BR102017004833A2 - bactericidal / germicidal / fungicidal / sporocidal product extracted from fatty acids to be administered orally to monogastric and / or ruminant farms and method of obtaining - Google Patents

Abstract

is a natural bactericidal and fungicidal product extracted from fatty acids to be administered orally to monogastric and / or ruminant farms such as cattle, horses, pigs, sheep, goats, dogs, cats and birds; More particularly, a bactericidal / germicidal / fungicidal / sporocidal product has, as an active ingredient, water soluble fatty acid esters, in particular ricinoleic acid which, composed at room temperature (25 to 30 oc) in concentrations indicated with liquid soda in 75% at room temperature (25 to 30 degrees Celsius) and water at a heated temperature (90 degrees Celsius) can be administered in the feed, salt or water of monogastric and / or ruminant animals for the fight against ectoparasites (ticks, bernes, horn fly and others), hoof disease, combating pneumonia, improves the quality of hair and feathers, among other applications.

Description

(54) Title: PRODUCT

BACTERICIDE / GERMICIDE / FUNGICIDE / ESPO ROCIDA EXTRACTED FROM FATTY ACIDS TO BE ADMINISTERED ORAL IN MONOGASTRIC AND / OR RUMINANT BREEDING ANIMALS AND METHOD OF OBTAINING (51) Int. Cl .: A61K 31/201; A61K 47/02; A61P 31/10; A61P 31/04 (73) Holder (s): MIGUEL LEITE (72) Inventor (s): MIGUEL LEITE (85) National Phase Start Date:

10/03/2017 (57) Abstract: It deals with a natural bactericidal and fungicidal product extracted from fatty acids to be administered orally in monogastric and / or ruminant animals, such as cattle, horses, pigs, sheep, goats, dogs , cats and birds; more especially a bactericidal / germicidal / fungicidal / sporocidater product, as an active ingredient, the esters of water-soluble fatty acids, especially ricinoleic acid which, composed at room temperature (25 to 30 oC) in concentrations indicated with liquid soda in a solution of 75 % at room temperature (25 to 30 oC) and water, at heated temperature (90 oC), can be administered in the feed, salt or water of monogastric animals and / or ruminants to combat ectoparasites (ticks, birds, flies) horn and others), hoof disease, combating pneumonia, improving the quality of hair and feathers, among other applications.

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BACTERICIDE / GERMICIDE / FUNGICIDE / SPOROCIDE PRODUCT EXTRACTED FROM FATTY ACIDS TO BE ADMINISTERED ORally IN MONOGASTRIC AND / OR RUMINANT BREEDING ANIMALS AND METHOD OF OBTAINING.

TECHNICAL FIELD [001] The present invention patent deals with a bactericidal / germicidal / fungicidal / sporocidal product extracted from fatty acids to be administered orally to monogastric and / or ruminant animals, such as cattle, horses, pigs, sheep, goats, dogs, cats and birds; more especially it is a natural product, non-toxic and that does not harm the environment, which has the esters of water-soluble fatty acids as an active ingredient, in particular ricinoleic acid which, composed at room temperature (25 to 30 ° C) in concentrations indicated with liquid soda in 75% solution at room temperature (25 to 30 ° C) and water, at heated temperature (90 ° C), can be administered in the ration, salt or water to combat ectoparasites (ticks, birds, horn fly and others), hoof disease, combating pneumonia, improving the quality of hair and feathers, among other applications.

FUNDAMENTALS OF THE TECHNIQUE [002] Essential fatty acids: linoleic (omega-6), linolenic (omega-3) and arachidonic, are so named because they need to be acquired through the diet, since the body cannot produce them in the amount necessary for organs and tissues. They are used in the formation of the membranes of all cells, are precursors of eicosanoids (essential factors in the immune and inflammatory responses), serve as a structural basis for the synthesis of some hormones, in addition to controlling the transepidermal movement of water and other skin molecules. All essential fatty acids are unsaturated because they have at least one double bond in their carbon chain.

[003] In some plant organisms, linoleic and alpha-linolenic acids (precursors of other omegas) are obtained from oleic acid, also known as omega-9, under the action of the enzyme delta-12-denaturase. The vast majority of monogastric animals and / or ruminants are unable to make this conversion and therefore,

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2/11 require the intake of linoleic and linolenic fatty acids.

[004] Chemically, a fatty acid consists of a series of carbon atoms linked to each other by single (saturated) or double (unsaturated) bonds, with a carboxyl group and a hydrocarbon tail called a methyl group. Based on the length of the carbon chain, number of double bonds and its first location from the methyl (omega) termination of the molecule, the essential fatty acids can be divided into omega-6 and omega-3.

[005] Omega-6 comes from linoleic acid (18: 2, n-6), as it has 18 carbon atoms and two double bonds, the first being between 06 ⁵ and 7 ⁵ carbon which, by enzymatic action, forms gamma-linolenic acids (GLA), di-homo-gamma-linolenic and arachidonic.

[006] The source component of omega-3 is alpha-linolenic acid (ALA), which can also be described as 18: 3, n-3. Through enzymatic actions, it can be converted into eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids.

[007] For the formation of acids from omegas 6 and 3, the presence of vitamins A and E is necessary, in addition to the minerals zinc and magnesium.

[008] Omega-6 fatty acid is naturally obtained from safflower, soy, sunflower, corn and animal fats. Omega-3 fatty acid is found in cold-water marine fish (salmon and trout), flax seeds and soybeans.

[009] Eicosanoids (omega-3) have important physiological activity, even at extremely low concentrations, affecting the functioning of endocrine and exocrine glands. Any imbalance resulting from low intake can lead to coronary heart disease, neurological changes and several inflammatory and immunological changes.

[010] Linoleic acid (omega-6) is the main fatty acid that regulates the transepidermal movement of water and other skin molecules.

[011] Linoleic acid (omega-6) deficiency can lead to eczema, skin rash, hair loss, liver degeneration, behavioral disorders, kidney degeneration, excessive sweating accompanied by thirst, low glandular production, deficiency in scarring wounds, male sterility, failures

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3/11 reproductive in females, arthritis, heart and circulatory problems.

[012] Alpha-linolenic acid (omega-3) deficiency can lead to growth retardation, weakness, impaired visual ability, ability to learn, motor incoordination and behavioral changes. High levels of blood triglycerides (fat), high blood pressure, platelet aggregation, tissue inflammation, edema, dry skin, mental deterioration, low metabolic rate and some types of immune disorders can respond to omega-3 supplementation.

ANALYSIS OF THE STATE OF THE TECHNIQUE [013] In research carried out in specialized databases, documents were found that include fatty acids in animal products, such as, for example, document ⁵ . PI 0415701-0 (Adisseo France SAS) which deals with a zootechnical, non-therapeutic process, consists of administering orally to monogastric removal animals, a stable derivative of vitamin E, alone or mixed with an additive and / or a food; said derivative being hydrolyzable in the assimilable form of vitamin E, and being administered to the animal, in the presence of at least one food emulsifier chosen from the non-ethoxylated esters of sorbitol and fatty acid.

[014] Another document of No. ⁵ . BR 11.2012.026223-8 (Sanluc International) which refers to formulations for animal feed that comprise granules that include a mixed butyrate lactate salt; in which the mixed buritan 1a salt is a at least bivalent metal, such as calcium, and butyrate and lactate are present in a molar ratio of between 3: 1 and 1: 3. The granules can be coated. In addition, the butyrate lactate salt can be combined with another active ingredient that can be selected from the group consisting of plant extracts, prebiotic compounds, probiotics, yeast extracts, fatty acids and medium chain, fatty acids from unsaturated long chain.

[015] The documents found, although dealing with solutions for applications in the area of aniamis treatment, do not present any of the characteristics of the object now requested, thus ensuring that the product in question meets the legal requirements for patentability.

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BRIEF DESCRIPTION OF THE PRODUCT [016] The Product in question is a bactericidal / germicidal / fungicidal / sporocidal fatty acid product whose active principle is the esters of water-soluble fatty acids and has a unique characteristic on the market since it acts completely different from bactericides , germicides, fungicides and sporocides on the market, in turn based on the fourth year of ammonia that burns and destroys microorganisms.

[017] The innovated product acts on the cell wall of microorganisms, that is, on the cell wall that protects microorganisms and which are made up of sugar molecules. The innovated product acts as a detergent, dissolving this wall and exposing microorganisms to the aqueous medium - where they do not survive - and, with that, they are eliminated by the animals' own organism.

[018] The product also acts on ectoparasites, dissolving the digestive system of said parasites and, without the digestive system, they are eliminated by starvation.

[019] The product does not harm nature and also does not enter the food chain. It is a natural product, non-toxic and does not harm the environment.

[020] It does not need special protection for its handling, due to its biodegradable property.

[021] The product in question can be used for the following treatments:

- Mastitis: consists of an inflammation of the mammary gland of the cow, being of microbial origin and its symptoms are swelling of the udder, which is red and painful to the touch and hot, the milk becomes watery or thick with yellowish color. In this case, the innovative product acts on the cell wall of the microbe by dissolving the cell wall and exposing the microbe to the aqueous medium, which they do not survive;

- Verminosis: it is a disease caused by several species of parasites. As it is caused by parasites, the innovated product acts by destroying your digestive system, which is composed of chitin, with this, the parasites are eliminated by starvation;

- Berne: is an ectoparasitosis caused by the fly's larva, Dermatobia hominis. As it is a parasite, the innovated product acts by destroying its digestive system that is composed of chitin, with that, the parasites are eliminated by starvation;

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- Actinomycosis: it is a disease caused by a bacterium called Actinomyces bovis, being a bacterium, the innovated Product acts by dissolving its cell wall that is composed of sugar molecules and thus, exposing the bacteria to the aqueous medium, in which they do not survive;

- Botulism: food poisoning produced by the bacterium Clostridium botulinum present in the gastrointestinal tract of animals, thus being a bacterium, the innovated Product acts by dissolving its cell wall and exposing the bacteria to the aqueous medium where they do not survive.

- Dermatofilose: it is an infectious process of skin caused by a bacterium called Dermatophilus congolensis, which is characterized by an exudative dermatitis, with rashes, crusted and scaly. As it is a bacterium, the innovated Product acts by dissolving the cell wall (which is a sugar molecule) and exposing the bacteria to the aqueous medium, where they do not survive;

- Bovine brucellosis: it mainly affects milk production and the birth rate of the herd, the cause is a bacterium that spreads in most cases through materials contaminated with uterine discharge or with the rest of the placenta and fetal fluids. As it is caused by a bacterium, the innovated product acts by destroying the cell wall and exposing the bacteria to the aqueous medium where they do not survive;

- Enzootic pneumonia: it is an infectious respiratory disease, it is observed mainly in young animals. The main agent involved is the Pasteurella multocida bacterium, which is also called pasteurellosis, in this case, the innovative product, works by eliminating the Pasteurella multocida bacterium, thus destroying its cell wall and exposing the bacteria to the aqueous medium;

- Actino Bacillosis: it is an infectious disease caused by a bacterium called Actinobacillus that affects the soft tissues, the bacteria penetrates and causes diseases when there are lesions in the lining of the mouth. As it is a bacterium, the innovated product acts by dissolving the cell wall, which is composed of sugar molecules and exposes the bacteria to the aqueous medium, where it does not survive;

- Infectious runny nose: it is caused by the bacterium Paragallinarum. It is transmitted from bird to bird, they can contract the disease by inhaling the bacteria present in the air and by consumption

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6/11 of contaminated food or water. As it is a bacterium, the innovated product acts by dissolving the cell wall (formed by sugar molecules) leaving the bacteria exposed to the aqueous medium, where it does not survive.

Colibacillosis: is a common disease in poultry. The causative bacterium is Escherichia coli and is found in the intestines of birds and eliminated in the faeces. As it is a bacterium, the innovated product acts by dissolving the cell wall (formed by sugar molecules) leaving the bacteria exposed to the aqueous medium, where they do not survive;

- Oestrose: it is a pathology of sheep caused by the larval phase of the parasite. Oestrus ovis, better known as the nasal flies of sheep, are obligatory parasites of the nasal sinuses of sheep. The larva of this parasite is deposited in the sheep's nostrils leading to parasitic rhinitis. These in turn, feed on contaminated or necrotic tissues and secretions for a few days. Because they are parasites, the innovated product acts by dissolving the digestive system (formed of chitin) and thus, with the digestive system destroyed, they are eliminated by starvation.

