BR0318562A - microsphere of two anti-tubercular drugs and a biodegradable polymer administered only by inhalation or combined with the oral route, and process - Google Patents
microsphere of two anti-tubercular drugs and a biodegradable polymer administered only by inhalation or combined with the oral route, and processInfo
- Publication number
- BR0318562A BR0318562A BRPI0318562-1A BR0318562A BR0318562A BR 0318562 A BR0318562 A BR 0318562A BR 0318562 A BR0318562 A BR 0318562A BR 0318562 A BR0318562 A BR 0318562A
- Authority
- BR
- Brazil
- Prior art keywords
- inhalation
- oral route
- microsphere
- combined
- composition
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"MICROSFERA DE DOIS FáRMACOS ANTI-TUBERCULARES E UM POLìMERO BIODEGRADáVEL ADMINISTRADO SOMENTE POR INALAçãO OU COMBINADA COM A VIA ORAL, E PROCESSO". A presente invenção refere-se a uma composição de micropartículas biodegradável útil para distribuição de fármacos alvo específica para controlar tuberculose pulmonar, a dita composição compreendendo dois fármacos anti-tuberculares, e um polímero biodegradável para distribuição de fármacos em uma razão de cerca de 1:2 a 2:1, e a um processo para preparação da composição e, finalmente, a um método de tratamento de tuberculose pulmonar em um indivíduo, o dito método compreendendo a administração somente por inalação ou em combinação com via oral, de quantidade farmaceuticamente efetiva da composição ao indivíduo necessitando a mesma, onde a dosagem para inalação varia entre 0,5 e 10 mg/ kg de peso do corpo /dia, e que para via oral varia entre 4 e 32 mg/ kg de peso do corpo /dia."MICROSPHERE OF TWO ANTI-TUBERCULAR DRUGS AND A BIODEGRADABLE POLYMER MANAGED ONLY BY INHALATION OR COMBINED WITH THE ORAL ROUTE AND PROCESS". The present invention relates to a biodegradable microparticle composition useful for drug delivery specific for controlling pulmonary tuberculosis, said composition comprising two anti-tubercular drugs, and a biodegradable drug delivery polymer in a ratio of about 1: 2 to 2: 1, and to a process for preparing the composition and, finally, to a method of treating pulmonary tuberculosis in an individual, said method comprising administering only by inhalation or in combination with the oral route of a pharmaceutically effective amount. of the composition to the individual in need thereof, wherein the dosage for inhalation ranges from 0.5 to 10 mg / kg body weight / day, and orally it ranges from 4 to 32 mg / kg body weight / day.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2003/004694 WO2005039529A1 (en) | 2003-10-16 | 2003-10-22 | Microsphere of two anti-tubercular drugs and a biodegradable polymer administered by inhalation alone or combined with oral route, and process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0318562A true BR0318562A (en) | 2006-10-10 |
Family
ID=34708461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318562-1A BR0318562A (en) | 2003-10-22 | 2003-10-22 | microsphere of two anti-tubercular drugs and a biodegradable polymer administered only by inhalation or combined with the oral route, and process |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1901878A (en) |
| AU (1) | AU2003269408A1 (en) |
| BR (1) | BR0318562A (en) |
| EA (1) | EA009878B1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110633B (en) * | 2013-02-28 | 2014-08-20 | 郑州大学 | Dry powder inhalant capable of preventing mycobacterium tuberculosis from transmitting through respiratory tract |
| CN104367554B (en) * | 2013-08-15 | 2018-08-21 | 中国医学科学院药用植物研究所 | A kind of preparation method of isoniazid sustained-release micro-spheres |
-
2003
- 2003-10-22 BR BRPI0318562-1A patent/BR0318562A/en not_active IP Right Cessation
- 2003-10-22 AU AU2003269408A patent/AU2003269408A1/en not_active Abandoned
- 2003-10-22 CN CN200380110741.5A patent/CN1901878A/en active Pending
- 2003-10-22 EA EA200600801A patent/EA009878B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003269408A1 (en) | 2005-05-11 |
| CN1901878A (en) | 2007-01-24 |
| EA009878B1 (en) | 2008-04-28 |
| EA200600801A1 (en) | 2006-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: A61K 31/00, A61K 31/445, A61K 31/455, A61K 9/00, A61K 31/00, A61P 11/00 Ipc: A61K 31/00 (2011.01), A61K 31/455 (2011.01), A61K |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |