BR0015170A - Hcv proteins with reversible redox and conformation similar to native - Google Patents

Hcv proteins with reversible redox and conformation similar to native

Info

Publication number
BR0015170A
BR0015170A BR0015170-0A BR0015170A BR0015170A BR 0015170 A BR0015170 A BR 0015170A BR 0015170 A BR0015170 A BR 0015170A BR 0015170 A BR0015170 A BR 0015170A
Authority
BR
Brazil
Prior art keywords
hcv proteins
native
conformation similar
reversible redox
relates
Prior art date
Application number
BR0015170-0A
Other languages
Portuguese (pt)
Inventor
Alfons Bosman
Erick Depla
Geert Maertens
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Publication of BR0015170A publication Critical patent/BR0015170A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"PROTEìNAS DE HCV COM OXIRREDUçãO REVERSìVEL E CONFORMAçãO SIMILAR à NATIVA". A presente invenção refere-se a proteínas de HCV nas quais os resíduos de cisteína são protegidos reversivelmente durante a purificação. Eventualmente, este procedimento de purificação resulta em proteínas de HCV com atividade biológica e uma conformação similar à nativa, que apresentam epítopos correspondentes. A presente invenção refere-se também a métodos de triagem de fármacos, usando essas proteínas de HCV, e aplicações diagnósticas e terapêuticas, tais como vacinas e medicamentos."HCV PROTEINS WITH REVERSIBLE OXYREDUCTION AND CONFORMATION SIMILAR TO NATIVE". The present invention relates to HCV proteins in which the cysteine residues are reversibly protected during purification. Eventually, this purification procedure results in HCV proteins with biological activity and a conformation similar to the native one, which have corresponding epitopes. The present invention also relates to methods of drug screening, using these HCV proteins, and diagnostic and therapeutic applications, such as vaccines and medications.

BR0015170-0A 1999-10-27 2000-10-25 Hcv proteins with reversible redox and conformation similar to native BR0015170A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99870225 1999-10-27
US16928899P 1999-12-07 1999-12-07
PCT/EP2000/010499 WO2001030815A1 (en) 1999-10-27 2000-10-25 Redox reversible hcv proteins with native-like conformation

Publications (1)

Publication Number Publication Date
BR0015170A true BR0015170A (en) 2002-06-25

Family

ID=30129297

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015170-0A BR0015170A (en) 1999-10-27 2000-10-25 Hcv proteins with reversible redox and conformation similar to native

Country Status (14)

Country Link
EP (1) EP1224214A1 (en)
JP (1) JP2003513022A (en)
CN (1) CN1384839A (en)
AU (1) AU1144501A (en)
BR (1) BR0015170A (en)
CA (1) CA2387666A1 (en)
CZ (1) CZ20021819A3 (en)
HU (1) HUP0203195A3 (en)
MX (1) MXPA02004052A (en)
NZ (1) NZ518095A (en)
PL (1) PL354990A1 (en)
RU (1) RU2002109480A (en)
WO (1) WO2001030815A1 (en)
ZA (1) ZA200203169B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064835A1 (en) * 2000-07-10 2002-05-30 Diosynth Rtp, Inc. Purification of human troponin I
EP1417298A2 (en) 2001-04-24 2004-05-12 Innogenetics N.V. Core-glycosylated hcv envelope proteins
EP1481984A1 (en) * 2003-05-28 2004-12-01 Innogenetics N.V. Modified hepatitis C virus (HCV) NS5
JP2016512241A (en) * 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ HCVNS3 recombinant antigen for improved antibody detection and mutants thereof
EP3756648A1 (en) * 2019-06-27 2020-12-30 Imnate Sarl Improved vaccine formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
EP0474789B1 (en) * 1989-06-02 1998-01-28 Genetic Systems Corporation Cysteine thiol-protected peptides for use in immunoassays
DK0721505T4 (en) * 1994-07-29 2006-08-14 Innogenetics Nv Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
GB9703406D0 (en) * 1997-02-19 1997-04-09 Chiron Spa Expression of heterologous proteins
EP0947525A1 (en) * 1998-03-27 1999-10-06 Innogenetics N.V. Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue

Also Published As

Publication number Publication date
MXPA02004052A (en) 2002-11-07
HUP0203195A3 (en) 2004-07-28
AU1144501A (en) 2001-05-08
WO2001030815A1 (en) 2001-05-03
PL354990A1 (en) 2004-03-22
CN1384839A (en) 2002-12-11
ZA200203169B (en) 2003-09-23
RU2002109480A (en) 2004-03-10
NZ518095A (en) 2003-09-26
HUP0203195A2 (en) 2002-12-28
CA2387666A1 (en) 2001-05-03
CZ20021819A3 (en) 2003-06-18
JP2003513022A (en) 2003-04-08
EP1224214A1 (en) 2002-07-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.