BR0010681A - Macrolide anti-infectious agents - Google Patents
Macrolide anti-infectious agentsInfo
- Publication number
- BR0010681A BR0010681A BR0010681-0A BR0010681A BR0010681A BR 0010681 A BR0010681 A BR 0010681A BR 0010681 A BR0010681 A BR 0010681A BR 0010681 A BR0010681 A BR 0010681A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- unsubstituted
- amino
- alkyl
- infectious agents
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Patente de Invenção: "AGENTES ANTIINFECCIOSOS DE MACROLIDO". Composto da fórmula (1), (2) ou (3) ou as formas 10, 11 anidro dos mesmos, onde: R~ a~ é H ou OH, preferivelmente OH; R~ b~ é H ou halogênio; R~ c~ é H ou um grupo de proteção; R~ d~ é metila; (3-10C) alquila não substituída; (1-10C) alquila substituída; (2-10C) alquenila substituída ou não substituída; (2-10C) alquinila substituída ou não substituída; (4-14C) arila substituída ou não substituída; (5-20C) arilalquila substituída ou não substituída; (5-20C) arilalquenila substituída ou não substituída; (5-20C) arilalquinila substituída ou não substituída; (5-20C) amidoarilalquila substituída ou não substituída; (5-20C) amidoarilalquenila substituída ou não substituída; (5-20C) amidoarilalquinila substituída ou não substituída; R~ e~ é H ou um grupo de proteção ou é carbonila amino mono ou dissubstituída; R~ f~ é H; (1-10C) alquila substituída ou não substituída; (1-10C) alquenila substituída ou não substituída; (110C)alquinila substituída ou não substituída; (4-14C) arila substituída ou não substituída; (5-20C) arilaquila substituída ou não substituída; ou OR~ f~ pode ser substituído por H; um de Z e Y é H e o outro é OH ou OH protegido ou é amino, mono ou dialquilamino, amino protegido ou um aminoheterociclo ou Z e Y em conjunto são =O, =NOH ou uma oxima derivatizada; incluindo quaisquer sais farmaceuticamente aceitáveis e quaisquer formas estereoisoméricas e misturas de formas estereoisoméricas dos mesmos sendo agentes antimicrobianos.Invention Patent: "MACROLIDE ANTI-INFECTIOUS AGENTS". A compound of the formula (1), (2) or (3) or the anhydrous forms 10, 11, where: R ~ a ~ is H or OH, preferably OH; R ~ b ~ is H or halogen; R ~ c ~ is H or a protecting group; R ~ d ~ is methyl; (3-10C) unsubstituted alkyl; (1-10C) substituted alkyl; (2-10C) substituted or unsubstituted alkenyl; (2-10C) substituted or unsubstituted alkynyl; (4-14C) substituted or unsubstituted aryl; (5-20C) substituted or unsubstituted arylalkyl; (5-20C) substituted or unsubstituted arylalkenyl; (5-20C) substituted or unsubstituted arylalkynyl; (5-20C) substituted or unsubstituted amidoarylalkyl; (5-20C) substituted or unsubstituted amidoarylalkenyl; (5-20C) substituted or unsubstituted amidoarylalkynyl; R ~ and ~ is H or a protecting group or is mono- or disubstituted amino carbonyl; R ~ f ~ is H; (1-10C) substituted or unsubstituted alkyl; (1-10C) substituted or unsubstituted alkenyl; (110C) substituted or unsubstituted alkynyl; (4-14C) substituted or unsubstituted aryl; (5-20C) substituted or unsubstituted arylalkyl; or OR ~ f ~ can be replaced by H; one of Z and Y is H and the other is OH or OH protected or is amino, mono or dialkylamino, protected amino or an amino heterocycle or Z and Y together are = O, = NOH or a derivatized oxime; including any pharmaceutically acceptable salts and any stereoisomeric forms and mixtures of stereoisomeric forms thereof being antimicrobial agents.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12972999P | 1999-04-16 | 1999-04-16 | |
| US14017599P | 1999-06-18 | 1999-06-18 | |
| US17215499P | 1999-12-17 | 1999-12-17 | |
| US17215999P | 1999-12-17 | 1999-12-17 | |
| US17380499P | 1999-12-30 | 1999-12-30 | |
| US17380599P | 1999-12-30 | 1999-12-30 | |
| PCT/US2000/009915 WO2000063225A2 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
| US09/551,162 US6451768B1 (en) | 1999-04-16 | 2000-04-14 | Macrolide antiinfective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010681A true BR0010681A (en) | 2002-02-05 |
Family
ID=27568858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010681-0A BR0010681A (en) | 1999-04-16 | 2000-04-14 | Macrolide anti-infectious agents |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1171448A2 (en) |
| JP (1) | JP2003523939A (en) |
| CN (1) | CN1636008A (en) |
| BR (1) | BR0010681A (en) |
| CA (1) | CA2369886A1 (en) |
| IL (1) | IL145776A0 (en) |
| MX (1) | MXPA01010529A (en) |
| NZ (1) | NZ514791A (en) |
-
2000
- 2000-04-14 BR BR0010681-0A patent/BR0010681A/en not_active Application Discontinuation
- 2000-04-14 NZ NZ514791A patent/NZ514791A/en unknown
- 2000-04-14 CA CA002369886A patent/CA2369886A1/en not_active Abandoned
- 2000-04-14 JP JP2000612315A patent/JP2003523939A/en not_active Withdrawn
- 2000-04-14 CN CNA008090726A patent/CN1636008A/en active Pending
- 2000-04-14 IL IL14577600A patent/IL145776A0/en unknown
- 2000-04-14 EP EP00925966A patent/EP1171448A2/en not_active Withdrawn
- 2000-04-14 MX MXPA01010529A patent/MXPA01010529A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1636008A (en) | 2005-07-06 |
| CA2369886A1 (en) | 2000-10-26 |
| EP1171448A2 (en) | 2002-01-16 |
| JP2003523939A (en) | 2003-08-12 |
| MXPA01010529A (en) | 2002-03-14 |
| NZ514791A (en) | 2004-02-27 |
| IL145776A0 (en) | 2002-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |