BR102020025794A2 - COMPOSITION OF FOOD ADDITIVE BASED ON VEGETABLE EXTRACTS, MICRO-ORGANISMS, MICROBIAL EXTRACTS, ORGANIC ACIDS, MINERALS AND VITAMINS WITH IMMUNOMODULATORY, PREBIOTIC, PROBIOTIC, NUTRACEUTICAL AND CONTROL AND PROPHYLAXIS OF PATHOGENIC BACTERIA AND IMMOBILIZATION TO INCREASE EFFICIENCY - Google Patents
COMPOSITION OF FOOD ADDITIVE BASED ON VEGETABLE EXTRACTS, MICRO-ORGANISMS, MICROBIAL EXTRACTS, ORGANIC ACIDS, MINERALS AND VITAMINS WITH IMMUNOMODULATORY, PREBIOTIC, PROBIOTIC, NUTRACEUTICAL AND CONTROL AND PROPHYLAXIS OF PATHOGENIC BACTERIA AND IMMOBILIZATION TO INCREASE EFFICIENCY Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
Abstract
COMPOSIÇÃO DE ADITIVO ALIMENTAR À BASE DE EXTRATOS VEGETAIS, MICRO-ORGANISMOS, EXTRATOS MICROBIANOS, ÁCIDOS ORG NICOS, MINERAIS E VITAMINAS COM FUNÇÃO IMUNOMODULADORA, PREBIÓTICA, PROBIÓTICA, NUTRACÊUTICA E DE CONTROLE E PROFILAXIA DE BACTÉRIAS PATOGÊNICAS E IMOBILIZAÇÃO PARA AUMENTO DE EFICIÊNCIA. Refere-se a uma composição, que pode ou não estar imobilizada em matrizes poliméricas, composta por extratos de Aloe vera, extratos de leveduras, extratos de spirulina, betaglucanos, mananooligossacarídeos, ácido cítrico, selênio e vitamina C e E, acrescidas ou não de canela, alho, gengibre, ginseng, Ginko biloba, Momordica charantia, chá verde, Emilia sonchifolia, Psidium guajava, zinco, cobre, manganês, quitosana, alginato, gelatina, carragenana, ácido fumárico, ácido sórbico, ácido maléico, ácido fórmico, ácido propiônico, ácido láctico, ácido butírico, ácido metillinoléico, ácido caprílico, ácido cáprico e ácido lignosulfônico.COMPOSITION OF FOOD ADDITIVE BASED ON VEGETABLE EXTRACTS, MICRO-ORGANISMS, MICROBIAL EXTRACTS, ORGANIC ACIDS, MINERALS AND VITAMINS WITH IMMUNOMODULATORY, PREBIOTIC, PROBIOTIC, NUTRACEUTICAL AND CONTROL AND PROPHYLAXIS OF PATHOGENIC BACTERIA AND IMMOBILIZATION TO INCREASE EFFICIENCY. It refers to a composition, which may or may not be immobilized in polymeric matrices, composed of Aloe vera extracts, yeast extracts, spirulina extracts, beta-glucans, mannan-oligosaccharides, citric acid, selenium and vitamin C and E, with or without cinnamon, garlic, ginger, ginseng, Ginko biloba, Momordica charantia, green tea, Emilia sonchifolia, Psidium guajava, zinc, copper, manganese, chitosan, alginate, gelatin, carrageenan, fumaric acid, sorbic acid, maleic acid, formic acid, acid propionic acid, lactic acid, butyric acid, methyllinoleic acid, caprylic acid, capric acid and lignosulfonic acid.
Description
[001] COMPOSIÇÃO DE ADITIVO ALIMENTAR À BASE DE EXTRATOS VEGETAIS, MICRO-ORGANISMOS, EXTRATOS MICROBIANOS, ÁCIDOS ORGÂNICOS, MINERAIS E VITAMINAS COM FUNÇÃO IMUNOMODULADORA, PREBIÓTICA, PROBIÓTICA, NUTRACÊUTICA E DE CONTROLE E PROFILAXIA DE BACTÉRIAS PATOGÊNICAS E IMOBILIZAÇÃO PARA AUMENTO DE EFICIÊNCIA refere-se a uma composição, que pode ou não estar imobilizada em matrizes poliméricas, composta por extratos de Aloe vera, extratos de leveduras, extratos de spirulina, betaglucanos, mananooligossacarídeos, ácido cítrico, selênio e vitamina C e E, acrescidas ou não de canela, alho, gengibre, ginseng, Ginko biloba, Momordica charantia, chá verde, Emilia sonchifolia, Psidium guajava, zinco, cobre, manganês, quitosana, alginato, gelatina, carragenana, ácido fumárico, ácido sórbico, ácido maléico, ácido fórmico, ácido propiônico, ácido láctico, ácido butírico, ácido metillinoléico, ácido caprílico, ácido cáprico e ácido lignosulfônico.[001] COMPOSITION OF FOOD ADDITIVE BASED ON VEGETABLE EXTRACTS, MICRO-ORGANISMS, MICROBIAL EXTRACTS, ORGANIC ACIDS, MINERALS AND VITAMINS WITH IMMUNOMODULATING, PREBIOTIC, PROBIOTIC, NUTRACEUTICAL AND CONTROL FUNCTION AND PROPHYLAXIS OF PATHOGENIC BACTERIA AND IMMOBILIZATION FOR AUTHENTICITY a composition, which may or may not be immobilized in polymeric matrices, composed of Aloe vera extracts, yeast extracts, spirulina extracts, beta-glucans, mannan-oligosaccharides, citric acid, selenium and vitamin C and E, with or without cinnamon , garlic, ginger, ginseng, Ginko biloba, Momordica charantia, green tea, Emilia sonchifolia, Psidium guajava, zinc, copper, manganese, chitosan, alginate, gelatin, carrageenan, fumaric acid, sorbic acid, maleic acid, formic acid, propionic acid , lactic acid, butyric acid, methyllinoleic acid, caprylic acid, capric acid and lignosulfonic acid.
[002] Evidências apontam que a regulação da microbiota comensal é benéfica para estimular o crescimento celular, inibir o crescimento de micro-organismos nocivos e auxiliar o sistema imunológico a responder mais prontamente aos patógenos, promovendo a defesa contra algumas doenças e melhorando a saúde de forma geral dos hospedeiros (Li et al., 2019. DOI=10.3389/fimmu.2019.01551). Pesquisas demonstram que o corpo dos seres vivos seja habitado por uma ampla gama de micro-organismos. A maioria da microbiota dos animais e dos seres humanos reside no intestino, enquanto populações distintas também podem ser encontradas nas superfícies da boca, pele e trato urinário.[002] Evidence points out that the regulation of commensal microbiota is beneficial to stimulate cell growth, inhibit the growth of harmful microorganisms and help the immune system to respond more promptly to pathogens, promoting defense against some diseases and improving the health of general form of the hosts (Li et al., 2019. DOI=10.3389/fimmu.2019.01551). Research shows that the body of living beings is inhabited by a wide range of microorganisms. The majority of the microbiota of animals and humans resides in the gut, while distinct populations can also be found on the surfaces of the mouth, skin, and urinary tract.
[003] A coevolução da microbiota comensal e seus hospedeiros resultou em uma condição mutuamente benéfica em que o hospedeiro pode se beneficiar da regulação fisiológica, metabólica e imunológica fornecida pela microbiota, enquanto a microbiota comensal depende absolutamente do hospedeiro para aquisição de nutrientes e locais de propagação.[003] The co-evolution of the commensal microbiota and its hosts has resulted in a mutually beneficial condition in which the host can benefit from the physiological, metabolic, and immunological regulation provided by the microbiota, while the commensal microbiota is absolutely dependent on the host for nutrient acquisition and breeding sites. propagation.
[004] Uma riqueza de evidências sugere que a comunidade microbiana incrivelmente diversa de um ser vivo seja regulada por fatores genéticos do hospedeiro e, mais importante, por fatores ambientais e dietéticos. A base alimentar de um hospedeiro pode exercer uma função de modular a imunidade em relação à patógenos, tais como, bactérias do gênero Vibrio, Pseudomonas, Aeromonas, Streptococcus, Salmonella, Escherichia coli, etc, além de vírus como o da síndrome da mancha branca (White Spot Syndrome Virus – WSSV), da doença da NIM - Síndrome da Necrose Idiopática Muscular, causada pelo vírus da Mionecrose infecciosa (IMNV) e o vírus da necrose hipodérmica hematopoiética infecciosa (Infectious Hypodermal and Hematopoietic Necrosis – IHHN), dentre outros.[004] A wealth of evidence suggests that the incredibly diverse microbial community of a living being is regulated by genetic factors of the host and, more importantly, by environmental and dietary factors. The food base of a host can play a role in modulating immunity against pathogens, such as bacteria of the genus Vibrio, Pseudomonas, Aeromonas, Streptococcus, Salmonella, Escherichia coli, etc., in addition to viruses such as white spot syndrome. (White Spot Syndrome Virus - WSSV), from the NIM disease - Idiopathic Muscle Necrosis Syndrome, caused by the Infectious Myonecrosis Virus (IMNV) and the Infectious Hypodermal and Hematopoietic Necrosis - IHHN virus, among others.
