BR0013368A - Use of a compound, compound, and pharmaceutical composition - Google Patents

Use of a compound, compound, and pharmaceutical composition

Info

Publication number
BR0013368A
BR0013368A BR0013368-0A BR0013368A BR0013368A BR 0013368 A BR0013368 A BR 0013368A BR 0013368 A BR0013368 A BR 0013368A BR 0013368 A BR0013368 A BR 0013368A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
ppar
sym
substituents
Prior art date
Application number
BR0013368-0A
Other languages
Portuguese (pt)
Inventor
Rodney Brian Hargreaves
Paul Robert Owen Whittamore
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0013368A publication Critical patent/BR0013368A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"USO DE UM COMPOSTO, COMPOSTO, E, COMPOSIçãO FARMACEUTICA". A presente invenção diz respeito ao uso de certos derivados de ácido benzóico de fórmula (I) onde os substituintes são como definidos no relatório descritivo, que atuam como agonistas receptores ativados por proliferador de peroxissomo (PPAR), em particular receptores gama (PPAR<SYM>), e desse modo são úteis no tratamento de estados de resistência a insulina, incluindo o diabete melitus tipo 2."USE OF A COMPOUND, COMPOUND, AND, PHARMACEUTICAL COMPOSITION". The present invention relates to the use of certain benzoic acid derivatives of formula (I) where the substituents are as defined in the specification, which act as peroxisome proliferator (PPAR) activated receptor agonists, in particular gamma receptors (PPAR <SYM >), and are therefore useful in the treatment of insulin resistance states, including type 2 diabetes mellitus.

BR0013368-0A 1999-08-18 2000-08-14 Use of a compound, compound, and pharmaceutical composition BR0013368A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9919411.0A GB9919411D0 (en) 1999-08-18 1999-08-18 Chemical compounds
PCT/GB2000/003140 WO2001012187A2 (en) 1999-08-18 2000-08-14 Benzoic acid derivatives and their use as ppar receptor agonists

Publications (1)

Publication Number Publication Date
BR0013368A true BR0013368A (en) 2002-05-07

Family

ID=10859283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013368-0A BR0013368A (en) 1999-08-18 2000-08-14 Use of a compound, compound, and pharmaceutical composition

Country Status (14)

