BE900322A - NEW 1,2,4-TRIAZOLE DERIVATIVES. - Google Patents

NEW 1,2,4-TRIAZOLE DERIVATIVES.

Info

Publication number
BE900322A
BE900322A BE0/213466A BE213466A BE900322A BE 900322 A BE900322 A BE 900322A BE 0/213466 A BE0/213466 A BE 0/213466A BE 213466 A BE213466 A BE 213466A BE 900322 A BE900322 A BE 900322A
Authority
BE
Belgium
Prior art keywords
new
triazole derivatives
deoxyclavulanate
triazol
benzyl
Prior art date
Application number
BE0/213466A
Other languages
French (fr)
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of BE900322A publication Critical patent/BE900322A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composé de formule I : où X représente un radical 1,2,4-triazolyle éventuellement substitué fixé par l'un de ses atomes d'azote, ou un sel ou ester de ce composé, par exemple le 9-(1',2',4'-triazol-1'-yl)-9-désoxyclavulanate de benzyle ou le 9-(1',2',4'-triazol-4'-yl)-9-désoxyclavulanate de benzyle. Procédé pour préparer ces composés et compositions les contenant. Les dérivés présentent une activité antibactérienne et inhibitrice de la beta-lactamase chez l'homme et les animaux.Compound of formula I: where X represents an optionally substituted 1,2,4-triazolyl radical attached by one of its nitrogen atoms, or a salt or ester of this compound, for example 9- (1 ', 2 Benzyl ', 4'-triazol-1'-yl) -9-deoxyclavulanate or benzyl 9- (1', 2 ', 4'-triazol-4'-yl) -9-deoxyclavulanate. Process for preparing these compounds and compositions containing them. The derivatives exhibit antibacterial and beta-lactamase inhibiting activity in humans and animals.

BE0/213466A 1983-02-10 1984-08-08 NEW 1,2,4-TRIAZOLE DERIVATIVES. BE900322A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838303649A GB8303649D0 (en) 1983-02-10 1983-02-10 Beta-lactam compounds

Publications (1)

Publication Number Publication Date
BE900322A true BE900322A (en) 1985-02-08

Family

ID=10537756

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213466A BE900322A (en) 1983-02-10 1984-08-08 NEW 1,2,4-TRIAZOLE DERIVATIVES.

Country Status (5)

Country Link
EP (1) EP0135521A1 (en)
JP (1) JPS60500620A (en)
BE (1) BE900322A (en)
GB (1) GB8303649D0 (en)
WO (1) WO1984003092A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA785711B (en) * 1977-10-10 1979-09-26 Glaxo Group Ltd B-lactam compounds,process for their preparation,pharmaceutical compositions containing them and intermediates of use in their preparation
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use

Also Published As

Publication number Publication date
GB8303649D0 (en) 1983-03-16
JPS60500620A (en) 1985-05-02
WO1984003092A1 (en) 1984-08-16
EP0135521A1 (en) 1985-04-03

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BEECHAM GROUP P.L.C.

Effective date: 19870831