[005] Existem diversas formas para modular a imunidade, como o uso de prebióticos: MOS (Manano-oligossacarídeos), FOS (Fruto-oligossacarídeos) e o GOS (Galacto-oligossacarídeos) (Teng e Kim, 2018. DOI=10.3389/fvets.2018.00245); o uso de ácidos orgânicos, tais como os ácidos orgânicos de cadeia curta, como o ácido cítrico e o ácido lático (Patil et al., 2019. DOI=10.1002/JLB.3MIR1118-415R); o uso de moduladores do sistema imunológico, tais como os betaglucanos, extratos de plantas e de micro/macroalgas (Akramiene et al., 2007. PMID: 17895634; Hai, 2015. DOI=10.1016/j.aquaculture.2015.03.014; Wu et al., 2016. PMID: 27259333); o uso de vitaminas antioxidantes, tais como a vitamina A, C e E (Nockels, 1996. DOI=10.1016/S0377-8401(96)01006-1); o uso de extratos nutricionais, tais como os extratos de levedura e de microalgas (Barkia et al., 2019. PMID: 31137657; Wu, et al., 2017. PMID: 29271244); o uso de micronutrientes essenciais, tais como o selênio e o zinco (Ferencík e Ebringer, 2003. PMID: 12879758) e, por fim, o uso de micro-organismos probióticos, que além de estimularem a imunidade, também favorecem o equilíbrio da microbiota comensal (Cuvas-Limón et al., 2020. DOI=10.9734/ARRB/2016/22622)[005] There are several ways to modulate immunity, such as the use of prebiotics: MOS (Mannan-oligosaccharides), FOS (Fructo-oligosaccharides) and GOS (Galacto-oligosaccharides) (Teng and Kim, 2018. DOI=10.3389/fvets .2018.00245); the use of organic acids, such as short-chain organic acids such as citric acid and lactic acid (Patil et al., 2019. DOI=10.1002/JLB.3MIR1118-415R); the use of immune system modulators such as beta-glucans, plant extracts and micro/macroalgae (Akramiene et al., 2007. PMID: 17895634; Hai, 2015. DOI=10.1016/j.aquaculture.2015.03.014; Wu et al., 2016. PMID: 27259333); the use of antioxidant vitamins such as vitamin A, C and E (Nockels, 1996. DOI=10.1016/S0377-8401(96)01006-1); the use of nutritional extracts, such as yeast and microalgae extracts (Barkia et al., 2019. PMID: 31137657; Wu, et al., 2017. PMID: 29271244); the use of essential micronutrients, such as selenium and zinc (Ferencík and Ebringer, 2003. PMID: 12879758) and, finally, the use of probiotic microorganisms, which, in addition to stimulating immunity, also favor the balance of the microbiota. dinner (Cuvas-Limón et al., 2020. DOI=10.9734/ARRB/2016/22622)
[006] Além de modular a imunidade, o controle de patógenos através do uso de ácidos orgânicos também desponta como excelente estratégia para fortalecer o organismo. O uso de ácidos orgânicos como substitutos aos antibióticos tradicionais, em especial os ácidos de cadeia curta, devido sua capacidade em penetrar nas membranas bacterianas com certa facilidade e promoverem uma ação rápida contra patógenos, como os ácidos butírico, fórmico, propiônico, sórbico, lático, cítrico, maléico, fumárico, succínico, dentre outros, é uma poderosa ferramenta no controle de patógenos (Dittoe et al., 2018. DOI=10.3389/fvets.2018.00216).[006] In addition to modulating immunity, the control of pathogens through the use of organic acids also emerges as an excellent strategy to strengthen the organism. The use of organic acids as substitutes for traditional antibiotics, especially short-chain acids, due to their ability to penetrate bacterial membranes with some ease and promote rapid action against pathogens, such as butyric, formic, propionic, sorbic, lactic acids , citrus, maleic, fumaric, succinic, among others, is a powerful tool in the control of pathogens (Dittoe et al., 2018. DOI=10.3389/fvets.2018.00216).
[007] Os extratos de ervas também possuem características antimicrobianas, além de propriedades imunoestimulantes, agindo contra um amplo espectro de patógenos, além de terem impacto ambiental limitado devido à sua biodegradabilidade (Ngo Van Hai, 2015. DOI=10.1016/j.aquaculture.2015.03.014). Destaca-se, aqui, o uso Aloe vera que possui propriedades cosméticas e medicinais popularmente conhecidas, tanto para a saúde humana e como também de animais, como: galinhas, camundongos, felinos, cães, peixes e camarões, que incluem a cicatrização de feridas, suas propriedades antibacterianas, antivirais, antifúngicas, antidiabéticas, anticancerígenas, gastroprotectoras e imunomodulatórias (Cuvas-Limón et al., 2020. DOI=10.9734/ARRB/2016/22622).[007] Herbal extracts also have antimicrobial characteristics in addition to immunostimulating properties, acting against a wide spectrum of pathogens, in addition to having limited environmental impact due to their biodegradability (Ngo Van Hai, 2015. DOI=10.1016/j.aquaculture. 2015.03.014). Here, the use of Aloe vera stands out, which has popularly known cosmetic and medicinal properties, both for human and animal health, such as: chickens, mice, felines, dogs, fish and shrimps, which include wound healing. , its antibacterial, antiviral, antifungal, antidiabetic, anticancer, gastroprotective and immunomodulatory properties (Cuvas-Limón et al., 2020. DOI=10.9734/ARRB/2016/22622).
[008] Importante ressaltar, que além de controlar os patógenos em potencial é importante focar no fortalecimento do sistema imunológico para alcançar melhorias reais na saúde. Principalmente em situações de adensamento produtivo e de criação em modo intensivo, onde a classificação, o transporte e a má qualidade da água e da alimentação são fatores que podem afetar a resposta imune de animais, favorecer o desenvolvimento de microbiotas patogênicas e/ou aumentar a virulência de patógenos.[008] Importantly, in addition to controlling potential pathogens, it is important to focus on strengthening the immune system to achieve real health improvements. Mainly in situations of productive densification and intensive farming, where classification, transport and poor quality of water and food are factors that can affect the immune response of animals, favor the development of pathogenic microbiota and/or increase the pathogen virulence.
[009] Os prebióticos estimulam o crescimento e/ou o metabolismo de bactérias promotoras da saúde do trato intestinal, que ocorrem naturalmente nesse ambiente, melhorando o balanço intestinal do organismo. Agem intimamente relacionados aos probióticos e constituem o alimento das bactérias probióticas, em processos simbióticos e sinergéticos.[009] Prebiotics stimulate the growth and/or metabolism of health-promoting bacteria in the intestinal tract, which naturally occur in this environment, improving the body's intestinal balance. They act closely related to probiotics and constitute the food of probiotic bacteria, in symbiotic and synergistic processes.
[010] Os micro-organismos mais frequentemente favorecidos pelos prebióticos são os pertencentes aos gêneros Lactobacillus e Bifidobacter, os quais tendem a limitar a presença de bactérias nocivas. Como exemplos de prebióticos temos os açúcares absorvíveis ou não, as fibras, os álcoois de açúcares e os oligossacarídeos, como os MOS (Manano-oligossacarídeos), o FOS (Fruto-oligossacarídeos), o GOS (Galacto-oligossacarídeos), a inulina, dentre outros.[010] The microorganisms most often favored by prebiotics are those belonging to the genera Lactobacillus and Bifidobacter, which tend to limit the presence of harmful bacteria. Examples of prebiotics are sugars, absorbable or not, fibers, sugar alcohols and oligosaccharides, such as MOS (Mannan-oligosaccharides), FOS (Fructo-oligosaccharides), GOS (Galacto-oligosaccharides), inulin, among others.
[011] Os aditivos alimentares probióticos são capazes de beneficiar o animal hospedeiro por meio da adição de bactérias benéficas que favorecem o equilíbrio intestinal, como as bactérias ácido-láticas (Lactobacillus, Lactococcus, Pediococcus, Enterococcus and Streptococcus), bactérias gram-positivas formadoras de esporos (Bacillus subtillis, B. licheniformis, B. circulans, B. coagulans, B. clausii, e B. megaterium), actinobactérias, como as do gênero Streptomyces, e fungos, como as leveduras (principalmente espécies dos gêneros Candida e Saccharomyces), dentre outros. Existem várias formas de atuação dos probióticos, tais como: a exclusão competitiva de bactérias patogênicas; a alteração das condições ambientais do intestino pelo aumento da produção de ácidos orgânicos; a produção de compostos com atividade antibacteriana pelas bactérias probióticas contra bactérias patogênicas (bacteriocinas, lactoferrina e lisozima) e a modulação da resposta imune intestinal. A modulação imune por via intestinal é de extrema relevância, em especial, para os crustáceos, pois estes organismos possuem apenas sistema imune inato e, portanto, não produzem anticorpos e necessitam de uma microbiota intestinal saudável para sobreviver.[011] Probiotic food additives are able to benefit the host animal through the addition of beneficial bacteria that favor intestinal balance, such as lactic acid bacteria (Lactobacillus, Lactococcus, Pediococcus, Enterococcus and Streptococcus), gram-positive forming bacteria of spores (Bacillus subtilis, B. licheniformis, B. circulans, B. coagulans, B. clausii, and B. megaterium), actinobacteria, such as those of the genus Streptomyces, and fungi, such as yeasts (mainly species of the genera Candida and Saccharomyces ), among others. There are several ways that probiotics act, such as: competitive exclusion of pathogenic bacteria; the alteration of the environmental conditions of the intestine by the increase of the production of organic acids; the production of compounds with antibacterial activity by probiotic bacteria against pathogenic bacteria (bacteriocins, lactoferrin and lysozyme) and the modulation of the intestinal immune response. Immune modulation via the intestine is extremely relevant, especially for crustaceans, as these organisms have only an innate immune system and, therefore, do not produce antibodies and need a healthy intestinal microbiota to survive.
[012] Adicionalmente, o uso de compostos antioxidantes e nutricionais são importantíssimos para auxiliar o organismo no enfrentamento de enfermidades, sejam elas bacterianas ou virais. Aminoácidos, nucleotídeos, vitaminas e micronutrientes, tais como vitaminas A, C e E, e minerais como zinco, cobre, selênio e manganês, fazem-se necessários e podem trazer benefícios sinérgicos à utilização de imunomoduladores.[012] Additionally, the use of antioxidant and nutritional compounds are very important to help the body in coping with diseases, whether bacterial or viral. Amino acids, nucleotides, vitamins and micronutrients, such as vitamins A, C and E, and minerals such as zinc, copper, selenium and manganese, are necessary and can bring synergistic benefits to the use of immunomodulators.
[013] A forma de administração destes diferentes insumos também pode influenciar a sua atividade, podendo ser utilizados na forma livre ou imobilizados. A imobilização é um processo que pode trazer inúmeros benefícios associados à liberação regulada de princípios ativos, à maior estabilidade frente a variações de parâmetros físico-químicos, à maior estabilidade catalítica, à manutenção da viabilidade celular e de moléculas bioativas por um período maior de tempo, à maior eficiência de assimilação pelo animal, e até vantagens frente a competições intra e interespecíficas entre os micro-organismos, entre outros. Dentre as matrizes disponíveis para imobilização, destacam-se biopolímeros como o alginato, a carragenana, a gelatina e a quitosana, por serem biocompatíveis, biodegradáveis, não tóxicos, fisiologicamente inertes, resistentes e bastante disponíveis.[013] The form of administration of these different inputs can also influence their activity, and can be used in free form or fixed assets. Immobilization is a process that can bring numerous benefits associated with the regulated release of active principles, greater stability in the face of variations in physicochemical parameters, greater catalytic stability, maintenance of cell viability and bioactive molecules for a longer period of time. , the greater efficiency of assimilation by the animal, and even advantages in the face of intra and interspecific competition between microorganisms, among others. Among the matrices available for immobilization, biopolymers such as alginate, carrageenan, gelatin and chitosan stand out, as they are biocompatible, biodegradable, non-toxic, physiologically inert, resistant and quite available.
[014] Foram encontradas diversas soluções que mostram funções imunomoduladora, prebiótica, probiótica, nutracêutica, de controle e profilaxia de bactérias patogênicas, separadamente ou em conjunto, usando extratos vegetais, micro-organismos, extratos microbianos, ácidos orgânicos, minerais e vitaminas, contudo, a solução proposta na presente invenção traz componentes compatíveis e com concentrações de utilização específicas que impactam em um resultado mais eficiente.[014] Several solutions were found that show immunomodulatory, prebiotic, probiotic, nutraceutical, control and prophylaxis functions of pathogenic bacteria, separately or together, using plant extracts, microorganisms, microbial extracts, organic acids, minerals and vitamins, however , the solution proposed in the present invention brings compatible components and with specific concentrations of use that impact on a more efficient result.
[015] O processo BR 10 2017 010683 7 descreve uma composição para aditivos empregados em rações animais, ou como promotores de crescimento, ou como nutracêuticos, ou como prebióticos, ou como aditivos para o controle e profilaxia de bactérias patogênicas no trato intestinal dos animais, ou animais de criação, desenvolvida a partir de fruto-oligossacarídeos (FOS), galacto-oligossacarídeos (GOS), manano-oligossacarídeos (MOS) e 1,3 e 1,6 Beta-glucanos, e difere da presente invenção em componentes, principalmente, o uso do Aloe vera, spirulina, ácido cítrico, selênio e vitamina C e E.[015] The process BR 10 2017 010683 7 describes a composition for additives used in animal feed, either as growth promoters, or as nutraceuticals, or as prebiotics, or as additives for the control and prophylaxis of pathogenic bacteria in the intestinal tract of animals , or farm animals, developed from fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), mannan-oligosaccharides (MOS) and 1,3 and 1,6 Beta-glucans, and differs from the present invention in components, mainly, the use of Aloe vera, spirulina, citric acid, selenium and vitamin C and E.
[016] O documento US2008193597 descreve uma composição de aditivo alimentar que favorece as defesas naturais a partir de Aloe vera e spirulina e difere da presente invenção por se limitar ao uso de apenas extratos de plantas e de algas.[016] The document US2008193597 describes a food additive composition that favors natural defenses from Aloe vera and spirulina and differs from the present invention by being limited to the use of only plant and algae extracts.
[017] O processo CN111149947 descreve um alimento melhorador de imunidade de frangos contendo vários compostos, inclusive o Aloe, mas que difere totalmente da estratégia da presente invenção que possui muito mais componentes ativos e formas de ação acarretando a ampliação de resultado.[017] The process CN111149947 describes an immunity-enhancing chicken feed containing several compounds, including Aloe, but which totally differs from the strategy of the present invention, which has many more active components and forms of action, resulting in the expansion of the result.
[018] O processo CN111165657 descreve um alimento que promove o ganho de peso e aumento de imunidade de peixe, contendo vários compostos, incluindo minerais, Aloe em pó e multivitaminas, mas que difere totalmente da presente invenção que possui muito mais componentes ativos e formas de ação.[018] Process CN111165657 describes a food that promotes weight gain and increases immunity in fish, containing various compounds, including minerals, Aloe powder and multivitamins, but which totally differs from the present invention which has many more active components and forms of action.
[019] Por fim, o processo CN106616017 descreve um alimento para prevenir infecções em camarão causadas por patógenos e parasitos presentes na água, desenvolvida a partir de penas, peróxido de hidrogênio, metabissulfito de sódio, farelo de trigo, farelo de semente de abóbora, taurina, folha de Yucca em pó, Lithospermum, Siji Green, Pulsatilla, produto fermentado de folha de pinheiro, proteína de folha de louro em pó, semente de rabanete em pó, gel de Aloe, atapulgita, carvão de bambu em pó, leite de soja cru, glicose, papaína, pepsina e tripsina, o que difere da presente invenção por apresentar composição totalmente diferente.[019] Finally, the CN106616017 process describes a food to prevent infections in shrimp caused by pathogens and parasites present in the water, developed from feathers, hydrogen peroxide, sodium metabisulfite, wheat bran, pumpkin seed bran, Taurine, Yucca Leaf Powder, Lithospermum, Siji Green, Pulsatilla, Fermented Pine Leaf Product, Bay Leaf Protein Powder, Radish Seed Powder, Aloe Gel, Attapulgite, Bamboo Charcoal Powder, Milk raw soy, glucose, papain, pepsin and trypsin, which differs from the present invention by presenting a totally different composition.
[020] Todos os estudos mencionados e processos apresentam ação limitada em relação à melhoria de sanidade, gerando a necessidade de produtos com mecanismos de ações mais estratégicos e eficiência mais robusta no combate a doenças, principalmente, as não controladas por estarem relacionadas a diferentes aspectos fisiológicos do animal e condições ambientais.[020] All the aforementioned studies and processes have limited action in relation to improving health, generating the need for products with more strategic action mechanisms and more robust efficiency in combating diseases, especially those not controlled because they are related to different aspects animal's physiological and environmental conditions.
[021] Nesse contexto, dentre as várias possíveis frentes de combate a bactérias e vírus indesejados, podemos citar:
- ● Os moduladores do sistema imunológico como os betaglucanos, os extratos vegetais, os ácidos orgânicos, os minerais, as vitaminas, os prebióticos e os probióticos;
- ● Os ingredientes naturais ativos com função microbicida direta contra patógenos como extratos vegetais e ácidos orgânicos;
- ● A nutrição de precisão com vitaminas, minerais, aminoácidos e nucleotídeos, que ofertam ingredientes estratégicos para um melhor funcionamento da homeostase do animal;
- ● Os probióticos que promovem o estabelecimento de uma microbiota intestinal estável com efeitos benéficos na imunidade, no controle de patógenos e na absorção de nutrientes.
- ● Immune system modulators such as beta-glucans, plant extracts, organic acids, minerals, vitamins, prebiotics and probiotics;
- ● Natural active ingredients with direct microbicidal function against pathogens such as plant extracts and organic acids;
- ● Precision nutrition with vitamins, minerals, amino acids and nucleotides, which offer strategic ingredients for a better functioning of the animal's homeostasis;
- ● Probiotics that promote the establishment of a stable intestinal microbiota with beneficial effects on immunity, pathogen control and nutrient absorption.
[022] A presente invenção alia todas essas estratégias em uma ação única e eficiente composição. De acordo com um primeiro aspecto da presente invenção, foi desenvolvida uma composição que possuísse as seguintes propriedades:
A - Abrangesse em sua formulação quantidades específicas de extratos de plantas, extratos microbianos, ácidos orgânicos, micro-organismos probióticos, vitaminas e minerais com modos de ação distintos, de forma a ser capaz de agir sinergicamente no combate de patógenos, na melhora da imunidade, na ação prebiótica e probiótica, no estabelecimento de uma microbiota intestinal saudável e na melhora da nutrição.
B - Compreendesse um produto modulador de sanidade atuando em 6 frentes simultâneas:
- ● Modulando o sistema imunológico;
- ● Reduzindo micro-organismos patógenos;
- ● Aumentando micro-organismos probióticos;
- ● Aumentando a produção de ácidos orgânicos de cadeia curta;
- ● Promovendo a oxidação dos radicais livres;
- ● Melhorando fatores nutricionais essenciais para o desenvolvimento.
D - Apresentasse custo final de produção e de venda acessíveis para uso na alimentação.[022] The present invention combines all these strategies in a single action and efficient composition. In accordance with a first aspect of the present invention, a composition has been developed having the following properties:
A - Cover in its formulation specific amounts of plant extracts, microbial extracts, organic acids, probiotic microorganisms, vitamins and minerals with different modes of action, in order to be able to act synergistically in the fight against pathogens, in the improvement of immunity , in prebiotic and probiotic action, in the establishment of a healthy intestinal microbiota and in the improvement of nutrition.
B - Comprises a sanity modulating product acting on 6 simultaneous fronts:
- ● Modulating the immune system;
- ● Reducing pathogenic microorganisms;
- ● Increasing probiotic microorganisms;
- ● Increasing the production of short-chain organic acids;
- ● Promoting the oxidation of free radicals;
- ● Improving essential nutritional factors for development.
D - Present a final cost of production and sale accessible for use in food.
[023] Para os fins desta invenção, os extratos de Aloe vera têm a finalidade de promover a modulação da imunidade dos animais e uma ação microbicida contra patógenos bacterianos e virais a partir de diferentes moléculas com atividade biológica como antraquinonas/antronas, Aloe emodina, ácido aloético, antranol, aloína A e B (ou coletivamente conhecidos como barbaloínas), isobarbaloína, emodina, éster de ácido cinâmico, além dos carboidratos como manana pura, manana acetilada, glucomanana acetilada, glucogalactomanana, galactomanana, galactogalacturano, arabinogalactano, galactoglucoarabinomanano, substância péctica, isoaloeresina D, isorabaicromona, neoaloesina. Os extratos de Aloe vera, categoria de extrato vegetal, também contribuem com fatores nutricionais essenciais para o desenvolvimento do animal como enzimas (amilase e lipase), aminoácidos (lisina, histidina, arginina, ácido aspártico, treonina, serina, ácido glutâmico, prolina, glicina, alanina, valina, metionina, isoleucina, leucina, tirosina, fenilalanina), vitaminas (vitaminas B1, B2, C, B6, niacinamida e colina), minerais (sódio, potássio, fósforo, cloreto, magnésio, cobre e zinco), constituintes bioquímicos (glucose, ácido salicílico, creatinina, triglicerídeos, lactato), entre outros. Todos esses componentes trabalham sinergicamente a fim de produzir os diversos efeitos benéficos ao animal.[023] For the purposes of this invention, Aloe vera extracts are intended to promote the modulation of animal immunity and a microbicidal action against bacterial and viral pathogens from different molecules with biological activity such as anthraquinones/antrones, Aloe emodina, aloectic acid, anthranol, aloin A and B (or collectively known as barbaloins), isobarbaloin, emodin, cinnamic acid ester, in addition to carbohydrates such as pure mannan, acetylated mannan, acetylated glucomannan, glucogalactomannan, galactomannan, galactogalacturan, arabinogalactan, galactoglucoarabinomannan, substance pectic, isoaloeresin D, isorabaichromone, neoalloesin. Aloe vera extracts, plant extract category, also contribute essential nutritional factors for the development of the animal such as enzymes (amylase and lipase), amino acids (lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine), vitamins (vitamins B1, B2, C, B6, niacinamide and choline), minerals (sodium, potassium, phosphorus, chloride, magnesium, copper and zinc), biochemical constituents (glucose, salicylic acid, creatinine, triglycerides, lactate), among others. All these components work synergistically in order to produce the various beneficial effects to the animal.
[024] Os 1,3 e 1,6 Betaglucanos possuem ação de modulação do sistema imunológico aumentando o número de células de defesa circulantes dentro do animal, possibilitando uma maior eficiência na resposta imunológica quando da ocorrência de infecções. Essas moléculas estimulam a multiplicação de hematócitos em crustáceos, como camarões, e a multiplicação de macrófagos em peixes, aves e mamíferos, com consequente aumento da atividade de fagocitose de bactérias patogênicas que invadem o sistema linfático ou se aderem às paredes intestinais.[024] The 1,3 and 1,6 Betaglucans have a modulating action of the immune system increasing the number of circulating defense cells within the animal, allowing a greater efficiency in the immune response when infections occur. These molecules stimulate the multiplication of hematocytes in crustaceans, such as shrimp, and the multiplication of macrophages in fish, birds and mammals, with a consequent increase in the phagocytosis activity of pathogenic bacteria that invade the lymphatic system or adhere to the intestinal walls.
[025] Os manano-oligossacarídeos (MOS) possuem mecanismo de ação prebiótica bioestimulante de micro-organismos benéficos autóctones ou de micro-organismos bioaumentados no sistema digestivo através da utilização de probióticos. Outro mecanismo de ação do MOS consiste na aglutinação das bactérias portadoras de fímbrias do tipo 1, que são indesejáveis, como Salmonella e Escherichia coli.[025] Mannan-oligosaccharides (MOS) have a prebiotic biostimulating mechanism of action of beneficial autochthonous microorganisms or bioaugmented microorganisms in the digestive system through the use of probiotics. Another mechanism of action of MOS is the agglutination of undesirable type 1 fimbriae bacteria, such as Salmonella and Escherichia coli.
[026] A utilização de probióticos promove o bioaumento de células microbianas de bactérias e leveduras benéficas no sistema digestivo. O expressivo aumento e seleção da microbiota benéfica pela utilização de probiótico, associado ao bioestímulo do prebiótico, têm como estratégia promover a exclusão competitiva das bactérias indesejáveis, através da competição por espaço de colonização, competição por nutrientes, inibição da comunicação quorum sensing em comunidades patogênicas, produção de bacteriocinas e ácidos orgânicos; o aumento de muco protetor no sistema digestivo; e o aumento de quantidade e tamanho das vilosidades intestinais; todos esses mecanismos de ação atuam para uma melhoria na sanidade e da conversão alimentar. Existem ainda outros benefícios de uma comunidade microbiana benéfica estável no intestino como estimulação do sistema imune e a melhora da integridade de órgãos pelo estímulo de crescimento e regeneração de células nos tecidos.[026] The use of probiotics promotes the bioincrease of microbial cells of beneficial bacteria and yeasts in the digestive system. The significant increase and selection of beneficial microbiota by the use of probiotics, associated with the biostimulation of prebiotics, have as a strategy to promote the competitive exclusion of undesirable bacteria, through competition for colonization space, competition for nutrients, inhibition of quorum sensing communication in pathogenic communities , production of bacteriocins and organic acids; the increase of protective mucus in the digestive system; and the increase in the number and size of intestinal villi; all these mechanisms of action work towards an improvement in health and feed conversion. There are also other benefits of a stable beneficial microbial community in the gut, such as stimulating the immune system and improving organ integrity by stimulating cell growth and regeneration in tissues.
[027] O ácido cítrico é um ácido tricarboxílico possui ação bactericida contra os principais patógenos gram-negativos que colonizam o intestino, tem mecanismos de ação de estimulador de imunidade e do mecanismo energético por ser um importante intermediário e participar do ciclo de Krebs durante a respiração celular.[027] Citric acid is a tricarboxylic acid has bactericidal action against the main gram-negative pathogens that colonize the intestine, has mechanisms of action of immunity stimulator and energy mechanism for being an important intermediary and participates in the Krebs cycle during cellular respiration.
[028] O selênio é um importante mineral para estimular a imunidade, participa da formação de enzimas de ação antioxidante e atua na neutralização dos radicais livres. As vitaminas C e E também são importantes vitaminas com ação moduladora de imunidade, antioxidante e neutralizadora de radicais livres. Sabe-se que a dieta pode influenciar parâmetros imunológicos, como número de leucócitos e produção de anticorpos. Nutrientes como as vitaminas C e E, e os minerais como selênio, cobre, zinco e manganês, influenciam notadamente o sistema imune, pois são antioxidantes potentes, e protegem macromoléculas celulares (DNA, proteínas, lipídios) contra oxidação por radicais livres durante o metabolismo normal, o metabolismo imunomodulado e em condições adversas, como doenças, poluição e estresses por alteração de parâmetros físico-químicos ambientais.[028] Selenium is an important mineral to stimulate immunity, participates in the formation of enzymes of antioxidant action and acts in the neutralization of free radicals. Vitamins C and E are also important vitamins with immunity modulating, antioxidant and free radical neutralizing action. It is known that diet can influence immunological parameters, such as the number of leukocytes and antibody production. Nutrients such as vitamins C and E, and minerals such as selenium, copper, zinc and manganese, notably influence the immune system, as they are potent antioxidants, and protect cellular macromolecules (DNA, proteins, lipids) against oxidation by free radicals during metabolism. normal, immunomodulated metabolism and in adverse conditions, such as diseases, pollution and stress due to alteration of environmental physical-chemical parameters.
[029] O extrato de leveduras e de spirulinas são riquíssimas fontes de nutrientes como aminoácidos, vitaminas e minerais. Possuem ação de fornecer uma nutrição de precisão com base em um aporte nutricional proveniente de extratos de alto valor nutritivo, os quais atendem aos requerimentos dos organismos alvos, de forma a aditivar os fatores nutricionais essenciais para o desenvolvimento do animal em um estado metabólico imunomodulado.[029] Yeast and spirulina extracts are rich sources of nutrients such as amino acids, vitamins and minerals. They have the action of providing precision nutrition based on a nutritional contribution from extracts of high nutritional value, which meet the requirements of target organisms, in order to add nutritional factors essential for the development of the animal in an immunomodulated metabolic state.
[030] Na formulação, cada ingrediente tem um mecanismo de ação específico e ocorre uma sinergia entre estes mecanismos de ação, compreendendo os seguintes componentes abaixo indicados:
- (a) Extrato de Aloe vera;
- (b) 1,3 e 1,6 Betaglucanos;
- (c) Manano-oligossacarídeos (MOS);
- (d) Micro-organismos probióticos: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc;
- (e) Ácido cítrico;
- (f) Selênio;
- (g) Vitamina C e E;
- (h) Extrato de leveduras e de spirulina.
- (a) Aloe vera extract;
- (b) 1,3 and 1,6 Beta Glucans;
- (c) Mannan-oligosaccharides (MOS);
- (d) Probiotic microorganisms: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc.;
- (e) Citric acid;
- (f) Selenium;
- (g) Vitamin C and E;
- (h) Yeast and spirulina extract.
[031] Uma das variações da invenção, tem em sua composição os constituintes:
- (a) Extrato de Aloe vera;
- (b) 1,3 e 1,6 Betaglucanos;
- (c) Manano-oligossacarídeos (MOS);
- (d) Micro-organismos probióticos: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc;
- (e) Ácido cítrico;
- (f) Selênio;
- (g) Vitamina C e E;
- (h) Extrato de leveduras e de spirulina;
- (i) Outros extratos naturais com ação moduladora de imunidade e/ou ação microbicida contra patógenos;
- (j) Outros ácidos orgânicos com ação moduladora de imunidade e/ou microbicida contra patógenos;
- (l) Outros minerais com ação moduladora de imunidade.
- (a) Aloe vera extract;
- (b) 1,3 and 1,6 Beta Glucans;
- (c) Mannan-oligosaccharides (MOS);
- (d) Probiotic microorganisms: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc.;
- (e) Citric acid;
- (f) Selenium;
- (g) Vitamin C and E;
- (h) Yeast and spirulina extract;
- (i) Other natural extracts with immunity modulating action and/or microbicidal action against pathogens;
- (j) Other organic acids with immunity modulating and/or microbicidal action against pathogens;
- (l) Other minerals with immunity modulating action.
[032] Outra variação da invenção, a composição imunomoduladora, de controle de populações patogênicas, de efeito prebiótico e probiótico, antioxidante, nutracêutica e promotora de sanidade, compreende os seguintes componentes principais:
- (a) Extrato de Aloe vera;
- (b) 1,3 e 1,6 Betaglucanos;
- (c) Manano-oligossacarídeos (MOS);
- (d) Micro-organismos probióticos: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc;
- (e) Ácido cítrico;
- (f) Selênio;
- (g) Vitamina C e E;
- (h) Extrato de leveduras e de spirulina;
- (i) Outros extratos naturais com ação moduladora de imunidade e/ou ação microbicida contra patógenos, como: canela, alho, gengibre, ginseng, Ginko biloba, Momordica charantia, chá verde, Emilia sonchifolia e Psidium guajava;
- (j) Outros ácidos orgânicos com ação moduladora de imunidade e/ou ação microbicida contra patógenos, como: ácido fumárico, ácido sórbico, ácido maléico, ácido fórmico, ácido propiônico, ácido láctico, ácido butírico, ácido metillinoléico, ácido caprílico, ácido cáprico e ácido lignosulfônico;
- (l) Outros minerais com ação moduladora de imunidade, como: zinco, cobre e manganês.
- (a) Aloe vera extract;
- (b) 1,3 and 1,6 Beta Glucans;
- (c) Mannan-oligosaccharides (MOS);
- (d) Probiotic microorganisms: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc.;
- (e) Citric acid;
- (f) Selenium;
- (g) Vitamin C and E;
- (h) Yeast and spirulina extract;
- (i) Other natural extracts with modulating immunity and/or microbicidal action against pathogens, such as: cinnamon, garlic, ginger, ginseng, Ginko biloba, Momordica charantia, green tea, Emilia sonchifolia and Psidium guajava;
- (j) Other organic acids with immunity modulating action and/or microbicidal action against pathogens, such as: fumaric acid, sorbic acid, maleic acid, formic acid, propionic acid, lactic acid, butyric acid, methyllinoleic acid, caprylic acid, capric acid and lignosulphonic acid;
- (l) Other minerals with immunity modulating action, such as: zinc, copper and manganese.
[033] Outra forma de realização da invenção, compreende os seguintes componentes:
- (a) Um ou mais extratos naturais com ação moduladora de imunidade e/ou ação microbicida contra patógenos escolhidos entre: Aloe vera, canela, alho, gengibre, ginseng, Ginko biloba, Momordica charantia, chá verde, Emilia sonchifolia e Psidium guajava;
- (b) 1,3 e 1,6 Betaglucanos;
- (c) Manano-oligossacarídeos (MOS);
- (d) Micro-organismos probióticos: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc;
- (e) Um ou mais ácidos orgânicos com ação moduladora de imunidade e/ou microbicida contra patógenos escolhidos entre: ácido cítrico, ácido fumárico, ácido sórbico, ácido maléico, ácido fórmico, ácido propiônico, ácido láctico, ácido butírico, ácido metillinoléico, ácido caprílico, ácido cáprico e ácido lignosulfônico;
- (f) Um ou mais minerais com ação moduladora de imunidade escolhidos entre: selênio, zinco, cobre e manganês;
- (g) Vitamina C e E;
- (h) Extrato de leveduras e de spirulina.
- (a) One or more natural extracts with an immunity modulating action and/or microbicidal action against pathogens chosen from: Aloe vera, cinnamon, garlic, ginger, ginseng, Ginko biloba, Momordica charantia, green tea, Emilia sonchifolia and Psidium guajava;
- (b) 1,3 and 1,6 Beta Glucans;
- (c) Mannan-oligosaccharides (MOS);
- (d) Probiotic microorganisms: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc.;
- (e) One or more organic acids with immunity modulating and/or microbicidal action against pathogens chosen from: citric acid, fumaric acid, sorbic acid, maleic acid, formic acid, propionic acid, lactic acid, butyric acid, methyllinoleic acid, caprylic, capric acid and lignosulphonic acid;
- (f) One or more minerals with an immunity modulating action chosen from: selenium, zinc, copper and manganese;
- (g) Vitamin C and E;
- (h) Yeast and spirulina extract.
[034] A tese central da presente invenção é a de que a utilização dos diferentes componentes promova um efeito sinérgico, complementar e compatível com o processo de imunomodulação, a partir da potencialização dos diferentes mecanismos de ação de combate de patógenos, de modulação da imunidade, de ação prebiótica, de estabelecimento de uma microbiota probiótica intestinal saudável, de antioxidação e de melhoria da nutrição de precisão, onde cada componente da invenção possui um ou mais de uma das formas de ação. De forma que a composição da invenção nas proporções descritas tenha um efeito superior e potencializado comparado ao efeito individual de cada um de seus componentes em dosagens equivalentes.[034] The central thesis of the present invention is that the use of the different components promotes a synergistic, complementary and compatible effect with the immunomodulation process, from the potentiation of the different mechanisms of action to combat pathogens, to modulate immunity , prebiotic action, establishment of a healthy intestinal probiotic microbiota, antioxidation and precision nutrition improvement, where each component of the invention has one or more than one of the forms of action. So that the composition of the invention in the proportions described has a superior and potentiated effect compared to the individual effect of each of its components in equivalent dosages.
[035] Avaliações realizadas em experimentações (exemplos 1, 2 e 3) utilizando a composição segundo a invenção revelam resultados melhores em relação a taxa de sobrevivência, taxa de crescimento, modulação da imunidade, microbiota probiótica, controle de patógenos e conversão alimentar, compatíveis com o estado imunomodulado.[035] Evaluations carried out in experiments (examples 1, 2 and 3) using the composition according to the invention reveal better results in relation to survival rate, growth rate, immunity modulation, probiotic microbiota, pathogen control and feed conversion, compatible with the immunomodulated state.
[036] A sinergia entre extratos vegetais, algais e microbianos, ácidos orgânicos, micronutrientes, antioxidantes, fatores nutricionais e bactérias/leveduras probióticas, contribui para se obter indivíduos imunocompetentes, bem nutridos, com microbiota benéfica estável e microbiota indesejável reduzida, o que dificulta a proliferação de patógenos e estimula uma sanidade diferenciada, favorecendo o enfrentamento de doenças ocasionadas pelas condições de cultivo.[036] The synergy between plant, algal and microbial extracts, organic acids, micronutrients, antioxidants, nutritional factors and probiotic bacteria/yeasts, contributes to obtaining immunocompetent, well-nourished individuals, with stable beneficial microbiota and reduced undesirable microbiota, which makes it difficult the proliferation of pathogens and stimulates a differentiated sanity, favoring the fight against diseases caused by the cultivation conditions.
[037] A composição ainda pode estar ou não na forma imobilizada em matrizes poliméricas como quitosana, alginato, gelatina, carragenana, etc. Variar a forma de uso deste produto, da sua forma livre para imobilizada, traz inúmeros benefícios associados à liberação regulada de princípios ativos, à maior eficiência de assimilação na alimentação, à melhor estabilidade frente a variações de parâmetros físico-químicos, à maior estabilidade catalítica, à vantagens competitivas de probióticos frente a competições intra e interespecíficas com outros micro-organismos e à proteção das células microbianas e/ou moléculas ativas por um maior período de tempo.[037] The composition may or may not be in immobilized form in polymeric matrices such as chitosan, alginate, gelatin, carrageenan, etc. Varying the use of this product, from its free to immobilized form, brings numerous benefits associated with the regulated release of active principles, greater efficiency of assimilation in food, better stability in the face of variations in physicochemical parameters, greater catalytic stability , the competitive advantages of probiotics against intra and interspecific competition with other microorganisms and the protection of microbial cells and/or active molecules for a longer period of time.
[038] A composição imunomoduladora, de controle de populações patogênicas, de efeito prebiótico e probiótico, antioxidante, nutracêutica e promotora de sanidade, segundo outra forma de realização da invenção compreende os seguintes componentes:
- (a) Um ou mais extratos naturais com ação moduladora de imunidade e/ou ação microbicida contra patógenos escolhidos entre: Aloe vera, canela, alho, gengibre, ginseng, Ginko biloba, Momordica charantia, chá verde, Emilia sonchifolia e Psidium guajava;
- (b) 1,3 e 1,6 Betaglucanos;
- (c) Manano-oligossacarídeos (MOS);
- (d) Micro-organismos probióticos: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc;
- (e) Um ou mais ácidos orgânicos com ação moduladora de imunidade e/ou ação microbicida contra patógenos escolhidos entre: ácido cítrico, ácido fumárico, ácido sórbico, ácido maléico, ácido fórmico, ácido propiônico, ácido láctico, ácido butírico, ácido metillinoléico, ácido caprílico, ácido cáprico e ácido lignosulfônico;
- (f) Um ou mais minerais com ação moduladora de imunidade escolhidos entre: selênio, zinco, cobre e manganês;
- (g) Vitamina C e E;
- (h) Extrato de levedura e de spirulina;
- (i) Um ou mais polímeros naturais para imobilização escolhidos entre: quitosana, alginato, gelatina, carragenana, etc.
- (a) One or more natural extracts with an immunity modulating action and/or microbicidal action against pathogens chosen from: Aloe vera, cinnamon, garlic, ginger, ginseng, Ginko biloba, Momordica charantia, green tea, Emilia sonchifolia and Psidium guajava;
- (b) 1,3 and 1,6 Beta Glucans;
- (c) Mannan-oligosaccharides (MOS);
- (d) Probiotic microorganisms: Bacillus subtilis, Bacillus licheniformis, Bacillus pumilus, Lactobacillus plantarum, Lactobacillus acidophilus, Pediococcus acidilati, Saccharomyces cerevisiae, etc.;
- (e) One or more organic acids with immunity modulating action and/or microbicidal action against pathogens chosen from: citric acid, fumaric acid, sorbic acid, maleic acid, formic acid, propionic acid, lactic acid, butyric acid, methyllinoleic acid, caprylic acid, capric acid and lignosulfonic acid;
- (f) One or more minerals with an immunity modulating action chosen from: selenium, zinc, copper and manganese;
- (g) Vitamin C and E;
- (h) Yeast and spirulina extract;
- (i) One or more natural polymers for immobilization chosen from: chitosan, alginate, gelatin, carrageenan, etc.
[039] Os extratos naturais e os ácidos orgânicos da composição desta invenção devem ser, preferencialmente, compatíveis com o uso de micro-organismos probióticos, de forma a não comprometer a viabilidade dos probióticos e de ter mecanismos de ação específico contra bactérias e vírus patogênicos.[039] The natural extracts and organic acids of the composition of this invention should preferably be compatible with the use of probiotic microorganisms, so as not to compromise the viability of probiotics and to have specific mechanisms of action against pathogenic bacteria and viruses. .
[040] Segundo a invenção, a composição contém as categorias de ingredientes em concentrações e proporções definidas por estudos para se atingir o máximo de eficiência com o produto final referente ao combate de patógenos, a melhora da imunidade, a ação prebiótica e probiótica, ao estabelecimento de uma microbiota intestinal saudável e a melhora da nutrição, sem comprometer ou causar estresses no animal e de forma a permitir uma melhor sanidade e performance[040] According to the invention, the composition contains the categories of ingredients in concentrations and proportions defined by studies to achieve maximum efficiency with the final product regarding the fight against pathogens, the improvement of immunity, prebiotic and probiotic action, while establishment of a healthy intestinal microbiota and the improvement of nutrition, without compromising or causing stress on the animal and in order to allow better health and performance
[041] Os teores em relação à massa total da composição, máximos e mínimos, considerando os constituintes puros, estão apresentados na tabela 1: [041] The contents in relation to the total mass of the composition, maximum and minimum, considering the pure constituents, are presented in table 1:
[042] Segundo uma forma preferencial de realização da invenção, os teores dos constituintes na forma pura, estão indicados na tabela 2 abaixo: [042] According to a preferred embodiment of the invention, the contents of the constituents in pure form are indicated in table 2 below:
[043] A presente invenção de composição possui indicação de ser utilizada na taxa de inclusão de 1,0 a 5,0 kg /Ton de ração, dependendo do animal e da finalidade de uso.[043] The present invention of composition is indicated to be used at the inclusion rate of 1.0 to 5.0 kg / ton of feed, depending on the animal and the purpose of use.
[044] Dentre as diferentes criações animais que a composição da invenção se destina podemos citar algumas como: camarão, peixe, animais de estimação, aves, suínos, etc.[044] Among the different animal creations that the composition of the invention is intended for, we can mention some such as: shrimp, fish, pets, poultry, swine, etc.
[045] As proporções dos componentes podem variar na composição dessa invenção de acordo com a finalidade de uso e com o tipo de indivíduo, sempre seguindo os intervalos indicados.[045] The proportions of the components may vary in the composition of this invention according to the purpose of use and the type of individual, always following the indicated intervals.
[046] A seguir são apresentados um rol exemplificativo do uso da composição com caráter meramente ilustrativo, não devendo serem tomados para efeitos limitativos da invenção.[046] The following is an exemplary list of the use of the composition with a merely illustrative character, and should not be taken for the purposes of limiting the invention.
[047] Teste da composição da presente invenção realizado em camarões Litopenaeus vannamei em condições de alta densidade, água com baixa salinidade, aeração constante e sem controle de temperatura, observados em um cultivo de 8 dias em condições desafiadoras variando apenas em relação aos tratamentos alimentares.[047] Test of the composition of the present invention carried out on Litopenaeus vannamei shrimp under conditions of high density, low salinity water, constant aeration and without temperature control, observed in an 8-day culture under challenging conditions varying only in relation to food treatments .
[048] Os experimentos foram realizados em caixas de PVC contendo 250 L de água com salinidade de 0,7 ppt e 40 animais por caixa (160 camarões/m³). Os animais possuíam peso médio de 7,8 g, foram aclimatados por 5 dias e distribuídos por tratamento.[048] The experiments were carried out in PVC boxes containing 250 L of water with a salinity of 0.7 ppt and 40 animals per box (160 shrimp/m³). The animals had an average weight of 7.8 g, were acclimatized for 5 days and distributed by treatment.
[049] Os tratamentos foram:
T1: Animais alimentados apenas com ração comercial (controle);
T2: Animais alimentados com ração comercial aditivada com a composição da presente invenção sem os micro-organismos probióticos na dosagem de 5 Kg/Ton de ração;
T3: Animais alimentados com ração comercial aditivada apenas com as linhagens probióticas da presente invenção na dosagem de 5 Kg/Ton de ração;
T4: Animais alimentados com ração comercial aditivada com a formulação completa da presente invenção na dosagem de 5 Kg/Ton de ração.[049] The treatments were:
T1: Animals fed only with commercial feed (control);
T2: Animals fed commercial feed with the composition of the present invention without probiotic microorganisms at a dosage of 5 kg/ton of feed;
T3: Animals fed with commercial ration added only with the probiotic strains of the present invention at a dosage of 5 Kg/Ton of ration;
T4: Animals fed with commercial feed additive with the complete formulation of the present invention at a dosage of 5 kg/ton of feed.
[050] Foram realizadas análises do potencial imunomodulatório pela técnica de contagem total de hemócitos (THC) circulante na hemolinfa; da performance zootécnica de sobrevivência nos diferentes tratamentos comparado ao uso de ração comercial não aditivada; e do efeito de inibição de bactérias patogênicas do gênero Vibrio no intestino pela técnica de espalhamento em placa (spread plate), utilizando amostras de intestinos maceradas, diluídas serialmente em solução salina 2,5 % (m/v), inoculadas em meio de cultura TCBS Agar (Agar Tiossulfato, Citrato, Bílis e Sacarose), incubadas a 35°C por 24 h para contagem de colônias e determinação da concentração em unidades formadoras de colônias (UFC) por grama de intestino.[050] Analyzes of the immunomodulatory potential were performed by the technique of total hemocyte count (THC) circulating in the hemolymph; the zootechnical performance of survival in the different treatments compared to the use of commercial feed without additives; and the effect of inhibiting pathogenic bacteria of the genus Vibrio in the intestine by the spread plate technique, using samples of macerated intestines, serially diluted in 2.5% saline solution (m/v), inoculated in a culture medium TCBS Agar (Thiosulfate, Citrate, Bile and Sucrose Agar), incubated at 35°C for 24 h to count colonies and determine the concentration in colony forming units (CFU) per gram of intestine.
[051] Os resultados estão apresentados a seguir: [051] The results are presented below:
[052] A sobrevivência e a modulação imunológica nos animais submetidos aos tratamentos com as variantes da formulação aditivadas à ração (T2, T3 e T4) foram melhores quando comparados ao controle (T1), sendo o melhor resultado de modulação imunológica e de sobrevivência utilizando a formulação completa da presente invenção.[052] Survival and immune modulation in animals subjected to treatments with the formulation variants added to the feed (T2, T3 and T4) were better when compared to control (T1), with the best result of immune modulation and survival using the complete formulation of the present invention.
[053] As respostas imunocelulares nos camarões estão diretamente relacionadas ao número de hemócitos circulantes na hemolinfa e ao potencial de sobrevivência do animal, pois estas células são responsáveis pela fagocitose de micro-organismos e pela formação de cápsulas e nódulos ao redor de corpos indesejáveis, além dos mecanismos citotóxicos e degradativos intracelulares, usados para degradar e eliminar patógenos.[053] Immune responses in shrimp are directly related to the number of circulating hemocytes in the hemolymph and the animal's survival potential, as these cells are responsible for the phagocytosis of microorganisms and for the formation of capsules and nodules around undesirable bodies, in addition to intracellular cytotoxic and degradative mechanisms used to degrade and eliminate pathogens.
[054] As análises microbianas revelaram uma diminuição de patógenos do gênero Vibrio nos 3 (três) tratamentos, enquanto no tratamento controle ocorreu um aumento de populações patogênicas. Os resultados atestam a capacidade dos ingredientes não microbianos (T2), do consórcio probiótico (T3) e da formulação completa da presente invenção (T4) em inibir patógenos.[054] Microbial analyzes revealed a decrease in pathogens of the genus Vibrio in the 3 (three) treatments, while in the control treatment there was an increase in pathogenic populations. The results attest to the ability of the non-microbial ingredients (T2), the probiotic consortium (T3) and the complete formulation of the present invention (T4) to inhibit pathogens.
[055] Os estudos atestam que a formulação da presente invenção (T4) possui eficiência no combate de patógenos bacterianos, tem a melhor modulação imunológica e possibilita a melhor taxa de sobrevivência. Os animais desse tratamento (T4) apresentaram melhor sanidade e maior resistência para enfrentar o desafio experimental em convivência com doenças.[055] The studies attest that the formulation of the present invention (T4) has efficiency in combating bacterial pathogens, has the best immunological modulation and enables the best survival rate. The animals of this treatment (T4) showed better sanity and greater resistance to face the experimental challenge in coexistence with diseases.
[056] Foi realizada uma composição, de acordo com a presente invenção, para ser testada como aditivo na alimentação do camarão Litopenaeus vannamei durante cultivo em viveiros abertos em zona afetada pelo vírus da Mancha Branca, utilizando densidades de povoamento entre de 23 a 25 camarões/m2 e salinidade de 40-45 ppt. Nessa região a densidade de povoamento praticada é de 5 a 10 camarões/m2 , devido ao histórico de baixas sobrevivências e altas taxas de perdas de cultivo.[056] A composition was made, according to the present invention, to be tested as an additive in the feed of Litopenaeus vannamei shrimp during cultivation in open ponds in an area affected by the White Spot virus, using stocking densities between 23 to 25 shrimp /m2 and salinity of 40-45 ppt. In this region, the population density practiced is 5 to 10 shrimp/m2, due to the history of low survival and high rates of crop losses.
[057] Foram selecionados 12 viveiros de forma aleatória, 6 viveiros para os tratamentos adicionando a presente invenção na ração e 6 viveiros para os controles utilizando ração comercial aditivada com um produto comercial composto de ácidos orgânicos (opção considerada a melhor alternativa disponível para o cultivo pela fazenda). Uma área de 22 hectares foi reservada para o estudo, 11 hectares para cada condição experimental (5 viveiros de 2 hectares e 1 viveiro de 1 hectare), sendo cada par de viveiros (1 tratamento e 1 controle) povoado utilizando sempre os mesmos lotes de larva com pesos médios iniciais variaram de 67 mg (15 PL/g) a 200 mg (5 PL/g). Foram utilizados manejos de água idênticos em todos os cultivos para minimizar as variáveis e avaliar a influência direta da estratégia alimentar.[057] 12 ponds were randomly selected, 6 ponds for the treatments adding the present invention to the feed and 6 ponds for the controls using commercial feed additive with a commercial product composed of organic acids (option considered the best alternative available for the cultivation by the farm). An area of 22 hectares was reserved for the study, 11 hectares for each experimental condition (5 ponds of 2 hectares and 1 pond of 1 hectare), with each pair of ponds (1 treatment and 1 control) populated using always the same plots of larvae with average initial weights ranged from 67 mg (15 PL/g) to 200 mg (5 PL/g). Identical water managements were used in all crops to minimize variables and assess the direct influence of food strategy.
[058] Foram avaliados o desempenho zootécnico, o estado imunológico pela técnica de contagem total de hemócitos (THC) circulante na hemolinfa e a microbiota intestinal em relação a presença de bactérias patogênicas do gênero Vibrio e a presença de micro-organismos probióticos como bactérias heterotróficas totais do gênero Bacillus, bactérias ácido-lácticas do gênero Lactobacillus e leveduras.[058] The zootechnical performance, the immunological status by the technique of total hemocyte count (THC) circulating in the hemolymph and the intestinal microbiota were evaluated in relation to the presence of pathogenic bacteria of the genus Vibrio and the presence of probiotic microorganisms such as heterotrophic bacteria. total bacteria of the genus Bacillus, lactic acid bacteria of the genus Lactobacillus and yeasts.
[059] As análises microbiológicas foram realizadas pela técnica de espalhamento em placa (spread plate), utilizando amostras de intestinos maceradas, diluídas seriadamente em soluções salinas, inoculadas em diferentes meios de cultura e incubadas a 35-37°C por 24 horas para contagem de colônias e determinação da concentração em unidades formadoras de colônias (UFC) por grama de intestino.[059] Microbiological analyzes were performed using the spread plate technique, using macerated intestine samples, serially diluted in saline solutions, inoculated in different culture media and incubated at 35-37°C for 24 hours for counting of colonies and determination of the concentration in colony forming units (CFU) per gram of intestine.
[060] Foram utilizados os seguintes meios de cultura: ATGE (Agar Triptona, Glicose e Extrato de Levedura) para quantificação de heterotróficos totais e detecção de bactérias do gênero Bacillus; AMRS Lactobacillus (Agar de Man, Rogosa and Sharpe) para quantificação de bactérias ácido-lácticas; AS (Ágar Sabouraud) para quantificação de leveduras e TCBS (Agar Tiossulfato, Citrato, Bílis e Sacarose) para quantificação de vibrios.[060] The following culture media were used: ATGE (Agar Tryptone, Glucose and Yeast Extract) for quantification of total heterotrophs and detection of bacteria of the genus Bacillus; AMRS Lactobacillus (Man, Rogosa and Sharpe Agar) for quantification of lactic acid bacteria; AS (Sabouraud Agar) for yeast quantification and TCBS (Thiosulfate, Citrate, Bile and Sucrose Agar) for vibrio quantification.
[061] Os resultados das análises microbiológicas estão apresentados a seguir: [061] The results of the microbiological analyzes are presented below:
[062] As análises microbiológicas nos intestinos revelaram que na condição utilizando a presente invenção existia uma maior quantidade de micro-organismos heterotróficos totais, de Lactobacillus e de Leveduras comparado à condição controle. As avaliações das morfologias coloniais nos meios de cultivo demonstraram que no intestino dos animais do tratamento as colônias possuíam morfologias características das cepas probióticas utilizadas na formulação, o que evidencia o processo de bioaumento promovido pelo uso da presente invenção aditivada na ração. Enquanto na condição controle, observou-se uma maior diversidade de morfologias coloniais oriundas da microbiota ambiental não relacionadas a probióticos. Importante ressaltar que as leveduras estavam presentes no intestino dos animais com ração aditivada com a presente invenção e que não foi verificada a presença de leveduras no intestino na condição controle, o que serve como parâmetro de padrão interno para confirmação da veiculação dos micro-organismos probióticos para o intestino.[062] Microbiological analyzes in the intestines revealed that in the condition using the present invention there was a greater amount of total heterotrophic microorganisms, Lactobacillus and Yeasts compared to the control condition. The evaluations of the colonial morphologies in the culture media showed that in the intestine of the animals of the treatment the colonies had morphologies characteristic of the probiotic strains used in the formulation, which evidences the process of bioaugmentation promoted by the use of the present invention with additives in the ration. While in the control condition, a greater diversity of colonial morphologies from the environmental microbiota not related to probiotics was observed. It is important to note that yeasts were present in the intestines of animals fed with additives with the present invention and that the presence of yeasts in the intestines was not verified in the control condition, which serves as an internal standard parameter to confirm the propagation of probiotic microorganisms. to the intestine.
[063] As análises microbiológicas de Vibrio spp. demonstraram uma quantidade menor de bactérias patogênicas na condição utilizando a presente invenção comparado à condição controle, o que comprova a eficiência da formulação aditivada na ração em controlar a microbiota patogênica no intestino do animal.[063] The microbiological analyzes of Vibrio spp. demonstrated a lower amount of pathogenic bacteria in the condition using the present invention compared to the control condition, which proves the efficiency of the additive formulation in the feed to control the pathogenic microbiota in the animal's intestine.
[064] Os resultados obtidos das análises do estado imunológico demonstraram uma melhor capacidade de fortalecer os animais com 1,5 X 107 THC/mL de hemolinfa no tratamento comparado a 1,0 X 107 THC/mL no controle.[064] The results obtained from the immunological status analyzes demonstrated a better ability to strengthen animals with 1.5 X 107 THC/mL of hemolymph in the treatment compared to 1.0 X 107 THC/mL in the control.
