BR102018077328A2 - whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product - Google Patents
whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product Download PDFInfo
- Publication number
- BR102018077328A2 BR102018077328A2 BR102018077328-3A BR102018077328A BR102018077328A2 BR 102018077328 A2 BR102018077328 A2 BR 102018077328A2 BR 102018077328 A BR102018077328 A BR 102018077328A BR 102018077328 A2 BR102018077328 A2 BR 102018077328A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- concentration
- centesimal
- acid
- agents
- Prior art date
Links
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 18
- 208000035475 disorder Diseases 0.000 title claims abstract description 15
- 230000002087 whitening effect Effects 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 206010040865 Skin hyperpigmentation Diseases 0.000 title claims description 6
- 239000012265 solid product Substances 0.000 title 1
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims abstract description 21
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims abstract description 20
- 229940116918 octadecenedioic acid Drugs 0.000 claims abstract description 11
- SBLKVIQSIHEQOF-UPHRSURJSA-N Octadec-9-ene-1,18-dioic-acid Chemical compound OC(=O)CCCCCCC\C=C/CCCCCCCC(O)=O SBLKVIQSIHEQOF-UPHRSURJSA-N 0.000 claims abstract description 10
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 claims abstract description 10
- 229960000271 arbutin Drugs 0.000 claims abstract description 10
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002738 chelating agent Substances 0.000 claims abstract description 9
- 239000011782 vitamin Substances 0.000 claims abstract description 9
- 229940088594 vitamin Drugs 0.000 claims abstract description 9
- 229930003231 vitamin Natural products 0.000 claims abstract description 9
- 235000013343 vitamin Nutrition 0.000 claims abstract description 9
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 8
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000007854 depigmenting agent Substances 0.000 claims abstract description 8
- 229940068041 phytic acid Drugs 0.000 claims abstract description 8
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 8
- 239000000467 phytic acid Substances 0.000 claims abstract description 8
- 239000013543 active substance Substances 0.000 claims abstract description 7
- 125000000129 anionic group Chemical group 0.000 claims abstract description 7
- 239000002585 base Substances 0.000 claims abstract description 7
- 229950006825 dexamethasone valerate Drugs 0.000 claims abstract description 7
- 239000003974 emollient agent Substances 0.000 claims abstract description 7
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 208000031066 hyperpigmentation of the skin Diseases 0.000 claims abstract description 7
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960004705 kojic acid Drugs 0.000 claims abstract description 7
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003223 protective agent Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 10
- 239000006210 lotion Substances 0.000 claims description 9
- 206010008570 Chloasma Diseases 0.000 claims description 5
- 208000003351 Melanosis Diseases 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 201000010272 acanthosis nigricans Diseases 0.000 claims description 3
- 206010000496 acne Diseases 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims description 2
- 206010040844 Skin exfoliation Diseases 0.000 claims description 2
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 2
- 229960004101 bemotrizinol Drugs 0.000 claims description 2
- 230000008021 deposition Effects 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- 229940108325 retinyl palmitate Drugs 0.000 claims description 2
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 2
- 239000011769 retinyl palmitate Substances 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- -1 vitamin acetate Chemical class 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 229940033280 alpha-arbutin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 8
- 230000009471 action Effects 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
- 206010040829 Skin discolouration Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000004061 bleaching Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 210000003630 histaminocyte Anatomy 0.000 description 3
- 230000003054 hormonal effect Effects 0.000 description 3
- 208000000069 hyperpigmentation Diseases 0.000 description 3
- 230000003810 hyperpigmentation Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229960004441 tyrosine Drugs 0.000 description 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 229940124558 contraceptive agent Drugs 0.000 description 2
- 239000003433 contraceptive agent Substances 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 208000021710 Hyperpigmentation disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229920001273 Polyhydroxy acid Polymers 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 239000000058 anti acne agent Substances 0.000 description 1
- 229940124340 antiacne agent Drugs 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000035614 depigmentation Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- 229940124642 endogenous agent Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 229950008325 levothyroxine Drugs 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 210000002824 peroxisome Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000006950 reactive oxygen species formation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
A invenção refere-se à uma composição farmacêutica clareadora para o tratamento de distúrbios que provocam o aumento de depósito de melanina e a hiperpigmentação da pele, compreendendo um complexo clareador composto pelos agentes farmaceuticamente ativos em uma concentração centesimal(p/p)de 5,00% a 15,00% para a hidroquinona; 8,00% a 10,00% para o ácido fitico 35%; 3% a 7% o para 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin); 2,00% a 5,00% para o ácido azeláico; 0,50% a 2,00% para o ácido octadecenodióico; 7,00 a 8,00% de gluconoloctona; 3,00% a 5,00% de Nano Kojico, 4,00% a 6,00% para o ácido kójico e 0,05% a 1,00% para o valerato de dexametasona; e os gentes farmaceuticamente inertes sendo os conservates, os emulsificantes, os agentes protetores anti UVA e UVB, os emolientes, os agentes despigmentantes, os quelantes, as bases aniônicas, as vitaminas e a água.The invention relates to a whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and hyperpigmentation of the skin, comprising a whitening complex composed of pharmaceutically active agents in a centesimal concentration (w / w) of 5, 00% to 15.00% for hydroquinone; 8.00% to 10.00% for phytic acid 35%; 3% to 7% o for 4-hydroxyphenyl-alpha-D-glucopyranoside (Alfa Arbutin); 2.00% to 5.00% for azelaic acid; 0.50% to 2.00% for octadecenedioic acid; 7.00 to 8.00% gluconolocton; 3.00% to 5.00% of Nano Kojico, 4.00% to 6.00% for kojic acid and 0.05% to 1.00% for dexamethasone valerate; and the pharmaceutically inert people being conservates, emulsifiers, anti UVA and UVB protective agents, emollients, depigmenting agents, chelators, anionic bases, vitamins and water.
Description
[001] A presente invenção é destinada ao setor da saúde, cujo o principal objetivo é o tratamento de distúrbios associadas ao aumento da hiperpigmentação da pele que pode acometer homens e mulheres.[001] The present invention is aimed at the health sector, whose main objective is the treatment of disorders associated with increased skin hyperpigmentation that can affect men and women.
[002] A presente invenção consiste de uma composição farmacêutica clareadora para o tratamento de distúrbios que provocam o aumento de depósito de melanina e a hiperpigmentação da pele compreendendo um complexo clareador composto pela hidroquinona, o ácido fitico 35%, o hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin), o ácido azeláico, o ácido octadecenodióico, o Nano Kojico, (VII) a valerato de dexametasona. E outros agentes, sendo os agentes farmaceuticamente inertes, como os conservantes, os emulsificantes, os agentes protetores anti UVA e UVB, os emolientes, os agentes despigmentantes, os quelantes, as bases aniônicas, as vitaminas e a água.[002] The present invention consists of a whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and hyperpigmentation of the skin comprising a whitening complex composed of hydroquinone, phytic acid 35%, hydroxyphenyl-alpha-D -glucopyranoside (Alfa Arbutin), azelaic acid, octadecenedioic acid, Nano Kojico, (VII) dexamethasone valerate. And other agents, being pharmaceutically inert agents, such as preservatives, emulsifiers, anti-UVA and UVB protective agents, emollients, depigmenting agents, chelators, anionic bases, vitamins and water.
[003] O tecido cutâneo é considerado o maior órgão do corpo humano. Estruturalmente, este tecido se divide em três camadas: a epiderme, a derme e a hipoderme. A epiderme é a camada mais superficial, composta de células epiteliais estratificadas e de forma pavimentosa, intimamente unidas e avascular e sendo até 90% de queratinócitos.[003] Skin tissue is considered the largest organ in the human body. Structurally, this tissue is divided into three layers: the epidermis, the dermis and the hypodermis. The epidermis is the most superficial layer, composed of stratified and pavement epithelial cells, intimately joined and avascular and being up to 90% of keratinocytes.
[004] A derme é composta por um tecido conjuntivo denso, irregular e elástico de grande resistência, formando um suporte entre a epiderme e o tecido subcutâneo subjacente. Apresentando grande quantidade de fibroblastos, colágenos, células do sistema imune como macrófagos e mastócitos.[004] The dermis is composed of a dense, irregular and elastic connective tissue of great resistance, forming a support between the epidermis and the underlying subcutaneous tissue. Presenting a large amount of fibroblasts, collagens, immune system cells such as macrophages and mast cells.
[005] A camada mais interna do tecido é a hipoderme ou tecido subcutâneo, composto por uma rede de células adiposas e vasos sanguineos. A hipoderme atua como um reservatório de energia devido ao seu grande número de células adiposas, assim, efetua um papel de destaque como um isolante de calor e na absorção de impactos, protegendo os órgãos mais internos.[005] The innermost layer of tissue is the hypodermis or subcutaneous tissue, composed of a network of adipose cells and blood vessels. The hypodermis acts as a reservoir of energy due to its large number of fat cells, thus, it plays a prominent role as an insulator of heat and in absorbing impacts, protecting the internal organs.
[006] Pelo fato deste tecido sofre ação constante de agentes nocivos externos de natureza quimica, biológica e de radiações ionizantes; bem como; dos agentes endógenos devido as alterações hormonais ou a formação de espécies reativas de oxigênio e metabólitos, ele apresenta um forte processo de renovação e proteção celular.[006] Due to the fact that this tissue suffers constant action from external harmful agents of a chemical, biological and ionizing radiation nature; as well as; of endogenous agents due to hormonal changes or the formation of reactive oxygen species and metabolites, it has a strong process of cell renewal and protection.
[007] Este mecanismo de renovação e proteção é constante e acelerado, sendo altamente efetivo. Entretanto, quando esse mecanismo falha podem aparecer distúrbios ou doenças de natureza inflamatória, resultando no aparecimento de manchas provocadas pela hiperpigmentação.[007] This renewal and protection mechanism is constant and accelerated, being highly effective. However, when this mechanism fails, disorders or diseases of an inflammatory nature may appear, resulting in the appearance of spots caused by hyperpigmentation.
[008] O melasma é um grande exemplo de distúrbios ocasionados pela ação dos agentes nocivos. É uma condição que se caracteriza pelo surgimento de manchas escuras na pele, mais comumente na face, mas também pode ser de ocorrência extra facial (Sociedade Brasileira de Dermatologia).[008] Melasma is a great example of disorders caused by the action of harmful agents. It is a condition that is characterized by the appearance of dark spots on the skin, most commonly on the face, but it can also be of extra facial occurrence (Sociedade Brasileira de Dermatologia).
[009] Afeta frequentemente as mulheres, mas podem ser observados em homens. Sua principal causa está relacionada ao fator hormonal, devido ao uso de anticoncepcionais por um longo tempo ou durante o periodo gestacional (cloasma gravidico) quando 50% das mulheres podem desenvolvê-lo em consequência das alterações hormonais durante o periodo gravidico (British Association of Dermatology).[009] It often affects women, but can be seen in men. Its main cause is related to the hormonal factor, due to the use of contraceptives for a long time or during the gestational period (chloasma gravidico) when 50% of women may develop it as a result of hormonal changes during the pregnancy period (British Association of Dermatology ).
[010] Um ouro distúrbio envolvendo o processo de hiperpigmentação é a ancatosis nigrasns, a qual afeta majoritariamente a região das pregas cutâneas (pescoço, virilhas, axilas e regiões em torno dos mamilos), se apresentando por vezes uma área acastanhada. Podem ser ocasionadas em pacientes com quadro de obesidade ou diabetes, e também por longos periodos de uso de corticoides e contraceptivos (Rosário; F. Caldeira; J. Medicina Interna. Vol.8, N.4, 2001).[010] A gold disorder involving the hyperpigmentation process is ancatosis nigrasns, which mainly affects the skin folds region (neck, groin, armpits and regions around the nipples), sometimes presenting a brownish area. They can be caused in patients with obesity or diabetes, and also for long periods of use of corticosteroids and contraceptives (Rosário; F. Caldeira; J. Medicina Interna. Vol.8, N.4, 2001).
[011] Os distúrbios de hiperpigmentação não causam dores ou queimações ou qualquer outro tipo de sintoma. Seu efeito é agravado por afetar o bem-estar do paciente, principalmente as mulheres que podem ser vitimas de constrangimento ou estresse psicológico.[011] Hyperpigmentation disorders do not cause pain or burning or any other symptoms. Its effect is aggravated by affecting the patient's well-being, especially women who may be victims of embarrassment or psychological stress.
[012] Dentro do estado da técnica são apresentadas diversas formas ou produtos para o tratamento de distúrbios relacionados com a hiperpigmentação. Os documentos de patentes PI 04155157, US 2013171079 e BR 1120130057033 ensinam produtos para o clareamento da pele contendo, em parte, os ativos presente na referida composição. Entretanto, o diferencial da presente invenção é a combinação de agentes ativos e não ativos em uma concentração centesimal (p/p) que representa alta eficiência e segurança no clareamento da pele. Um segundo diferencial apresentado por esta invenção no clareamento da pele é o uso combinado de um creme e uma loção amplificadora durante o tratamento de clareamento da pele.[012] Within the state of the art, various forms or products are presented for the treatment of disorders related to hyperpigmentation. Patent documents PI 04155157, US 2013171079 and BR 1120130057033 teach skin lightening products containing, in part, the active ingredients present in the said composition. However, the differential of the present invention is the combination of active and non-active agents in a centesimal concentration (w / w) that represents high efficiency and safety in skin lightening. A second differential presented by this invention in skin lightening is the combined use of a cream and an amplifying lotion during the skin lightening treatment.
[013] O principal objeto desta invenção é uma composição farmacêutica clareadora para o tratamento de distúrbios que provocam o aumento de depósito de melanina e a hiperpigmentação da pele, compreendendo um complexo clareador composto pelos agentes farmaceuticamente ativos em uma concentração centesimal(p/p)de 5,00% a 15,00% para a hidroquinona; 8,00% a 10,00% para o ácido fitico 35%; 3% a 7% o para 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin); 2,00% a 5,00% para o ácido azeláico; 0,50% a 2,00% para o ácido octadecenodióico; 7,00 a 8,00% de gluconoloctona; 3,00% a 5,00% de Nano Kojico, 4,00% a 6,00% para o ácido kójico e 0,05% a 1,00% para o valerato de dexametasona; e os gentes farmaceuticamente inertes sendo os conservates, os emulsificantes, os agentes protetores anti UVA e UVB, os emolientes, os agentes despigmentantes, os quelantes, as bases aniônicas, as vitaminas e a água.[013] The main object of this invention is a bleaching pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and hyperpigmentation of the skin, comprising a bleaching complex composed of pharmaceutically active agents in a centesimal concentration (w / w) from 5.00% to 15.00% for hydroquinone; 8.00% to 10.00% for phytic acid 35%; 3% to 7% o for 4-hydroxyphenyl-alpha-D-glucopyranoside (Alfa Arbutin); 2.00% to 5.00% for azelaic acid; 0.50% to 2.00% for octadecenedioic acid; 7.00 to 8.00% gluconolocton; 3.00% to 5.00% of Nano Kojico, 4.00% to 6.00% for kojic acid and 0.05% to 1.00% for dexamethasone valerate; and the pharmaceutically inert people being conservates, emulsifiers, anti UVA and UVB protective agents, emollients, depigmenting agents, chelators, anionic bases, vitamins and water.
[014] Um outro objeto da invenção é o uso da referida composição para a fabricação de um produto cosmético apresentado na forma farmacêutica semi-sólida.[014] Another object of the invention is the use of said composition for the manufacture of a cosmetic product presented in semi-solid pharmaceutical form.
[015] O último objeto da presente invenção é o uso do produto cosmético semi-sólido, fabricado a partir da composição ensinada nesta invenção, ser aplicado para o tratamento de distúrbios que provocam o aumento de depósito de melanina e hiperpigmentação da pele, como exemplo o melasma, a psoriase, a acne, a acantose nigricans.[015] The last object of the present invention is the use of the semi-solid cosmetic product, manufactured from the composition taught in this invention, to be applied for the treatment of disorders that cause the increase of melanin deposit and hyperpigmentation of the skin, as an example melasma, psoriasis, acne, acanthosis nigricans.
[016] Para o melhor entendimento da invenção, foi denominado de agente farmaceuticamente ativo aquela matéria prima contida na formulação que apresentam uma ação farmacológica, tendo como o resultado a redução do depósito de melanina ou uma ação anti-inflamatória. O agente farmaceuticamente inativo é a matéria prima sem efeito farmacológico, mas que fornece caracteristicas organolépticas, estabilidade e conservam a composição.[016] For a better understanding of the invention, the raw material contained in the formulation that has a pharmacological action was called a pharmaceutically active agent, resulting in the reduction of the melanin deposit or an anti-inflammatory action. The pharmaceutically inactive agent is the raw material with no pharmacological effect, but which provides organoleptic characteristics, stability and preserves the composition.
