BR112012017775A2 - [4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis. - Google Patents
[4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis.Info
- Publication number
- BR112012017775A2 BR112012017775A2 BR112012017775A BR112012017775A BR112012017775A2 BR 112012017775 A2 BR112012017775 A2 BR 112012017775A2 BR 112012017775 A BR112012017775 A BR 112012017775A BR 112012017775 A BR112012017775 A BR 112012017775A BR 112012017775 A2 BR112012017775 A2 BR 112012017775A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolo
- piperidin
- aminomethyl
- pyridin
- synthesis
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
patente de invenção: [4[4-(5-aminometil-2fluro-fenil)-piperidin-1-il]-(1h-pirrolo-piridin-il)-metanonas e sua síntese. a presente invenção se refere aqui a compostos e composições para o tratamento e melhora de doença inflamatória. especificamente, a presente invenção se refere a compostos que têm uma atividade de inibição da triptase e seus intermediários,composições farmacêuticas compreendendo tais compostos e um método de tratamento de indivíduos que sofrem de uma condição de doença ou distúrbio que pode ser melhorado pela administração de um inibidor da triptase, incluindo, mas não limitado a, por exemplo, asma e outras doenças inflamatórias, incluindo a degeneração macular relacionada com a idade.[4- [4- (5-Aminomethyl-2-fluorophenyl) -piperidin-1-yl] - (1H-pyrrolo-pyridin-yl) -methanones and their synthesis. The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically, the present invention relates to compounds having a tryptase inhibiting activity and intermediates thereof, pharmaceutical compositions comprising such compounds and a method of treating individuals suffering from a disease or disorder condition that may be ameliorated by the administration of a tryptase inhibitor, including, but not limited to, for example, asthma and other inflammatory diseases, including age-related macular degeneration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28956509P | 2009-12-23 | 2009-12-23 | |
FR1057606 | 2010-09-22 | ||
PCT/US2010/060006 WO2011078984A1 (en) | 2009-12-23 | 2010-12-13 | [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012017775A2 true BR112012017775A2 (en) | 2019-09-24 |
Family
ID=68062716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012017775A BR112012017775A2 (en) | 2009-12-23 | 2010-12-13 | [4- [4- (5-Aminomethyl-2-fluoro-phenyl) -piperidin-1-yl] - (1h-pyrrolo-pyridin-yl) -methane and its synthesis. |
Country Status (1)
Country | Link |
---|---|
BR (1) | BR112012017775A2 (en) |
-
2010
- 2010-12-13 BR BR112012017775A patent/BR112012017775A2/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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B08F | Application fees: dismissal - article 86 of industrial property law | ||
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |