BR102018071551A2 - compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy - Google Patents

compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy Download PDF

Info

Publication number
BR102018071551A2
BR102018071551A2 BR102018071551A BR102018071551A BR102018071551A2 BR 102018071551 A2 BR102018071551 A2 BR 102018071551A2 BR 102018071551 A BR102018071551 A BR 102018071551A BR 102018071551 A BR102018071551 A BR 102018071551A BR 102018071551 A2 BR102018071551 A2 BR 102018071551A2
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical composition
ionized
neutral
prevention
Prior art date
Application number
BR102018071551A
Other languages
Portuguese (pt)
Inventor
André Arigony Souto
Priscylla Andrade Volkart
Giovana Ravizzoni Onzi
Guido Lenz
Original Assignee
União Brasileira De Educação E Assistência - Mantenedora Da Pucrs
Universidade Federal Do Rio Grande Do Sul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by União Brasileira De Educação E Assistência - Mantenedora Da Pucrs, Universidade Federal Do Rio Grande Do Sul filed Critical União Brasileira De Educação E Assistência - Mantenedora Da Pucrs
Priority to BR102018071551A priority Critical patent/BR102018071551A2/en
Priority to PCT/BR2019/050447 priority patent/WO2020077428A1/en
Publication of BR102018071551A2 publication Critical patent/BR102018071551A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system

Abstract

a presente invenção descreve os compostos, o uso dos compostos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os compostos de fórmula a, seus derivados ou análogos, neutros ou ionizados, para prevenção e/ou terapia senolítica. especificamente, a presente invenção compreende os compostos, o uso dos compostos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os compostos de fórmula a, seus derivados ou análogos, neutros ou ionizados, para prevenção e/ou terapia senolítica, por meio de eliminação seletiva de células senolíticas.the present invention describes the compounds, the use of the compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising the compounds of formula a, their derivatives or analogs, neutral or ionized, for prevention and / or senolytic therapy. specifically, the present invention comprises the compounds, the use of the compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising the compounds of formula a, their derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy, by means of elimination selection of senolytic cells.

BR102018071551A 2018-10-19 2018-10-19 compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy BR102018071551A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR102018071551A BR102018071551A2 (en) 2018-10-19 2018-10-19 compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy
PCT/BR2019/050447 WO2020077428A1 (en) 2018-10-19 2019-10-17 Compounds, use of compounds in the preparation of a pharmaceutical composition, and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno[2,1-c]chromene-3,6a,9,10-tetrol, neutral or ionized derivatives or analogues thereof, for senolytic prevention and/or therapy purposes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102018071551A BR102018071551A2 (en) 2018-10-19 2018-10-19 compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy

Publications (1)

Publication Number Publication Date
BR102018071551A2 true BR102018071551A2 (en) 2020-04-28

Family

ID=70284176

Family Applications (1)

Application Number Title Priority Date Filing Date
BR102018071551A BR102018071551A2 (en) 2018-10-19 2018-10-19 compounds, use of compounds in the preparation of a pharmaceutical composition and pharmaceutical composition comprising 7,11b-dihydro-6h-indeno [2,1-c] chromene-3,6a, 9,10-tetrol, its derivatives or analogues, neutral or ionized, for prevention and / or senolytic therapy

Country Status (2)

Country Link
BR (1) BR102018071551A2 (en)
WO (1) WO2020077428A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112608296B (en) * 2021-01-12 2023-04-28 山西省肿瘤研究所 Synthesis method of Brazilane natural product Brazilane
CN116283880A (en) * 2023-02-10 2023-06-23 五邑大学 Synthetic method of indeno [2,1, c ] chromene compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930000028B1 (en) * 1990-04-26 1993-01-06 문창규 Immuno modulator composition containing brazilin
KR100750657B1 (en) * 2005-12-09 2007-08-20 한국과학기술연구원 Use of the extract of Caesalpinia sappan L. and compounds therefrom
KR20130024395A (en) * 2011-08-31 2013-03-08 주식회사 진생사이언스 Topical pharmaceutical composition and cosmetic composition comprising brazilin or the pharmaceutically acceptable salt thereof for preventing and improving skin aging
CN104173328B (en) * 2013-05-28 2019-07-02 中国医学科学院药物研究所 The purposes of brazilin in medicine preparation

Also Published As

Publication number Publication date
WO2020077428A1 (en) 2020-04-23

Similar Documents

Publication Publication Date Title
BR112019007393A2 (en) 6,7,8,9-tetrahydro-3h-pyrazolo [4,3-f] isoquinoline derivatives useful in treating cancer
BR112016028288A2 (en) compound, pharmaceutical composition, methods for treating an individual with a disease or condition and for inhibiting kinase, and use of a compound.
BR112019006712A2 (en) compound, pharmaceutical composition, composition for use in treating a disease, implantable element, and device.
BR112018008397A2 (en) dihydroimidazopyrazinone derivatives useful in cancer treatment
BR112017002053A2 (en) compound according to formula (i), pharmaceutical composition, and uses of a compound
UY37645A (en) INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE DENGUE VIRIC REPLICATION
BR112016003348A2 (en) pharmaceutically acceptable compound or salt thereof, pharmaceutical composition and uses of effective amount of the pharmaceutically acceptable compound or salt thereof or pharmaceutical composition
UY37646A (en) INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE DENGUE VIRIC REPLICATION
BR112012023660B8 (en) uses of a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof, for the treatment of cancer
BR112018070123A2 (en) oxiesterós and methods of use thereof
CL2008000959A1 (en) Compounds derived from 1,2,4-thiadiazine or 1,4-thiazine; pharmaceutical compositions containing them; and its use for the prevention and / or treatment of infections caused by the hepatitis c virus.
BR112016030733A2 (en) INDANE AND INDOLINE DERIVATIVES AND THEIR USE AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
BR112014018953A8 (en) TRITERPENOID LUPANE DERIVATIVES AND PHARMACEUTICAL USE THEREOF
BRPI0706992C8 (en) compound of formula (I) and pharmaceutical formulation
BR112015030399B8 (en) HETEROCYCLIC DERIVATIVES, USE OF SUCH DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF DISEASES ASSOCIATED WITH STAT3 PROTEIN ACTIVATION
BR112018013985A2 (en) highly soluble steviol glycosides
BR112018070536A2 (en) compound, pharmaceutical composition, combination, use of a compound or a pharmaceutically acceptable salt thereof, and method of treating a disease or condition
BR112021011325A2 (en) Rapamycin derivatives
BR112021023927A2 (en) Compound and pharmaceutical composition
BR112023002951A2 (en) PHOSPHOLIPID COMPOUNDS AND USES THEREOF
BR112019005318A2 (en) aza-indazole compounds for use in tendon and / or ligament injuries
BR112018001035A2 (en) ring phenoxyacetamide compounds, pharmaceutically acceptable salt, method of synthesis, combination of medicament and use thereof
BRPI0611550A2 (en) use of a compound selected from the group consisting of 4-hydroxy isoleucine isomers, 4-hydroxy isoleucine analogs, and lactones, salts, metabolites, solvates and / or pharmaceutically acceptable prodrugs of said isomers and analogs, compound, pharmaceutical kit , pharmaceutical composition, use of the compound and kit with compound
BR112022001568A2 (en) Compound, method for preparing the compound, pharmaceutical composition, and use of the compound
BR112021020297A2 (en) Hexahydro-1h-pyrazino[1,2-a]pyrazine compounds for the treatment of autoimmune disease

Legal Events

Date Code Title Description
B03A Publication of an application: publication of a patent application or of a certificate of addition of invention