BR0011478A - Immune combination composition, methods of inducing an immune response in an animal, and of immunizing a host against pneumococcal infection, and immunogenic composition for intranasal administration - Google Patents

Immune combination composition, methods of inducing an immune response in an animal, and of immunizing a host against pneumococcal infection, and immunogenic composition for intranasal administration

Info

Publication number
BR0011478A
BR0011478A BR0011478-2A BR0011478A BR0011478A BR 0011478 A BR0011478 A BR 0011478A BR 0011478 A BR0011478 A BR 0011478A BR 0011478 A BR0011478 A BR 0011478A
Authority
BR
Brazil
Prior art keywords
methods
intranasal administration
composition
immunizing
inducing
Prior art date
Application number
BR0011478-2A
Other languages
Portuguese (pt)
Inventor
Robert C Huebner
Jacquelyn S Sampson
George M Carlone
Edwin Ades
David E Briles
Original Assignee
Uab Research Foundation
Aventis Pasteur
Ct S For Disease Control And P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation, Aventis Pasteur, Ct S For Disease Control And P filed Critical Uab Research Foundation
Publication of BR0011478A publication Critical patent/BR0011478A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçãO DE COMBINAçãO IMUNOLóGICA, MéTODOS DE INDUZIR UMA RESPOSTA IMUNOLóGICA EM UM ANIMAL, E DE IMUNIZAR um HOSPEDEIRO CONTRA INFECçãO PNEUMOCóCICA, E, COMPOSIçãO IMUNOGêNICA PARA ADMINISTRAçãO INTRANASAL". A presente invenção refere-se a combinações imunogênicas sinérgicas, contendo duas ou mais proteínas de superfície pneumocócicas, incluído PspA e/ou PspC e/ou PsaA, vantajosamente PspA e PsaA. São também providos métodos de administração intranasal de tais combinações imunogênicas, para reduzir o transporte nasofaríngeo de pneumocócicos e métodos de uso de tais combinações imunogênicas, na prevenção e tratamento de infecção por S. pneumoniae."COMPOSITION OF IMMUNOLOGICAL COMBINATION, METHODS OF INDUCING AN IMMUNOLOGICAL RESPONSE IN AN ANIMAL, AND OF IMMUNIZING A HOST FOR CONTINUING PNEUMOCOCCAL INFECTION, AND IMMUNOGENIC COMPOSITION FOR INTRANASAL ADMINISTRATION". The present invention relates to synergistic immunogenic combinations, containing two or more pneumococcal surface proteins, including PspA and / or PspC and / or PsaA, advantageously PspA and PsaA. Methods of intranasal administration of such immunogenic combinations are also provided to reduce nasopharyngeal pneumococcal transport and methods of using such immunogenic combinations in the prevention and treatment of S. pneumoniae infection.

BR0011478-2A 1999-06-10 2000-06-09 Immune combination composition, methods of inducing an immune response in an animal, and of immunizing a host against pneumococcal infection, and immunogenic composition for intranasal administration BR0011478A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13842299P 1999-06-10 1999-06-10
US58783300A 2000-06-06 2000-06-06
PCT/US2000/040176 WO2000076541A1 (en) 1999-06-10 2000-06-09 Pneumococcal surface protein combination vaccine

Publications (1)

Publication Number Publication Date
BR0011478A true BR0011478A (en) 2002-03-19

Family

ID=26836182

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011478-2A BR0011478A (en) 1999-06-10 2000-06-09 Immune combination composition, methods of inducing an immune response in an animal, and of immunizing a host against pneumococcal infection, and immunogenic composition for intranasal administration

Country Status (7)

Country Link
EP (1) EP1189632A4 (en)
JP (1) JP2003519089A (en)
AU (1) AU6121000A (en)
BR (1) BR0011478A (en)
CA (1) CA2379327A1 (en)
MX (1) MXPA01012721A (en)
WO (1) WO2000076541A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
EP1477802A1 (en) * 2003-05-16 2004-11-17 Erasmus Universiteit Rotterdam Method for selecting and producing vaccine components and vaccines based thereon
AU2007285775B2 (en) * 2006-08-17 2011-03-03 Sanofi Pasteur Ltd. Immunogenic PcpA polypeptides and uses thereof
RU2510281C2 (en) * 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") HYBRID PROTEIN VACCINE AGAINST PNEUMONIA CAUSED BY Streptococcus pneumoniae
GB201318170D0 (en) * 2013-10-14 2013-11-27 Univ Edinburgh Proteins with Diagnostic and Therapeutic Uses
KR101627285B1 (en) * 2014-06-05 2016-06-07 한국생명공학연구원 A pharmeceutical composition for preventing or treating degenerative brain disease comprising PspA, as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854416A (en) * 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
AU5958594A (en) * 1992-12-24 1994-07-19 Med Immune, Inc. Method of protection against (streptococcus pneumoniae) with transformed mycobacteria
WO1999045121A1 (en) * 1998-03-02 1999-09-10 The Government Of The United States Of America, Represented By The Secretary Of The Department Health And Human Services EPITOPE PEPTIDES IMMUNOGENIC AGAINST $i(STREPTOCOCCUS PNEUMONIAE)
CA2328399A1 (en) * 1998-04-23 1999-10-28 University Of Alabama At Birmingham Pneumococcal surface protein c(pspc), epitopic regions and strain selection thereof, and uses therefor

Also Published As

Publication number Publication date
AU6121000A (en) 2001-01-02
EP1189632A1 (en) 2002-03-27
MXPA01012721A (en) 2004-10-14
EP1189632A4 (en) 2002-08-21
JP2003519089A (en) 2003-06-17
WO2000076541A1 (en) 2000-12-21
CA2379327A1 (en) 2000-12-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.