BR112013018738A2 - novos derivados de tetrahidroquinolina - Google Patents
novos derivados de tetrahidroquinolinaInfo
- Publication number
- BR112013018738A2 BR112013018738A2 BR112013018738A BR112013018738A BR112013018738A2 BR 112013018738 A2 BR112013018738 A2 BR 112013018738A2 BR 112013018738 A BR112013018738 A BR 112013018738A BR 112013018738 A BR112013018738 A BR 112013018738A BR 112013018738 A2 BR112013018738 A2 BR 112013018738A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydroquinoline derivatives
- new
- new tetrahydroquinoline
- derivatives
- hyperglycemia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
novos derivados de tetrahidroquinolina um composto da fórmula (i) ou um sal farmaceuticamente aceitável ou éster do mesmo, em que r^ 1^ a r^ 8^, a^ 1^ a a^ 3^ apresentam o significado fornecido na reivindicação 1, podendo ser empregado como um modulador de ampk para o tratamento de obesidade, hiperglicemia ou diabetes tipo 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011070644 | 2011-01-26 | ||
PCT/EP2012/050922 WO2012101068A1 (en) | 2011-01-26 | 2012-01-23 | Novel tetrahydroquinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013018738A2 true BR112013018738A2 (pt) | 2016-10-25 |
Family
ID=45498008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013018738A BR112013018738A2 (pt) | 2011-01-26 | 2012-01-23 | novos derivados de tetrahidroquinolina |
Country Status (8)
Country | Link |
---|---|
US (1) | US8809369B2 (pt) |
EP (1) | EP2668165A1 (pt) |
JP (1) | JP2014503569A (pt) |
BR (1) | BR112013018738A2 (pt) |
CA (1) | CA2823804A1 (pt) |
MX (1) | MX2013008256A (pt) |
RU (1) | RU2013137112A (pt) |
WO (1) | WO2012101068A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
CN104418801B (zh) * | 2013-08-19 | 2016-10-05 | 上海润诺生物科技有限公司 | 苯并哌啶环与苯并吗啉环类化合物、其制法及医药应用 |
KR20230012597A (ko) | 2020-05-19 | 2023-01-26 | 칼리오페, 인크. | Ampk 활성화제 |
AU2021297323A1 (en) | 2020-06-26 | 2023-02-16 | Kallyope, Inc. | AMPK activators |
WO2024084390A1 (en) * | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Compounds for the activation of ampk |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138412B2 (en) * | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
UA106037C2 (uk) | 2008-02-04 | 2014-07-25 | Мерк'Юрі Терап'Ютікс, Інк. | Модулятори ampk (амф-активованої протеїнкінази) |
US8344137B2 (en) * | 2010-04-14 | 2013-01-01 | Hoffman-La Roche Inc. | 3,3-dimethyl tetrahydroquinoline derivatives |
-
2012
- 2012-01-19 US US13/353,351 patent/US8809369B2/en not_active Expired - Fee Related
- 2012-01-23 MX MX2013008256A patent/MX2013008256A/es active IP Right Grant
- 2012-01-23 CA CA2823804A patent/CA2823804A1/en not_active Abandoned
- 2012-01-23 BR BR112013018738A patent/BR112013018738A2/pt not_active IP Right Cessation
- 2012-01-23 RU RU2013137112/04A patent/RU2013137112A/ru not_active Application Discontinuation
- 2012-01-23 JP JP2013550842A patent/JP2014503569A/ja active Pending
- 2012-01-23 WO PCT/EP2012/050922 patent/WO2012101068A1/en active Application Filing
- 2012-01-23 EP EP12700504.9A patent/EP2668165A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2014503569A (ja) | 2014-02-13 |
US8809369B2 (en) | 2014-08-19 |
US20120190677A1 (en) | 2012-07-26 |
CA2823804A1 (en) | 2012-08-02 |
EP2668165A1 (en) | 2013-12-04 |
WO2012101068A1 (en) | 2012-08-02 |
MX2013008256A (es) | 2013-08-12 |
RU2013137112A (ru) | 2015-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |