conversion of guluronic acid to D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) to L-iduronic acid (Step 15); an enzymatic conversion of L-iduronic acid to idaric acid (Step 7b); and an enzymatic conversion of 5-ketogluconate to 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments, methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Several pathways are also provided for converting glucose to 5-dehydro-4-deoxyglucarate (DDG), and for converting glucose to 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of genetically modified enzymes that carry out reactions with high specificity and efficiency. Additional products that can be produced include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or routes of the invention.

BR112016021298A 2014-03-21 2015-03-20 COMPOSITIONS AND METHODS FOR PRODUCING CHEMICAL PRODUCTS AND DERIVATIVES THEREOF BR112016021298A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/222,453 US9528133B2 (en) 2012-09-21 2014-03-21 Compositions and methods for producing chemicals and derivatives thereof
PCT/US2015/021848 WO2015143381A2 (en) 2014-03-21 2015-03-20 Compositions and methods for producing chemicals and derivatives thereof

Publications (1)

Publication Number Publication Date
BR112016021298A2 true BR112016021298A2 (en) 2017-10-03

Family

ID=54145486

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016021298A BR112016021298A2 (en) 2014-03-21 2015-03-20 COMPOSITIONS AND METHODS FOR PRODUCING CHEMICAL PRODUCTS AND DERIVATIVES THEREOF

Country Status (7)

Country Link
EP (1) EP3119899A4 (en)
CN (1) CN106414753A (en)
AU (1) AU2015231000B2 (en)
BR (1) BR112016021298A2 (en)
CA (1) CA2943348A1 (en)
SG (1) SG11201607745WA (en)
WO (1) WO2015143381A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10927363B2 (en) 2016-04-04 2021-02-23 Mie University DNA sequence and expression vector for alginate lyase
CN107954959A (en) * 2017-11-22 2018-04-24 南京工业大学 A kind of method for preparing 2,5- furandicarboxylic acids and its precursor substance
CN109824630B (en) * 2019-03-13 2020-08-04 浙江大学 Method for preparing furfuryl alcohol by one-pot xylose method under hydrogen supply of formic acid
BR112021024209A2 (en) * 2019-07-11 2022-01-18 Bp Corp North America Inc Gluconate dehydratase enzymes and recombinant cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184479A (en) * 1965-05-18 Process for the preparation of
JP2850515B2 (en) * 1990-09-25 1999-01-27 東洋紡績株式会社 Glucose dehydrogenase and method for producing the same
ATE528388T1 (en) * 2007-05-08 2011-10-15 Ensuiko Sugar Refining METHOD FOR PRODUCING GLUCURONIC ACID BY FERMENTING GLUCURONIC ACID
DK2274417T3 (en) * 2008-04-04 2013-10-28 Massachusetts Inst Technology Cellular production of glucuric acid
EP2279248B1 (en) * 2008-04-30 2015-04-01 DuPont Nutrition Biosciences ApS Proteins
FI20086236A0 (en) * 2008-12-23 2008-12-23 Valtion Teknillinen Conversion of hexuronic acid to hexaric acid
US8363666B2 (en) * 2010-02-22 2013-01-29 Cisco Technology, Inc. Multiple network architecture providing for migration of devices
CA2869649C (en) * 2012-04-04 2019-01-29 Stichting Dienst Landbouwkundig Onderzoek Catalytic oxidation of uronic acids to aldaric acids
CN105026548B (en) * 2012-06-04 2019-06-18 盐水港精糖株式会社 D-Glucose diacid produces the manufacturing method of bacterium and D-Glucose diacid
WO2014047510A1 (en) * 2012-09-21 2014-03-27 Synthetic Genomics, Inc. Compositions and methods for producing chemicals and derivatives thereof

Also Published As

Publication number Publication date
EP3119899A2 (en) 2017-01-25
CN106414753A (en) 2017-02-15
EP3119899A4 (en) 2017-11-29
CA2943348A1 (en) 2015-09-24
AU2015231000B2 (en) 2017-10-26
SG11201607745WA (en) 2016-11-29
AU2015231000A1 (en) 2016-10-13
WO2015143381A3 (en) 2015-11-12
WO2015143381A2 (en) 2015-09-24

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]