BE806307A - Carbocyclic fused pyridine thiocarboxides and nitriles - carboxamides, free carboxylic acids and esters, as anti ulcer agents - Google Patents

Carbocyclic fused pyridine thiocarboxides and nitriles - carboxamides, free carboxylic acids and esters, as anti ulcer agents

Info

Publication number
BE806307A
BE806307A BE136894A BE136894A BE806307A BE 806307 A BE806307 A BE 806307A BE 136894 A BE136894 A BE 136894A BE 136894 A BE136894 A BE 136894A BE 806307 A BE806307 A BE 806307A
Authority
BE
Belgium
Prior art keywords
alkyl
thiocarboxides
carboxamides
nitriles
esters
Prior art date
Application number
BE136894A
Other languages
French (fr)
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of BE806307A publication Critical patent/BE806307A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpd. (I): (where R', R2 and R6 are H, CF3 alkyl, aralkyl or aryl opt. substd. by alkyl, alkoxy, halo, NO2 or Cf3 or R'+R2 are -CH2-(CH2)n-CH2-; n is 1, 2 or 3; R7 is H, alkyl, aralkyl or aryl opt. substd. by alkyl, alkoxy, halo, NO2 or CF3; when R' + R2 is alkylene, the ring so formed may be substd. by R7; X is CN, CONR3R4, CSNR3R4 or CO2R5; R3, R4 and R5 are H, alkyl, aralkyl or aryl opt. substd. by alkyl, alkoxy, halo, NO2 or CF3; m is 1, 2 or 3 provided when R' and R2 is an alkylene chain n may be equal to m) are prepd. by known methods for introducing X or converting X = CO2R into X = CONR3R4, CSNR3R4 or CN. Thus 2-phenyl-5,6,7,8-tetra hydroquinoline thiocarboxamide is prepd. by forming the free acid from 2-phenyl-5,6,7,8 tetrahydroquinoline PhLi and CO2, converting this to the ester then the amide and heating this with P2S5. The nitrile is also formed.
BE136894A 1972-10-21 1973-10-19 Carbocyclic fused pyridine thiocarboxides and nitriles - carboxamides, free carboxylic acids and esters, as anti ulcer agents BE806307A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4859572 1972-10-21

Publications (1)

Publication Number Publication Date
BE806307A true BE806307A (en) 1974-04-19

Family

ID=10449182

Family Applications (1)

Application Number Title Priority Date Filing Date
BE136894A BE806307A (en) 1972-10-21 1973-10-19 Carbocyclic fused pyridine thiocarboxides and nitriles - carboxamides, free carboxylic acids and esters, as anti ulcer agents

Country Status (2)

Country Link
BE (1) BE806307A (en)
ZA (1) ZA738121B (en)

Also Published As

Publication number Publication date
ZA738121B (en) 1975-05-28

Similar Documents

Publication Publication Date Title
TR19917A (en) THE USE OF CYCLOPROPAN CARBOXYLIC ACIDS AS SUBSTITUEED PRIDIN METIL ESTERS AND ITS INDEXTS
AT323994B (en) PROCESS FOR THE PRODUCTION OF OIL-SOLUBLE POLYALKYL METHACRYLATES
NZ178641A (en) Esters of vinylcycloprpane carboxylic acids and intermediates
ES471826A1 (en) 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters
BE806307A (en) Carbocyclic fused pyridine thiocarboxides and nitriles - carboxamides, free carboxylic acids and esters, as anti ulcer agents
AT313868B (en) Process for the preparation of new 3- (3'-OR-trans-1'-alkenyl) -cyclopentanone-2-carboxylic acid alkyl esters
PH10148A (en) Method of flocculating with tertiary aminohydroxyalkyl esters of carboxylic acid polymers
SE7601462L (en) PROCEDURE FOR THE PRODUCTION OF SILK STEEL WITH HIGH PERMEABILITY
AT168593B (en) Method and device for the production of steel granulate
SE396374B (en) METHOD AND DEVICE FOR REGULATING THE ACID STRENGTH IN AN ALKYLER INSTALLATION OF THE KIND IN WHICH ISOPARAFFIN IS REACTIONED WITH OLEFIN IN THE PRESENCE OF THE ACID
ES410019A1 (en) Anti-inflammatory agents, cosmetic preparations and method of preventing inflammation
SE405725B (en) NEW PROCEDURE FOR THE PREPARATION OF CARBOXYLIC ACID AMIDES
IT1044638B (en) PROCEDURE FOR THE PRODUCTION OF CARBOXYLIC ACID AMIDES
AT300783B (en) Process for the preparation of new heterocyclic carboxylic acid esters
CH522625A (en) Process for the preparation of new heterocyclic carboxylic acids
FR908931A (en) Tensioner connector for the instant connection or hooking up of tensioned metal wires and cables
DK128850B (en) Analogous process for the preparation of pyrrolidinone carboxylic acid alkyl esters.
FR2205310A1 (en) Alpha penicillanamido penicillanic acids - long acting antibacterials prepd. by amidation of a mixed anhydride with an alpha amino penicillin
BE777347A (en) NEW ESTERS OF DIARYL-2,2-CYCLOPROPANE CARBOXYLIC ACIDS
FR2081566A2 (en) Thiazolidine-2,4-dicarboxylic acids
BE807482A (en) Alpha-sulphobenzyl penicillins - as antibacterials and food additives
BG16180A3 (en) METHOD FOR OBTAINING NEW, SUBSTITUTED ARYLOXY AND ARYLTIOACETIC ACIDS, THEIR LOWER ALKYL ESTERS AND THEIR SALTS
SU459509A1 (en) The method of heating the slag melt
CH522627A (en) Process for the preparation of new heterocyclic carboxylic acids
FR2034121A7 (en) Substd phenylacetic acid derivs analgesic antipyretic an - tiphlogistic

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: JOHN WYETH & BROTHER LTD

Effective date: 19891031