BG102896A - Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration - Google Patents

Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration

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Publication number
BG102896A
BG102896A BG102896A BG10289698A BG102896A BG 102896 A BG102896 A BG 102896A BG 102896 A BG102896 A BG 102896A BG 10289698 A BG10289698 A BG 10289698A BG 102896 A BG102896 A BG 102896A
Authority
BG
Bulgaria
Prior art keywords
ivermectine
catalytic system
rhodium
selective hydration
preparation
Prior art date
Application number
BG102896A
Other languages
Bulgarian (bg)
Other versions
BG64169B1 (en
Inventor
Курти КУРТЕВ
Божидар ПЕТКОВ
Иван БАТАКЛИЕВ
Илия ЗАЙКОВ
Original Assignee
"Биовет" Ад
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "Биовет" Ад filed Critical "Биовет" Ад
Priority to BG102896A priority Critical patent/BG64169B1/en
Publication of BG102896A publication Critical patent/BG102896A/en
Publication of BG64169B1 publication Critical patent/BG64169B1/en

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  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method for the preparation of ivermectine by the application of rhodium-containing catalytic system for selective hydration of ivermectine B1a and B1b. The ivermectine has considerable antiparasitic activity and is used as antihelminth agent, ektoparasiticide, insecticide and acaricide.The catalytic system is produced in situ, by adding an activator,trimethylaminooxide (CH3)3NO or dichlorbis (acetonitrile) palladium Pd Cl2(CH3CN)2, which can accept triphenylphosphinic ligands,to the RhCl(Ph3)3 Wilkinson complex for selective hydration of double carbon-carbon bonds. In this way the time needed for the activation of the complex, and the total time of the process are reduced. 2 claims
BG102896A 1998-11-04 1998-11-04 Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration BG64169B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG102896A BG64169B1 (en) 1998-11-04 1998-11-04 Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG102896A BG64169B1 (en) 1998-11-04 1998-11-04 Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration

Publications (2)

Publication Number Publication Date
BG102896A true BG102896A (en) 2000-07-31
BG64169B1 BG64169B1 (en) 2004-03-31

Family

ID=3927598

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102896A BG64169B1 (en) 1998-11-04 1998-11-04 Method for the preparation of ivermectine by making use of a rhodium-containing catalytic system for selective hydration

Country Status (1)

Country Link
BG (1) BG64169B1 (en)

Also Published As

Publication number Publication date
BG64169B1 (en) 2004-03-31

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