[017] A presente invenção ensina uma composição farmacêutica clareadora para o tratamento de distúrbios que provocam o aumento da hiperpigmentação da pele, compreendendo um complexo clareador composto pelos agentes farmaceuticamente ativos como a hidroquinona, o ácido fitico 35%, 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin), ácido azeláico, o ácido octadecenodióico, de gluconoloctona, de Nano Kojico, o ácido kójico e o valerato de dexametasona; e os agentes farmaceuticamente inertes sendo os conservates, os emulsificantes, os agentes protetores anti UVA e UVB, os emolientes, os agentes despigmentantes, os quelantes, as bases aniônicas, as vitaminas e a água.[017] The present invention teaches a whitening pharmaceutical composition for the treatment of disorders that cause increased skin hyperpigmentation, comprising a whitening complex composed of pharmaceutically active agents such as hydroquinone, phytic acid 35%, 4-hydroxyphenyl-alpha- D-glucopyranoside (Alfa Arbutin), azelaic acid, octadecenedioic acid, gluconoloctone, Nano Kojico, kojic acid and dexamethasone valerate; and pharmaceutically inert agents being conservates, emulsifiers, anti UVA and UVB protective agents, emollients, depigmenting agents, chelators, anionic bases, vitamins and water.
[018] Em uma concentração farmaceuticamente aceitável, os agentes ativos que compreende o complexo clareador da presente invenção, apresentam uma concentração centesimal (p/p) que varia entre 5,00% a 15,00% para a hidroquinona; 8,00% a 10,00% para o ácido fitico 35%; 3% a 7% para o 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin); 2,00% a 5,00% para o ácido azeláico; 0,50% a 2,00% para o ácido octadecenodióico; 7,00 a 8,00% de gluconoloctona; 3,00% a 5,00% de Nano Kojico, 4,00% a 6,00% para o ácido kójico e 0,05% a 1,00% para o valerato de dexametasona.[018] In a pharmaceutically acceptable concentration, the active agents that comprise the bleaching complex of the present invention, have a centesimal concentration (w / w) that varies between 5.00% to 15.00% for hydroquinone; 8.00% to 10.00% for phytic acid 35%; 3% to 7% for 4-hydroxyphenyl-alpha-D-glucopyranoside (Alfa Arbutin); 2.00% to 5.00% for azelaic acid; 0.50% to 2.00% for octadecenedioic acid; 7.00 to 8.00% gluconolocton; 3.00% to 5.00% Nano Kojico, 4.00% to 6.00% for kojic acid and 0.05% to 1.00% for dexamethasone valerate.
[019] A eficácia da composição farmacêutica para o clareamento da pele é devido a associação dos diferentes ativos dentro de uma concentração segura para o paciente. Os ativos possuem mecanismos de ação diferentes, quem em conjuntos desempenham efeitos sinérgicos aumentando a eficiência do tratamento.[019] The effectiveness of the pharmaceutical composition for lightening the skin is due to the association of the different actives within a safe concentration for the patient. The assets have different mechanisms of action, who together have synergistic effects increasing the efficiency of the treatment.
[020] A seguir, são apresentados a indicação e o mecanismo de ação dos ativos empregados na composição:[020] The following are the indication and the mechanism of action of the assets used in the composition:
[021] -Hidroquinona - Despigmentante. Atua provocando mudanças estruturais nas membranas das organelas dos melanócitos, acelerando a degradação dos melanossomas;[021] -Hydroquinone - Depigmenting agent. It acts by causing structural changes in the membranes of the organelles of melanocytes, accelerating the degradation of melanosomes;
[022] -Ácido Fitico - é um agente despigmentante, mas também apresenta bons efeitos como agente quelante e conservante.[022] -Fitic Acid - is a depigmenting agent, but it also has good effects as a chelating and preservative agent.
