BR102017015071A2 - recombinant peptides associated with tuberculosis, use and diagnostic composition - Google Patents
recombinant peptides associated with tuberculosis, use and diagnostic composition Download PDFInfo
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- BR102017015071A2 BR102017015071A2 BR102017015071A BR102017015071A BR102017015071A2 BR 102017015071 A2 BR102017015071 A2 BR 102017015071A2 BR 102017015071 A BR102017015071 A BR 102017015071A BR 102017015071 A BR102017015071 A BR 102017015071A BR 102017015071 A2 BR102017015071 A2 BR 102017015071A2
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- Brazil
- Prior art keywords
- tuberculosis
- recombinant peptides
- diagnostic composition
- peptides associated
- recombinant
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- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 201000008827 tuberculosis Diseases 0.000 title abstract 4
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 229940099472 immunoglobulin a Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 238000002823 phage display Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
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- Peptides Or Proteins (AREA)
Abstract
peptídeos recombinantes associados à tuberculose, uso e composição diagnóstica. a presente invenção refere-se à seleção, caracterização e utilização de peptídeos recombinantes que mimetizam proteínas antigênicas de mycobacterium tuberculosis, agente etiológico da tuberculose (tb). os peptídeos recombinantes foram selecionados pela técnica de phage display, utilizando uma biblioteca comercial phd-12 contra imunoglobulina a (iga) de saliva de indivíduos com tuberculose. os clones selecionados, sequenciados, traduzidos e sintetizados quimicamente foram avaliados quanto as potenciais aplicações diagnósticas. são aplicáveis como sondas, através de ensaios imunológicos, comumente utilizados em laboratórios e para fins terapêuticos.recombinant peptides associated with tuberculosis, use and diagnostic composition. the present invention relates to the selection, characterization and use of recombinant peptides that mimic antigenic proteins of mycobacterium tuberculosis, the etiological agent of tuberculosis (tb). recombinant peptides were selected using the phage display technique, using a commercial library phd-12 against immunoglobulin a (iga) from saliva of individuals with tuberculosis. the selected clones, sequenced, translated and chemically synthesized were evaluated for potential diagnostic applications. they are applicable as probes, through immunological tests, commonly used in laboratories and for therapeutic purposes.
Priority Applications (1)
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BR102017015071A BR102017015071A2 (en) | 2017-07-13 | 2017-07-13 | recombinant peptides associated with tuberculosis, use and diagnostic composition |
Applications Claiming Priority (1)
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BR102017015071A BR102017015071A2 (en) | 2017-07-13 | 2017-07-13 | recombinant peptides associated with tuberculosis, use and diagnostic composition |
Publications (1)
Publication Number | Publication Date |
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BR102017015071A2 true BR102017015071A2 (en) | 2020-04-28 |
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BR102017015071A BR102017015071A2 (en) | 2017-07-13 | 2017-07-13 | recombinant peptides associated with tuberculosis, use and diagnostic composition |
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BR (1) | BR102017015071A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021258179A1 (en) * | 2020-06-26 | 2021-12-30 | Universidade Federal de Uberlândia | Synthetic mimotope peptides of an antigenic protein from m. tuberculosis, recombinant antibody or fragment thereof, aptamers, use thereof in the diagnosis of tuberculosis and method of diagnosis of tuberculosis |
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2017
- 2017-07-13 BR BR102017015071A patent/BR102017015071A2/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021258179A1 (en) * | 2020-06-26 | 2021-12-30 | Universidade Federal de Uberlândia | Synthetic mimotope peptides of an antigenic protein from m. tuberculosis, recombinant antibody or fragment thereof, aptamers, use thereof in the diagnosis of tuberculosis and method of diagnosis of tuberculosis |
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B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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