BR0315275A - Antibodies that bind to erythropoietin receptor - Google Patents
Antibodies that bind to erythropoietin receptorInfo
- Publication number
- BR0315275A BR0315275A BR0315275-8A BR0315275A BR0315275A BR 0315275 A BR0315275 A BR 0315275A BR 0315275 A BR0315275 A BR 0315275A BR 0315275 A BR0315275 A BR 0315275A
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- bind
- erythropoietin receptor
- relates
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
"ANTICORPOS QUE SE LIGAM A RECEPTOR DE ERITROPOIETINA". A presente invenção se refere a anticorpos e a fragmentos destes anticorpos que se ligam a um receptor de eritropoietina e o ativam. A presente invenção também se refere a métodos de modulação da atividade endógena de um receptor de eritropoietina em um mamífero empregando-se tais anticorpos, assim como a composições farmacêuticas contendo tais anticorpos."Antibodies that bind to the erythropoietin receptor". The present invention relates to antibodies and fragments of these antibodies that bind to and activate an erythropoietin receptor. The present invention also relates to methods of modulating the endogenous activity of an erythropoietin receptor in a mammal using such antibodies, as well as pharmaceutical compositions containing such antibodies.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/269,711 US20040071694A1 (en) | 2002-10-14 | 2002-10-14 | Erythropoietin receptor binding antibodies |
US10/684,109 US7396913B2 (en) | 2002-10-14 | 2003-10-10 | Erythropoietin receptor binding antibodies |
PCT/US2003/032243 WO2004035603A2 (en) | 2002-10-14 | 2003-10-14 | Erythropoietin receptor binding antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315275A true BR0315275A (en) | 2005-08-30 |
Family
ID=32109805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315275-8A BR0315275A (en) | 2002-10-14 | 2003-10-14 | Antibodies that bind to erythropoietin receptor |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1578779A4 (en) |
JP (2) | JP4411472B2 (en) |
KR (1) | KR20050059263A (en) |
CN (1) | CN103524618A (en) |
AU (2) | AU2003282588B2 (en) |
BR (1) | BR0315275A (en) |
CA (1) | CA2501984C (en) |
MX (1) | MXPA05003997A (en) |
NZ (1) | NZ539263A (en) |
PL (1) | PL379985A1 (en) |
TW (1) | TWI320716B (en) |
WO (1) | WO2004035603A2 (en) |
ZA (1) | ZA201004902B (en) |
Families Citing this family (93)
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AU2002356844C1 (en) * | 2001-10-23 | 2010-03-04 | Amgen Fremont Inc. | PSMA antibodies and protein multimers |
AR045563A1 (en) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | ANTIBODIES DIRECTED TO M-CSF |
ES2533492T3 (en) * | 2004-02-06 | 2015-04-10 | University Of Massachusetts | Antibodies against Clostridium difficile toxins and their uses |
US20050227289A1 (en) * | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
EP2205280B1 (en) | 2007-09-27 | 2019-09-04 | Amgen Inc. | Pharmaceutical formulations |
WO2009064838A1 (en) | 2007-11-15 | 2009-05-22 | Amgen, Inc. | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
AU2009206306B2 (en) | 2008-01-25 | 2013-06-06 | Amgen Inc. | Ferroportin antibodies and methods of use |
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LT2699293T (en) | 2011-04-20 | 2019-04-25 | Amgen Inc. | Autoinjector apparatus |
AR086924A1 (en) * | 2011-06-15 | 2014-01-29 | Hoffmann La Roche | HUMAN EPO ANTI-RECEIVER ANTIBODIES AND THE METHODS FOR USE |
EP3335747B1 (en) | 2011-10-14 | 2021-04-07 | Amgen Inc. | Injector and method of assembly |
ES2780395T3 (en) | 2012-11-21 | 2020-08-25 | Amgen Inc | Drug delivery device |
US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
JP6336564B2 (en) | 2013-03-15 | 2018-06-06 | アムゲン・インコーポレーテッド | Drug cassette, auto-injector, and auto-injector system |
MX359794B (en) | 2013-03-15 | 2018-10-10 | Intrinsic Lifesciences Llc | Anti-hepcidin antibodies and uses thereof. |
CN113559363B (en) | 2013-03-22 | 2023-10-31 | 美国安进公司 | Syringe and method of assembly |
US11097055B2 (en) | 2013-10-24 | 2021-08-24 | Amgen Inc. | Injector and method of assembly |
JP7051293B2 (en) | 2013-10-24 | 2022-04-11 | アムジエン・インコーポレーテツド | Drug delivery system with temperature sensing control |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
SG11201609219QA (en) | 2014-05-07 | 2016-12-29 | Amgen Inc | Autoinjector with shock reducing elements |
KR102506249B1 (en) | 2014-06-03 | 2023-03-03 | 암겐 인코포레이티드 | Drug delivery system and method of use |
WO2016049036A1 (en) | 2014-09-22 | 2016-03-31 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
CA2957960C (en) | 2014-10-14 | 2023-08-22 | Amgen, Inc. | Drug injection device with visual and audible indicators |
EP3233159B1 (en) | 2014-12-19 | 2020-03-04 | Amgen Inc. | Drug delivery device with live button or user interface field |
JP6716566B2 (en) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | Drug delivery device with proximity sensor |
ES2748750T3 (en) | 2015-02-17 | 2020-03-17 | Amgen Inc | Drug delivery device with vacuum assisted clamping and / or feedback |
ES2905870T3 (en) | 2015-02-27 | 2022-04-12 | Amgen Inc | Drug delivery device having a needle guard mechanism with an adjustable threshold resistance to movement of the needle guard |
WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
US11351308B2 (en) | 2015-12-09 | 2022-06-07 | Amgen Inc. | Auto-injector with signaling cap |
CN105542006A (en) * | 2015-12-11 | 2016-05-04 | 北京大学第一医院 | Preparation method and use of anti-EPOR fusion protein antibody |
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WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
WO2017192287A1 (en) | 2016-05-02 | 2017-11-09 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
AU2017263558B2 (en) | 2016-05-13 | 2022-12-22 | Amgen Inc. | Vial sleeve assembly |
US11238150B2 (en) | 2016-05-16 | 2022-02-01 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
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WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
US20200261643A1 (en) | 2016-10-25 | 2020-08-20 | Amgen Inc. | On-body injector |
AU2018210301A1 (en) | 2017-01-17 | 2019-08-01 | Amgen Inc. | Injection devices and related methods of use and assembly |
JP7064501B2 (en) | 2017-02-17 | 2022-05-10 | アムジエン・インコーポレーテツド | Drug delivery device with sterile fluid flow path and related assembly methods |
AU2018221351B2 (en) | 2017-02-17 | 2023-02-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
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JP2020509837A (en) | 2017-03-09 | 2020-04-02 | アムジエン・インコーポレーテツド | Insertion mechanism for drug delivery device |
CN110446499A (en) | 2017-03-20 | 2019-11-12 | 豪夫迈·罗氏有限公司 | A kind of method of external glycosyl engineering erythropoiesis stimulating protein |
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WO2019022951A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
WO2019022950A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | Drug delivery device with container access system and related method of assembly |
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WO2019090079A1 (en) | 2017-11-03 | 2019-05-09 | Amgen Inc. | System and approaches for sterilizing a drug delivery device |
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US20210228815A1 (en) | 2018-07-24 | 2021-07-29 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
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AU2019350660A1 (en) | 2018-09-28 | 2021-03-18 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
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CA3109988A1 (en) | 2018-10-15 | 2020-04-23 | Amgen Inc. | Platform assembly process for drug delivery device |
WO2020092056A1 (en) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Drug delivery devices with partial needle retraction |
MA54057A (en) | 2018-11-01 | 2022-02-09 | Amgen Inc | DRUG DELIVERY ELEMENT PARTIAL RETRACTION DRUG DELIVERY DEVICES |
EP3873566A1 (en) | 2018-11-01 | 2021-09-08 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
US20220160972A1 (en) | 2019-04-24 | 2022-05-26 | Amgen Inc. | Syringe sterilization verification assemblies and methods |
CA3148261A1 (en) | 2019-08-23 | 2021-03-04 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
WO2022246055A1 (en) | 2021-05-21 | 2022-11-24 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990008822A1 (en) * | 1989-02-03 | 1990-08-09 | Genetics Institute, Inc. | Erythropoietin receptor |
US5885574A (en) * | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
AU6163196A (en) * | 1995-06-07 | 1996-12-30 | Smithkline Beecham Corporation | Method for obtaining receptor agonist antibodies |
US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
AU3492497A (en) * | 1996-06-21 | 1998-01-07 | Arris Pharmaceutical Corporation | Bivalent molecules that form an activating complex with an erythropoietin receptor |
WO2000061637A1 (en) * | 1999-04-14 | 2000-10-19 | Smithkline Beecham Corporation | Erythropoietin receptor antibodies |
-
2003
- 2003-10-13 TW TW092128277A patent/TWI320716B/en not_active IP Right Cessation
- 2003-10-14 KR KR1020057006487A patent/KR20050059263A/en not_active Application Discontinuation
- 2003-10-14 PL PL379985A patent/PL379985A1/en not_active Application Discontinuation
- 2003-10-14 CA CA2501984A patent/CA2501984C/en not_active Expired - Fee Related
- 2003-10-14 NZ NZ539263A patent/NZ539263A/en not_active IP Right Cessation
- 2003-10-14 CN CN201110126552.3A patent/CN103524618A/en active Pending
- 2003-10-14 EP EP03774776A patent/EP1578779A4/en not_active Withdrawn
- 2003-10-14 WO PCT/US2003/032243 patent/WO2004035603A2/en active Search and Examination
- 2003-10-14 AU AU2003282588A patent/AU2003282588B2/en not_active Ceased
- 2003-10-14 JP JP2004544846A patent/JP4411472B2/en not_active Expired - Fee Related
- 2003-10-14 BR BR0315275-8A patent/BR0315275A/en not_active Application Discontinuation
- 2003-10-14 MX MXPA05003997A patent/MXPA05003997A/en active IP Right Grant
-
2009
- 2009-02-12 JP JP2009029449A patent/JP2009149665A/en active Pending
-
2010
- 2010-07-12 ZA ZA2010/04902A patent/ZA201004902B/en unknown
- 2010-09-02 AU AU2010214778A patent/AU2010214778A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004035603A2 (en) | 2004-04-29 |
ZA201004902B (en) | 2012-06-27 |
EP1578779A2 (en) | 2005-09-28 |
TW200418505A (en) | 2004-10-01 |
AU2003282588A1 (en) | 2004-05-04 |
CN103524618A (en) | 2014-01-22 |
AU2003282588B2 (en) | 2010-06-03 |
KR20050059263A (en) | 2005-06-17 |
AU2010214778A1 (en) | 2010-09-23 |
JP2009149665A (en) | 2009-07-09 |
PL379985A1 (en) | 2006-11-27 |
MXPA05003997A (en) | 2005-06-22 |
JP4411472B2 (en) | 2010-02-10 |
EP1578779A4 (en) | 2011-11-16 |
TWI320716B (en) | 2010-02-21 |
CA2501984A1 (en) | 2004-04-29 |
WO2004035603A3 (en) | 2006-04-27 |
NZ539263A (en) | 2009-07-31 |
JP2006523083A (en) | 2006-10-12 |
CA2501984C (en) | 2011-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal: dismissal of application maintained |