BR102018010699A2 - resorbable surgical suture thread with antibacterial oil coating - Google Patents
resorbable surgical suture thread with antibacterial oil coating Download PDFInfo
- Publication number
- BR102018010699A2 BR102018010699A2 BR102018010699A BR102018010699A BR102018010699A2 BR 102018010699 A2 BR102018010699 A2 BR 102018010699A2 BR 102018010699 A BR102018010699 A BR 102018010699A BR 102018010699 A BR102018010699 A BR 102018010699A BR 102018010699 A2 BR102018010699 A2 BR 102018010699A2
- Authority
- BR
- Brazil
- Prior art keywords
- surgical
- oil coating
- suture thread
- surgical suture
- oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
Abstract
a presente invenção traz um valor agregado ao fio de sutura por reduzir a frequência de bactérias no sítio cirúrgico, visando a diminuição da prevalência e gravidade de infecções pós-operatórias. o dito fio de sutura é constituído por fibra sintética, trançada de poliglactina 910(1) composta por copolímero obtido a partir ácido glicólico e l-lactida na proporção 9:1 e superfície com óleo de lippia sidoides com atividade de inibição(2)(3) do crescimento de staphylococcus aureus(fig. 3) e escherichia coli(fig. 4), frequentes em infecções de sítio cirúrgico.The present invention brings added value to the suture by reducing the frequency of bacteria at the surgical site, aiming at reducing the prevalence and severity of postoperative infections. said suture consists of synthetic fiber, braided polyglactin 910 (1) composed of copolymer obtained from glycolic acid and 1-lactide in a 9: 1 ratio and surface with inhibiting activity lippiaidosides oil (2) ( 3) growth of staphylococcus aureus (fig. 3) and escherichia coli (fig. 4), common in surgical site infections.
Description
“FIO DE SUTURA CIRÚRGICO REABSORVÍVEL COM REVESTIMENTO DE ÓLEO ANTIBACTERIANO” [001] A presente invenção trata de um fio de sutura cirúrgica reabsorível com revestimento de óleo da planta Lippia sidoides com aplicação na área de biotecnologia em materiais médico-hospitalares redução de bactérias presentes em infecções em sítios cirúrgicos.“REABSORVIBLE SURGICAL SURGICAL SUTURE THREAD WITH ANTIBACTERIAL OIL COATING” [001] The present invention deals with a resorbable surgical suture with oil coating from the Lippia menosides plant with application in the area of biotechnology in medical-hospital materials reduction of bacteria present in infections in surgical sites.
[002] Atualmente, o mercado médico-odontológico dispõe de fios absorvíveis pelo organismo (categute, colágeno, ácido poliglicólico, poliglactina 910) e não absorvíveis (seda, náilon, poliéster, poliamida, polipropileno, Polibutalato com cobertura de poliéster trançado e Poliglactina 910). O fio de Poliglactina 910 é uma fibra sintética, trançada, composta por copolímero obtido a partir ácido glicólico e L-lactida na proporção 9:1.[002] Currently, the medical and dental market has threads that are absorbable by the body (catgut, collagen, polyglycolic acid, polyglactin 910) and non-absorbable (silk, nylon, polyester, polyamide, polypropylene, Polybutylene with braided polyester cover and Polyglactin 910 ). Polyglactin 910 yarn is a synthetic fiber, braided, composed of a copolymer obtained from glycolic acid and L-lactide in a 9: 1 ratio.
[003] É sabido que os fios de sutura existentes representam uma superfície propensa a colonização de micro-organismos infecciosos, principalmente os multifilamentar, e, consequentemente, predispõem ao desenvolvimento de infecção pós-cirúrgica. O organismo humano possui naturalmente várias espécies de bactérias com potencial para contaminar o sítio cirúrgico. Dentre as bactérias, destaca-se o Staphylococcus aureus e a Escherichia coli por representar os mais comuns patógeno nos sítios cirúrgicos infectados (SIEVERT et al., 2013).[003] It is known that the existing suture threads represent a surface prone to colonization of infectious microorganisms, especially multifilament ones, and, consequently, predispose to the development of post-surgical infection. The human organism naturally has several species of bacteria with the potential to contaminate the surgical site. Among the bacteria, Staphylococcus aureus and Escherichia coli stand out for representing the most common pathogen in infected surgical sites (SIEVERT et al., 2013).
[004] Com o intuito de solucionar tais problemas propõe-se a presente invenção através da qual o fio de sutura multifilamentar possui um revestimento com atividade antibacteriana contra S. aureus e E. coli. Tal processo é conseguido com adsorção dos princípios ativos timol e carvacrol presentes no óleo de Lippia sidoides na superfície do fio pelo processo de carreamento pelo ácido graxo Ácido Palmítico após a evaporação do álccol metanol, como descrito na patente US8012173B2. A atividade abtibacteriana foi verificada pelo teste de difusão em poços. O fio de sutura foi imerso em placa de Petri contendo meio sólido Brain Heart Infusion (BHI) e inóculo bacteriano S. aureus e E. coli padronizados na escala de Mc Farland. Após o período de 24 h (S. aureus) e 48 h (E. coli) a 37 °C, foi observado e mensurado o halo de inibição. A adsorção do óleo ao fio de sutura permitiu inibição de crescimento bacteriano de 10 mm e 5 mm para S. aureus e E. coli, respectivamente. Enquanto, no fio de sutura sem revestimento, não foi observado halo de inibição.[004] In order to solve such problems the present invention is proposed through which the multifilament suture thread has a coating with antibacterial activity against S. aureus and E. coli. Such a process is achieved with adsorption of the active principles thymol and carvacrol present in the oil of Lippia sidoides on the surface of the wire by the process of carrying by the fatty acid Palmitic acid after the evaporation of the methanol alcohol, as described in the patent US8012173B2. Abtibacterial activity was verified by the well diffusion test. The suture thread was immersed in a Petri dish containing solid Brain Heart Infusion (BHI) medium and bacterial inoculum S. aureus and E. coli standardized on the Mc Farland scale. After the period of 24 h (S. aureus) and 48 h (E. coli) at 37 ° C, the inhibition zone was observed and measured. The adsorption of the oil to the suture allowed inhibition of bacterial growth of 10 mm and 5 mm for S. aureus and E. coli, respectively. While, in the uncoated suture, no inhibition halo was observed.
[005] A invenção poderá ser melhor compreendida através da seguinte descrição detalhada, em consonância com as figuras em anexo, onde: [006] A FIGURA 1 representa o fio de sutura trançado multifilamentar na solução de revestimento;[005] The invention can be better understood through the following detailed description, in line with the attached figures, where: [006] FIGURE 1 represents the multifilament braided suture in the coating solution;
[007] A FIGURA 2 representa o fio cortado em segmentos de 2 cm para teste antibacteriano;[007] FIGURE 2 represents the wire cut into 2 cm segments for antibacterial testing;
[008] A FIGURA 3 apresenta o resultado da atividade antibacteriana do fio de sutura com revestimento do óleo de Lippia sidoides contra S. aureus.[008] FIGURE 3 shows the result of the antibacterial activity of the suture thread coated with Lippia menosides oil against S. aureus.
[009] A FIGURA 4 apresenta o resultado da atividade antibacteriana do fio de sutura com revestimento do óleo de Lippia sidoides contra E. coli.[009] FIGURE 4 shows the result of the antibacterial activity of the suture thread coated with Lippia menosides oil against E. coli.
[010] Com referência a estas figuras, pode-se observar a superfície do fio absorvível multifilamentar(1).[010] With reference to these figures, it is possible to observe the surface of the multifilament absorbable thread (1).
[011] Halo de inibição de crescimento bacteriano ao redor do fio de sutura medido em milímetros, sendo 10 mm para S. aureus(2) e 5 mm para E. coli(3).[011] Bacterial growth inhibition halo around the suture thread measured in millimeters, 10 mm for S. aureus (2) and 5 mm for E. coli (3).
REIVINDICAÇÕES
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102018010699A BR102018010699A2 (en) | 2018-05-25 | 2018-05-25 | resorbable surgical suture thread with antibacterial oil coating |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102018010699A BR102018010699A2 (en) | 2018-05-25 | 2018-05-25 | resorbable surgical suture thread with antibacterial oil coating |
Publications (1)
Publication Number | Publication Date |
---|---|
BR102018010699A2 true BR102018010699A2 (en) | 2019-12-10 |
Family
ID=68765827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR102018010699A BR102018010699A2 (en) | 2018-05-25 | 2018-05-25 | resorbable surgical suture thread with antibacterial oil coating |
Country Status (1)
Country | Link |
---|---|
BR (1) | BR102018010699A2 (en) |
-
2018
- 2018-05-25 BR BR102018010699A patent/BR102018010699A2/en not_active Application Discontinuation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230346367A1 (en) | Packaged antimicrobial medical device having improved shelf life and method of preparing same | |
ES2342415T3 (en) | ANTIMICROBIAL SUTURES AND PROCEDURES FOR PREPARATION. | |
JP2022105086A (en) | Antibacterial wound closure material including antibacterial suture thread, and wound closure method using the same | |
BRPI0704047B1 (en) | SURGICAL SURFACE MATERIAL WITH ANTIMICROBIAN SURFACE AND PROCESS FOR ANTIMICROBIAN COATING OF SURGICAL SURFACE MATERIAL | |
KR20110064937A (en) | Antimicrobial suture for medical use with grapefruit extract, and manufacturing method thereof | |
US20180213789A1 (en) | Antimicrobial compositions for surgical applications | |
BR102018010699A2 (en) | resorbable surgical suture thread with antibacterial oil coating | |
US3388704A (en) | Microbiocidal sutures containing quaternary ammonium compounds and method for making | |
Etemadi et al. | Bacterial Accumulation on Triclosan-Coated and Silk Sutures After Dental Implant Surgery | |
ES2348645T3 (en) | BIOCOMPATIBLE ANTIMICROBIAL SUTURE MATERIAL. | |
Bhende et al. | In vivo and in vitro anti-bacterial efficacy of absorbable barbed polydioxanone monofilament tissue control device with triclosan | |
KR20100078883A (en) | Antimicrobial suture | |
Reśliński et al. | The influence of octenidine dihydrochloride on bacterial biofilm on the surface of a polypropylene mesh | |
Khan et al. | Anti-microbial efficacy of Allium sativum against Streptococcus mutans biofilm formation on orthodontic mini-implants | |
Grigoras et al. | In vitro Study About Bacterial Adhesion to the Surface of Suture Materials Used in Oro-maxilo-facial Surgery | |
Indhumathi et al. | Application of antibacterial suture materials in oral and maxillofacial surgery. | |
KR101553250B1 (en) | Antimicrobial Suture | |
US20220125987A1 (en) | Wound closure devices comprising protocatechuic acid | |
Puttamayutanon et al. | Nanofiber production using polyvinylalcohol (PVA) and Thai honey and its properties | |
Prasetya et al. | Attachment of Streptococcus Mutans to Intraoral Suture Materials: An in Vitro Study | |
BR102016024715A2 (en) | SURGICAL SUTURE THREAD WITH ANTIMICROBIAN NANOPARTIC COVERAGE | |
Shrestha et al. | Guduchi fibres (Tinospora cordifolia Linn.) as a skin suturing material-A Controlled Clinical Trial | |
Deng | Development of Drug-Eluting Surgical Sutures for the Wound-Healing Process Using Melt Extrusion Technology | |
Linden et al. | Antimicrobial evaluation of sutures containing Lippia sidoides Cham essential oil | |
Unachukwu et al. | Antimicrobial spectrum of honey for aerobic organisms as seen at the National Orthopaedic Hospital, Enugu |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |