BE878084R - PROCESS FOR ENCAPSULATION OF A LABILE BIOLOGICAL MATERIAL. - Google Patents

PROCESS FOR ENCAPSULATION OF A LABILE BIOLOGICAL MATERIAL.

Info

Publication number
BE878084R
BE878084R BE0/196609A BE196609A BE878084R BE 878084 R BE878084 R BE 878084R BE 0/196609 A BE0/196609 A BE 0/196609A BE 196609 A BE196609 A BE 196609A BE 878084 R BE878084 R BE 878084R
Authority
BE
Belgium
Prior art keywords
emi
encapsulation
biological material
phase
labile biological
Prior art date
Application number
BE0/196609A
Other languages
French (fr)
Inventor
D Moss
F Lim
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Corp filed Critical Damon Corp
Application granted granted Critical
Publication of BE878084R publication Critical patent/BE878084R/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Description

       

   <EMI ID=1.1>  

  
 <EMI ID=2.1>  

  
 <EMI ID=3.1> 

  
 <EMI ID=4.1> 

  
 <EMI ID=5.1> 

  
relativement épais est produit autour des gouttelettes lors

  
 <EMI ID=6.1> 

  
 <EMI ID=7.1> 

  
 <EMI ID=8.1> 

  
 <EMI ID=9.1> 

  
 <EMI ID=10.1>   <EMI ID=11.1> 

  
 <EMI ID=12.1> 

  
'phases et remises en Suspension dans une nouvelle phase: 

  
 <EMI ID=13.1> 

  
la polarité diffère de celle de la phase continue utilisée 

  
à l'origine. Selon, la présente invention, un solvant miscible

  
 <EMI ID=14.1>  <EMI ID=15.1>  <EMI ID=16.1>   <EMI ID=17.1> 

  
 <EMI ID=18.1> 

  
polymères précités, les Solvants préférés pour la phase

  
 <EMI ID=19.1> 

  
forme pour le diluer selon ce qui est, approprié . L'affinité 

  
 <EMI ID=20.1> 

  
 <EMI ID=21.1>  de monomères., très divers. qui. forment des. chaînes polymères.. <EMI ID=22.1> 

  
 <EMI ID=23.1>   <EMI ID=24.1> 

  
former une phase aqueuse discontinue ou phase- de gouttelettes" La dimension des. gouttelettes, détermine la .dimension des- <EMI ID=25.1>  spécifique', on peut utiliser un où plusieurs filtres pour 

  
 <EMI ID=26.1>  capsules.: Pour. un exposé détaillé sur le procédé permettant

  
de faire varier la dimension 'des. capsules, on' peut se référer ; 

  
 <EMI ID=27.1> 

  
 <EMI ID=28.1> 

  
été. produites, un second. monomère hydrophobe, soluble dans la -phase continue et capable de former un polymère par <EMI ID=29.1>  est introduit dans la suspension. Une polymérisation ne se.' 

  
 <EMI ID=30.1> 

  
 <EMI ID=31.1> 

  
être choisis panai ceux présentant des propriétés convenables

  
 <EMI ID=32.1> 

  
 <EMI ID=33.1> 

  
on ne peut exercer qu'un, contrôle de réglage grossier sur la 

  
 <EMI ID=34.1>   <EMI ID=35.1>  <EMI ID=36.1> 

  
dans la "phase discontinue. Ainsi, on peut; -régler l'épaisseur  <EMI ID=37.1>  <EMI ID=38.1> 

  
 <EMI ID=39.1> 

  
Dans une forme préférée de. réalisation, la phase continue pour la première étape de polymérisation est-choisie

  
 <EMI ID=40.1> 

  
 <EMI ID=41.1>  l'affinité de la phase continue pour le prêter monomère; .est. 

  
 <EMI ID=42.1> 

  
 <EMI ID=43.1>   <EMI ID=44.1> 

  
différente. La poursuite de la polymérisation, est ensuite

  
 <EMI ID=45.1> 

  
 <EMI ID=46.1> 

  
 <EMI ID=47.1> 

  
-Dans l'autre procédé de la présente invention, l'affinité de la phase continue pour le premier monomère est . augmentée ou diminuée"; selon les désirs, par la dilution de la phase conti- <EMI ID=48.1> 

  
 <EMI ID=49.1> 

  
 <EMI ID=50.1> 

  
 <EMI ID=51.1> 

  
 <EMI ID=52.1>   <EMI ID=53.1> 

  
dont la limite de perméabilité; est inférieure 5 environ 

  
 <EMI ID=54.1>   <EMI ID=55.1> 

  
miscibles entre eux;. 

  
2) les solvants respectifs doivent, être du type 

  
 <EMI ID=56.1> 

  
 <EMI ID=57.1> 

  
 <EMI ID=58.1> 

  
 <EMI ID=59.1> 

  
 <EMI ID=60.1> 

  
 <EMI ID=61.1> 

  
 <EMI ID=62.1> 

  
 <EMI ID=63.1>  

  
 <EMI ID=64.1>   <EMI ID=65.1> 

  
 <EMI ID=66.1> 

  
 <EMI ID=67.1> 

  
 <EMI ID=68.1>  l'aide d'une tige d'agitation.... 

  
 <EMI ID=69.1>  <EMI ID=70.1>  

  
 <EMI ID=71.1> 

  
 <EMI ID=72.1> 

  
 <EMI ID=73.1> 

  
 <EMI ID=74.1>  <EMI ID=75.1>  <EMI ID=76.1> 

  
pendant 20 minutés supplémentaires. Deux minutes avant ' , - <EMI ID=77.1> 

  
 <EMI ID=78.1> 

  
 <EMI ID=79.1> 

  
 <EMI ID=80.1> 

  
 <EMI ID=81.1>  <EMI ID=82.1>  <EMI ID=83.1> 

  
 <EMI ID=84.1>   <EMI ID=85.1> 

  
 <EMI ID=86.1> 

  
 <EMI ID=87.1> 

  
 <EMI ID=88.1> 

  
albumine de bovin comme -matières . de charge. Les substances -

  
 <EMI ID=89.1> 

  
plupart des anticorps) ne peuvent pénétrer ou traverser les membranes. Des substances dont le'poids moléculaire est

  
 <EMI ID=90.1> 

  
 <EMI ID=91.1> 



   <EMI ID = 1.1>

  
 <EMI ID = 2.1>

  
 <EMI ID = 3.1>

  
 <EMI ID = 4.1>

  
 <EMI ID = 5.1>

  
relatively thick is produced around the droplets when

  
 <EMI ID = 6.1>

  
 <EMI ID = 7.1>

  
 <EMI ID = 8.1>

  
 <EMI ID = 9.1>

  
 <EMI ID = 10.1> <EMI ID = 11.1>

  
 <EMI ID = 12.1>

  
'' phases and resuspension in a new phase:

  
 <EMI ID = 13.1>

  
the polarity differs from that of the continuous phase used

  
originally. According to the present invention, a miscible solvent

  
 <EMI ID = 14.1> <EMI ID = 15.1> <EMI ID = 16.1> <EMI ID = 17.1>

  
 <EMI ID = 18.1>

  
polymers mentioned above, the preferred solvents for the

  
 <EMI ID = 19.1>

  
form to dilute it as appropriate. Affinity

  
 <EMI ID = 20.1>

  
 <EMI ID = 21.1> of monomers, very diverse. who. form. polymer chains .. <EMI ID = 22.1>

  
 <EMI ID = 23.1> <EMI ID = 24.1>

  
to form a discontinuous aqueous phase or droplet phase.

  
 <EMI ID = 26.1> capsules .: For. a detailed presentation of the process allowing

  
to vary the dimension 'of. capsules, one 'can refer;

  
 <EMI ID = 27.1>

  
 <EMI ID = 28.1>

  
summer. produced, a second. hydrophobic monomer, soluble in the continuous -phase and capable of forming a polymer by <EMI ID = 29.1> is introduced into the suspension. Polymerization does not occur. '

  
 <EMI ID = 30.1>

  
 <EMI ID = 31.1>

  
be chosen among those with suitable properties

  
 <EMI ID = 32.1>

  
 <EMI ID = 33.1>

  
only one, coarse adjustment control can be exerted on the

  
 <EMI ID = 34.1> <EMI ID = 35.1> <EMI ID = 36.1>

  
in the "discontinuous phase. Thus, we can; -set the thickness <EMI ID = 37.1> <EMI ID = 38.1>

  
 <EMI ID = 39.1>

  
In a preferred form of. realization, the continuous phase for the first polymerization step is chosen

  
 <EMI ID = 40.1>

  
 <EMI ID = 41.1> the affinity of the continuous phase to lend it monomer; .East.

