BG106997A - Method for the preparation of n-formyl-(s)-isoserine - Google Patents

Method for the preparation of n-formyl-(s)-isoserine

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Publication number
BG106997A
BG106997A BG106997A BG10699702A BG106997A BG 106997 A BG106997 A BG 106997A BG 106997 A BG106997 A BG 106997A BG 10699702 A BG10699702 A BG 10699702A BG 106997 A BG106997 A BG 106997A
Authority
BG
Bulgaria
Prior art keywords
mol
isoserine
filtered
formyl
produced
Prior art date
Application number
BG106997A
Other languages
Bulgarian (bg)
Inventor
Величко И. Търпанов
Пепа Д. Мечкарова-Тодорова
Константин Н. Докторов
Дикран А. Крикорян
Стоян П. Парушев
Original Assignee
Балканфарма Холдинг АД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Балканфарма Холдинг АД filed Critical Балканфарма Холдинг АД
Priority to BG106997A priority Critical patent/BG106997A/en
Publication of BG106997A publication Critical patent/BG106997A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to method for the preparation of a compound which is formyl derivative of the non-natural amino acid (S)-2-hydroxy-3-aminopropionic acid, used as acylating means. By the method high yield is produced of crystal product N-formyl-(S)-isoserine by the formylation of (S)-isoserine in a medium of acetonitrile and formic acid at room temperature at continuous agitation with 1.5-3 mol/mol 2-formylmercaptobenzothiazole, preferably 2.5 mol/mol. After the termination of the formylation process, the reaction mixture is cooled with icy water and the separated 2-mercaptobenzothiazole is filtered, and the excess of 2-formylmercaptobenzothiazole are filtered. The sludge is washed with acetonitrilke, the filtrate produced is concentrated to 1/4 of its initial volume, and the separated sludge us filtered again. The filtrate is purified by boiling in an influx and crystallization occurs during cooling, twice from ethyhlacetate and twice from acetone. The produced N-formyl-(S)-isoserine crystals mare filtered, washed in cooled acetone and are dried at room temperature. 2 claims
BG106997A 2002-08-14 2002-08-14 Method for the preparation of n-formyl-(s)-isoserine BG106997A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG106997A BG106997A (en) 2002-08-14 2002-08-14 Method for the preparation of n-formyl-(s)-isoserine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG106997A BG106997A (en) 2002-08-14 2002-08-14 Method for the preparation of n-formyl-(s)-isoserine

Publications (1)

Publication Number Publication Date
BG106997A true BG106997A (en) 2004-03-31

Family

ID=32097287

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106997A BG106997A (en) 2002-08-14 2002-08-14 Method for the preparation of n-formyl-(s)-isoserine

Country Status (1)

Country Link
BG (1) BG106997A (en)

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