BR0010693A - Azaindole derivatives for treating depression - Google Patents

Azaindole derivatives for treating depression

Info

Publication number
BR0010693A
BR0010693A BR0010693-3A BR0010693A BR0010693A BR 0010693 A BR0010693 A BR 0010693A BR 0010693 A BR0010693 A BR 0010693A BR 0010693 A BR0010693 A BR 0010693A
Authority
BR
Brazil
Prior art keywords
treating depression
azaindole derivatives
depression
affected
ring
Prior art date
Application number
BR0010693-3A
Other languages
Portuguese (pt)
Inventor
Richard Eric Mewshaw
Kristin Lynne Meagher
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR0010693A publication Critical patent/BR0010693A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Patente de Invenção: "DERIVADOS AZAINDOL PARA TRATAMENTO DE DEPRESSãO". Compostos úteis no tratamento de doenças afetadas por desordens dos sistemas neurológicos afetados - serotonina, tais como depressão e ansiedade, são providos tendo a fórmula (1) onde: R~ 1~ e R~ 2~ formam um anel carbocíclico ou heterocíclico de 5 a 7 átomos, onde o dito anel pode ser saturado ou insaturado; e X é independentemente hidrogênio, ciano, carbamoíla, halogênio ou alcóxi; ou seus sais farmaceuticamente aceitáveis.Invention Patent: "AZAINDOL DERIVATIVES FOR TREATING DEPRESSION". Compounds useful in the treatment of diseases affected by disorders of the affected neurological systems - serotonin, such as depression and anxiety, are provided having the formula (1) where: R ~ 1 ~ and R ~ 2 ~ form a 5 to a carbocyclic or heterocyclic ring 7 atoms, where said ring can be saturated or unsaturated; and X is independently hydrogen, cyano, carbamoyl, halogen or alkoxy; or their pharmaceutically acceptable salts.

BR0010693-3A 1999-04-22 2000-04-20 Azaindole derivatives for treating depression BR0010693A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29673699A 1999-04-22 1999-04-22
PCT/US2000/010628 WO2000064898A1 (en) 1999-04-22 2000-04-20 Azaindole derivatives for the treatment of depression

Publications (1)

Publication Number Publication Date
BR0010693A true BR0010693A (en) 2002-02-05

Family

ID=23143341

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010693-3A BR0010693A (en) 1999-04-22 2000-04-20 Azaindole derivatives for treating depression

Country Status (8)

Country Link
EP (1) EP1171439A1 (en)
JP (1) JP2002543079A (en)
CN (1) CN1348451A (en)
AR (1) AR028475A1 (en)
AU (1) AU4364400A (en)
BR (1) BR0010693A (en)
CA (1) CA2367681A1 (en)
WO (1) WO2000064898A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100338062C (en) * 2002-03-28 2007-09-19 卫材株式会社 Azaindoles as inhibitors of c-Jun N-terminal kinases
JP2008521771A (en) 2004-11-26 2008-06-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Isoxazoline-indole derivatives having improved antipsychotic and anxiolytic activity
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CR20170089A (en) 2009-04-03 2017-07-17 Plexxikon Inc PROPANE-ACID COMPOSITIONS-1 - SULFONIC {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUORO-PHENIL} -AMIDA AND THE USE OF THE SAME
RS57869B1 (en) 2009-06-17 2018-12-31 Vertex Pharma Inhibitors of influenza viruses replication
NZ599866A (en) 2009-11-06 2014-09-26 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
KR20140014110A (en) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 Inhibitors of influenza viruses replication
MA34948B1 (en) 2011-02-07 2014-03-01 Plexxikon Inc COMPOUNDS AND METHODS FOR MODULATING KINASE, AND INDICATIONS THEREOF
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
UA118010C2 (en) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед INFLUENCES OF INFLUENZA VIRUS REPLICATION
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP6615755B2 (en) 2013-11-13 2019-12-04 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitors of influenza virus replication
SI3068782T1 (en) 2013-11-13 2018-10-30 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
JP6857617B2 (en) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Influenza virus replication inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
JP2002543079A (en) 2002-12-17
AR028475A1 (en) 2003-05-14
CN1348451A (en) 2002-05-08
AU4364400A (en) 2000-11-10
CA2367681A1 (en) 2000-11-02
EP1171439A1 (en) 2002-01-16
WO2000064898A1 (en) 2000-11-02

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B25D Requested change of name of applicant approved