[023] - Hidroxifenil-alfa-D-glucopiranósido (Alfa arbutin)-despigmentante. Atua bloqueando a biossintese epidermal da melanina, através da inibição da oxidação enzimática da tirosina, a DOPA;[023] - Hydroxyphenyl-alpha-D-glucopyranoside (Alfa arbutin) -depigmentant. It works by blocking the melanin epidermal biosynthesis, by inhibiting the enzymatic oxidation of tyrosine, DOPA;
[024] -Ácido Azeláico - ácido dicarboxilico e atua como antiacnéico. Controla o ciclo de renovação celular dentro do foliculo piloso, evitando seu bloqueio por material queratinoso e devido a isso, possui ação anticomedogênica. Além de ter uma ação anti-inflamatória;[024] - Azelaic Acid - dicarboxylic acid and acts as an anti-acne agent. Controls the cell renewal cycle within the hair follicle, preventing its blockage by keratinous material and due to this, it has anticomedogenic action. In addition to having an anti-inflammatory action;
[025] -Ácido octadecenodióico (Oda White) - Despigmentante. Atua inibindo os fatores de PPAR (Peroxisome Proliferator-Activated Recepto) que regulam a expressão dos genes para a produção da melanina;[025] -Octadecenedioic acid (Oda White) - Depigmenting agent. It works by inhibiting the factors of PPAR (Peroxisome Proliferator-Activated Receptum) that regulate the expression of genes for the production of melanin;
[026] -Gluconoloctona - Polihidroxiácido esfoleante, que descama suavemente a pele sem provocar seu ressecamento, devido à sua ação hidratante;[026] -Gluconoloctona - Exfoliating polyhydroxy acid, which gently peels the skin without causing it to dry out, due to its moisturizing action;
[027] -Nano Kójico - Despigmentante. Inibe a tirosina;[027] -Nano Kójico - Depigmenting. Inhibits tyrosine;
[028] -Ácido Kójico - Despigmentante. Inibe a oxidação a L-tiroxina por ser um agente quelante do cobre. íon fundamental para a conversão do L-tirosina em L-dihidroxifenilalanina (L-DOPA).[028] -Kójico Acid - Depigmenting. It inhibits oxidation to L-thyroxine because it is a copper chelating agent. fundamental ion for the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA).
[029] -Valerato de Dexametasona - Corticoide com forte ação anti-inflamatória, principalmente no combate a reações alérgicas em fase aguda. Seu mecanismo de ação atua diminuindo a densidade de mastócitos, diminuição da quimiotaxia e ativação dos eosinófilos, diminuição da produção de citocinas por linfócitos, monócitos, mastócitos e eosinófilos, e inibindo o metabolismo do ácido araquidônico.[029] -Dexamethasone Valerate - Corticoid with strong anti-inflammatory action, mainly in combating allergic reactions in the acute phase. Its mechanism of action acts by decreasing the density of mast cells, decreasing chemotaxis and activating eosinophils, decreasing the production of cytokines by lymphocytes, monocytes, mast cells and eosinophils, and inhibiting the metabolism of arachidonic acid.
[030] São empregados mais de um agente inerte na referida composição para que seja alcançado a melhor estabilidade e eficiência, podem ser qualquer um conhecido do estado da técnica, contanto que esteja em uma concentração centesimal (p/p) farmaceuticamente aceitável, sendo preferencialmente o 8% de Ascorsilane C, e/ou 0,5% de Unicid, e/ou 0,3% de metabissulfito de sódio, e/ou 0,08% de butil hidroxitolueno (BTH) e/ou 0,50% de Optiphen e/ou 4,00% propanediol como agentes conservantes; 5,00% de Tinosorb S como agente protetor anti UVA/UVB; 2,00% de Emullium 22, e/ou 2,50% de Aristoflex AVL e/ou 1,00% de Amphsol K como agentes emulsificantes; 2,00% de Dermol e/ou 2,00% Net FS como agentes emolientes; 0,30% de dissodio EDTA como um agente quelante; 0,24% de CI 77491, e/ou 0,22% de CI 77492 e/ou 0,16% CI 77499 e/ou 5,00% dióxido de titânio como corantes; 6,00% de Lanette N e/ou Emulzome como base aniônica; 5,00% de palmitato de vitamina A e/ou 0,50% de acetato de vitamina como agentes vitaminicos; 1,00% de álcool desodorizado e 22,85% de água.[030] More than one inert agent is used in said composition in order to achieve the best stability and efficiency, they can be any known in the state of the art, as long as it is in a pharmaceutically acceptable centesimal concentration (w / w), being preferably o 8% Ascorsilane C, and / or 0.5% Unicid, and / or 0.3% sodium metabisulfite, and / or 0.08% butyl hydroxytoluene (BTH) and / or 0.50% Optiphen and / or 4.00% propanediol as preservative agents; 5.00% of Tinosorb S as an anti-UVA / UVB protective agent; 2.00% Emullium 22, and / or 2.50% Aristoflex AVL and / or 1.00% Amphsol K as emulsifying agents; 2.00% Dermol and / or 2.00% Net FS as emollient agents; 0.30% EDTA disodium as a chelating agent; 0.24% CI 77491, and / or 0.22% CI 77492 and / or 0.16% CI 77499 and / or 5.00% titanium dioxide as dyes; 6.00% of Lanette N and / or Emulzome as an anionic base; 5.00% vitamin A palmitate and / or 0.50% vitamin acetate as vitamin agents; 1.00% deodorized alcohol and 22.85% water.
[031] A referida composição compreendendo seus agentes farmaceuticamente ativos e inertes é usada para fabricação de um produto cosmético podendo ser apresentado nas seguintes formas farmacêuticas semi-sólidas: cremes, pomadas, géis, unguentos, loções e demais formas conhecidas dentro do estado da técnica. Preferencialmente, a composição farmacêutica é usada na fabricação de cremes e loções que são aplicadas no tratamento de distúrbios associados ao aumento de depósito de melanina e a hiperpigmentação da pele.[031] Said composition comprising its pharmaceutically active and inert agents is used for the manufacture of a cosmetic product and can be presented in the following semi-solid pharmaceutical forms: creams, ointments, gels, ointments, lotions and other forms known within the state of the art . Preferably, the pharmaceutical composition is used in the manufacture of creams and lotions that are applied in the treatment of disorders associated with increased melanin deposits and skin hyperpigmentation.
[032] O tratamento consiste na aplicação do creme e da loção, que durante a terapia desempenham ações sinérgicas que lavam à cura ou a redução dos efeitos dos distúrbios associadas ao aumento de depósito de melanina e a hiperpigmentação da pele.[032] The treatment consists of the application of the cream and lotion, which during therapy perform synergistic actions that wash to cure or reduce the effects of the disorders associated with the increase in melanin deposit and hyperpigmentation of the skin.
[033] Durante o tratamento o creme desempenha um maior efeito para a despigmentação da pele. Por essa razão, a concentração dos ativos com ação despigmentantes deve ser maior comparado com a loção. Numa relação de concentração centesimal (p/p), que apresenta eficácia e segurança durante o tratamento é preferencialmente 12,00% de hidroquinona; 10,00% de ácido fitico 35%; 8,00% de Ascorbosilane C; 5,00% 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin); 3,00% nano kójico; 2,5% de ácido azelaico; 1,00% de ácido octadecenodióico.[033] During treatment, the cream has a greater effect on depigmentation of the skin. For this reason, the concentration of active ingredients with depigmenting actions should be higher compared to the lotion. In a ratio of centesimal concentration (w / w), which presents efficacy and safety during treatment, it is preferably 12.00% hydroquinone; 10.00% phytic acid 35%; 8.00% Ascorbosilane C; 5.00% 4-hydroxyphenyl-alpha-D-glucopyranoside (Alfa Arbutin); 3.00% kojic nano; 2.5% azelaic acid; 1.00% octadecenedioic acid.
[034] A loção tem a função amplificar ou prolongar por algumas semanas o efeito despigmentante apresentado pelo creme durante o tratamento. Por essa razão, a concentração dos ativos com ação despigmentantes deve ser menor do que comparado com a do creme; sendo uma concentração centesimal (p/p) aceitável preferencialmente 8,00% de gluconoloctona; 5,00% de ácido azelaico; 5,00% de hidroquinona; 5,00% de 4-hidroxifenil-alfa-D-glucopiranósido (Alfa Arbutin); 5,00% de ácido kójico e 1,00% de ácido octadecenodióico.[034] The lotion has the function of amplifying or prolonging for a few weeks the depigmenting effect presented by the cream during the treatment. For this reason, the concentration of active ingredients with depigmenting actions should be lower than that of the cream; being a centesimal concentration (w / w) acceptable, preferably 8.00% of gluconolocton; 5.00% azelaic acid; 5.00% hydroquinone; 5.00% 4-hydroxyphenyl-alpha-D-glucopyranoside (Alfa Arbutin); 5.00% kojic acid and 1.00% octadecenedioic acid.
[035] Os distúrbios que promovem o aumento de depósito de melanina e a hiperpigmentação da pele, para os quais são indicados o creme e a loção amplificadora ensinadas nessa invenção, compreendem preferencialmente mas, não se limitando a estas, como o melasma, a psoriase, a acne, a acantose nigricans; sendo ainda capaz de promover o processo de esfoliação da pele.[035] The disorders that promote an increase in the deposition of melanin and hyperpigmentation of the skin, for which the amplifying cream and lotion taught in this invention are indicated, preferably include, but are not limited to, such as melasma, psoriasis , acne, acanthosis nigricans; being able to promote the skin exfoliation process.
Claims (13)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102018077328-3A BR102018077328A2 (en) | 2018-12-27 | 2018-12-27 | whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102018077328-3A BR102018077328A2 (en) | 2018-12-27 | 2018-12-27 | whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR102018077328A2 true BR102018077328A2 (en) | 2020-07-07 |
Family
ID=71451489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR102018077328-3A BR102018077328A2 (en) | 2018-12-27 | 2018-12-27 | whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR102018077328A2 (en) |
-
2018
- 2018-12-27 BR BR102018077328-3A patent/BR102018077328A2/en active Search and Examination
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5570992B2 (en) | Method and composition for treating skin diseases or skin lesions | |
| US10869822B2 (en) | Compositions for treatment of dermatological diseases and conditions and methods of use thereof | |
| KR100224284B1 (en) | Composition for treatment of cellulite containing retinoids | |
| US6008254A (en) | Method of treating skin disorders with high-strength tretinoin | |
| TWI682782B (en) | Methods and compositions for topical delivery for skin care | |
| CN111920764A (en) | Composition for exfoliation and use thereof | |
| KR100673044B1 (en) | The composition for external use by percutaneous administration | |
| JP2013518920A (en) | Dermatological composition comprising a combination of adapalene and benzoyl peroxide for the treatment of acne with reduced post-inflammatory pigmentation in non-Caucasian races | |
| Putra et al. | Skin changes and safety profile of topical products during pregnancy | |
| Bellandi et al. | Repigmentation of hair after latanoprost therapy. | |
| Tosti et al. | Color atlas of chemical peels | |
| BRPI0204618B1 (en) | Cosmetic methods for treating fine lines and / or wrinkles, and for improving the aesthetic appearance of the skin or lips, and topical composition. | |
| Grimes et al. | CUTIS Do Not Copy | |
| BR102018077328A2 (en) | whitening pharmaceutical composition for the treatment of disorders that cause an increase in melanin deposits and skin hyperpigmentation; and its use for the manufacture of a semi-solid product | |
| JP2011513192A (en) | Topical composition comprising fluocinolone acetonide for use in skin decolorization | |
| Maluf et al. | Current cosmetic treatments in pregnancy | |
| Sarkar et al. | Chemical Peels: Special Considerations | |
| Sarkar et al. | Combination peels | |
| LUBOWE | Treatment of the aging skin by dermatologic methods | |
| BUTTERWORTH | Dermatological aspects of cretinism | |
| Tedeschi et al. | Chemical peel | |
| Alomar et al. | Bleaching agents | |
| BR102019011839A2 (en) | MELASMA MEDICINE | |
| Draelos | Formulation for special populations | |
| Kushniruk | Senescent skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A ANUIDADE. |
|
| B11Z | Dismissal: petition dismissal - article 216, par 2 of industrial property law |
Free format text: ARQUIVAMENTO DA PETICAO ART.216 2O DA LPI (NAO APRESENTADA PROCURACAO) - REFERENTE A PETICAO 800220370618, DE 27/10/2022, QUE NAO FOI APRESENTADA A PROCURACAO DEVIDA (NOME: KASZNAR LEONARDOS PROPRIEDADE INTELECTUAL) NO PRAZO DE 60 DIAS CONTADOS DA PRATICA DO REFERIDO ATO, CONFORME ART. 216, PARAGRAFO 2O, DA LPI. DESTA DATA CORRE O PRAZO DE 60 DIAS PARA EVENTUAL RECURSO DO INTERESSADO. |
|
| B12C | Appeal against dismissal [chapter 12.3 patent gazette] | ||
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |