BR0309982A - Method for identifying a ligand, by which the residence time at the receptor is measured - Google Patents

Method for identifying a ligand, by which the residence time at the receptor is measured

Info

Publication number
BR0309982A
BR0309982A BR0309982-2A BR0309982A BR0309982A BR 0309982 A BR0309982 A BR 0309982A BR 0309982 A BR0309982 A BR 0309982A BR 0309982 A BR0309982 A BR 0309982A
Authority
BR
Brazil
Prior art keywords
ligand
receptor
identifying
measured
residence time
Prior art date
Application number
BR0309982-2A
Other languages
Portuguese (pt)
Inventor
Patrick Karl Dorr
Manoussos Perros
Anthony Graham Rickett
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0211923A external-priority patent/GB0211923D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR0309982A publication Critical patent/BR0309982A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Abstract

"MéTODO PARA IDENTIFICAçãO DE UM LIGANDO, PELO QUAL O TEMPO DE RESIDêNCIA NO RECEPTOR é MEDIDO". A presente invenção refere-se ao uso de um ensaio que mede o tempo de residência de um ligando no seu receptor in vitro, para a identificação de um ligando para esse receptor, previsto como sendo eficaz in vivo no tratamento de uma doença que responde à modulação da função natural desse receptor."METHOD FOR IDENTIFYING A LIGAND BY WHICH RECEIVER RESIDENCE TIME IS MEASURED". The present invention relates to the use of an assay that measures the time of residence of a ligand at its receptor in vitro for the identification of a ligand for that receptor predicted to be effective in vivo in the treatment of a disease responsive to modulation of the natural function of this receptor.

BR0309982-2A 2002-05-23 2003-05-14 Method for identifying a ligand, by which the residence time at the receptor is measured BR0309982A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0211923A GB0211923D0 (en) 2002-05-23 2002-05-23 Method
GB0309392 2003-04-24
PCT/IB2003/002023 WO2003100427A1 (en) 2002-05-23 2003-05-14 Method for identification of a ligand whereby receptor residence time is measured

Publications (1)

Publication Number Publication Date
BR0309982A true BR0309982A (en) 2005-03-22

Family

ID=29585818

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309982-2A BR0309982A (en) 2002-05-23 2003-05-14 Method for identifying a ligand, by which the residence time at the receptor is measured

Country Status (7)

Country Link
EP (1) EP1506405A1 (en)
JP (1) JP2005533999A (en)
AU (1) AU2003230129A1 (en)
BR (1) BR0309982A (en)
CA (1) CA2485825A1 (en)
MX (1) MXPA04011577A (en)
WO (1) WO2003100427A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3343220B1 (en) 2016-12-27 2020-04-08 IMEC vzw Bioparticle characterization

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20001420A1 (en) * 1998-12-23 2000-12-18 Pfizer CCR5 MODULATORS
TR200400541T4 (en) * 2000-05-26 2004-04-21 Pfizer Inc. Tropan derivatives useful in therapy.

Also Published As

Publication number Publication date
EP1506405A1 (en) 2005-02-16
AU2003230129A1 (en) 2003-12-12
JP2005533999A (en) 2005-11-10
CA2485825A1 (en) 2003-12-04
WO2003100427A1 (en) 2003-12-04
MXPA04011577A (en) 2005-03-07

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