BR112012017775A2 - [4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis. - Google Patents

[4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis.

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Publication number
BR112012017775A2
BR112012017775A2 BR112012017775A BR112012017775A BR112012017775A2 BR 112012017775 A2 BR112012017775 A2 BR 112012017775A2 BR 112012017775 A BR112012017775 A BR 112012017775A BR 112012017775 A BR112012017775 A BR 112012017775A BR 112012017775 A2 BR112012017775 A2 BR 112012017775A2
Authority
BR
Brazil
Prior art keywords
pyrrolo
piperidin
aminomethyl
pyridin
synthesis
Prior art date
Application number
BR112012017775A
Other languages
Portuguese (pt)
Inventor
B Poli Gregory
T Stoklosa Gregory
Wai-Kwok Shum Patrick
R Nieduzak Thaddeus
Mi Choi-Sledeski Yong
Zhao Zhicheng
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Priority claimed from PCT/US2010/060006 external-priority patent/WO2011078984A1/en
Publication of BR112012017775A2 publication Critical patent/BR112012017775A2/en

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Abstract

patente de invenção: [4[4-(5-aminometil-2fluro-fenil)-piperidin-1-il]-(1h-pirrolo-piridin-il)-metanonas e sua síntese. a presente invenção se refere aqui a compostos e composições para o tratamento e melhora de doença inflamatória. especificamente, a presente invenção se refere a compostos que têm uma atividade de inibição da triptase e seus intermediários,composições farmacêuticas compreendendo tais compostos e um método de tratamento de indivíduos que sofrem de uma condição de doença ou distúrbio que pode ser melhorado pela administração de um inibidor da triptase, incluindo, mas não limitado a, por exemplo, asma e outras doenças inflamatórias, incluindo a degeneração macular relacionada com a idade.[4- [4- (5-Aminomethyl-2-fluorophenyl) -piperidin-1-yl] - (1H-pyrrolo-pyridin-yl) -methanones and their synthesis. The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically, the present invention relates to compounds having a tryptase inhibiting activity and intermediates thereof, pharmaceutical compositions comprising such compounds and a method of treating individuals suffering from a disease or disorder condition that may be ameliorated by the administration of a tryptase inhibitor, including, but not limited to, for example, asthma and other inflammatory diseases, including age-related macular degeneration.

BR112012017775A 2009-12-23 2010-12-13 [4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis. BR112012017775A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28956509P 2009-12-23 2009-12-23
FR1057606 2010-09-22
PCT/US2010/060006 WO2011078984A1 (en) 2009-12-23 2010-12-13 [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof

Publications (1)

Publication Number Publication Date
BR112012017775A2 true BR112012017775A2 (en) 2019-09-24

Family

ID=68062716

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012017775A BR112012017775A2 (en) 2009-12-23 2010-12-13 [4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis.

Country Status (1)

Country Link
BR (1) BR112012017775A2 (en)

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.