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Application filed by Jiri Stohandl, Jroslav Frantisek, Zdenek Zapadlo, Marta StohandlovafiledCriticalJiri Stohandl
Priority to BG108940ApriorityCriticalpatent/BG108940A/en
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Process for the preparation of sertraline by reductive amination of racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone, carried out as one-reaction-vessel process without isolation of intermediates, in the form of pure separated cis and trans isomers, the way of conversion of trans isomer to cis isomer and preparation of FII polymorph of 1S-cis isomer from any other polymorph.
BG108940A2004-11-182004-11-18Process for the manufacture of sertraline
BG108940A
(en)
Improved manufacturing procedure for the preparation of polymorphic form ii of cis-(1s)-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthleneamine hydrochloride (sertraline hydrochloride)