BR102016029708B1 - SOLVENTS MIXTURE, COMPOSITION COMPRISING THE SOLVENTS MIXTURE, METHODS OF PREPARING THE SOLVENTS MIXTURE COMPOSITION, AND USE OF THE SOLVENTS MIXTURE COMPOSITION - Google Patents
SOLVENTS MIXTURE, COMPOSITION COMPRISING THE SOLVENTS MIXTURE, METHODS OF PREPARING THE SOLVENTS MIXTURE COMPOSITION, AND USE OF THE SOLVENTS MIXTURE COMPOSITION Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
mistura de solventes, composição compreendendo a mistura de solventes, métodos de preparação da composição de mistura de solventes, e uso da composição de mistura de solventes. a presente invenção refere-se ao uso de uma mistura quádrupla de solventes em formulação agroquímica líquida contendo dmso (dimetilsulfóxido, dimethyl sulfoxide, cas 67-68-5), solvesso 200 (solvente aromático pesado, heavy aromatic solvent, cas 64742-94-5), álcool benzílico (benzyl alcohol, cas 100-51-6) e éster metílico de óleo de soja (soybean oil methyl ester, cas 67784-80-9) em diversas proporções. a invenção ainda descreve uma composição agrícola compreendendo a mistura de solventes, métodos de preparação da composição de mistura de solventes, bem como o uso da composição de mistura de solventes.solvent mixture, composition comprising the solvent mixture, methods of preparing the solvent mixture composition, and use of the solvent mixture composition. the present invention relates to the use of a quadruple mixture of solvents in a liquid agrochemical formulation containing dmso (dimethyl sulfoxide, dimethyl sulfoxide, cas 67-68-5), solvesso 200 (heavy aromatic solvent, cas 64742-94- 5), benzyl alcohol (benzyl alcohol, cas 100-51-6) and soybean oil methyl ester (soybean oil methyl ester, cas 67784-80-9) in different proportions. The invention further describes an agricultural composition comprising the solvent mixture, methods of preparing the solvent mixture composition, as well as the use of the solvent mixture composition.
Description
[001] A presente invenção refere-se a uma mistura de solventes compreendendo dimetilsulfóxido (DMSO), solvesso 200, álcool benzílico e éster metílico de óleo de soja, a qual é aplicada em formulações agroquímicas e visam a solubilização de ingredientes ativos com variadas características físico-químicas.[001] The present invention refers to a mixture of solvents comprising dimethylsulfoxide (DMSO), solvesso 200, benzyl alcohol and soybean oil methyl ester, which is applied in agrochemical formulations and aim at the solubilization of active ingredients with varied characteristics physicochemical.
[002] É de conhecimento que composições agroquímicas envolvendo múltiplos ingredientes ativos com variadas características físico-químicas, bem como formulações contendo um único ingrediente ativo com um perfil de solubilidade limitado, poderiam gerar um produto final instável.[002] It is known that agrochemical compositions involving multiple active ingredients with varied physicochemical characteristics, as well as formulations containing a single active ingredient with a limited solubility profile, could generate an unstable final product.
[003] Neste sentido, deve-se salientar que tal instabilidade poderia se refletir em quebra da emulsão, cristalização quando exposto a baixas temperaturas, ou mesmo precipitação de componentes quando da preparação da calda de aplicação.[003] In this sense, it should be noted that such instability could be reflected in emulsion breakage, crystallization when exposed to low temperatures, or even precipitation of components when preparing the application solution.
[004] Para resolver essas questões, o documento US2010234227 descreve uma microemulsão concentrada (ME), destinada ao setor de proteção de culturas, contendo (a) uma ou mais substâncias ativas agroquímicas, (b) um ou mais solventes alcoólicos com pelo menos 5 átomos de carbono, e (c) um ou mais tensoativos não iônicos.[004] To resolve these issues, document US2010234227 describes a concentrated microemulsion (ME), intended for the crop protection sector, containing (a) one or more agrochemical active substances, (b) one or more alcoholic solvents with at least 5 carbon atoms, and (c) one or more nonionic surfactants.
[005] Interessante notar que a invenção de US2010234227 é extremamente genérica e ampla, com um rol decombinações muito extenso.[005] Interesting to note that the invention of US2010234227 is extremely generic and broad, with a very extensive list of combinations.
[006] A patente BR0719277-0, por sua vez, trata de uma formulação fitossanitária concentrada compreendendo um produto fitossanitário ativo e um sistema solvente compreendendo pelo menos dois solventes, os quais são escolhidos dentre: um acetato de alquila onde o grupo alquílico contém pelo menos 3 átomos de carbono, um sulfóxido e uma cetona.[006] Patent BR0719277-0, in turn, deals with a concentrated phytosanitary formulation comprising an active phytosanitary product and a solvent system comprising at least two solvents, which are chosen from: an alkyl acetate where the alkyl group contains at least minus 3 carbon atoms, one sulfoxide and one ketone.
[007] Assim, salienta-se que a mistura de solventes descrita no documento BR0719277-0 visa, especificamente, a utilização de DMSO, um acetato de alquila e uma cetona em sua formulação.[007] Thus, it is noteworthy that the mixture of solvents described in document BR0719277-0 aims specifically at the use of DMSO, an alkyl acetate and a ketone in its formulation.
[008] Ainda, é possível citar o documento internacional WO2013083405 descreve um concentrado emulsificável que compreende um pesticida que não é solúvel em água, DMSO, álcool benzílico, lactato de alquila e um diéster de fórmula (I), como segue:
[009] Ainda, o documento internacional WO2005074685 reivindica proteção do processo de preparação de dito concentrado emulsificável, bem como do método para controlar fungos fitopatogênicos, vegetação indesejada, ataques indesejáveis de insetos ou ácaros e/ou para regular ocrescimento de plantas.[009] Still, the international document WO2005074685 claims protection of the process of preparation of said emulsifiable concentrate, as well as the method to control phytopathogenic fungi, unwanted vegetation, undesirable attacks by insects or mites and/or to regulate plant growth.
[010] Portanto, mesmo com os esforços já efetuados, ainda existe o problema relacionado à ausência de uma formulação que seja devidamente estável quando existe a combinação de múltiplos ingredientes ativos/componentes com variadas características físico-químicas, bem como uma formulação cuja instabilidade não gere quebra de emulsão, cristalização quando exposto a baixas temperaturas, ou mesmo precipitação de componentes quando da preparação da calda de aplicação.[010] Therefore, even with the efforts already made, there is still the problem related to the absence of a formulation that is properly stable when there is a combination of multiple active ingredients/components with varied physicochemical characteristics, as well as a formulation whose instability does not generates emulsion breakage, crystallization when exposed to low temperatures, or even precipitation of components when preparing the application solution.
[011] Assim sendo, a presente invenção resolve tais problemas técnicos por meio de uma composição que consiste na mistura dos seguintes solventes: dimetilsulfóxido (DMSO), solvesso 200, álcool benzílico e éster metílico deóleo de soja.[011] Therefore, the present invention solves such technical problems by means of a composition that consists of a mixture of the following solvents: dimethylsulfoxide (DMSO), solvesso 200, benzyl alcohol and soybean oil methyl ester.
[012] A presente invenção refere-se a umamistura de solventes compreendendo dimetilsulfóxido (DMSO),solvesso 200, álcool benzílico e éster metílico de óleo de soja. Tal mistura é aplicada em formulações agroquímicas e visam a solubilização de ingredientes ativos com as mais variadas características físico-químicas.[012] The present invention relates to a mixture of solvents comprising dimethylsulfoxide (DMSO), solvesso 200, benzyl alcohol and soybean oil methyl ester. This mixture is applied in agrochemical formulations and aims to solubilize active ingredients with the most varied physicochemical characteristics.
[013] Assim, a presente invenção descreve uma composição agrícola que compreender: (a) mistura de solventes: (i) dimetilsulfóxido (DMSO), (ii) solvesso 200, (iii) álcool benzílico e (iv) éster metílico de óleo de soja; (b) pelo menos um ingrediente ativo; e (c) pelo menos um componente adicional selecionado a partir do grupo que consiste em: solventes, dispersantes, umectantes, emulsionantes, antiespumantes, modificadores reológicos, conservantes, cargas, corantes, dentre outros.[013] Thus, the present invention describes an agricultural composition comprising: (a) mixture of solvents: (i) dimethylsulfoxide (DMSO), (ii) solvesso 200, (iii) benzyl alcohol and (iv) oil methyl ester. Soy; (b) at least one active ingredient; and (c) at least one additional component selected from the group consisting of: solvents, dispersants, humectants, emulsifiers, defoamers, rheological modifiers, preservatives, fillers, colorants, among others.
[014] Assim, as faixas de concentração dos solventes são: - dimetilsulfóxido (DMSO): 1,0 a 30,0%, - solvesso 200: 1,0 a 20,0%, - álcool benzílico: 1,0 a 20,0%, e- éster metílico de óleo de soja: 1,0 a 20,0%.[014] Thus, the concentration ranges of the solvents are: - dimethylsulfoxide (DMSO): 1.0 to 30.0%, - solvesso 200: 1.0 to 20.0%, - benzyl alcohol: 1.0 to 20 .0%, e-soybean oil methyl ester: 1.0 to 20.0%.
[015] Os componentes adicionais descritos na composição da presente invenção podem ser ao menos um dentre os abaixo descritos:- tensoativos com função dispersante, umectante e emulsionante, podendo ser não iônicos ou iônicos:dentre os não iônicos destacam-se alquil alcoxilados com grau de alcoxilação de cerca de 1 a cerca de 10.000 e cadeia carbônica com 5 a 50 carbonos, podendo conter ramificações e insaturações, copolímeros etoxilados e propoxilados com grau de alcoxilação de cerca 3 a cerca de 1000 e alquil fenol alcoxilados com grau de alcoxilação de cerca de 1 a cerca de 10.000 e cadeia carbônica com 5 a 50 carbonos, podendo conter ramificações e insaturações. Como exemplo pode-se citar nonil fenol etoxilado, triestirilfenol etoxilado, octilfenol etoxilado, álcool cetílico etoxilado, álcool ceto-estearílico etoxilado, álcool isodecílico etoxilado, álcool láurico etoxilado, polietilenoglicóis, álcool isotridecílico etoxilado/propoxilado, poliacrilatos e policarboxilatos; e dentre os iônicos destacam-se os sais de ácido graxo de metais alcalinos e alcalinos terrosos, incluindo oleatos e estearatos de metal alcalino e alcalinos terrosos; lauril sulfatos de metais alcalinos e alcalinos terrosos; sais de metais alcalinos e alcalinos terrosos de sulfosuccinato de diisooctila; alquil aril sulfatos ou sulfanatos, alquilbenzenos sulfonatos de metais alcalinos e alcalinos terrosos e naftaleno sulfonato de sódios, triestirilfenol etoxilado fosfatado, naftalenoformaldeído sulfonato de sódio, nonilfenol etoxilado fosfatado e nonilfenoletoxilado sulfatado; cloreto de alquil trimetil amônio, cloreto de dialquil dimetil amônio, cloreto de alquilbenzil dimetil amônio, cloreto de cetil trimetil amônio, esterquat de trietanolamina ácida di-oléica, cloreto de diesteril dimetil amônio, cloreto de dialquil dimetil amônio, esterquat de trietanolamina ácida dialquílica e esterquate de trietanolamina. - antiespumantes: derivados de silicones, polietilenoglicóis, óleos minerais e vegetais, ceras parafínicas e de ácidos graxos; - modificadores reológicos: Agar-agar, alginato, hidroxipropilcelulose, hidroxipropilmetilcelulose, celulose microcristalina, pectina, gomas xantana, carragenana, gelana, cássia, celulose, konjac, guar; - conservantes: isotiazolinonas, benzoatos, sorbatos, formol; - cargas: inertes utilizados para compatibilizar a fórmula, como água, dióxido de silício, talcos, carbonatos, terras, polivinilpirrolidonas, lactose e seus derivados, dextrina e seus derivados, etc.[015] The additional components described in the composition of the present invention can be at least one of those described below:- surfactants with dispersing, wetting and emulsifying functions, which may be non-ionic or ionic: among the non-ionic, we highlight alkyl alkoxylated grades of alkoxylation from about 1 to about 10,000 and carbon chain with 5 to 50 carbons, which may contain branches and unsaturations, ethoxylated and propoxylated copolymers with a degree of alkoxylation from about 3 to about 1000, and alkoxylated alkyl phenols with a degree of alkoxylation of about from 1 to about 10,000 and a carbon chain with 5 to 50 carbons, which may contain branches and unsaturations. As an example, mention may be made of ethoxylated nonyl phenol, ethoxylated tristyrylphenol, ethoxylated octylphenol, ethoxylated cetyl alcohol, ethoxylated cetostearyl alcohol, ethoxylated isodecyl alcohol, ethoxylated lauric alcohol, polyethylene glycols, ethoxylated/propoxylated isotridecyl alcohol, polyacrylates; and among the ionic ones stand out the fatty acid salts of alkali and alkaline earth metals, including alkali metal and alkaline earth metal oleates and stearates; alkali and alkaline earth metal lauryl sulfates; alkali and alkaline earth metal salts of diisooctyl sulfosuccinate; alkyl aryl sulphates or sulfanates, alkali metal and alkaline earth metal alkylbenzene sulphonates and sodium naphthalene sulphonate, ethoxylated tristyrylphenol phosphate, sodium naphthaleneformaldehyde sulphonate, ethoxylated nonylphenol phosphate and sulphated nonylphenol ethoxylate; alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, alkylbenzyl dimethyl ammonium chloride, cetyl trimethyl ammonium chloride, dioleic acid triethanolamine esterquat, diesteryl dimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, dialkyl acid triethanolamine esterquat and triethanolamine esterquate. - defoamers: silicone derivatives, polyethylene glycols, mineral and vegetable oils, paraffin waxes and fatty acids; - rheological modifiers: agar-agar, alginate, hydroxypropylcellulose, hydroxypropylmethylcellulose, microcrystalline cellulose, pectin, xanthan gums, carrageenan, gellan, cassia, cellulose, konjac, guar; - preservatives: isothiazolinones, benzoates, sorbates, formalin; - fillers: inerts used to make the formula compatible, such as water, silicon dioxide, talc, carbonates, earth, polyvinylpyrrolidones, lactose and its derivatives, dextrin and its derivatives, etc.
[016] Cabe ainda salientar que dito pelo menos um ingrediente ativo está na faixa de 1,0 a 50,0%, podendo pertencer a ao menos um dos seguintes grupos: fungicidas, herbicidas e inseticidas, ou misturas destes, sendo que preferencialmente tal ativo pode ser: - Inseticidas descritos no IRAC (Insecticide Resistance Action Committee) com os seguintes modos de ação: Grupo 1: Grupo 2: Inibidores de Acetilcolinesterase Antagonistas dos canais de cloro (AChE); regulados por GABA; Grupo 3: Moduladores dos canais de sódio; Grupo 4 : Moduladores competitivos do receptor nicotínico de acetilcolina (nAChR); Grupo 5: Moduladores alostéricos do receptor nicotínico de acetilcolina (nAChR); Grupo 6: Moduladores alostéricos dos canais fechados de cloretos de glutamato (GluCl); Grupo 7: Simuladores do hormônio juvenil; Grupo 8: Inibidores inespecíficos (múltiplos sítios); Grupo 9: Canais moduladores de órgão cordotonal (TRPV); Grupo 10: Inibidores de crescimento de ácaros; Grupo 11: Disruptores microbianos do intestino dos insetos; Grupo 12: Inibidores da ATP sintase mitocôndria; Grupo 13: Desacopladores da fosforilação oxidativa via interrupção do gradiente de prótons; Grupo 14: Bloqueadores dos receptores nicotínicos de acetilcolina (nAChR); Grupo 15: Inibidores da biossíntese de quitina, tipo 0; Grupo 16: Inibidores da biossíntese de quitina, tipo 1; Grupo 17: Agentes que interferem na ecdise, dípteros; Grupo 18: Agonistas do receptor de ecdisona; Grupo 19: Agonistas do receptor de Octopamina; Grupo 20: Inibidores de transporte de elétrons, complexo mitocondrial III; Grupo 21: Inibidores de transporte de elétrons, complexo mitocondrial I; Grupo 22: Bloqueadores dos canais de sódio dependentes de voltagem; Grupo 23: Inibidores de acetil CoA carboxilase; Grupo 24: Inibidores de transporte de elétrons, complexo mitocondrial IV; Grupo 25: Inibidores de transporte de elétrons, complexo mitocondrial II; Grupo 28: Moduladores dos receptores de Rianodina; Grupo 29: Moduladores de órgãos sensoriais: alvo de ação indefinido; Grupo UN: Compostos com modo de ação desconhecido ou incerto. - Fungicidas descritos no FRAC (Fungicide Resistance Action Committee) com os seguintes modos de ação: A: Síntese de ácidos nucleicos; B: Inibição da mitose e divisão celular; C: Inibidores da Respiração; D: Inibição da síntese de aminoácidos e proteínas; E: Transdução de sinal; F: Síntese de lipídios e membrana; G: Inibição da Biossíntese de esterol; H: Glucanas e síntese da parede celular; I: Inibição da biossíntese de melanina (MBI’s); P: Indutores de defesas em plantas hospedeiras; M:Interferência generalizada das funções celulares (atividade multissítio); Mecanismo de ação indefinido. - Herbicidas descritos no HRAC (Herbicide Resistance Action Committee) com os seguintes modos de ação: A: Inibidores da síntese de lipídeos (inibidores da ACCase) B: Inibidores da ALS (síntese de aminoácidos de cadeia ramificada) C: Inibidores da fotossíntese (fotossistema II); D: Captores de elétrons do fotossistema I; E: Inibidores da Protoporfirina oxidase; F: Inibidores da síntese de pigmentos; F1: Inibidores da fitoenodesidrogenase (PDS) F2: Inibidores da 4-hidroxifenilpiruvato dioxigenase (4-HPPD); F4: Inibidores da 1-deoxi-D-xilulose 5-fosfato sintase (DOXP synthase); G: Inibidores da 5-enolpiruvilshikimato-3-fosfato sintase (EPSP); H: Inibidores da glutamina sintase; I: Inibidores da dihidropteroato (DHP) K1: Inibidores da formação de microtúbulos; K2: Inibidores da organização de microtúbulos; K3: Inibidores da divisão celular; L: Inibidores da síntese de celulose; M: Desacopladores da fosforilação oxidativa; N: Inibidores da síntese de lipídeos (independentes da ACCase); O: Auxinas sintéticas; P: Inibidores do transporte de auxinas; Z e F3: modo de ação ou alvo desconhecido.[016] It should also be noted that said at least one active ingredient is in the range of 1.0 to 50.0%, and may belong to at least one of the following groups: fungicides, herbicides and insecticides, or mixtures thereof, preferably such active can be: - Insecticides described in the IRAC (Insecticide Resistance Action Committee) with the following modes of action: Group 1: Group 2: Acetylcholinesterase Inhibitors Chlorine channel antagonists (AChE); regulated by GABA; Group 3: Sodium channel modulators; Group 4: Competitive modulators of the nicotinic acetylcholine receptor (nAChR); Group 5: Allosteric modulators of the nicotinic acetylcholine receptor (nAChR); Group 6: Allosteric modulators of glutamate chloride closed channels (GluCl); Group 7: juvenile hormone simulators; Group 8: Nonspecific inhibitors (multiple sites); Group 9: Cordotonal organ modulator channels (TRPV); Group 10: Mites growth inhibitors; Group 11: Insect gut microbial disruptors; Group 12: mitochondrial ATP synthase inhibitors; Group 13: Uncouplers of oxidative phosphorylation via interruption of the proton gradient; Group 14: Nicotinic acetylcholine receptor (nAChR) blockers; Group 15: Inhibitors of chitin biosynthesis, type 0; Group 16: Chitin biosynthesis inhibitors, type 1; Group 17: Agents that interfere with ecdysis, dipterans; Group 18: Ecdysone receptor agonists; Group 19: Octopamine receptor agonists; Group 20: Electron transport inhibitors, mitochondrial complex III; Group 21: Electron transport inhibitors, mitochondrial complex I; Group 22: Voltage-dependent sodium channel blockers; Group 23: Acetyl CoA carboxylase inhibitors; Group 24: Electron transport inhibitors, mitochondrial complex IV; Group 25: Electron transport inhibitors, mitochondrial complex II; Group 28: Rianodine receptor modulators; Group 29: Sensory organ modulators: undefined target of action; UN Group: Compounds with unknown or uncertain mode of action. - Fungicides described in the FRAC (Fungicide Resistance Action Committee) with the following modes of action: A: Nucleic acid synthesis; B: Inhibition of mitosis and cell division; C: Respiration inhibitors; D: Inhibition of amino acid and protein synthesis; E: Signal transduction; F: Lipid and membrane synthesis; G: Inhibition of sterol biosynthesis; H: Glucans and cell wall synthesis; I: Inhibition of melanin biosynthesis (MBI's); P: Defense inducers in host plants; M: Generalized interference of cellular functions (multisite activity); Undefined mechanism of action. - Herbicides described in the HRAC (Herbicide Resistance Action Committee) with the following modes of action: A: Inhibitors of lipid synthesis (ACCase inhibitors) B: Inhibitors of ALS (branched chain amino acid synthesis) C: Inhibitors of photosynthesis (photosystem II); D: Photosystem I electron scavengers; E: Protoporphyrin oxidase inhibitors; F: Inhibitors of pigment synthesis; F1: Phytoene dehydrogenase (PDS) inhibitors F2: 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitors; F4: Inhibitors of 1-deoxy-D-xylulose 5-phosphate synthase (DOXP synthase); G: 5-enolpyruvylshikimate-3-phosphate synthase (EPSP) inhibitors; H: Glutamine synthase inhibitors; I: Inhibitors of dihydropteroate (DHP) K1: Inhibitors of microtubule formation; K2: Inhibitors of microtubule organization; K3: Cell division inhibitors; L: Inhibitors of cellulose synthesis; M: Oxidative phosphorylation uncouplers; N: Inhibitors of lipid synthesis (ACCase-independent); O: Synthetic auxins; P: Auxin transport inhibitors; Z and F3: action mode or unknown target.
[017] Mais especificamente, poderá ser selecionado ao menos um dentre, bem como misturas de:(i) inseticida: dinotefuran, lambda cialotrina, ciclaniliprol, piriproxifen, benfuracarbe, metomil, fipronil, cloridrato de cartape, broflanilide, fenpropatrina, enxofre, acetamiprida, alfa cipermetrina, milbemectina, tebufenozida, ciflumetofen, fenitrotiona, esfenvarelato, novalurom, abamectina,etofenproxi, piridaben, tolfenpirad.(ii) fungicida: sais de cobre, piribencarbe, tifluzamida, fluazinam, metominostrobina, tebuconazol, azoxistrobina, flutolanil, flutriafol, tiofanato metílico, clorotalonil, bentiavalicarbe isopropil, cimoxanil, piraclostrobina, epoxiconazol, procimidona, triflumizol; e(iii) herbicida: 2,4D, dicamba, terbutilazina, atrazina, amicarbazona, sulfentrazona, piroxasulfona, pirazolssulfurom etílico, bispiribaque sódico, piritiobaque sódico, quizalofope p-etílico, glifosato, bentazona, flumioxazina, paraquate, flumicloraque pentílico, haloxifope p-metílico.[017] More specifically, at least one can be selected from among, as well as mixtures of: (i) insecticide: dinotefuran, lambda cyhalothrin, cyclaniliprol, pyriproxyfen, benfuracarb, methomyl, fipronil, cartape hydrochloride, broflanilide, fenpropatrin, sulfur, acetamiprid , alpha cypermethrin, milbemectin, tebufenozide, cyflumetofen, fenitrothion, esfenvarelate, novaluron, abamectin, ethofenproxy, pyridaben, tolfenpyrad.(ii) fungicide: copper salts, pyribencarb, tifluzamide, fluazinam, metominotriazole, aphtazole, tebustrobin methyl, chlorothalonil, isopropyl bentiavalcarb, cymoxanil, pyraclostrobin, epoxiconazole, procymidone, triflumizole; and (iii) herbicide: 2,4D, dicamba, terbuthylazine, atrazine, amicarbazone, sulfentrazone, pyroxasulfone, ethyl pyrazolsulfuron, sodium bispyribaque, sodium pyrithiobac, p-ethyl quizalofop, glyphosate, bentazone, flumioxazine, p-haloxyloracquet, flumioxazine, p-ethylraquat methyl.
[018] Assim, a composição compreende sua porção solvente estar na faixa de 15,0-90,0% do peso total da composição para formulações do tipo concentrado emulsionável (EC) e microemulsão (ME), e de 5,0-45,0% do peso total da composição para formulações do tipo emulsão de óleo em água (EW) e suspoemulsão (SE).[018] Thus, the composition comprises its solvent portion being in the range of 15.0-90.0% of the total weight of the composition for formulations of the emulsifiable concentrate (EC) and microemulsion (ME) type, and of 5.0-45 .0% of total composition weight for oil-in-water (EW) and suspoemulsion (SE) type formulations.
[019] O dispersante se encontra na faixa de concentração de 1,0-15,0% do peso total da composição.[019] The dispersant is in the concentration range of 1.0-15.0% of the total weight of the composition.
[020] O umectante está na faixa de concentração de 1,0-15,0% do peso total da composição.[020] The humectant is in the concentration range of 1.0-15.0% of the total weight of the composition.
[021] O emulsionante está na faixa deconcentração de 1,0-25,0% do peso total da composição.[021] The emulsifier is in the concentration range of 1.0-25.0% of the total weight of the composition.
[022] O antiespumante está na faixa deconcentração de 0,1-1,0% do peso total da composição.[022] The defoamer is in the concentration range of 0.1-1.0% of the total weight of the composition.
[023] O modificador reológico está na faixa de concentração de 0,1-4,0% do peso total da composição.[023] The rheological modifier is in the concentration range of 0.1-4.0% of the total weight of the composition.
[024] O conservante está na faixa de concentração de 0,05-1,0% do peso total da composição.[024] The preservative is in the concentration range of 0.05-1.0% of the total weight of the composition.
[025] A carga estar na faixa de concentração de 0,5-50,0% do peso total da composição.[025] The charge will be in the concentration range of 0.5-50.0% of the total weight of the composition.
[026] O corante está na faixa de concentração de 0,01-1,0% do peso total da composição.[026] The dye is in the concentration range of 0.01-1.0% of the total weight of the composition.
[027] A composição como ora pleiteada se apresenta sob o aspecto de formulações líquidas. De forma mais específica, as citadas formulações líquidas podem ser do tipo concentrados emulsionáveis (EC), emulsões de óleo em água (EW), microemulsões (ME) e suspoemulsões (SE).[027] The composition as claimed is presented under the aspect of liquid formulations. More specifically, said liquid formulations can be of the emulsifiable concentrates (EC), oil-in-water (EW) emulsions, microemulsions (ME) and suspoemulsions (SE) types.
[028] Além disso, a composição de mistura de solventes em pleito deve permitir que a formulação seja aplicada em campo após diluição em água, gerando uma calda estável e não cristalizada.[028] In addition, the solvent mixture composition in question must allow the formulation to be applied in the field after dilution in water, generating a stable and non-crystallized syrup.
