BR0214832A - Inibição de tristetraprolina para proteção do coração contra danos cardìacos - Google Patents

Inibição de tristetraprolina para proteção do coração contra danos cardìacos

Info

Publication number
BR0214832A
BR0214832A BR0214832-3A BR0214832A BR0214832A BR 0214832 A BR0214832 A BR 0214832A BR 0214832 A BR0214832 A BR 0214832A BR 0214832 A BR0214832 A BR 0214832A
Authority
BR
Brazil
Prior art keywords
heart
inhibition
tristetraproline
protect
damage
Prior art date
Application number
BR0214832-3A
Other languages
English (en)
Inventor
Franz-Werner Kluxen
Bernd Hentsch
Thomas Ehring
Marian Braendle
Joerg Dietrich Hoheisel
Marcus Frohme
Dimitri Zubakov
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0214832A publication Critical patent/BR0214832A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"INIBIçãO DE TRISTETRAPROLINA PARA PROTEçãO DO CORAçãO CONTRA DANOS CARDìACOS". A presente invenção refere-se a compostos adequados para o tratamento de condições que podem ser melhoradas, pelo menos em parte, através do aumento da produção de TNF<244>. A invenção refere-se ainda a ensaios para a identificação de um indivíduo sob alto risco de ou sofrendo de tais condições e a métodos de avaliação de compostos quanto à sua habilidade em aumentar a biossíntese de TNF<244>.
BR0214832-3A 2001-12-12 2002-11-30 Inibição de tristetraprolina para proteção do coração contra danos cardìacos BR0214832A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01129564 2001-12-12
PCT/EP2002/013545 WO2003054541A2 (en) 2001-12-12 2002-11-30 Inhibition of tristetraproline for protection of the heart from cardiac injuries

Publications (1)

Publication Number Publication Date
BR0214832A true BR0214832A (pt) 2004-08-31

Family

ID=8179511

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214832-3A BR0214832A (pt) 2001-12-12 2002-11-30 Inibição de tristetraprolina para proteção do coração contra danos cardìacos

Country Status (17)

Country Link
US (2) US20050084860A1 (pt)
EP (1) EP1454142B1 (pt)
JP (1) JP2005512579A (pt)
KR (1) KR20040068559A (pt)
CN (1) CN1602427A (pt)
AR (1) AR037788A1 (pt)
AT (1) ATE538388T1 (pt)
AU (2) AU2002352201B2 (pt)
BR (1) BR0214832A (pt)
CA (1) CA2470148C (pt)
ES (1) ES2378228T3 (pt)
HU (1) HUP0402153A2 (pt)
MX (1) MXPA04005628A (pt)
PL (1) PL369849A1 (pt)
RU (1) RU2004121681A (pt)
WO (1) WO2003054541A2 (pt)
ZA (1) ZA200405449B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100012714A (ko) * 2008-07-29 2010-02-08 재단법인서울대학교산학협력재단 Ｒｎａ 분자와 단백질 사이의 상호작용을 조절하는 물질을동정하기 위한 분석 방법
CA2761142C (en) 2009-05-06 2021-06-08 Opko Curna, Llc Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN113777312B (zh) * 2021-09-03 2024-02-02 普十生物科技(北京)有限公司 乙肝抗体片段的制备方法、乙肝抗体片段、试剂盒及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
WO1997042820A1 (en) 1996-05-16 1997-11-20 Duke University Tristetraprolin
WO2001012213A2 (en) 1999-08-13 2001-02-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ttp-related zinc finger domains and methods of use

Also Published As

Publication number Publication date
MXPA04005628A (es) 2004-12-06
WO2003054541A2 (en) 2003-07-03
WO2003054541A3 (en) 2003-11-06
CA2470148A1 (en) 2003-07-03
AU2002352201B2 (en) 2009-01-29
US20090104182A1 (en) 2009-04-23
US20050084860A1 (en) 2005-04-21
HUP0402153A2 (hu) 2005-01-28
JP2005512579A (ja) 2005-05-12
ES2378228T3 (es) 2012-04-10
RU2004121681A (ru) 2005-04-20
ATE538388T1 (de) 2012-01-15
ZA200405449B (en) 2005-06-20
AU2002352201A1 (en) 2003-07-09
EP1454142A2 (en) 2004-09-08
AU2009201627B2 (en) 2012-09-06
AR037788A1 (es) 2004-12-01
AU2009201627A1 (en) 2009-05-21
CA2470148C (en) 2015-03-17
KR20040068559A (ko) 2004-07-31
PL369849A1 (en) 2005-05-02
CN1602427A (zh) 2005-03-30
EP1454142B1 (en) 2011-12-21

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]