  
 <EMI ID = 42.1>

  
 <EMI ID = 43.1> <EMI ID = 44.1>

  
different. Further polymerization is then

  
 <EMI ID = 45.1>

  
 <EMI ID = 46.1>

  
 <EMI ID = 47.1>

  
-In the other process of the present invention, the affinity of the continuous phase for the first monomer is. increased or decreased "; as desired, by dilution of the continuous phase - <EMI ID = 48.1>

  
 <EMI ID = 49.1>

  
 <EMI ID = 50.1>

  
 <EMI ID = 51.1>

  
 <EMI ID = 52.1> <EMI ID = 53.1>

  
including the permeability limit; is less than about 5

  
 <EMI ID = 54.1> <EMI ID = 55.1>

  
miscible with each other ;.

  
2) the respective solvents must be of the type

  
 <EMI ID = 56.1>

  
 <EMI ID = 57.1>

  
 <EMI ID = 58.1>

  
 <EMI ID = 59.1>

  
 <EMI ID = 60.1>

  
 <EMI ID = 61.1>

  
 <EMI ID = 62.1>

  
 <EMI ID = 63.1>

  
 <EMI ID = 64.1> <EMI ID = 65.1>

  
 <EMI ID = 66.1>

  
 <EMI ID = 67.1>

  
 <EMI ID = 68.1> using a stir rod ....

  
 <EMI ID = 69.1> <EMI ID = 70.1>

  
 <EMI ID = 71.1>

  
 <EMI ID = 72.1>

  
 <EMI ID = 73.1>

  
 <EMI ID = 74.1> <EMI ID = 75.1> <EMI ID = 76.1>

  
for another 20 minutes. Two minutes before ', - <EMI ID = 77.1>

  
 <EMI ID = 78.1>

  
 <EMI ID = 79.1>

  
 <EMI ID = 80.1>

  
 <EMI ID = 81.1> <EMI ID = 82.1> <EMI ID = 83.1>

  
 <EMI ID = 84.1> <EMI ID = 85.1>

  
 <EMI ID = 86.1>

  
 <EMI ID = 87.1>

  
 <EMI ID = 88.1>

  
bovine albumin as -materials. dump. Substances -

  
 <EMI ID = 89.1>

  
most antibodies) cannot penetrate or cross membranes. Substances whose molecular weight is

  
 <EMI ID = 90.1>

  
 <EMI ID = 91.1>

Claims (1)

<EMI ID=92.1> <EMI ID = 92.1> <EMI ID=93.1> <EMI ID = 93.1> <EMI ID=94.1> <EMI ID = 94.1> <EMI ID=95.1> <EMI ID = 95.1> <EMI ID=96.1> <EMI ID = 96.1> obtient une couché supplémentaire de polymère autour des obtains an additional coating of polymer around the .gouttelettes de la phase, discontinue. .droplets of the phase, discontinuous. <EMI ID=97.1> <EMI ID = 97.1> <EMI ID=98.1> <EMI ID = 98.1> <EMI ID=99.1> <EMI ID = 99.1> <EMI ID=100.1> <EMI ID = 100.1> <EMI ID=101.1> <EMI ID=102.1> <EMI ID = 101.1> <EMI ID = 102.1> <EMI ID=103.1> <EMI ID = 103.1> <EMI ID=104.1> <EMI ID = 104.1> <EMI ID=105.1> <EMI ID = 105.1> <EMI ID=106.1> <EMI ID = 106.1> <EMI ID=107.1> <EMI ID = 107.1> <EMI ID=108.1> <EMI ID = 108.1>
BE0/196609A 1978-08-04 1979-08-03 PROCESS FOR ENCAPSULATION OF A LABILE BIOLOGICAL MATERIAL. BE878084R (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93117778A 1978-08-04 1978-08-04

Publications (1)

Publication Number Publication Date
BE878084R true BE878084R (en) 1979-12-03

Family

ID=25460332

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/196609A BE878084R (en) 1978-08-04 1979-08-03 PROCESS FOR ENCAPSULATION OF A LABILE BIOLOGICAL MATERIAL.

Country Status (2)

Country Link
JP (1) JPS5544387A (en)
BE (1) BE878084R (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132492A (en) * 1994-10-13 2000-10-17 Advanced Technology Materials, Inc. Sorbent-based gas storage and delivery system for dispensing of high-purity gas, and apparatus and process for manufacturing semiconductor devices, products and precursor structures utilizing same

Also Published As

Publication number Publication date
JPS6152735B2 (en) 1986-11-14
JPS5544387A (en) 1980-03-28

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: DAMON BIOTECH INC.

Effective date: 19871130