BE749165A - Crystalline cephalosporine - Google Patents

Crystalline cephalosporine

Info

Publication number
BE749165A
BE749165A BE749165DA BE749165A BE 749165 A BE749165 A BE 749165A BE 749165D A BE749165D A BE 749165DA BE 749165 A BE749165 A BE 749165A
Authority
BE
Belgium
Prior art keywords
crystalline
cephalosporine
cephalescine
monohydrate
antibiotic
Prior art date
Application number
Other languages
French (fr)
Inventor
E M Van Heyningen
A J Barnes
R R Pfeiffer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE749165A publication Critical patent/BE749165A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Crystalline cephalescine monohydrate (I) has X-ray diffraction data as follows : d RI d I/I 15.15 0.40 2.98 0.40 11.85 1.00 2.90 0.60 11.00 0.30 2.81 0.40 9.36 0.20 2.73 0.20 8.55 0.50 2.68 0.40 7.86 0.50 2.63 0.10 6.89 0.20 2.47 0.30 5.98 0.40 2.41 0.15 5.39 1.00 2.31 0.30 4.97 0.50 2.25 0.30 4.76 0.40 2.12 0.10 4.57 0.40 2.09 0.05 4.39 0.60 2.01 0.02 4.22 0.60 1.93 0.05 4.00 0.70 1.87 0.05 3.86 0.70 1.85 0.05 3.60 0.80 1.82 0.10 3.46 0.30 1.72 0.05 3.24 0.60 1.66 0.02 3.10 0.60 1.62 0.02 (where d = separation; RI = relative intensity). The new form of the antibiotic is extremely useful for oral administration.
BE749165D 1969-04-21 1970-04-20 Crystalline cephalosporine BE749165A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81813869A 1969-04-21 1969-04-21
US81805769A 1969-04-21 1969-04-21

Publications (1)

Publication Number Publication Date
BE749165A true BE749165A (en) 1970-10-20

Family

ID=27124223

Family Applications (1)

Application Number Title Priority Date Filing Date
BE749165D BE749165A (en) 1969-04-21 1970-04-20 Crystalline cephalosporine

Country Status (1)

Country Link
BE (1) BE749165A (en)

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ELI LILLY AND CY

Effective date: 19900420