BG106058A - Modulation of excitable tissue function by peripherally administered erythropoietin - Google Patents

Modulation of excitable tissue function by peripherally administered erythropoietin

Info

Publication number
BG106058A
BG106058A BG106058A BG10605801A BG106058A BG 106058 A BG106058 A BG 106058A BG 106058 A BG106058 A BG 106058A BG 10605801 A BG10605801 A BG 10605801A BG 106058 A BG106058 A BG 106058A
Authority
BG
Bulgaria
Prior art keywords
excitable
function
erythropoietin
tissues
excitable tissue
Prior art date
Application number
BG106058A
Other languages
Bulgarian (bg)
Other versions
BG65353B1 (en
Inventor
Michael Brines
Anthony Cerami
Carla Cerami
Original Assignee
Kenneth S. Warren Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth S. Warren Laboratories filed Critical Kenneth S. Warren Laboratories
Publication of BG106058A publication Critical patent/BG106058A/en
Publication of BG65353B1 publication Critical patent/BG65353B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals for synthetic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of the function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an eryhropoietin. 32 claims, 9 figures
BG106058A 1999-04-13 2001-10-26 Pharmaceutical composition containing erythroprotein and use thereof in the production of drugs BG65353B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29093899A 1999-04-13 1999-04-13
US54722000A 2000-04-11 2000-04-11

Publications (2)

Publication Number Publication Date
BG106058A true BG106058A (en) 2002-12-29
BG65353B1 BG65353B1 (en) 2008-03-31

Family

ID=26966493

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106058A BG65353B1 (en) 1999-04-13 2001-10-26 Pharmaceutical composition containing erythroprotein and use thereof in the production of drugs

Country Status (21)

Country Link
EP (1) EP1171147A4 (en)
JP (1) JP2003520194A (en)
KR (2) KR100883232B1 (en)
CN (1) CN1607957B (en)
AU (1) AU784550B2 (en)
BG (1) BG65353B1 (en)
BR (1) BR0009737A (en)
CA (1) CA2383940A1 (en)
CR (1) CR6501A (en)
CZ (1) CZ20013695A3 (en)
EA (1) EA004766B1 (en)
HU (1) HUP0201598A3 (en)
IL (2) IL145895A0 (en)
IS (1) IS6104A (en)
MX (1) MXPA01010177A (en)
NO (1) NO20014991L (en)
NZ (4) NZ514690A (en)
PL (1) PL352223A1 (en)
SK (1) SK14412001A3 (en)
TR (2) TR200402194T2 (en)
WO (1) WO2000061164A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19857609A1 (en) 1998-12-14 2000-06-15 Hannelore Ehrenreich Use of erythropoietin for the treatment of human cerebral ischemia
US6855544B1 (en) 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US7604960B2 (en) 1999-04-15 2009-10-20 Crucell Holland B.V. Transient protein expression methods
US8236561B2 (en) 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
US7521220B2 (en) 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US7527961B2 (en) 1999-11-26 2009-05-05 Crucell Holland B.V. Production of vaccines
WO2002002135A1 (en) 2000-06-30 2002-01-10 Tokyo Metropolitan Institute Of Gerontology Preventives and remedies for diseases in association with demyelination
DE10043457A1 (en) * 2000-09-04 2002-03-28 Hannelore Ehrenreich Processes for treating schizophrenia and related psychoses, and using erythropoietin or erythropoietin derivatives to treat schizophrenia and related psychoses
PA8536201A1 (en) * 2000-12-29 2002-08-29 Kenneth S Warren Inst Inc PROTECTION AND IMPROVEMENT OF CELLS, FABRICS AND ORGANS RESPONDING TO Erythropoietin
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
EP1471871B1 (en) * 2001-02-02 2007-05-02 Ortho-McNeil Pharmaceutical, Inc. Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin
US20030118630A1 (en) * 2001-12-07 2003-06-26 Anthony Cerami Immune modulation device for use in animals
BR0213402A (en) 2001-10-29 2004-10-13 Crucell Holland Bv Methods for identifying a mammalian cell capable of producing a proteinaceous molecule, for selecting a mammalian cell capable of producing a proteinaceous molecule, for obtaining a mammalian cell from a heterogeneous population of cells, and for producing a proteinaceous molecule, pharmaceutically acceptable composition, recombinantly produced erythropoietin, uses of a mammalian cell, recombinantly produced erythropoietin, and an erythropoietin-like molecule composition, pharmaceutical preparation, method for the preventive and / or therapeutic treatment of a disorder, similar molecule composition to erythropoietin, methods for producing proteinaceous molecules in a mammalian cell, to produce a fraction enriched in a proteinaceous molecule, and to fractionate a mixture containing proteinaceous molecules, fraction, and, uses of a fraction or composition, and erythropoietin recombinantly produced in a mammalian cell
KR100979025B1 (en) 2001-12-07 2010-08-30 크루셀 홀란드 비.브이. Production of viruses, viral isolates and vaccines
EP1471930B1 (en) 2002-01-09 2007-04-11 Crucell Holland B.V. Use of erythropoietin for the preventive or curative treatment of cardiac failure
AU2002307635A1 (en) * 2002-04-19 2003-11-03 Crucell Holland B.V. Methods and means for producing proteins with predetermined post-translational modifications
GB0211578D0 (en) * 2002-05-21 2002-06-26 Univ Belfast Medicaments
WO2004003176A2 (en) * 2002-07-01 2004-01-08 The Kenneth S. Warren Institute, Inc. Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs
DE10234192B4 (en) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Use of erythropoietin
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
EP1633383A4 (en) * 2003-03-27 2008-05-21 Janssen Pharmaceutica Nv Use of erythropoietin in stroke recovery
US7718363B2 (en) 2003-04-25 2010-05-18 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
ATE414144T1 (en) 2003-05-09 2008-11-15 Crucell Holland Bv CULTURES OF E1-IMMORALIZED CELLS AND METHOD FOR CULTIVATION THEM TO INCREASE THE PRODUCT YIELDS THEREOF
DE102004063927A1 (en) * 2004-01-23 2005-12-15 Epoplus Gmbh Co.Kg Use of low dose erythropoietin to stimulate endothelial progenitor cells as well as organ regeneration and progression slowing of end organ damage
AT500929B1 (en) 2004-11-09 2007-03-15 Medizinische Uni Wien Muw PHARMACEUTICAL PREPARATION CONTAINING ERYTHROPOIETIN
AU2006278264B2 (en) 2005-08-05 2012-12-06 Araim Pharmaceuticals, Inc. Tissue protective peptides and uses thereof
US20070072795A1 (en) * 2005-09-28 2007-03-29 Anton Haselbeck Treatment of neurodegenerative disorders
GB0525540D0 (en) * 2005-12-15 2006-01-25 Isis Innovation New treatment
DE102006004008A1 (en) 2006-01-27 2007-08-02 Hannelore Prof. Dr. Dr. Ehrenreich Treating or preventing multiple sclerosis comprises administering erythropoietin for periods separated by intervals in which no erythropoietin is administered
CN101062407A (en) * 2006-04-29 2007-10-31 中国科学院上海生命科学研究院 Function of erythropoietin in the preventing and treating of retinal injury
US8133860B2 (en) * 2006-07-20 2012-03-13 Rosalind Franklin University Of Medicine And Science Facilitation of resuscitation from cardiac arrest by erythropoietin
CN101610782A (en) * 2007-01-10 2009-12-23 爱迪生药物公司 Use has the compounds for treating respiratory chain disorders of erythropoietin or TPO activity
WO2009010107A1 (en) 2007-07-19 2009-01-22 Hannelore Ehrenreich Use of epo receptor activation or stimulation for the improvement of the edss score in patients with multiple sclerosis
SG10202011946PA (en) 2008-01-22 2020-12-30 Araim Pharmaceuticals Inc Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
RU2519695C2 (en) * 2010-07-21 2014-06-20 Олег Ильич Эпштейн Medication for treating attention deficit disorder and method of treating attention deficit disorder
CN111066727B (en) * 2019-12-20 2021-08-27 中国人民解放军陆军军医大学 Method for constructing mouse model of action mechanism in permeability of hypoxic blood testis barrier

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6197229A (en) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd Stable erythropoietin preparation
US5614184A (en) * 1992-07-28 1997-03-25 New England Deaconess Hospital Recombinant human erythropoietin mutants and therapeutic methods employing them
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
US20020052309A1 (en) * 1996-09-11 2002-05-02 Athanasius A. Anagnostou Method of treating endothelial injury
DE19857609A1 (en) * 1998-12-14 2000-06-15 Hannelore Ehrenreich Use of erythropoietin for the treatment of human cerebral ischemia

Also Published As

Publication number Publication date
EA200101073A1 (en) 2002-10-31
MXPA01010177A (en) 2004-09-10
WO2000061164A1 (en) 2000-10-19
AU4348700A (en) 2000-11-14
IL145895A (en) 2010-05-31
KR20070094997A (en) 2007-09-27
NZ533098A (en) 2006-04-28
TR200103785T2 (en) 2002-06-21
CA2383940A1 (en) 2000-10-19
NZ514690A (en) 2004-07-30
SK14412001A3 (en) 2002-03-05
CR6501A (en) 2004-04-15
HUP0201598A3 (en) 2002-10-28
BG65353B1 (en) 2008-03-31
JP2003520194A (en) 2003-07-02
CZ20013695A3 (en) 2002-02-13
IS6104A (en) 2001-10-11
EA004766B1 (en) 2004-08-26
KR101012932B1 (en) 2011-02-08
CN1607957B (en) 2012-10-10
NO20014991D0 (en) 2001-10-12
EP1171147A4 (en) 2003-05-14
NZ560696A (en) 2010-03-26
AU784550B2 (en) 2006-05-04
BR0009737A (en) 2003-01-14
NZ545478A (en) 2008-04-30
HUP0201598A2 (en) 2002-09-28
PL352223A1 (en) 2003-08-11
IL145895A0 (en) 2002-07-25
NO20014991L (en) 2001-11-15
CN1607957A (en) 2005-04-20
TR200402194T2 (en) 2004-10-21
KR100883232B1 (en) 2009-02-10
KR20020000874A (en) 2002-01-05
EP1171147A1 (en) 2002-01-16

Similar Documents

Publication Publication Date Title
BG106058A (en) Modulation of excitable tissue function by peripherally administered erythropoietin
ES2131525T3 (en) THERAPEUTIC USES OF MELANINE.
Goudarzvand et al. Vitamins E and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide
DE69333775D1 (en) SYNTHETIC CATALYTIC FREE RADICAL RECIPIENTS, USED AS ANTIOXIDANTS FOR THE PREVENTION AND THERAPY OF DISEASES
TR200103469T2 (en) Prevention and treatment of amyloidogenic disease
ATE314067T1 (en) CANNABINOL-11 ACID DERIVATIVES AS ANTI-INFLAMMATORY AND ANALGESICS
CA2223510A1 (en) Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
NO990088L (en) Pharmaceutical preparations comprising S - (-) - N-propargyl-1-aminoindamine
BR9714677A (en) "3-pyridyl enantiomers and their use as analgesics"
ATE280758T1 (en) AGENTS FOR PROTECTING NERVE CELLS
Vin et al. Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury
EP0616032A3 (en) Preventive or therapeutic agents for Alzheimer's disease, a screening method for Alzheimer's disease, and human tau-protein kinase.
WO2002100836A8 (en) Compounds, compositions and methods for modulating beta-amyloid production
Grandas et al. Blink reflex recovery cycle in patients with blepharospasm unilaterally treated with botulinum toxin
DE68928169D1 (en) Composition for the treatment of degenerative diseases of the nervous system
DE69314586D1 (en) Medicament composition containing TCF-II
WO2001019851A3 (en) Opaminergic neuronal survival-promoting factors and uses thereof
EP1020192A3 (en) Composition against cellulitis
DE69612671D1 (en) BUTYRATE MEDICINE PREPARATIONS OF LACTIC ACID
CA2255748A1 (en) Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
DE69736241D1 (en) NEUROTROPHIC CILIARY FACTOR WITH CHANGED ACTIVITY AREA AGAINST THE WILD TYPE MOLECULE
Zhu et al. The dynamic change and regulation of IGF-1 on axonal regeneration after sciatic nerve transaction
Krutmann III. Immunology of UV-irradiated skin
WO1999038967A3 (en) Recombinant proteins derived from hgf and msp
Porreca et al. Nitric oxide modulates neuropeptide Y regulation of ion transport in mouse ileum