BR112012018021A2 - anticoagulant antidotes. - Google Patents
anticoagulant antidotes.Info
- Publication number
- BR112012018021A2 BR112012018021A2 BR112012018021A BR112012018021A BR112012018021A2 BR 112012018021 A2 BR112012018021 A2 BR 112012018021A2 BR 112012018021 A BR112012018021 A BR 112012018021A BR 112012018021 A BR112012018021 A BR 112012018021A BR 112012018021 A2 BR112012018021 A2 BR 112012018021A2
- Authority
- BR
- Brazil
- Prior art keywords
- antidotes
- anticoagulant
- anticoagulant antidotes
- ancoagulants
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Abstract
antídotos anticoagulantes. a presente invenção refere-se a moléculas de anticorpo contra anticoagulantes, em particular dabigatrano, e seu uso como antídotos de tais antcoagulantes.anticoagulant antidotes. The present invention relates to anticoagulant antibody molecules, in particular dabigatran, and their use as antidotes to such ancoagulants.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10151239 | 2010-01-20 | ||
EP10151239.0 | 2010-01-20 | ||
US38391410P | 2010-09-17 | 2010-09-17 | |
US61/383,914 | 2010-09-17 | ||
PCT/EP2011/050749 WO2011089183A2 (en) | 2010-01-20 | 2011-01-20 | Anticoagulant antidotes |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012018021A2 true BR112012018021A2 (en) | 2017-06-20 |
BR112012018021B1 BR112012018021B1 (en) | 2020-12-08 |
Family
ID=42061991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012018021-5A BR112012018021B1 (en) | 2010-01-20 | 2011-01-20 | antibody molecule capable of neutralizing dabigatran activity and its manufacturing method |
Country Status (43)
Families Citing this family (23)
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AR079944A1 (en) * | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | NEUTRALIZING ANTIBODY OF THE ACTIVITY OF AN ANTICOAGULANT |
WO2012097313A2 (en) | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
CA2824885A1 (en) * | 2011-01-19 | 2012-07-26 | Bayer Intellectual Property Gmbh | Binding proteins to inhibitors of coagulation factors |
MA34978B1 (en) * | 2011-03-30 | 2014-03-01 | Boehringer Ingelheim Int | ANTIDOTES FOR ANTICOAGULANTS |
DK2785700T3 (en) | 2011-11-29 | 2016-06-13 | Perosphere Inc | Agent for preventing the action of anti-coagulants. |
CA2916421A1 (en) | 2013-03-14 | 2014-09-25 | Bayer Healthcare Llc | Monoclonal antibodies against antithrombin beta complexed with heparin |
JP2016539926A (en) * | 2013-10-25 | 2016-12-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Anticoagulant antidote |
TW201623331A (en) * | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | Anti-MCAM antibodies and associated methods of use |
CN105223348A (en) * | 2014-05-26 | 2016-01-06 | 北京九强生物技术股份有限公司 | The latex enhancing immune turbidimetry detection kit of people's Antithrombin III |
EP2980218A1 (en) * | 2014-07-30 | 2016-02-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamer thrombin complex for use as an antidote to direct acting thrombin inhibitors |
JP6776221B2 (en) * | 2014-07-31 | 2020-10-28 | ヘモネティクス・コーポレーションHaemonetics Corporation | Detection and classification of anticoagulants using coagulation analysis |
US10300154B2 (en) | 2014-09-17 | 2019-05-28 | David R Elmaleh | Anticoagulant derivatives for cardiovascular imaging |
WO2016107605A1 (en) | 2014-12-31 | 2016-07-07 | 昆明积大制药股份有限公司 | Pharmaceutical composition and preparation method therefor |
US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
IL275453B1 (en) * | 2017-12-24 | 2024-02-01 | Noile Immune Biotech Inc | Immunocompetent cell that expresses a cell surface molecule specifically recognizing human mesothelin, il-7 and ccl19 |
TW202003034A (en) | 2018-03-13 | 2020-01-16 | 英商塔斯克療法有限公司 | Anti-CD25 antibody agents |
WO2019217705A1 (en) * | 2018-05-11 | 2019-11-14 | Proplex Technologies, LLC | Binding proteins and chimeric antigen receptor t cells targeting gasp-1 granules and uses thereof |
KR20210086682A (en) | 2018-10-29 | 2021-07-08 | 화하이 유에스 인코퍼레이티드 | Novel dipeptide compounds and uses thereof |
US20220175748A1 (en) | 2019-03-06 | 2022-06-09 | University Of Rochester | Anticoagulant compositions and uses thereof |
CN114306245A (en) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | Pharmaceutical composition of amorphous solid dispersion and preparation method thereof |
TW202321311A (en) * | 2021-08-02 | 2023-06-01 | 日商諾伊爾免疫生物科技股份有限公司 | Antibody binding to linker of scFv or like |
US11446286B1 (en) * | 2022-02-28 | 2022-09-20 | King Faisal University | Treatment of fungal infections using dabigatran etexilate |
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AR079944A1 (en) * | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | NEUTRALIZING ANTIBODY OF THE ACTIVITY OF AN ANTICOAGULANT |
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2011
- 2011-01-19 AR ARP110100179A patent/AR079944A1/en active IP Right Grant
- 2011-01-19 TW TW100102006A patent/TWI513466B/en active
- 2011-01-20 DK DK11703410.8T patent/DK2525812T3/en active
- 2011-01-20 PT PT117034108T patent/PT2525812T/en unknown
- 2011-01-20 EP EP16205771.5A patent/EP3195876A1/en not_active Withdrawn
- 2011-01-20 MY MYPI2012002840A patent/MY162323A/en unknown
- 2011-01-20 BR BR112012018021-5A patent/BR112012018021B1/en active IP Right Grant
- 2011-01-20 HU HUE11703410A patent/HUE032263T2/en unknown
- 2011-01-20 KR KR1020127019086A patent/KR101781787B1/en active IP Right Grant
- 2011-01-20 JP JP2012549355A patent/JP5575923B2/en active Active
- 2011-01-20 NZ NZ599508A patent/NZ599508A/en unknown
- 2011-01-20 MX MX2012008360A patent/MX2012008360A/en active IP Right Grant
- 2011-01-20 AU AU2011208719A patent/AU2011208719C1/en active Active
- 2011-01-20 LT LTEP11703410.8T patent/LT2525812T/en unknown
- 2011-01-20 WO PCT/EP2011/050749 patent/WO2011089183A2/en active Application Filing
- 2011-01-20 PL PL11703410T patent/PL2525812T3/en unknown
- 2011-01-20 GE GEAP201112836A patent/GEP20156341B/en unknown
- 2011-01-20 EA EA201201016A patent/EA028371B1/en active Protection Beyond IP Right Term
- 2011-01-20 SG SG2012052445A patent/SG182552A1/en unknown
- 2011-01-20 ES ES11703410.8T patent/ES2614992T3/en active Active
- 2011-01-20 MA MA35080A patent/MA33936B1/en unknown
- 2011-01-20 SI SI201131156A patent/SI2525812T1/en unknown
- 2011-01-20 UA UAA201209779A patent/UA110470C2/en unknown
- 2011-01-20 UY UY0001033196A patent/UY33196A/en active IP Right Grant
- 2011-01-20 ME MEP-2017-29A patent/ME02602B/en unknown
- 2011-01-20 CN CN201180006616.4A patent/CN102711813B/en active Active
- 2011-01-20 CA CA2787566A patent/CA2787566A1/en not_active Abandoned
- 2011-01-20 EP EP11703410.8A patent/EP2525812B1/en active Active
- 2011-01-20 US US13/010,403 patent/US8486398B2/en active Active
- 2011-01-20 RS RS20170195A patent/RS55683B1/en unknown
- 2011-01-20 AP AP2012006242A patent/AP2012006242A0/en unknown
- 2011-01-20 PE PE2012000997A patent/PE20121516A1/en active IP Right Grant
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2012
- 2012-04-19 ZA ZA2012/02876A patent/ZA201202876B/en unknown
- 2012-04-25 IL IL219427A patent/IL219427B/en active IP Right Grant
- 2012-07-18 TN TNP2012000366A patent/TN2012000366A1/en unknown
- 2012-07-23 CO CO12123109A patent/CO6571889A2/en active IP Right Grant
- 2012-08-14 EC ECSP12012105 patent/ECSP12012105A/en unknown
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2013
- 2013-01-23 HK HK13101025.2A patent/HK1173957A1/en unknown
- 2013-06-13 US US13/916,994 patent/US9034822B2/en active Active
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2014
- 2014-07-02 JP JP2014136811A patent/JP2014210794A/en active Pending
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2015
- 2015-04-13 US US14/684,576 patent/US20150210778A1/en not_active Abandoned
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2017
- 2017-03-22 CY CY20171100361T patent/CY1118875T1/en unknown
- 2017-04-14 HR HRP20170613TT patent/HRP20170613T1/en unknown
- 2017-07-06 NL NL300882C patent/NL300882I2/en unknown
- 2017-07-10 FR FR17C1026C patent/FR17C1026I2/en active Active
- 2017-07-10 LT LTPA2017021C patent/LTC2525812I2/en unknown
- 2017-07-10 CY CY2017025C patent/CY2017025I1/en unknown
- 2017-07-11 NO NO2017034C patent/NO2017034I1/en unknown
- 2017-07-12 LU LU00028C patent/LUC00028I2/fr unknown
- 2017-07-13 HU HUS1700030C patent/HUS1700030I1/en unknown
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2022
- 2022-08-12 NO NO2022036C patent/NO2022036I1/en unknown
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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