[029] Deste modo, a presente invenção trata de uma mistura de solventes que compreende DMSO, álcool benzílico, éster metílico de óleo de soja e solvesso 200, sendo que dita mistura pode ainda incluir outros componentes, como solventes, dispersantes, umectantes, emulsionantes, antiespumantes, modificadores reológicos, conservantes, cargas, corantes, etc, sendo que ditos componentes podem ser utilizados em diversas proporções, dependendo das características físico-químicas do princípio ativo e da formulação.[029] Thus, the present invention deals with a mixture of solvents comprising DMSO, benzyl alcohol, methyl ester of soybean oil and solvesso 200, and said mixture may also include other components, such as solvents, dispersants, wetting agents, emulsifiers , defoamers, rheological modifiers, preservatives, fillers, dyes, etc., and said components can be used in different proportions, depending on the physicochemical characteristics of the active ingredient and the formulation.
[030] A mistura pretendida pela presente invenção permite a solubilização de diversos ativos agroquímicos, viabilizando, assim, sua aplicação em formulações agroquímicas líquidas dos diversos tipos já mencionados (por exemplo, concentrados emulsionáveis (EC), emulsões de óleo em água (EW) e suspoemulsões (SE), etc).[030] The mixture intended by the present invention allows the solubilization of various agrochemical actives, thus enabling its application in liquid agrochemical formulations of the various types already mentioned (for example, emulsifiable concentrates (EC), oil-in-water (EW) emulsions and suspoemulsions (SE), etc.).
[031] Deste modo, a mistura desejada, por conta da combinação de seus componentes em proporções diferenciadas, apresenta uma ampla gama de polaridade.[031] Thus, the desired mixture, due to the combination of its components in different proportions, presents a wide range of polarity.
[032] O solvesso 200 ajuda na solubilização de moléculas com frações aromáticas de características planas e ricas em elétrons (especialmente hidrocarbonetos).[032] The solvesso 200 helps in the solubilization of molecules with aromatic fractions with flat characteristics and rich in electrons (especially hydrocarbons).
[033] O DMSO apresenta alta afinidade por heteroátomos (O, N, S), sendo tanto doador quanto aceptor de elétrons.[033] The DMSO has high affinity for heteroatoms (O, N, S), being both donor and acceptor of electrons.
[034] O álcool benzílico tem a capacidade de compatibilizar o solvesso 200 com o DMSO.[034] Benzyl alcohol has the ability to compatibilize Solesso 200 with DMSO.
[035] O éster metílico interage com as partes lineares da molécula do ingrediente ativo, ajudando na solubilização das cadeias alifáticas e na estabilidade da emulsão.[035] The methyl ester interacts with the linear parts of the active ingredient molecule, helping in the solubilization of aliphatic chains and in the stability of the emulsion.
[036] Desta forma, existe uma grande compatibilidade entre a mistura e as possíveis moléculas usadas como ativos agroquímicos, tendo em vista que esses ativos possuem tanto cadeias alifáticas/aromáticas, como grupos polares e heteroátomos.[036] In this way, there is a great compatibility between the mixture and the possible molecules used as agrochemical actives, considering that these actives have both aliphatic/aromatic chains, as polar groups and heteroatoms.
[037] Dentre as características desejáveis, a formulação final obtida deve ser estável durante o período de pelo menos 3 anos, não deve apresentar cristalização quando incubado a 0°C durante 7 dias, não deve apresentar cristalização quando diluído a 1% em água a 5°C e não pode apresentar quebra de emulsão quando diluído a 1% em água e incubado a 30°C durante 24h.[037] Among the desirable characteristics, the final formulation obtained must be stable for a period of at least 3 years, must not show crystallization when incubated at 0°C for 7 days, must not show crystallization when diluted to 1% in water 5°C and cannot show emulsion breakage when diluted to 1% in water and incubated at 30°C for 24h.
[038] A invenção ainda descreve métodos depreparação da composição de mistura de solventes.[038] The invention further describes methods of preparing the composition of mixed solvents.
[039] Na forma de EC ou ME, o método parapreparar a composição ora pleiteada compreendendo as etapas de: (a) adicionar o ingrediente ativo; (b) adicionar os solventes, preferencialmente na seguinte ordem: DMSO, álcool benzílico, solvesso 200 e éster metílico de óleo de soja; e (c) acrescentar os tensoativos (dispersantes, umectantes e emusionantes).[039] In the form of EC or ME, the method to prepare the composition now claimed comprising the steps of: (a) adding the active ingredient; (b) adding the solvents, preferably in the following order: DMSO, benzyl alcohol, solvesso 200 and soybean oil methyl ester; and (c) add surfactants (dispersants, humectants and emulsifiers).
[040] Na forma de EW, compreende as etapas de: Fase 1: - adicionar na seguinte ordem e sob agitação: (i) ingrediente ativo da fase solvente; (ii) solventes, preferencialmente na seguinte ordem: DMSO, álcool benzílico, solvesso 200 e éster metílico de óleo de soja; (iii) tensoativos (dispersantes, umectantes e emusionantes); Fase 2 : - adicionar na seguinte ordem e sob agitação: (i) ingrediente ativo da fase aquosa; (ii) água; (iii) tensoativos (dispersantes, umectantes e emusionantes); (iv) conservantes; e (v) modificadores reológicos; - verter a fase 1 sobre a fase 2; e - agitar vigorosamente.[040] In the form of EW, comprises the steps of: Phase 1: - add in the following order and under stirring: (i) active ingredient of the solvent phase; (ii) solvents, preferably in the following order: DMSO, benzyl alcohol, solvesso 200 and soybean oil methyl ester; (iii) surfactants (dispersants, humectants and emulsifiers); Phase 2: - add in the following order and under stirring: (i) active ingredient from the aqueous phase; (ii) water; (iii) surfactants (dispersants, humectants and emulsifiers); (iv) preservatives; and (v) rheological modifiers; - pouring phase 1 over phase 2; and - shake vigorously.
[041] Na forma de SE, compreende as etapas de: Fase 1: - adicionar na seguinte ordem e sob agitação: (i) ingrediente ativo da fase solvente; (ii) solventes, preferencialmente na seguinte ordem: DMSO, álcool benzílico, solvesso 200 e éster metílico de óleo de soja; (iii) tensoativos (dispersantes, umectantes e emusionantes); Fase 2 : - adicionar na seguinte ordem e sob agitação: (i) ingrediente ativo da fase aquosa; (ii) água; (iii) tensoativos (dispersantes, umectantes e emusionantes); (iv) conservantes; (v)- modificadores reológicos - moer o material em moinho de esferas até tamanho médio de partícula de aproximadamente 2,0μ m; - verter a fase 1 sobre a fase 2; e - agitar vigorosamente.[041] In the form of SE, comprises the steps of: Phase 1: - add in the following order and under stirring: (i) active ingredient of the solvent phase; (ii) solvents, preferably in the following order: DMSO, benzyl alcohol, solvesso 200 and soybean oil methyl ester; (iii) surfactants (dispersants, humectants and emulsifiers); Phase 2: - add in the following order and under stirring: (i) active ingredient from the aqueous phase; (ii) water; (iii) surfactants (dispersants, humectants and emulsifiers); (iv) preservatives; (v)- rheological modifiers - grinding the material in a ball mill to an average particle size of approximately 2.0μm; - pouring phase 1 over phase 2; and - shake vigorously.
[042] Adicionalmente, é objeto da invenção o uso da composição de mistura de solventes para auxiliar na solubilização de ativos agroquímicos em formulações líquidas.[042] Additionally, it is the object of the invention to use the composition of a mixture of solvents to assist in the solubilization of agrochemical actives in liquid formulations.
[043] Exemplos de formulações agroquímicas que empregam a dita mistura de solventes. Tais exemplos fornecidos à seguir possuem caráter meramente exemplificativo, e não visam limitar ou restringir a matériado presente pedido de patente.[043] Examples of agrochemical formulations that employ said mixture of solvents. Such examples provided below are merely illustrative, and are not intended to limit or restrict the scope of this patent application.
[044] EXEMPLO 1:
[045] O processo de fabricação envolve a solubilização do ingrediente ativo fase 2 é adicionada em recipiente vertida sobre a fase 2 sob agitação vigorosa. O produto final é uma emulsão óleo em água (EW).[045] The manufacturing process involves the solubilization of the phase 2 active ingredient is added in a container poured over the phase 2 under vigorous stirring. The final product is an oil-in-water (EW) emulsion.
[046] EXEMPLO 2:
[047] O processo de fabricação envolve a solubilização do ingrediente ativo nos solventes. A seguir fase 2 é adicionada em recipiente separado e a fase 1 é vertida sobre a fase 2 sob agitação vigorosa. Após a formação da emulsão adiciona-se o antiespumante e a fase 3. O produto final é uma emulsão óleo em água (EW).[047] The manufacturing process involves the solubilization of the active ingredient in solvents. Then phase 2 is added in a separate container and phase 1 is poured over phase 2 under vigorous stirring. After the formation of the emulsion, the defoamer and phase 3 are added. The final product is an oil-in-water (EW) emulsion.
[048] EXEMPLO 3
[049] O processo de fabricação envolve a solubilização do ingrediente ativo nos solventes. A seguir a mistura é adicionada dos tensoativos sob agitação. O produto final é um concentrado emulsionável (EC).[049] The manufacturing process involves the solubilization of the active ingredient in solvents. Then the mixture is added to the surfactants under stirring. The final product is an emulsifiable concentrate (EC).
Claims (21)
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