BG60272B1 - METHOD FOR THE PREPARATION OF PEPTIDE ALCOHOLS - Google Patents

METHOD FOR THE PREPARATION OF PEPTIDE ALCOHOLS

Info

Publication number
BG60272B1
BG60272B1 BG085251A BG8525188A BG60272B1 BG 60272 B1 BG60272 B1 BG 60272B1 BG 085251 A BG085251 A BG 085251A BG 8525188 A BG8525188 A BG 8525188A BG 60272 B1 BG60272 B1 BG 60272B1
Authority
BG
Bulgaria
Prior art keywords
peptide
preparation
alcohols
resin
alcohol
Prior art date
Application number
BG085251A
Other languages
Bulgarian (bg)
Other versions
BG60272B2 (en
Inventor
Monika Mergler
Walter Prikoszovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG60272B1 publication Critical patent/BG60272B1/en
Publication of BG60272B2 publication Critical patent/BG60272B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Методът за получаване на пептидни алкохоли в твърда фаза, по-специално на такива, които в с-края на пептидната верига имат две алкохолни или една алкохолна и една тиолова група, е приложим в химическата промишленост, по-специално при производството на фармакологично активни пептидни алкохоли. С него отделянето на алкохола от смолата се осъществява при меки реакционни условия. Методът за получаване на пептидните алкохоли с обща формула в която у е остатък от пептиден алкохол, съдържащ защитни групи, r1 е водороден атом или метил и х е кислороден или серен атом, се осъществява, като пептидният алкохол, свързан чрез ацетална група със смола, съдържаща формилфенилови остатъци, се отцепва от смолата чрез киселинна хидролиза при стайна температура в присъствие на разредена киселина. Полученият продукт е в твърда фаза и съдържа защитни групи. 4 претенцииThe process for the preparation of solid phase peptide alcohols, in particular those having two alcoholic or one alcoholic and one thiol group at the c-terminus of the peptide chain, is applicable in the chemical industry, in particular in the production of pharmacologically active peptide alcohols. With it, the separation of the alcohol from the resin takes place under mild reaction conditions. The process for the preparation of peptide alcohols of general formula in which y is a peptide alcohol residue containing protecting groups, r1 is a hydrogen atom or methyl and x is an oxygen or sulfur atom is carried out by the peptide alcohol bonded via an acetal group to a resin, containing formylphenyl residues is cleaved from the resin by acid hydrolysis at room temperature in the presence of dilute acid. The resulting product is in the solid phase and contains protecting groups. 4 claims

BG85251A 1987-08-17 1988-08-16 Method for the preparation of peptide alcohols BG60272B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH315387 1987-08-17

Publications (2)

Publication Number Publication Date
BG60272B1 true BG60272B1 (en) 1994-03-31
BG60272B2 BG60272B2 (en) 1994-03-31

Family

ID=4249761

Family Applications (1)

Application Number Title Priority Date Filing Date
BG85251A BG60272B2 (en) 1987-08-17 1988-08-16 Method for the preparation of peptide alcohols

Country Status (9)

Country Link
BG (1) BG60272B2 (en)
CZ (1) CZ281518B6 (en)
DD (1) DD298932A5 (en)
FR (1) FR2619566B1 (en)
PL (1) PL154068B1 (en)
RO (1) RO101204B (en)
RU (1) RU1792418C (en)
SK (1) SK278318B6 (en)
YU (1) YU48368B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method

Also Published As

Publication number Publication date
CZ281518B6 (en) 1996-10-16
FR2619566B1 (en) 1993-12-10
SK561888A3 (en) 1996-10-01
DD298932A5 (en) 1992-03-19
CZ561888A3 (en) 1996-08-14
RO101204B (en) 1992-01-10
YU157988A (en) 1990-04-30
YU48368B (en) 1998-07-10
BG60272B2 (en) 1994-03-31
SK278318B6 (en) 1996-10-02
PL154068B1 (en) 1991-06-28
FR2619566A1 (en) 1989-02-24
RU1792418C (en) 1993-01-30

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