BR102019001982A2 - TRANSDERMAL ESTRO ADHESIVE (CIO) INDUCTOR FOR PRODUCTION RUMINANTS AND NON-RUMINANTS - Google Patents
TRANSDERMAL ESTRO ADHESIVE (CIO) INDUCTOR FOR PRODUCTION RUMINANTS AND NON-RUMINANTS Download PDFInfo
- Publication number
- BR102019001982A2 BR102019001982A2 BR102019001982-4A BR102019001982A BR102019001982A2 BR 102019001982 A2 BR102019001982 A2 BR 102019001982A2 BR 102019001982 A BR102019001982 A BR 102019001982A BR 102019001982 A2 BR102019001982 A2 BR 102019001982A2
- Authority
- BR
- Brazil
- Prior art keywords
- ruminants
- adhesive
- transdermal
- inductor
- animal
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 13
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 13
- 241000282849 Ruminantia Species 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 241001465754 Metazoa Species 0.000 claims abstract description 14
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 14
- 210000004207 dermis Anatomy 0.000 claims abstract description 8
- 239000000186 progesterone Substances 0.000 claims abstract description 7
- 229960003387 progesterone Drugs 0.000 claims abstract description 7
- 230000012173 estrus Effects 0.000 claims abstract description 6
- 239000000411 inducer Substances 0.000 claims abstract description 5
- 239000012528 membrane Substances 0.000 claims abstract description 3
- 206010033675 panniculitis Diseases 0.000 claims description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000001464 adherent effect Effects 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- 229920000642 polymer Polymers 0.000 abstract description 3
- 239000004821 Contact adhesive Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 239000005556 hormone Substances 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 4
- 241000283707 Capra Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000001144 hymen Anatomy 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D9/00—Bandages, poultices, compresses specially adapted to veterinary purposes
Abstract
patente de invenção para um indutor de estro em forma de adesivo transdérmico de liberação programada e contínua com progesterona ou análogo sintético, para ser aderido a derme do animal, adesivo de contato feito a base de polímeros, membrana de liberação e revestimento, extinguindo a necessidade de contato direto com a mucosa vaginal e locais próximos.invention patent for an estrus inducer in the form of a transdermal adhesive of programmed and continuous release with progesterone or synthetic analogue, to be adhered to the animal's dermis, contact adhesive made with polymers, release membrane and coating, extinguishing the need direct contact with the vaginal mucosa and nearby sites.
Description
[001] A presente patente de invenção tem por objetivo um indutor de estro elaborado com adesivo transdérmico para ruminantes (bovinos, bubalinos, caprinos e ovinos) e não-ruminantes (equinos e suínos), para uso em criatórios e similares e ao qual foi criado visando melhorar seu uso e eficiência quando comparado a produtos de mesmo segmento existentes.[001] The purpose of this invention patent is an oestrus inducer made with transdermal adhesive for ruminants (cattle, buffaloes, goats and sheep) and non-ruminants (horses and pigs), for use in livestock and similar and for which it was created to improve its use and efficiency when compared to existing products in the same segment.
[002] Existem no mercado dispositivos intravaginais com função de indução de cio, sendo um de silicone e em forma de T impregnado de progesterona, esponja impregnada com progesterona ou análogo sintético, além de um dispositivo que é colocado no tecido subcutâneo (camada abaixo da pele) na base da orelha em ovelhas e cabras principalmente e permanece durante todo o tratamento.[002] There are intravaginal devices with estrus induction function on the market, one of which is silicone and in the form of a T impregnated with progesterone, a sponge impregnated with progesterone or synthetic analog, in addition to a device that is placed in the subcutaneous tissue (layer below the at the base of the ear in sheep and goats mainly and remains throughout the treatment.
[003] A utilização desses indutores causa alguns inconvenientes, como até 100% de infecções locais após a retirada da esponja em questão, consequentemente necessitando também do uso de antibióticos após e retirada, ou fazendo com que produtores façam uso dos antimicrobianos antes mesmo de colocarem a esponja, possivelmente levando a resistência de certos microrganismos a alguns dos fármacos utilizados. Informações essas já confirmadas em diversos experimentos de pesquisa científica já realizados e publicados em revistas científicas de elevado respaldo, ocorrendo inclusive em alguns casos, óbito em infecção decorrente do uso de dispositivo intravaginal.[003] The use of these inducers causes some inconveniences, such as up to 100% of local infections after the removal of the sponge in question, consequently also requiring the use of antibiotics after and removal, or causing producers to use the antimicrobials before even putting them on. the sponge, possibly leading to the resistance of certain microorganisms to some of the drugs used. This information has already been confirmed in several scientific research experiments already carried out and published in highly supported scientific journals, including in some cases, death from infection due to the use of an intravaginal device.
[004] Outro problema encontrado ao utilizar a esponja, é a necessidade de rompimento do hímen, situação essa, passível de interferência no bem-estar e estado sanitário do animal. Além do fato de haver sangramento no momento do rompimento, sendo o sangue um excelente meio de cultura para microrganismos e sua presença tornando passível a ocorrência de aderências no local. Com relação ao dispositivo introduzido na orelha, é também um método invasivo pois é introduzido no tecido subcutâneo (camada profunda da pele), o que provavelmente causa dor no momento em que é aplicado. Assim, os dispositivos existentes (implantes de orelha, dispositivos vaginais e outros mencionados) podem causar desconforto no momento da colocação e/ou durante todo o período de utilização.[004] Another problem encountered when using the sponge, is the need to break the hymen, a situation that could interfere with the well-being and health of the animal. In addition to the fact that there is bleeding at the moment of rupture, blood being an excellent culture medium for microorganisms and its presence making it possible for adhesions to occur on the site. Regarding the device inserted in the ear, it is also an invasive method because it is introduced into the subcutaneous tissue (deep layer of the skin), which probably causes pain the moment it is applied. Thus, existing devices (ear implants, vaginal devices and others mentioned) can cause discomfort at the time of placement and / or throughout the period of use.
[005] Tendo em vista esses problemas e no propósito de superá-los, foi desenvolvido o adesivo transdérmico de indução de cio, objeto da presente patente, o qual funciona de maneira não invasiva permitindo melhor bem-estar e saúde dos animais.[005] In view of these problems and in order to overcome them, the transdermal heat-induction patch, object of the present patent, was developed, which works in a non-invasive way allowing better animal welfare and health.
[006] Este material (adesivo) usado como indutor de cio nos ruminantes soluciona os inconvenientes aventados, uma vez que o adesivo é apenas colado de forma superficial na pele do animal, sem causar estresse, lesão, dor ou infecções no animal, o que impede a interferência de outros fatores, como sangramento ou meios invasivos prejudicando o bem-estar animal. Além disso, o produtor poderá reduzir seus custos com medicamentos veterinários e cuidados animais obtendo ainda ganhos na produtividade animal.[006] This material (adhesive) used as a heat-inducing agent in ruminants solves the inconveniences suggested, since the adhesive is only glued superficially to the animal's skin, without causing stress, injury, pain or infections in the animal, which prevents interference from other factors, such as bleeding or invasive means, harming animal welfare. In addition, the producer will be able to reduce his costs with veterinary medicines and animal care while also obtaining gains in animal productivity.
[007] Essa forma de fabricação soluciona inconvenientes, uma vez que não necessita ser colocado internamente no animal, evitando processos infecciosos e rompimento do hímen, evitando estresse fisiológico e psicológico.[007] This form of manufacture solves inconveniences, since it does not need to be placed internally in the animal, avoiding infectious processes and rupture of the hymen, avoiding physiological and psychological stress.
[008] Por outro lado, a colocação do indutor no animal torna-se extremamente mais simples quando comparado aos indutores existentes, devido ao fato de ser necessário apenas aderi-lo a derme do animal, sem nenhum tipo de contato mais invasivo.[008] On the other hand, the placement of the inductor in the animal becomes extremely simpler when compared to existing inductors, due to the fact that it is only necessary to adhere it to the animal's dermis, without any type of more invasive contact.
[009] O adesivo transdérmico é fabricado utilizando como base um polímero, pois possui as propriedades necessárias para interagir de forma eficiente com o hormônio utilizado e é bastante apropriado para a fabricação de adesivos para aderir a derme. Possui membrana de liberação, que permitirá que a progesterona ou análogo sintético seja liberado de forma programada e contínua durante todo o tratamento. O mesmo possui uma camada de substância que permitirá aderência a derme e uma camada de cobertura, a qual ficará em contato com o ambiente e evitará interferências do mesmo, como por exemplo, a umidade. A progesterona ou análogo sintético está presente em toda a extensão do adesivo.[009] The transdermal patch is manufactured using a polymer base, as it has the necessary properties to interact efficiently with the hormone used and is quite suitable for the manufacture of adhesives to adhere to the dermis. It has a release membrane, which will allow the progesterone or synthetic analog to be released in a programmed and continuous manner throughout the treatment. It has a layer of substance that will allow adherence to the dermis and a covering layer, which will be in contact with the environment and avoid its interference, such as humidity. Progesterone or a synthetic analogue is present throughout the adhesive.
[010] Assim, o indutor de cio adesivo transdérmico, funciona em aspecto semelhante com os usuais, pois com a utilização do hormônio, permite a indução do cio através da liberação gradual e programada de hormônio ou análogo sintético, porém sua conformação se apresenta como uma grande vantagem, visto que sua utilização não se faz de forma invasiva. Sendo necessário apenas aderi-lo a derme e o mesmo permanecer no local durante a duração do tratamento.[010] Thus, the transdermal adhesive heat inducer works in a similar aspect with the usual ones, because with the use of the hormone, it allows the induction of heat through the gradual and programmed release of hormone or synthetic analog, however its conformation is presented as a great advantage, since its use is not done invasively. It is only necessary to adhere it to the dermis and remain in place for the duration of the treatment.
[011] Quando o adesivo é colado no animal (na parte ventral ou interior da coxa ou próximo a base da cauda, garupa ou lombo) se adere à derme do mesmo em toda a sua extensão e extremidades, liberando o hormônio de forma gradual e programada pelo período determinado.[011] When the patch is glued to the animal (on the ventral or inner part of the thigh or near the base of the tail, rump or loin) it adheres to the dermis in its entire length and extremities, releasing the hormone gradually and programmed for the specified period.
[012] O modelo de adesivo transdémico indutor de estro (cio) para ruminantes, objeto da presente patente, consiste em um adesivo transdérmico composto de diferentes polímeros, utilizando progesterona ou análogo deste hormônio, aderindo-se a derme de forma reversível pela presença de substância aderente.[012] The model of transdermal estrus-inducing adhesive for ruminants, object of the present patent, consists of a transdermal adhesive composed of different polymers, using progesterone or analog of this hormone, adhering to the dermis reversibly by the presence of adherent substance.
[013] Logicamente, a fabricação do adesivo pode ser feita em tamanhos variados de acordo com a espécie animal.[013] Of course, the manufacture of the adhesive can be done in sizes varying according to the animal species.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102019001982-4A BR102019001982A2 (en) | 2019-01-31 | 2019-01-31 | TRANSDERMAL ESTRO ADHESIVE (CIO) INDUCTOR FOR PRODUCTION RUMINANTS AND NON-RUMINANTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102019001982-4A BR102019001982A2 (en) | 2019-01-31 | 2019-01-31 | TRANSDERMAL ESTRO ADHESIVE (CIO) INDUCTOR FOR PRODUCTION RUMINANTS AND NON-RUMINANTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR102019001982A2 true BR102019001982A2 (en) | 2020-08-11 |
Family
ID=72241910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR102019001982-4A BR102019001982A2 (en) | 2019-01-31 | 2019-01-31 | TRANSDERMAL ESTRO ADHESIVE (CIO) INDUCTOR FOR PRODUCTION RUMINANTS AND NON-RUMINANTS |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR102019001982A2 (en) |
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2019
- 2019-01-31 BR BR102019001982-4A patent/BR102019001982A2/en active Search and Examination
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| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08G | Application fees: restoration [chapter 8.7 patent gazette] |