Country Link
EP (1) EP1210343A2 (en)
JP (1) JP2003507327A (en)
KR (1) KR20020020817A (en)
CN (1) CN1379774A (en)
AU (1) AU6583400A (en)
BR (1) BR0013368A (en)
CA (1) CA2380775A1 (en)
GB (1) GB9919411D0 (en)
IL (1) IL147821A0 (en)
MX (1) MXPA02001598A (en)
NO (1) NO20020765L (en)
NZ (1) NZ517059A (en)
WO (1) WO2001012187A2 (en)
ZA (1) ZA200200669B (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495949B1 (en) 1999-11-03 2002-12-17 Orion Electric Co., Ltd. Electron tube cathode
US6503907B2 (en) * 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
US7291639B2 (en) 2001-06-20 2007-11-06 Wyeth Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
EP1397130B1 (en) 2001-06-20 2007-07-25 Wyeth Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
WO2003035602A1 (en) * 2001-10-25 2003-05-01 Sankyo Company, Limited Lipid modulators
DE60327922D1 (en) 2002-02-05 2009-07-23 Lilly Co Eli UREA-LINKER COMPOUNDS AND ITS USE AS PPAR REGULATORS
SE0201937D0 (en) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
DE60319084T2 (en) 2002-06-20 2009-01-29 Astrazeneca Ab ORTHO-SUBSTITUTED BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF INSULIN RESISTANCE
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DE60306548T2 (en) 2002-12-10 2007-06-21 Wyeth SUBSTITUTED 3-CARBONYL-1-YL-ACETIC DERIVATIVES AS PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) INHIBITORS
US7056943B2 (en) 2002-12-10 2006-06-06 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
ES2268480T3 (en) 2002-12-10 2007-03-16 Wyeth ACID DERIVATIVES 3-RENT- AND 3-ARILALQUILO-1H-INDOL-1-IL-ACETICO REPLACED AS INHIBITORS OF THE INHIBITOR OF THE PLASMINOGEN-1 ACTIVATOR (PAI-1).
CN1723198A (en) 2002-12-10 2006-01-18 惠氏公司 Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
DE10308352A1 (en) * 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Branched side chain arylcycloalkyl derivatives, process for their preparation and their use as medicaments
TWI289141B (en) 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
US20060264496A1 (en) * 2003-04-25 2006-11-23 H. Lundbeck A/S Substituted indoline and indole derivatives
CN102060806A (en) 2003-09-11 2011-05-18 iTherX药品公司 Cytokine inhibitors
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
BRPI0514544A (en) 2004-08-23 2008-06-17 Wyeth Corp oxazol-naphthyl acids as modulators of plasminogen activator inhibitor type-1 (pai-1)
RU2394027C2 (en) * 2004-10-27 2010-07-10 Ф. Хоффманн-Ля Рош Аг Novel indole or benzimidazole derivatives
EA013123B1 (en) * 2005-04-13 2010-02-26 Ньюрэксон, Инк. Substituted indole compounds having nos inhibitory activity
AU2006279496A1 (en) 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
WO2007022946A1 (en) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as binding partners for 5-ht5 receptors
TW200808780A (en) * 2006-04-13 2008-02-16 Neuraxon Inc 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
CA2651942A1 (en) 2006-05-11 2008-07-03 Janssen Pharmaceutica N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
CA2651817A1 (en) 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
US7432255B2 (en) * 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
WO2008020302A2 (en) * 2006-08-17 2008-02-21 Pfizer Products Inc. Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
KR20090127307A (en) 2007-03-01 2009-12-10 얀센 파마슈티카 엔.브이. Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
BRPI0812851A2 (en) * 2007-07-02 2014-09-30 Glaxosmithkline Llc COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT OF A DISEASE AND CONDITION IN AN INDIVIDUAL, PROCESS FOR PREPARING A COMPOUND, AND USE OF A COMPOUND
FR2921366B1 (en) * 2007-09-26 2009-12-04 Servier Lab NOVEL HETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
CN101910157B (en) 2007-11-16 2014-05-07 纽尔亚商股份有限公司 Indole compounds and methods for treating visceral pain
WO2009100294A2 (en) 2008-02-07 2009-08-13 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
RU2591188C2 (en) 2010-11-08 2016-07-10 Альбирео Аб Ibat inhibitor for treating hepatic disorders
ES2586956T3 (en) 2010-11-08 2016-10-19 Albireo Ab Pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder
US9051265B2 (en) * 2011-06-06 2015-06-09 The Scripps Research Institute N-benzylindole modulators of PPARG
US8957093B2 (en) 2011-06-06 2015-02-17 The Scripps Research Institute N-biphenylmethylindole modulators of PPARG
EP2736330A4 (en) * 2011-07-29 2015-05-27 Tempero Pharmaceuticals Inc Compounds and methods
WO2013078240A1 (en) 2011-11-22 2013-05-30 Ripka Amy S N-biphenylmethylbenzimidazole modulators of pparg
WO2013096496A2 (en) * 2011-12-21 2013-06-27 Allergan, Inc. Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response
US9321750B2 (en) 2012-04-20 2016-04-26 Innov17 Llc ROR modulators and their uses
EP2844259A4 (en) 2012-04-30 2015-11-11 Anderson Gaweco Ror modulators and their uses
CN104788358A (en) * 2014-01-20 2015-07-22 中国科学院上海药物研究所 N-(3-fluoro-4-chlorobenzyl)indole derivative and use thereof
KR101585605B1 (en) * 2014-03-20 2016-01-21 현대약품 주식회사 Compounds that binding with PPARG(Peroxisome Proliferator Activated Receptor-Gamma) but not act as an agonist and pharmaceutical composition for diseases related with PPARG containing the same as an active ingredient
WO2015161108A1 (en) 2014-04-16 2015-10-22 The Scripps Research Institute Pparg modulators for treatment of osteoporosis
CN107176914B (en) * 2016-03-09 2022-06-28 浙江旭晨医药科技有限公司 GVS series compound and its use
EP3632910B1 (en) * 2017-05-26 2024-07-17 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. 3,4-dihydroquinolinones as fxr receptor agonists
KR102242658B1 (en) * 2018-08-29 2021-04-21 숙명여자대학교산학협력단 A substituted indole derivatives, preparation method therof and pharmaceutical composition for use in preventing or treating PPARα, PPARγ and PPARδ related diseases containing the same as an active ingredient
US11319330B2 (en) * 2018-09-07 2022-05-03 Medshine Discovery Inc. Tricyclic furan-substituted piperidinedione compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4894386A (en) * 1987-04-15 1990-01-16 Ici Americas Inc. Aliphatic carboxamides
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
ES2108641B1 (en) * 1995-07-31 1998-08-16 Menarini Lab QUINOLONIC SULFONIMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.
JPH09176162A (en) * 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk Thiazolidinedione derivative, its production and medicinal composition containing the same
AU7237998A (en) * 1997-05-16 1998-12-08 Chugai Seiyaku Kabushiki Kaisha Indole derivatives and mono- and diazaindole derivatives

Also Published As

Publication number Publication date
WO2001012187A2 (en) 2001-02-22
ZA200200669B (en) 2003-06-25
WO2001012187A3 (en) 2001-06-07
GB9919411D0 (en) 1999-10-20
MXPA02001598A (en) 2002-07-02
NO20020765L (en) 2002-04-17
KR20020020817A (en) 2002-03-15
NO20020765D0 (en) 2002-02-15
IL147821A0 (en) 2002-08-14
EP1210343A2 (en) 2002-06-05
JP2003507327A (en) 2003-02-25
CA2380775A1 (en) 2001-02-22
AU6583400A (en) 2001-03-13
NZ517059A (en) 2004-05-28
CN1379774A (en) 2002-11-13

Similar Documents

Publication Publication Date Title
BR0013368A (en) Use of a compound, compound, and pharmaceutical composition
BR0213253A (en) Compound, use thereof, pharmaceutical composition, and methods for treating nuclear receptor-mediated conditions and type i diabetes, type ii diabetes, dyslipidemia, syndrome x (including metabolic syndrome, ie impaired glucose tolerance, insulin resistance , hypertriglyceridemia and / or obesity), cardiovascular disease (including atherosclerosis) or hypercholesteremia
BR0314335A (en) Compound, use thereof, pharmaceutical composition, and methods for treating and / or preventing nuclear receptor-mediated conditions, and of type i diabetes, type ii diabetes, impaired glucose tolerance, insulin resistance, or obesity.
ATE430743T1 (en) BENZIMIDAZOLE SUBSTITUTED THIOPHENE DERIVATIVES ACTING ON IKK3
PE20040655A1 (en) NEW THIOPHENE GLYCOSIDE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND DRUGS CONTAINING THEM
BR0114310A (en) Glycopyranosyloxybenzylbenzene derivatives and medicinal compositions containing them
BR0313825A (en) Compound, pharmaceutical composition, method for treating type 2 diabetes mellitus in a mammal, and, compound use
BR0300314A (en) Antidiabetic Agents
BR0214239A (en) Compounds, use of a compound, pharmaceutical composition, cosmetic composition and cosmetic use
PT1437123E (en) Composition for dyeing keratin fibres and dyeing method using same
BRPI0410760A (en) compounds, process for making same, pharmaceutical compositions and use of these compounds
DK0604848T3 (en) Quick-drying gel-like disinfectant for hands and fingers
BRPI0116607B8 (en) glycopyranosyloxypyrazole derivatives , pharmaceutical compositions containing them and their uses
CO6150170A2 (en) DERIVATIVES OF 1 - (- D-GLUCOPIRANOSIL) -3- (4-CYCLOPROPYLPENHYLMETHYL) -4-INDOL HALOGEN AND USE OF THE SAME AS INHIBITORS OF SODIUM DEPENDENT GLUCOSE CONVEYORS
BR0315047A (en) Compound, pharmaceutical composition comprising the same, process for preparing the pharmaceutical composition, use of the compounds, method of treatment and process for the preparation of the compound
BRPI0418148A (en) compound, prodrug of a compound, gpr40 receptor function modulator, pharmaceutical agent, use of a compound and methods of modifying a gpr40 receptor function in a mammal, prophylaxis or treating diabetes in a mammal and producing a compound
BR0112582A (en) Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
BR0012880A (en) Mutilin derivatives and their use as antibacterials
BR0212983A (en) Compound, Compound Use, and, Synthesis Intermediates
TR200103409T2 (en) Naphthalene ureas as enhancers of glucose output.
BR0316099A (en) Antidiabetic Agents
BR0107902A (en) Compound, pharmaceutical composition, methods for treating diseases, and for the treatment and / or prevention of, conditions mediated by nuclear receptors, and diabetes and / or obesity, use of a compound, process for preparing a compound, and, method for treating type i diabetes, type ii diabetes, impaired glucose tolerance, insulin resistance or obesity
SV2004001294A (en) DERIVATIVES OF ACETIC ACID REF. READ 35699-SV
BR0315683A (en) A compound, use thereof, pharmaceutical composition, and method for treating and / or preventing nuclear receptor mediated conditions and for treating and / or preventing type i diabetes, type ii diabetes, impaired glucose tolerance, resistance to insulin or obesity
BR0317359A (en) Use of alpha-phenylthiocarboxylic and alpha-phenyloxycarboxylic acids with serum glucose lowering and serum lipid lowering activity

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.