BR0308472A - Process for preparing crystalline cabergoline form i - Google Patents

Process for preparing crystalline cabergoline form i

Info

Publication number
BR0308472A
BR0308472A BR0308472-8A BR0308472A BR0308472A BR 0308472 A BR0308472 A BR 0308472A BR 0308472 A BR0308472 A BR 0308472A BR 0308472 A BR0308472 A BR 0308472A
Authority
BR
Brazil
Prior art keywords
cabergoline
toluene
preparing crystalline
cabergoline form
mixture
Prior art date
Application number
BR0308472-8A
Other languages
Portuguese (pt)
Inventor
Ahmad Y Sheikh
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0308472A publication Critical patent/BR0308472A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Abstract

"PROCESSO PARA PREPARAR A FORMA I CRISTALINA DE CABERGOLINA". a presente invenção refere-se a um processo para produzir a forma I cristalina de cabergolina, cujo processo compreende a cristalização da forma desejada de uma mistura de tolueno/heptano ou tolueno/hexano começando de cabergolina bruta, seguida pela recuperação e remoção do solvente da Forma X de solvato de tolueno resultante. A nova Forma X de solvato de cabergolina, intermediário útil, e sua preparação são também fornecidos."PROCESS FOR PREPARING THE CRYSTALINE CABERGOLINE FORM". The present invention relates to a process for producing crystalline cabergoline form I, the process of which comprises crystallizing the desired form from a mixture of toluene / heptane or toluene / hexane starting from crude cabergoline, followed by recovering and removing solvent from the mixture. Form X of resulting toluene solvate. The new Cabergoline solvate Form X, useful intermediate, and its preparation are also provided.

BR0308472-8A 2002-03-15 2003-03-10 Process for preparing crystalline cabergoline form i BR0308472A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36456702P 2002-03-15 2002-03-15
US41025302P 2002-09-12 2002-09-12
PCT/US2003/007138 WO2003078392A2 (en) 2002-03-15 2003-03-10 Process for preparing crystalline form i of cabergoline

Publications (1)

Publication Number Publication Date
BR0308472A true BR0308472A (en) 2005-01-11

Family

ID=28045415

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308472-8A BR0308472A (en) 2002-03-15 2003-03-10 Process for preparing crystalline cabergoline form i

Country Status (14)

Country Link
EP (1) EP1507777A4 (en)
JP (1) JP2005520831A (en)
KR (1) KR100605794B1 (en)
CN (1) CN1642953A (en)
AU (1) AU2003224665A1 (en)
BR (1) BR0308472A (en)
CA (1) CA2478149A1 (en)
IL (1) IL163779A0 (en)
MX (1) MXPA04008935A (en)
PL (1) PL372371A1 (en)
RS (1) RS77704A (en)
RU (1) RU2277536C2 (en)
TW (1) TW200306312A (en)
WO (1) WO2003078392A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155545A (en) 2003-04-21 2009-12-24 Finetech Pharmaceutical Ltd Solvate form of cabergoline
WO2004101510A2 (en) 2003-05-08 2004-11-25 Ivax Corporation Polymorphs of cabergoline
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
GB0515430D0 (en) * 2005-07-27 2005-08-31 Resolution Chemicals Ltd Preparation of cabergoline
EP1953157A1 (en) * 2007-01-31 2008-08-06 LEK Pharmaceuticals D.D. New crystal form of cabergoline

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526892A (en) * 1981-03-03 1985-07-02 Farmitalia Carlo Erba, S.P.A. Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
GB0007308D0 (en) * 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Process for preparing crystalline form | of cabergoline
BR0308304A (en) * 2002-03-15 2004-12-28 Pharmacia Corp Process for preparing crystalline cabergoline form I

Also Published As

Publication number Publication date
TW200306312A (en) 2003-11-16
WO2003078392A3 (en) 2003-12-11
RU2277536C2 (en) 2006-06-10
EP1507777A2 (en) 2005-02-23
KR100605794B1 (en) 2006-08-01
WO2003078392A2 (en) 2003-09-25
EP1507777A4 (en) 2007-03-07
MXPA04008935A (en) 2004-11-26
RS77704A (en) 2006-10-27
IL163779A0 (en) 2005-12-18
CN1642953A (en) 2005-07-20
JP2005520831A (en) 2005-07-14
AU2003224665A1 (en) 2003-09-29
RU2004127582A (en) 2006-01-27
CA2478149A1 (en) 2003-09-25
PL372371A1 (en) 2005-07-25
KR20050002858A (en) 2005-01-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.