BE893984A - DIHYDROPYRIDINES HAVING POSITIVE INOTROPIC ACTION, THEIR USE AS MEDICAMENTS AND A PROCESS FOR THEIR PREPARATION - Google Patents

DIHYDROPYRIDINES HAVING POSITIVE INOTROPIC ACTION, THEIR USE AS MEDICAMENTS AND A PROCESS FOR THEIR PREPARATION

Info

Publication number
BE893984A
BE893984A BE0/208713A BE208713A BE893984A BE 893984 A BE893984 A BE 893984A BE 0/208713 A BE0/208713 A BE 0/208713A BE 208713 A BE208713 A BE 208713A BE 893984 A BE893984 A BE 893984A
Authority
BE
Belgium
Prior art keywords
dihydropyridines
medicaments
preparation
positive inotropic
inotropic action
Prior art date
Application number
BE0/208713A
Other languages
French (fr)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BE893984A publication Critical patent/BE893984A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/208713A 1981-07-30 1982-07-30 DIHYDROPYRIDINES HAVING POSITIVE INOTROPIC ACTION, THEIR USE AS MEDICAMENTS AND A PROCESS FOR THEIR PREPARATION BE893984A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813130041 DE3130041A1 (en) 1981-07-30 1981-07-30 Dihydropyridines having a positive inotropic effect, novel compounds, their use in medicaments, and processes for their preparation

Publications (1)

Publication Number Publication Date
BE893984A true BE893984A (en) 1983-01-31

Family

ID=6138075

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/208713A BE893984A (en) 1981-07-30 1982-07-30 DIHYDROPYRIDINES HAVING POSITIVE INOTROPIC ACTION, THEIR USE AS MEDICAMENTS AND A PROCESS FOR THEIR PREPARATION

Country Status (3)

Country Link
BE (1) BE893984A (en)
DE (1) DE3130041A1 (en)
ZA (1) ZA825456B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206747A2 (en) 1985-06-17 1986-12-30 Warner-Lambert Company 1,4-Dihydropyridine derivatives useful in the treatment of cardiovascular disorders, and a process for producing the derivatives
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3206671A1 (en) * 1982-02-25 1983-09-01 Bayer Ag, 5090 Leverkusen Dihydropyridines having positively inotropic action, novel compounds, their use in medicaments and processes for their preparation
DE3348281C2 (en) * 1983-04-30 1989-06-15 Bayer Ag, 5090 Leverkusen, De Microemulsion of non lipoid surfactant and partly miscible solvent
DE3315805A1 (en) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Active substance compositions
DE3410645A1 (en) * 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-ALKYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE LACTONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
US5162338A (en) * 1986-01-11 1992-11-10 Bayer Aktiengesellschaft Circulation active 4-aminoaryldihydropryidine lactones
DE3600596A1 (en) * 1986-01-11 1987-07-16 Bayer Ag 4-AMINOARYLDIHYDROPYRIDINLACTONE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
CA2385908A1 (en) * 2000-08-02 2002-02-07 Abbott Laboratories Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (en) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals
DE2242786A1 (en) * 1972-08-31 1974-03-14 Bayer Ag PROCESS FOR THE MANUFACTURING OF NEW 2-AMINO-1,4-DIHYDROPYRIDINES WITH A CARBONYL FUNCTION AND THEIR USE AS A MEDICINAL PRODUCT
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2752820A1 (en) * 1977-11-26 1979-05-31 Bayer Ag NEW NITRO-SUBSTITUTED 1,4-DIHYDROPYRIDINE, THE METHOD FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2841667A1 (en) * 1978-09-25 1980-04-10 Bayer Ag FLUORINE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
EP0206747A2 (en) 1985-06-17 1986-12-30 Warner-Lambert Company 1,4-Dihydropyridine derivatives useful in the treatment of cardiovascular disorders, and a process for producing the derivatives
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6277989B1 (en) 1998-08-28 2001-08-21 Scios, Inc. Quinazoline derivatives as medicaments
US6903096B2 (en) 1998-08-28 2005-06-07 Scios, Inc. Quinazoline derivatives as medicaments
US7345045B2 (en) 1998-08-28 2008-03-18 Scios, Inc. Pyrido-pyrimidine compounds as medicaments

Also Published As

Publication number Publication date
DE3130041A1 (en) 1983-02-17
ZA825456B (en) 1983-06-29

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BAYER A.G.

Effective date: 19970731