[065] Os dados zootécnicos do experimento estão apresentados a seguir: [065] The zootechnical data of the experiment are presented below:
[066] Os resultados atestam que o uso da presente invenção aditivada na ração impactou positivamente os dados zootécnicos e econômicos do cultivo comparado ao controle por possibilitar uma maior produtividade, maior sobrevivência, maior densidade final de animais e maior taxa de crescimento em Kg/Hectare/Dia. Importante ressaltar que mesmo com uma maior densidade final e maior biomassa nos viveiros foi possível obter um maior peso médio final dos animais, o que promove uma maior receita por impactar em um melhor preço de venda do Kg de camarão produzido.[066] The results attest that the use of the present invention with additives in the ration positively impacted the zootechnical and economic data of the crop compared to the control by allowing greater productivity, greater survival, greater final density of animals and higher growth rate in kg/hectare /Day. It is important to emphasize that even with a higher final density and higher biomass in the ponds, it was possible to obtain a higher average final weight of the animals, which promotes greater revenue by impacting on a better selling price of the kg of shrimp produced.
[067] A conversão alimentar foi menor no tratamento comparado ao controle, o que revela a obtenção de biomassa com menor utilização de ração e o aproveitamento mais eficiente do alimento pelo animal devido aos benefícios do uso da presente invenção[067] The feed conversion was lower in the treatment compared to the control, which reveals the obtaining of biomass with less use of feed and the more efficient use of food by the animal due to the benefits of using the present invention
[068] A utilização da presente invenção possibilitou melhores resultados por modular o sistema imunológico; reduzir micro-organismos patógenos; aumentar micro-organismos probióticos; aumentar a produção de ácidos orgânicos; promover a oxidação dos radicais livres e melhorar fatores nutricionais essenciais para o desenvolvimento dos animais.[068] The use of the present invention enabled better results by modulating the immune system; reduce pathogenic microorganisms; increase probiotic microorganisms; increase the production of organic acids; promote the oxidation of free radicals and improve nutritional factors essential for the development of animals.
[069] Foram realizados testes variando o manejo de alimentação do camarão Litopenaeus vannamei durante cultivo em viveiros abertos em zona afetada pelo vírus da Mancha Branca, utilizando densidades de povoamento com 25 camarões/m2 e salinidade de 50 ppt. Foi avaliada a influência da estratégia alimentar pela adição da composição, de acordo com a presente invenção, na ração dos animais comparado ao uso apenas de ração comercial.[069] Tests were performed varying the feeding management of Litopenaeus vannamei shrimp during cultivation in open ponds in an area affected by the White Spot virus, using stocking densities of 25 shrimp/m2 and salinity of 50 ppt. The influence of the feeding strategy by the addition of the composition, according to the present invention, in the animal feed compared to the use of commercial feed alone was evaluated.
[070] Uma área de 20 hectares foi reservada, 10 hectares para cada condição experimental (4 viveiros de 2,5 hectares por condição), onde cada par de viveiros (1 tratamento e 1 controle) foi povoado diretamente utilizando larvas de aproximadamente 2,5 mg (400 PL/g). Nessa fazenda não se realiza manejo de água com probióticos para melhorar a ambiência, o que aumenta o desafio de cultivo e diminui taxas de sucesso.[070] An area of 20 hectares was set aside, 10 hectares for each experimental condition (4 ponds of 2.5 hectares per condition), where each pair of ponds (1 treatment and 1 control) was directly populated using larvae of approximately 2.5 hectares. 5 mg (400 PL/g). On this farm, water management with probiotics is not carried out to improve the environment, which increases the challenge of cultivation and decreases success rates.
[071] Foram avaliados o desempenho zootécnico, o estado imunológico pela técnica de contagem total de hemócitos (THC) circulante na hemolinfa e a microbiota intestinal em relação a presença de bactérias patogênicas do gênero Vibrio e a presença de micro-organismos probióticos como bactérias heterotróficas totais do gênero Bacillus, bactérias ácido-lácticas do gênero Lactobacillus e leveduras. Os resultados microbiológicos foram expressos em unidades formadoras de colônias (UFC) por grama de intestino. A metodologia de análise microbiológica e os meios de culturas foram idênticos aos mencionados anteriormente no exemplo 2.[071] The zootechnical performance, the immunological status by the technique of total hemocyte count (THC) circulating in the hemolymph and the intestinal microbiota were evaluated in relation to the presence of pathogenic bacteria of the genus Vibrio and the presence of probiotic microorganisms such as heterotrophic bacteria. total bacteria of the genus Bacillus, lactic acid bacteria of the genus Lactobacillus and yeasts. Microbiological results were expressed in colony forming units (CFU) per gram of intestine. The microbiological analysis methodology and culture media were identical to those mentioned above in example 2.
[072] Os resultados das análises microbiológicas estão apresentados a seguir: [072] The results of the microbiological analyzes are presented below:
[073] A condição alimentar utilizando a presente invenção apresentou maiores quantidades de micro-organismos probióticos (heterotróficos totais, Lactobacillus e Leveduras) nos três meios de cultura comparado à condição controle. A condição controle não apresentou leveduras no intestino, assim como observado nos testes do exemplo 2, enquanto na condição com uso da formulação foi verificado presença de uma comunidade microbiana de leveduras, o que evidencia a efetiva colonização dos micro-organismos probióticos no intestino[073] The food condition using the present invention showed higher amounts of probiotic microorganisms (total heterotrophs, Lactobacillus and Yeasts) in the three culture media compared to the control condition. The control condition did not present yeasts in the intestine, as observed in the tests of example 2, while in the condition with the use of the formulation, the presence of a microbial community of yeasts was verified, which evidences the effective colonization of probiotic microorganisms in the intestine.
[074] As morfologias das colônias nos meios de cultivo foram similares às morfologias das cepas probióticas utilizadas na presente invenção, enquanto na condição controle foi encontrada uma maior diversidade de colônias oriundas da micro-organismos ambientais não relacionados aos probióticos utilizados.[074] The morphologies of the colonies in the culture media were similar to the morphologies of the probiotic strains used in the present invention, while in the control condition a greater diversity of colonies from environmental microorganisms unrelated to the probiotics used was found.
[075] Em relação às análises de Vibrio, verificou-se uma quantidade maior de bactérias patogênicas na condição controle em relação a condição utilizando a presente invenção, o que revela a eficiência da formulação aditivada em modular a microbiota patogênica no intestino do animal.[075] Regarding the analysis of Vibrio, there was a greater amount of pathogenic bacteria in the control condition compared to the condition using the present invention, which reveals the efficiency of the additive formulation in modulating the pathogenic microbiota in the animal's intestine.
[076] As avaliações do estado imunológico dos animais demonstraram uma maior quantidade de células de defesa (hematócitos) circulante na hemolinfa nos animais alimentados com ração aditivada com a composição da presente invenção (1,1 X 107 THC/mL) comparado a condição controle (8,4 X 106 THC/mL).[076] The evaluations of the immunological status of the animals showed a greater amount of defense cells (hematocytes) circulating in the hemolymph in the animals fed with feed additive with the composition of the present invention (1.1 X 107 THC/mL) compared to the control condition (8.4 X 10 6 THC/ml).
[077] O estado imunomodulado está diretamente relacionado ao potencial de sobrevivência do animal, devido ao fato dessas células de defesa serem responsáveis pela fagocitose de micro-organismos e pela formação de cápsulas e nódulos ao redor de corpos indesejáveis, além dos mecanismos citotóxicos e degradativos intracelulares, usados para degradar e eliminar patógenos.[077] The immunomodulated state is directly related to the survival potential of the animal, due to the fact that these defense cells are responsible for the phagocytosis of microorganisms and for the formation of capsules and nodules around undesirable bodies, in addition to cytotoxic and degradative mechanisms. intracellular, used to degrade and eliminate pathogens.
[078] Os dados zootécnicos do experimento estão apresentados a seguir: [078] The zootechnical data of the experiment are presented below:
[079] Uma melhor assimilação dos nutrientes da alimentação foi observada na condição utilizando a composição da invenção, possibilitando uma maior obtenção de biomassa com menor utilização de ração. As análises comparativas dos experimentos de campo revelam melhores resultados zootécnicos e econômicos na condição utilizando a presente invenção comparado ao controle. Observou-se uma maior produtividade, maior sobrevivência, maior densidade final de animais e maior taxa de crescimento em Kg/Hectare/Dia. Esses dados demonstram a eficiência da invenção em melhorar a convivência do animal com patógenos no cultivo possibilitando melhores resultados através da modulação do sistema imunológico; redução de micro-organismos patógenos; aumento de micro-organismos probióticos; aumento da produção de ácidos orgânicos; melhora da oxidação dos radicais livres e oferta de fatores nutricionais pivotais para o desenvolvimento dos animais.[079] A better assimilation of nutrients from the feed was observed in the condition using the composition of the invention, allowing a greater obtainment of biomass with less use of feed. Comparative analyzes of field experiments reveal better zootechnical and economic results in the condition using the present invention compared to the control. Higher productivity, higher survival, higher final density of animals and higher growth rate in Kg/Hectare/Day were observed. These data demonstrate the efficiency of the invention in improving the coexistence of the animal with pathogens in the culture, enabling better results through the modulation of the immune system; reduction of pathogenic microorganisms; increase in probiotic microorganisms; increased production of organic acids; improvement of free radical oxidation and supply of pivotal nutritional factors for the development of animals.
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