BR112013008772A2 - antimicrobial protein - Google Patents

antimicrobial protein Download PDF

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Publication number
BR112013008772A2
BR112013008772A2 BR112013008772-2A BR112013008772A BR112013008772A2 BR 112013008772 A2 BR112013008772 A2 BR 112013008772A2 BR 112013008772 A BR112013008772 A BR 112013008772A BR 112013008772 A2 BR112013008772 A2 BR 112013008772A2
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Brazil
Prior art keywords
use according
human
composition
seq
animal
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BR112013008772-2A
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Portuguese (pt)
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Alexandra Manuela Lourenço Carreira
Sara Alexandra Valadas da Silva Monteiro
Ricardo Manuel De Seixas Boavida FERREIRA
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Consumo Em Verde - Biotecnologia Das Plantas, S.A.
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Priority claimed from PT10533010A external-priority patent/PT105330A/en
Priority claimed from GB1017284.9A external-priority patent/GB2484509A/en
Application filed by Consumo Em Verde - Biotecnologia Das Plantas, S.A. filed Critical Consumo Em Verde - Biotecnologia Das Plantas, S.A.
Publication of BR112013008772A2 publication Critical patent/BR112013008772A2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/34635—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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Abstract

USOS DE UMA COMPOSIÇÃO QUE COMPREENDE UM PEPTÍDEO ANTIMICROBIANO E MÉTODO PARA MATAR OU INIBIR O CRESCIMENTO DE UM MICRO-ORGANISMO PATOGÊNICO. A presente invenção refere-se ao uso de uma composição compreendendo um polipeptídeo antimicrobiano compreendendo o Blad ou uma variante ativa da mesma, na fabricação de um medicamento para o tratamento ou prevenção de uma infecção em, ou sobre, um paciente por um micro-organismo. Também é proporcionado o uso de um a composição compreendendo um polipeptídeo antimicrobiano compreendendo o Blad ou uma variante ativa do mesmo para matar, ou inibir o crescimento de, um micro-organismo que é patogênico para um ser humano ou um animal em um local que não é sobre o, ou no, corpo humano ou animal, bem como um método de matar, ou inibir o crescimento de, um micro-organismo que é patogênico para um ser humano ou um animal em um local que não é sobre o, ou no, corpo humano ou animal.USES OF A COMPOSITION COMPRISING AN ANTIMICROBIAL PEPTIDE AND METHOD TO KILL OR INHIBIT THE GROWTH OF A PATHOGENIC MICROORGANISM. The present invention relates to the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof, in the manufacture of a medicament for the treatment or prevention of an infection in or on a patient by a microorganism . Also provided is the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to kill, or inhibit the growth of, a microorganism that is pathogenic to a human or an animal in a non-local location. is about the, or in, human or animal body, as well as a method of killing, or inhibiting the growth of, a micro-organism that is pathogenic to a human or animal in a location that is not on, or in the , human or animal body.

Description

Relatório Descritivo da Patente de Invenção para "USOS DE UMA COMPOSIÇÃO QUE COMPREENDE UM PEPTÍDEO ANTIMICROBI- ANO E MÉTODO PARA MATAR OU INIBIR O CRESCIMENTO DE UM MI- CRO-ORGANISMO PATOGÊNICO". 5 Campo da Invenção A presente invenção refere-se ao campo dos agentes antimicro- bianos, e especialmente àqueles que alvejam patógenos humanos/animais.Patent Descriptive Report for "USES OF A COMPOSITION COMPRISING AN ANTIMICROBIAL PEPTIDE AND METHOD TO KILL OR INHIBIT THE GROWTH OF A PATHOGENIC MICROORGANISM". Field of the Invention The present invention relates to the field of antimicrobial agents, and especially those that target human/animal pathogens.

Introdução Infecções bacterianas As bactérias são, sem dúvida, os agentes etiológicos mais co- muns da infecção humana.Introduction Bacterial infections Bacteria are, without a doubt, the most common etiological agents of human infection.

Mais do que um terço da população do mundo é provavelmente infectado por patógenos bacterianos, e dois milhões de fata- lidades ocorrem por ano a partir de infecções bacterianas.More than a third of the world's population is likely infected with bacterial pathogens, and two million fatalities occur each year from bacterial infections.

De acordo com o Centro para o Controle de Doenças (CCD) e a Organização Mundial da Sa- úde (OMS), as seguintes infecções bacterianas estão incluídas na lista das doenças infecciosas mais comuns por todo o mundo, no momento atual: Cólera: esta é uma doença espalhada principalmente através de água potável contaminada e condições insalubres.According to the Centers for Disease Control (CCD) and the World Health Organization (WHO), the following bacterial infections are included in the list of the most common infectious diseases worldwide at the present time: Cholera: this it is a disease spread mainly through contaminated drinking water and unsanitary conditions.

Ela é endêmica no sub- continente africano, Rússia, e região africana ao sul do Deserto de Saara.It is endemic to the African sub-continent, Russia, and the African region south of the Sahara Desert.

Ela é uma infecção aguda do intestino com a bactéria Vibrio cholerae.It is an acute infection of the intestine with the bacteria Vibrio cholerae.

O sin- toma principal é a diarreia abundante.The main symptom is profuse diarrhea.

Entre 5% e 10% dos infectados com a doença desenvolverão sintomas graves, que incluem vômito e câimbras nas pernas.Between 5% and 10% of those infected with the disease will develop severe symptoms, which include vomiting and leg cramps.

Em sua forma grave, o cólera pode causar a morte por desidratação.In its severe form, cholera can cause death from dehydration.

São descritos uns 200.000 casos estimados pela OMS anualmente.Some 200,000 cases estimated by WHO are described annually.

Meningite: frequentemente conhecida como meningite espinhal, esta é uma infecção da medula espinhal.Meningitis: Often known as spinal meningitis, this is an infection of the spinal cord.

Ela é normalmente o resultado de uma infecção viral ou bacteriana.It is usually the result of a viral or bacterial infection.

A meningite bacteriana é mais grave do que a meningite viral e pode causar dano ao cérebro, perda de audição, e incapaci- dades de aprendizado.Bacterial meningitis is more serious than viral meningitis and can cause brain damage, hearing loss, and learning disabilities.

Ela pode ser causada, por exemplo, por Haemophilus influenzae tipo b, Neisseria meningitidis, ou Streptococcus pneumoniae. 1,2 milhão de casos estimados de meningite bacteriana ocorrem a cada ano, mais do que um décimo dos quais são fatais.It can be caused, for example, by Haemophilus influenzae type b, Neisseria meningitidis, or Streptococcus pneumoniae. An estimated 1.2 million cases of bacterial meningitis occur each year, more than a tenth of which are fatal.

Os sintomas incluem dor de cabeça grave, febre, náusea, vômito, letargia, delírio, fotofobia, e um pescoço rígido.Symptoms include severe headache, fever, nausea, vomiting, lethargy, delirium, photophobia, and a stiff neck.

Claims (14)

REIVINDICAÇÕES 1. Uso de uma composição compreendendo um polipeptídeo antimicrobiano compreendendo a sequência Blad mostrada na SEQ ID Nº: 4, ou uma variante ativa da mesma, caracterizado pelo fato de ser na fabrica- 5 ção de um medicamento para o tratamento ou prevenção de uma infecção em, ou sobre, um paciente por um micro-organismo, em que a dita variante ativa possui atividade antimicrobiana e compreende uma sequência que tem pelo menos 40% de identidade com a SEQ ID Nº: 4 ou com um fragmento da SEQ ID Nº: 4 que possui pelo menos 60 resíduos de aminoácidos de comprimento.1. Use of a composition comprising an antimicrobial polypeptide comprising the Blad sequence shown in SEQ ID NO: 4, or an active variant thereof, characterized in that it is in the manufacture of a medicament for the treatment or prevention of an infection in or on a patient by a microorganism, wherein said active variant has antimicrobial activity and comprises a sequence that has at least 40% identity with SEQ ID NO: 4 or with a fragment of SEQ ID NO: 4 which is at least 60 amino acid residues in length. 2. Uso de acordo com a reivindicação 1, caracterizado pelo fato de que a composição adicionalmente compreende um veículo ou diluente farmaceuticamente aceitável.2. Use according to claim 1, characterized in that the composition additionally comprises a pharmaceutically acceptable carrier or diluent. 3. Uso de acordo com a reivindicação 1 ou 2, caracterizado pelo fato de que a composição adicionalmente compreende um agente quelante.3. Use according to claim 1 or 2, characterized in that the composition additionally comprises a chelating agent. 4. Uso de acordo com qualquer uma das reivindicações 1 a 3, caracterizado pelo fato de que o sujeito tem um sistema imune comprometi- do ou está criticamente doente.4. Use according to any one of claims 1 to 3, characterized by the fact that the subject has a compromised immune system or is critically ill. 5. Uso de uma composição que compreende um polipeptídeo antimicrobiano compreendendo a sequência Blad mostrada na SEQ ID Nº: 4, ou uma variante ativa da mesma, caracterizado pelo fato de ser para matar, ou inibir o crescimento de, um micro-organismo que é patogênico para um ser humano ou um animal, em um local que não está sobre o, ou no, corpo humano ou animal, em que a dita variante ativa possui atividade antimicrobi- ana e compreende uma sequência que tem pelo menos 40% de identidade com a SEQ ID Nº: 4 ou com um fragmento da SEQ ID Nº: 4 que possui pelo menos 60 resíduos de aminoácidos de comprimento.5. Use of a composition comprising an antimicrobial polypeptide comprising the Blad sequence shown in SEQ ID NO: 4, or an active variant thereof, characterized in that it is for killing, or inhibiting the growth of, a microorganism that is pathogenic to a human or an animal, in a location that is not on, or in, the human or animal body, where said active variant has antimicrobial activity and comprises a sequence that has at least 40% identity with to SEQ ID NO:4 or with a fragment of SEQ ID NO:4 that is at least 60 amino acid residues in length. 6. Uso de acordo com a reivindicação 5, caracterizado pelo fato de que a dita composição é usada para desinfetar, em relação a um micro- organismo patogênico humano ou animal, um artigo que é para ser ingerido por, ou colocado diretamente sobre ou em, um ser humano ou animal, ou uma superfície que necessita da mesma.6. Use according to claim 5, characterized in that said composition is used to disinfect, in relation to a human or animal pathogenic microorganism, an article that is to be ingested by, or placed directly on or in , a human or animal, or a surface that needs it. 7. Uso de acordo com a reivindicação 6, caracterizado pelo fato de que o dito artigo é um gênero alimentício ou um dispositivo ou instrumen- to médico.7. Use according to claim 6, characterized in that said article is a foodstuff or a medical device or instrument. 8. Uso de acordo com a reivindicação 6, caracterizado pelo fato 5 de que a dita superfície está localizada dentro de um ambiente onde: (a) o exame médico, a diagnose ou o tratamento é para ocorrer; (b) um gênero alimentício é para ser preparado ou de outro modo manuseado ou armazenado; (c) a lavagem e/ou a sanitização pessoal é para ocorrer; e/ou (d) uma pessoa correndo o risco particular de (i) adquirir uma infecção por um micro-organismo; e/ou (ii) ser incapaz de remover uma infecção microbiana sem in- tervenção médica; está situada.8. Use according to claim 6, characterized in that said surface is located within an environment where: (a) medical examination, diagnosis or treatment is to take place; (b) a foodstuff is to be prepared or otherwise handled or stored; (c) personal washing and/or sanitizing is to take place; and/or (d) a person at particular risk of (i) acquiring an infection by a microorganism; and/or (ii) being unable to remove a microbial infection without medical intervention; is located. 9. Uso de acordo com qualquer uma das reivindicações 5 a 8, caracterizado pelo fato de que a dita composição adicionalmente compreen- de um agente quelante.9. Use according to any one of claims 5 to 8, characterized in that said composition additionally comprises a chelating agent. 10. Uso de acordo com qualquer uma das reivindicações 1 a 9, caracterizado pelo fato de que o micro-organismo é uma bactéria ou um fun- go.10. Use according to any one of claims 1 to 9, characterized in that the micro-organism is a bacterium or a fungus. 11. Uso de acordo com a reivindicação 10, caracterizado pelo fato de que a bactéria é uma espécie patogênica a partir de um dos seguin- tes gêneros: Pseudomonas, Listeria, Bacillus, Staphylococcus e Salmonella.11. Use according to claim 10, characterized in that the bacterium is a pathogenic species from one of the following genera: Pseudomonas, Listeria, Bacillus, Staphylococcus and Salmonella. 12. Uso de acordo com a reivindicação 10, caracterizado pelo fato de que o fungo é uma espécie patogênica a partir de um dos seguintes gêneros: Candida, Aspergillus, Alternaria, Fusarium, Cryptococcus e Tri- chosporon.12. Use according to claim 10, characterized in that the fungus is a pathogenic species from one of the following genera: Candida, Aspergillus, Alternaria, Fusarium, Cryptococcus and Trichosporon. 13. Uso de acordo com a reivindicação 12, caracterizado pelo fato de que o fungo pode causar infecção fúngica invasiva, preferivelmente Candida albicans, Aspergillus fumigatus ou Alternaria alternata.13. Use according to claim 12, characterized in that the fungus can cause invasive fungal infection, preferably Candida albicans, Aspergillus fumigatus or Alternaria alternata. 14. Método de matar, ou inibir o crescimento de, um micro- organismo que é patogênico para um ser humano ou um animal em um local que não é sobre o, ou no, corpo humano ou animal, o dito método caracteri- zado pelo fato de que compreende administrar ao dito local uma composição compreendendo uma quantidade efetiva de uma composição como definida na reivindicação 5.14. Method of killing, or inhibiting the growth of, a micro-organism that is pathogenic to a human or an animal in a location that is not on, or in, the human or animal body, said method characterized by fact that it comprises administering to said location a composition comprising an effective amount of a composition as defined in claim 5.
BR112013008772-2A 2010-10-12 2011-10-12 antimicrobial protein BR112013008772A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PT105330 2010-10-12
PT10533010A PT105330A (en) 2010-10-12 2010-10-12 ANTIMICROBIAL PROTEIN
GB1017284.9A GB2484509A (en) 2010-10-13 2010-10-13 Lupin beta-conglutin derived protein fragment Blad as an antimicrobial agent
GB1017284.9 2010-10-13
PCT/EP2011/067824 WO2012049215A1 (en) 2010-10-12 2011-10-12 Antimicrobial protein

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BR112013008772A2 true BR112013008772A2 (en) 2021-04-27

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US (3) US10421792B2 (en)
EP (1) EP2627201B1 (en)
JP (1) JP5934225B2 (en)
CN (2) CN110227145B (en)
AU (1) AU2011315525B2 (en)
BR (1) BR112013008772A2 (en)
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