BE902475A - BIOLOGICALLY ACTIVE TRIDECAPEPTIDES. - Google Patents

BIOLOGICALLY ACTIVE TRIDECAPEPTIDES.

Info

Publication number
BE902475A
BE902475A BE0/215051A BE215051A BE902475A BE 902475 A BE902475 A BE 902475A BE 0/215051 A BE0/215051 A BE 0/215051A BE 215051 A BE215051 A BE 215051A BE 902475 A BE902475 A BE 902475A
Authority
BE
Belgium
Prior art keywords
pro
alkoxycarbonyl
alkyl
aralkoxycarbonyl
aralkyl
Prior art date
Application number
BE0/215051A
Other languages
French (fr)
Inventor
G Perseo
M Gigli
R De Castiglione
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE902475A publication Critical patent/BE902475A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Des peptides répondant à la formule Glp-X-Lys-Pro-Tyr-Trp-Pro-Pro-Pro-Y-Tyr-Pro-W-C où X = L-alpha-amino-acide neutre ou acide; A = H ou groupe acyle, alcoxycarbonyle, aralcoxycarbonyle, alkyle ou aralkyle protecteur du groupe amino; B = H ou groupe acyle, alkyle, aralkyle, alcoxycarbonyle ou aralcoxycarbonyle protecteur du groupe hydroxy phénolique; Y et W = L -alpha-amino-acide neutre; C = OH, amino ou Or, NHR, NHR, NR2 ou NH-NH-R' ; R = alkyle en C1- C11, phényle ou aralkyle en C7-C14 et R' = H, R, acyle aliphatique en C1-C11, alcoxycarbonyle en C3-C11 ou aralcoxycarbonyle.Les peptides synthétisées sont utiles dans des procédés de traitement thérapeutique chez l'homme ou l'animal et notamment une stimulation de la sécrétion de la prolactine prituitaire, elles exercent des effets sédatifs inhibant le transit intestinal, et sont antipyrétiques.Peptides corresponding to the formula Glp-X-Lys-Pro-Tyr-Trp-Pro-Pro-Pro-Y-Tyr-Pro-W-C where X = L-alpha-amino acid neutral or acid; A = H or acyl, alkoxycarbonyl, aralkoxycarbonyl, alkyl or aralkyl group protecting the amino group; B = H or acyl, alkyl, aralkyl, alkoxycarbonyl or aralkoxycarbonyl group protecting the phenolic hydroxy group; Y and W = L -alpha-amino acid neutral; C = OH, amino or Gold, NHR, NHR, NR2 or NH-NH-R '; R = C1-C11 alkyl, phenyl or C7-C14 aralkyl and R '= H, R, C1-C11 aliphatic acyl, C3-C11 alkoxycarbonyl or aralkoxycarbonyl. The synthesized peptides are useful in therapeutic treatment processes in humans or animals, and in particular stimulation of the secretion of prolactin proliferative, they exert sedative effects inhibiting intestinal transit, and are antipyretic.

BE0/215051A 1984-05-24 1985-05-22 BIOLOGICALLY ACTIVE TRIDECAPEPTIDES. BE902475A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848413272A GB8413272D0 (en) 1984-05-24 1984-05-24 Biologically active tridecapeptides

Publications (1)

Publication Number Publication Date
BE902475A true BE902475A (en) 1985-09-16

Family

ID=10561441

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215051A BE902475A (en) 1984-05-24 1985-05-22 BIOLOGICALLY ACTIVE TRIDECAPEPTIDES.

Country Status (4)

Country Link
JP (1) JPS6197A (en)
BE (1) BE902475A (en)
DE (1) DE3518086A1 (en)
GB (2) GB8413272D0 (en)

Also Published As

Publication number Publication date
DE3518086A1 (en) 1985-11-28
JPS6197A (en) 1986-01-06
GB8512761D0 (en) 1985-06-26
GB2156822A (en) 1985-10-16
GB8413272D0 (en) 1984-06-27

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19900531