BR0208891A - Dihydro-benzo [b] - [1,4] diazepin-2-one derivatives as mglur2 ii antagonists - Google Patents

Dihydro-benzo [b] - [1,4] diazepin-2-one derivatives as mglur2 ii antagonists

Info

Publication number
BR0208891A
BR0208891A BR0208891-6A BR0208891A BR0208891A BR 0208891 A BR0208891 A BR 0208891A BR 0208891 A BR0208891 A BR 0208891A BR 0208891 A BR0208891 A BR 0208891A
Authority
BR
Brazil
Prior art keywords
diazepin
benzo
derivatives
antagonists
dihydro
Prior art date
Application number
BR0208891-6A
Other languages
Portuguese (pt)
Inventor
Geo Adam
Erwin Goetschi
Vincent Mutel
Juergen Wichmann
Thomaz Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0208891A publication Critical patent/BR0208891A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

"DERIVADOS DE DIHIDRO-BENZO[B]-[1,4]DIAZEPIN-2-ONA COMO ANTAGONISTAS DE mGIuR2 II". Esta invenção refere-se a derivados de dihidro-benzo[b][1,4]diazepin-2-ona de fórmula geral, em que R1, R2, R3, X e Y são como definidos no relatório descritivo. A invenção também refere-se aos medicamentos contendo estes compostos, um processo para sua fabricação bem como seu uso para a preparação de medicamentos para o tratamento ou prevenção de distúrbios neurológicos agudos e/ou crónicos."DIHIDRO-BENZO DERIVATIVES [B] - [1,4] DIAZEPIN-2-ONA AS MGIuR2 II ANTAGONISTS". This invention relates to dihydro-benzo [b] [1,4] diazepin-2-one derivatives of general formula wherein R 1, R 2, R 3, X and Y are as defined in the specification. The invention also relates to medicaments containing these compounds, a process for their manufacture as well as their use for the preparation of medicaments for the treatment or prevention of acute and / or chronic neurological disorders.

BR0208891-6A 2001-04-12 2002-04-02 Dihydro-benzo [b] - [1,4] diazepin-2-one derivatives as mglur2 ii antagonists BR0208891A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01109125 2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en) 2001-04-12 2002-04-02 DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (1)

Publication Number Publication Date
BR0208891A true BR0208891A (en) 2004-04-20

Family

ID=8177126

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208891-6A BR0208891A (en) 2001-04-12 2002-04-02 Dihydro-benzo [b] - [1,4] diazepin-2-one derivatives as mglur2 ii antagonists

Country Status (38)

Country Link
US (1) US6544985B2 (en)
EP (1) EP1379511B1 (en)
JP (1) JP4071115B2 (en)
KR (1) KR100566171B1 (en)
CN (1) CN1264825C (en)
AR (1) AR035816A1 (en)
AT (1) ATE299868T1 (en)
AU (1) AU2002312788B2 (en)
BG (1) BG108254A (en)
BR (1) BR0208891A (en)
CA (1) CA2442557C (en)
CZ (1) CZ20033003A3 (en)
DE (1) DE60205100T2 (en)
DK (1) DK1379511T3 (en)
EC (1) ECSP034797A (en)
ES (1) ES2246012T3 (en)
GT (1) GT200200073A (en)
HK (1) HK1068888A1 (en)
HR (1) HRP20030792A2 (en)
HU (1) HUP0400851A3 (en)
IL (2) IL157873A0 (en)
JO (1) JO2285B1 (en)
MA (1) MA27012A1 (en)
MX (1) MXPA03009311A (en)
MY (1) MY140271A (en)
NO (1) NO20034576L (en)
NZ (1) NZ528315A (en)
PA (1) PA8543301A1 (en)
PE (1) PE20021041A1 (en)
PL (1) PL367064A1 (en)
PT (1) PT1379511E (en)
RU (1) RU2263112C2 (en)
SI (1) SI1379511T1 (en)
SK (1) SK13682003A3 (en)
UY (1) UY27258A1 (en)
WO (1) WO2002083652A1 (en)
YU (1) YU79003A (en)
ZA (1) ZA200307243B (en)

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Also Published As

Publication number Publication date
WO2002083652A1 (en) 2002-10-24
AR035816A1 (en) 2004-07-14
ECSP034797A (en) 2003-12-01
PT1379511E (en) 2005-10-31
CZ20033003A3 (en) 2004-05-12
GT200200073A (en) 2002-11-07
US20020193367A1 (en) 2002-12-19
KR20030087076A (en) 2003-11-12
MA27012A1 (en) 2004-12-20
PL367064A1 (en) 2005-02-21
YU79003A (en) 2006-05-25
CN1535266A (en) 2004-10-06
KR100566171B1 (en) 2006-03-29
PE20021041A1 (en) 2002-11-19
DE60205100T2 (en) 2006-06-01
CN1264825C (en) 2006-07-19
UY27258A1 (en) 2002-10-31
NO20034576D0 (en) 2003-10-10
PA8543301A1 (en) 2003-01-24
AU2002312788B2 (en) 2005-11-10
EP1379511B1 (en) 2005-07-20
CA2442557C (en) 2008-12-23
IL157873A0 (en) 2004-03-28
NO20034576L (en) 2003-11-12
SK13682003A3 (en) 2004-07-07
BG108254A (en) 2004-09-30
IL157873A (en) 2008-11-26
JP2004529925A (en) 2004-09-30
ES2246012T3 (en) 2006-02-01
MY140271A (en) 2009-12-31
JP4071115B2 (en) 2008-04-02
SI1379511T1 (en) 2005-10-31
DK1379511T3 (en) 2005-11-07
EP1379511A1 (en) 2004-01-14
RU2003130637A (en) 2005-04-10
NZ528315A (en) 2005-04-29
RU2263112C2 (en) 2005-10-27
MXPA03009311A (en) 2004-02-12
HUP0400851A2 (en) 2004-07-28
CA2442557A1 (en) 2002-10-24
ATE299868T1 (en) 2005-08-15
DE60205100D1 (en) 2005-08-25
ZA200307243B (en) 2004-12-16
US6544985B2 (en) 2003-04-08
JO2285B1 (en) 2005-09-12
HRP20030792A2 (en) 2005-10-31
HUP0400851A3 (en) 2010-03-29
HK1068888A1 (en) 2005-05-06

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Legal Events

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements