BG50610A3 - Method for the preparation of derivatives of 1h, 3h- pyrol (1, 2- c) thiazole- 7- carboxamide - Google Patents

Abstract

These extracted compounds are used in medicine for treating allergic diseases, inflammatory processes, as well as diseases of the digestive system. By this method, the following are extracted :derivatives of 1H, 3H-pyrrol/1,2-c/thiazol-7-carboxamide with a common formula<IMAGE>,where R1 is a hydrogen or halogen atom, alkyl, alkyloxy, CF3, NH2, alkyl amino, dialkylamino, -OH, -CN, phenyl or phenoxy radical; Ar is phenyl, naphthyl, pyridyl, quinolyl, isoquinolinyl, thienyl, potentially replaced with a halogen atom, alkyl, alkyloxy, CF3, NH2, alkyl amino, dialkylamino, -OH or CN radical, p is an integer - 0, 1 or 2, or Z is a valency bond, while R2 is H, or Z is a valency bond and R2 is a pyridyl, quinoclydinyl, 3-pyrrolydinyl, 3- or 4-pypyridyl radical, potentially replaced with alkyl, hydroxyalkyl, phenyl or phenyl alkyl radical, or Z is C1-4 alkylene radical and R2 with 2-, 3- or 4-pyridyl, 3-quinoclydinyl, 2-pyrrolydinyl, 2-, 3- or 4- pypyridyl radical, potentially replaced with alkyl, hydroxyalkyl, phenyl or phenyl alkyl radical, or is the group CON/R3//R4/, in which R3 or R4 form with the nitrogen atom pyperazine cycle, potentially replaced with alkyl, hydroxyalkyl, pyridyl, phenyl or phenyl alkyl radical, or R3 is a hydrogen atom, alkyl, phenyl or phenyl alkyl radical or the group /CH2/nN/R5/R6, where n is an integer between 1 and 4, while R5 and R6 are a hydrogen atom, alkyl, phenyl, phenyl alkyl radical, or R5 and R6 form a morpholine, thiomorpholine, pyrrolidine, piperidine or pyperazine ring, potentially replaced with alkyl, hydroxyalkyl, pyridyle, phenyl, phenyl alkyl or phenyl carbonyl radical, and R4 is /CH2/nN/R5//R6/, where R5, R6 and n have the above-mentioned meanings, or Z is C1-4 alkylene radical, while R2 is N/R3/ /R4/ or N/R5//R6/, while R3, R4, R5 and R6 have the above-mentioned meanings, provided that in all above-mentioned meanings, the alkyl radicals and the alkyl part contain between 1 and 4 carbon atoms, as well as their race mates, enantiomers, their mixtures, pure diastereo-isomers or their composites, isomers E and Z, as well as their pharmaceutically acceptable salts as a compound with a formula<IMAGE>,in R or S form or their composites, interacts with a common formula<IMAGE>,where Ar, Z, R1 and R2 have the meanings, mentioned above, in E and Z form or their composites.