- Caseous lymphadenitis (stone disease): it is a contagious disease that affects sheep and goats. Caused by the bacterium Corynebacterium pseudotuberculosis, it is characterized by the presence of abscesses (lumps) in the lymph nodes (lymph nodes) and internal organs. Being caused by bacteria, the innovated product acts by dissolving the cell wall of the microorganism (formed by molecules and sugar) exposing the bacteria to the aqueous medium, where they do not survive;

- Wounds: the wounds that come to be affected, should be treated with the innovated Product, in a dilution of 1 /; 20 (1 part of the product to 20 of water) and applied in place 3 (three) times a day. It can be used for bacterial or fungal infections.

- Ehrlichiosis (tick disease): is an infection transmitted by ticks that carry the bacterium of the genus Erlichia. Animals can trigger anemia, hemorrhage, kidney failure, eye inflammation. In this case, as the agent is a parasite, the innovated product acts by destroying the digestive system of these parasites that are composed of chitin. As a result, they are eliminated by starvation;

- Canine ringworm: the most common parasites identified in fungi in dogs are animals and the ones that hide in the ground are called zoophilic and geophilic. As

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7/11 is caused by parasites, the innovative product acts by dissolving the digestive system of these parasites and thus, without the digestive system they are eliminated by starvation.

- Ticks and fleas: in these infestations, as they are parasites, the innovated Product acts by dissolving the digestive system of these parasites and thus, without the digestive system they are eliminated by starvation.

DETAILED DESCRIPTION OF THE OBJECT [022] The present invention patent refers to the BACTERICIDE / GERMICIDE / FUNGICIDE / SPOROCIDE PRODUCT EXTRACTED FROM THE FATTY ACIDS TO BE ADMINISTERED ORALLY IN MONOGRAPHIC AND / OR RUMINANT BREEDING ANIMALS AND METHODS, AND MORE METHODS AND MORE METHODS bactericide and natural fungicide that has as an active ingredient the esters of water-soluble fatty acids, especially ricinoleic acid, which, formulated with liquid soda in a 75% solution and water, makes up the raw material that, in indicated concentrations, can be administered in the feed, salt or water of monogastric and / or ruminant livestock aiming to act on animal performance, being a product developed for livestock and maintenance of herds fighting various ectoparasites, hoof disease, combating pneumonia, improves hair quality and feathers, among other applications, such as favoring weight gain, improving the digestion of fibrous foods, combating possible micro infections digestive system organisms and others.

[023] In one embodiment the raw material comprises Ricinoleic acid (Ambient temperature - 25 ° C to 30 ° C); 75% liquid soda (Ambient Temperature 25 ° C to 30 ° C) and Water (Temperature 90 ° C) [024] In a preferred embodiment, the formula comprises: Mt = total mass to be produced where it is added: Mt x 0.22 = ricinoleic acid; Mt x 0.11 = 75% liquid soda and Mt x 0.67 = water at 90 ° C, making up the final product (Mf).

[025] In a constructive option, for example to produce 100 Kg of the Product (Mf), the following quantities are adopted: (i) Ricinoleic acid - 22% of 100 Kg = 22 Kg at room temperature; (ii) 75% -11% liquid soda of 100 kg = 11 kg at room temperature; and (iii) Water - 67% of 100 Kg = 67 Kg at a temperature of 90 ° C, making up 100

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Kg of product Mf (22 + 11 + 67).

[026] In one embodiment of the method of obtaining it comprises the following steps:

(a) In a container (stirrer) put the 22 kg of ricinoleic acid;

(b) Add water at 90 ° C and stir well until the mixture is homogenized;

(c) After homogenizing, add 75% liquid soda at room temperature (25 to 30 ° C);

(d) Stir well to fully dissolve the mixture;

(e) The product is expected to cool (Mf) which, after this stage, is ready for use.

EXAMPLE 1 - USE OF THE PRODUCT (Mf) IN CATTLE [027] For males: add 140 grams (g) of the product (Mf) in 1 kg of salt and mix that salt with 100 kg of mineral salt and offer it to the cattle.

[028] You can also dilute 1 L of the product in 2000 liters of water to offer cattle to drink.

[029] For females: add 140 g of the product in 1 kg of salt and mix this salt in 100 kg of mineral salt and offer it to the cattle.

[030] You can also dilute 1 L of the product in 2000 L of water and offer the cattle to drink. Improves immune responses.

[031] Mastitis: in addition to ingesting the product in salt or water, make a 1:10 dilution of the product (1 of product to 10 of water) and inject into the ceilings of females with mastitis.

[032] For both male and female, foot bath can be made, diluting 1 L of the product in 1000 L of water, thus alleviating hoof diseases.

[033] For males it is used to combat ticks, breeds, horn fly, hoof disease, fight pneumonia, improve hair quality and also meat quality, favoring weight gain between 2 to 3 arrobas in the same time used for fattening. Combats possible infections of microorganisms of the digestive system. For females it is used to combat ticks, breeds, horn flies, mastitis, pneumonia, hoof diseases, improves milk quality by increasing the

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9/11 production between 20 to 30%, improves the quality of hair and meat, improves reproduction. Combats possible infections of microorganisms of the digestive system.

EXAMPLE 2 - USE OF THE PRODUCT (Mf) IN EQUINE [034] Add 140 g of the product in 100 kg of mineral salt or feed and offer it to the animal.

[035] You can also dilute 1 L of the product in 2000 L of water and offer the animal to drink.

[036] You can make foot baths, diluting 1 L of product to 1000 L of water, thus alleviating hoof diseases. Improves joints and joints.

[037] To avoid diseases in newborn foals, one of the techniques is to make the animal ingest as much colostrum as possible in the first 36 hours. If the female is ingesting the Product (Mf), the quality of her milk will be much higher, with that the possibility of the foal having some disease decreases a lot.

[038] With the Product (Mf) it fights flies, mosquitoes, ticks and any ectoparasites; the animal ingesting the product will be preventing infectious anemia and equine encephalitis.

[039] Used to combat ticks, breeds, hoof diseases, it favors weight gain, improves female reproduction, improves the immune response, improves the digestion of fibrous foods and absorbs food, improves the quality of the coat. Combats possible infections of microorganisms of the digestive system.

EXAMPLE 3 - USE OF THE PRODUCT (Mf) IN SWINE [040] Add 149 g in 1 kg of salt and add the salt in 500 kg of feed and offer to the animals.

[041] You can also dilute 1 L of the product (Mf) in 2000 L of water and offer it to the animals.

[042] You can also dilute the product (Mf) in 1 part to 20 parts of water (1:20) and spray it on the pigs on the back and belly, thus avoiding flies and mosquitoes.

[043] Favors weight gain, fights flies, mosquitoes, worms, salmonellosis and mastitis, improves meat quality (favors young piglets

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10/11 born the iron intake he needs) because the females ingesting the Product (Mf) will be giving quality to the milk with this transferring to the piglets. Combats possible infections of microorganisms of the digestive system.

[044] Due to the overcrowding of the stalls and the lack of hygiene, pigs can suffer from enzootic pneumonia, with the ingestion of the product (Mf), it is possible to avoid, because the bugs, mosquitoes will be controlled.

EXAMPLE 4 - USE OF THE PRODUCT (Mf) IN BIRDS [045] I - FOR HATCHING CHICKEN AND CHICKEN - Add 140 g of the product (Mf) in 1 kg of salt and mix this salt in 600 kG of feed and offer the birds . You can also dilute 1 L of the product (Mf) in 2500 L of water and offer the birds.

[046] II - FOR CHICKS (up to 10 days old) - Add 140 g of the product in 1 kg of salt and mix this salt in 2000 kg of feed and offer to the chicks. You can also dilute 1 L of the product in 5000 L of water and offer to the chicks.

[047] III - FROM 10 TO 20 DAYS - Add 140 g of the product in 1 kg of salt and this salt in 1500 kg of feed and offer to the chickens. You can also dilute 1 L of the product in 3500 L of water and offer it to the chickens. From 20 days until slaughter, make the initial dilution described in item I.

[048] BIRDS: (broiler hen and broiler chicken) - due to its bactericidal / fungicidal power, the ingestion of the innovated product contributes a lot to the control of salmonellosis, infectious coryza, colibacillosis, pasteurellosis, botulism, borreliosis (transmitted by ticks) , aspergillosis (fungi / molds).

Fights pneumonia, promotes meat improvement and faster growth. EXAMPLE 5 - USE OF THE PRODUCT (Mf) IN SHEEP AND CAPRINOS [049] Add 140 kg of the product in 1 kg of salt and add the salt in 500 kg of feed.

[050] You can also dilute 1 L of the product in 2000 L of water and offer it to the animals. [051] You can also dilute the product in 1 part 50 parts of water (1:50) and spray the animals on the back and belly, thus avoiding flies and mosquitoes. [052] Favors weight gain at the same time used for fattening, improves the quality of meat and milk, improves the quality of meat and milk, improves

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11/11 hair quality, prevents ovine ostrose (infection by flies), toxoplasmosis, caseous lymphadenitis and brucellosis (only in sheep). Combats possible infections of microorganisms of the digestive system.

EXAMPLE 6 - USE OF THE PRODUCT (Mf) IN CAMELS [053] Add 140 g of the product (Mf) in 1 kg of salt and add that salt in 150 kg of mineral salt or feed, such as any type of food used and offer to animals.

[054] You can also add 1 L of the product (Mf) in 2000 L of water and offer it to the animals.

[055] If there are any infections or wounds on the hooves, make a foot bath in the proportion of 1L of the product to 500 L of water (1: 500).

[056] Favors the improvement of meat and milk, improves the quality of hair, combats flies, mosquitoes, combats microorganisms in the digestive system, improves food absorption. It should be used for any bacterial or fungal infestation. EXAMPLE 7 - USE OF THE PRODUCT (Mf) IN DOGS [057] Add 140 g of the product in 700 kg of feed and offer it to the animals.

[058] Do not add in salt, primarily because the rations already contain this substance (it would be too salty).

[059] It is true that when the present invention is put into practice, modifications may be made with regard to certain details of construction and shape, without this implying departing from the fundamental principles that are clearly substantiated in the claim framework, becoming thus understood that the terminology used was not intended to be limiting.

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Claims (5)

1) BACTERICIDE / GERMICIDE / FUNGICIDE / SPOROCIDE PRODUCT EXTRACTED FROM FATTY ACIDS TO BE ADMINISTERED ORAL IN MONOGASTRIC AND / OR RUMINANT BREEDING ANIMALS AND OBTAINING METHOD, characterized by the bactericidal / germicidal / fungicidal product, as an active ingredient, to be sporated esters of water-soluble fatty acids, in particular ricinoleic acid which, compounded at room temperature (25 to 30 ° C) in concentrations indicated with liquid soda in 75% solution at room temperature (25 to 30 ° C) and water, in heated temperature (90 ° C), can be administered in the feed, salt or water of monogastric and / or ruminant animals. 2) PRODUCT, according to claim 1 and in an embodiment, characterized in that the formula comprises the identification of Mt = total mass to be produced where it is added: Mt x 0.22 = ricinoleic acid; Mt x 0.11 = 75% liquid soda and Mt x 0.67 = water at 90 ° C, making up the final product (Mf). 3) PRODUCT, according to claim 1 and in a production option of 100 Kg of Product (Mf), characterized by comprising: (a) Ricinoleic acid - 22% of 100 Kg = 22 Kg at room temperature (25 to 30 ° Ç); (b) Liquid soda 75% -11% of 100 kg = 11 kg at room temperature (25 to 30 ° C); Water at a temperature of 90 ° C - 67% of 100 kg = 67 kg. 4) PRODUCT, according to the previous claims, characterized in that the product (Mf), in indicated concentrations, can be administered in the feed, salt or water of monogastric animals and / or ruminants. 5) METHOD OF OBTAINING, characterized in that the raw material and formulation described in claims 1 and 2 comprise the following steps: (a) In a container (stirrer) put the 22 kg of ricinoleic acid; (b) Add water at 90 ° C and stir well until the mixture is homogenized; (c) After homogenizing, add 75% liquid soda at room temperature (25 to 30 ° C); (d) Stir well to fully dissolve the mixture; (e) The product is expected to cool (Mf), which is then ready for use. Petition 870170015710, of 03/10/2017, p. 17/18 1/1