BR112014028431A2 - nano-powder of organic compound, method to produce the same and suspension - Google Patents
nano-powder of organic compound, method to produce the same and suspensionInfo
- Publication number
- BR112014028431A2 BR112014028431A2 BR112014028431A BR112014028431A BR112014028431A2 BR 112014028431 A2 BR112014028431 A2 BR 112014028431A2 BR 112014028431 A BR112014028431 A BR 112014028431A BR 112014028431 A BR112014028431 A BR 112014028431A BR 112014028431 A2 BR112014028431 A2 BR 112014028431A2
- Authority
- BR
- Brazil
- Prior art keywords
- nano
- suspension
- powder
- produce
- same
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
- B02C17/18—Details
- B02C17/20—Disintegrating members
- B02C17/205—Adding disintegrating members to the tumbling mill
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/06—Selection or use of additives to aid disintegrating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/18—Adding fluid, other than for crushing or disintegrating by fluid energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Saccharide Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012-108972 | 2012-05-11 | ||
JP2012108972 | 2012-05-11 | ||
PCT/JP2013/003023 WO2013168437A1 (en) | 2012-05-11 | 2013-05-11 | Organic compound nanopowder, production method therefor, and suspension |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014028431A2 true BR112014028431A2 (en) | 2017-06-27 |
BR112014028431B1 BR112014028431B1 (en) | 2022-01-11 |
Family
ID=49550500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014028431-8A BR112014028431B1 (en) | 2012-05-11 | 2013-05-11 | ORGANIC COMPOUND NANOPOWDER, METHOD TO PRODUCE THE SAME AND SUSPENSION |
Country Status (17)
Country | Link |
---|---|
US (1) | US9278071B2 (en) |
EP (1) | EP2848243B1 (en) |
JP (1) | JP6054380B2 (en) |
KR (1) | KR101772263B1 (en) |
CN (1) | CN104203217B (en) |
AU (1) | AU2013259150B2 (en) |
BR (1) | BR112014028431B1 (en) |
CA (1) | CA2867236C (en) |
ES (1) | ES2952419T3 (en) |
IL (1) | IL234327B (en) |
IN (1) | IN2014MN02002A (en) |
MX (1) | MX341663B (en) |
PL (1) | PL2848243T3 (en) |
PT (1) | PT2848243T (en) |
RU (1) | RU2613109C2 (en) |
TW (1) | TWI579004B (en) |
WO (1) | WO2013168437A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105658203B (en) * | 2013-11-08 | 2021-03-16 | 株式会社活效制药 | Aqueous suspension of nanoparticles containing macrolide antibacterial agents |
RS62381B1 (en) | 2014-02-03 | 2021-10-29 | Apurano Pharmaceuticals Gmbh | Nanosuspension of natural materials and preparation method thereof |
US20170014352A1 (en) * | 2014-03-10 | 2017-01-19 | The University Of Tokyo | Water-dispersible amorphous particles and method for preparing same |
ES2966595T3 (en) * | 2015-01-26 | 2024-04-23 | Bausch & Lomb | Ophthalmic suspension composition |
TWI773641B (en) * | 2015-05-08 | 2022-08-11 | 日商活效製藥股份有限公司 | Aqueous suspension containing nano particles of glucocorticoids |
JP6612081B2 (en) * | 2015-07-31 | 2019-11-27 | 東洋精糖株式会社 | Method for producing α-glucosylrutin-containing pteridine derivative nanoparticles and α-glucosylrutin-containing pteridine derivative nanoparticles |
WO2017021491A1 (en) * | 2015-08-04 | 2017-02-09 | Apurano Life Sciences Gmbh | Nanosuspension containing particles and extract of natural materials |
CZ307916B6 (en) * | 2017-05-08 | 2019-08-21 | mcePharma s. r. o. | Orodispersible tablet with bioavailable curcumin and its use |
CN111253498B (en) * | 2020-03-10 | 2021-11-09 | 中国科学院海洋研究所 | Preparation of brown algae polysaccharide derivative nano micelle |
SI3962455T1 (en) | 2020-05-18 | 2022-11-30 | Orexo Ab | New pharmaceutical composition for drug delivery |
CN113209031A (en) * | 2021-04-30 | 2021-08-06 | 青岛农业大学 | Double-targeting composite nano system loaded with amphotericin B and beta-1, 3-glucanase, preparation method and application thereof |
CN113620937A (en) * | 2021-08-03 | 2021-11-09 | 湖南复瑞生物医药技术有限责任公司 | Preparation method of high-purity pranlukast with small particle size |
EP4236921A1 (en) | 2021-11-25 | 2023-09-06 | Orexo AB | Pharmaceutical composition comprising adrenaline |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US7939105B2 (en) | 1998-11-20 | 2011-05-10 | Jagotec Ag | Process for preparing a rapidly dispersing solid drug dosage form |
ES2325057T3 (en) * | 2000-08-31 | 2009-08-25 | Jagotec Ag | MOLDED PARTICLES. |
JP2006089386A (en) | 2004-09-21 | 2006-04-06 | Nippon Tenganyaku Kenkyusho:Kk | Suspension medicine composition containing steroid or steroid derivative |
US20100003332A1 (en) * | 2006-07-27 | 2010-01-07 | Amorepacific Corporation | Process For Preparing Powder Comprising Nanoparticles of Sparingly Soluble Drug |
TWI405590B (en) * | 2007-04-06 | 2013-08-21 | Activus Pharma Co Ltd | Method of producing pulverized organic compound particle |
PT2345426E (en) | 2008-09-19 | 2014-06-09 | Activus Pharma Co Ltd | Composite organic compound powder for medical use, method for producing same and suspension of same |
EP2551237A4 (en) * | 2010-03-22 | 2014-01-22 | Bio Synectics Inc | Method for preparing nano-particles |
-
2013
- 2013-05-11 ES ES13787260T patent/ES2952419T3/en active Active
- 2013-05-11 PT PT137872602T patent/PT2848243T/en unknown
- 2013-05-11 AU AU2013259150A patent/AU2013259150B2/en active Active
- 2013-05-11 IN IN2002MUN2014 patent/IN2014MN02002A/en unknown
- 2013-05-11 EP EP13787260.2A patent/EP2848243B1/en active Active
- 2013-05-11 CA CA2867236A patent/CA2867236C/en active Active
- 2013-05-11 JP JP2014514390A patent/JP6054380B2/en active Active
- 2013-05-11 MX MX2014010772A patent/MX341663B/en active IP Right Grant
- 2013-05-11 KR KR1020147022644A patent/KR101772263B1/en active IP Right Grant
- 2013-05-11 WO PCT/JP2013/003023 patent/WO2013168437A1/en active Application Filing
- 2013-05-11 PL PL13787260.2T patent/PL2848243T3/en unknown
- 2013-05-11 US US14/001,645 patent/US9278071B2/en active Active
- 2013-05-11 BR BR112014028431-8A patent/BR112014028431B1/en active IP Right Grant
- 2013-05-11 CN CN201380017953.2A patent/CN104203217B/en active Active
- 2013-05-11 RU RU2014148792A patent/RU2613109C2/en active
- 2013-05-13 TW TW102116820A patent/TWI579004B/en active
-
2014
- 2014-08-27 IL IL234327A patent/IL234327B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2867236C (en) | 2017-02-28 |
EP2848243B1 (en) | 2023-07-12 |
PL2848243T3 (en) | 2024-04-08 |
KR20150008376A (en) | 2015-01-22 |
ES2952419T3 (en) | 2023-10-31 |
MX341663B (en) | 2016-08-30 |
US9278071B2 (en) | 2016-03-08 |
IN2014MN02002A (en) | 2015-08-07 |
US20140328917A1 (en) | 2014-11-06 |
WO2013168437A1 (en) | 2013-11-14 |
TW201400142A (en) | 2014-01-01 |
BR112014028431B1 (en) | 2022-01-11 |
CN104203217A (en) | 2014-12-10 |
KR101772263B1 (en) | 2017-08-28 |
CN104203217B (en) | 2017-02-15 |
MX2014010772A (en) | 2014-10-14 |
AU2013259150A1 (en) | 2014-08-28 |
JPWO2013168437A1 (en) | 2016-01-07 |
RU2014148792A (en) | 2016-06-27 |
EP2848243A4 (en) | 2015-12-23 |
CA2867236A1 (en) | 2013-11-14 |
JP6054380B2 (en) | 2016-12-27 |
PT2848243T (en) | 2023-08-02 |
IL234327B (en) | 2018-06-28 |
TWI579004B (en) | 2017-04-21 |
AU2013259150B2 (en) | 2016-07-14 |
RU2613109C2 (en) | 2017-03-15 |
EP2848243A1 (en) | 2015-03-18 |
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UA28835S (en) | BOLT |
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