BE659797A - - Google Patents

Info

Publication number
BE659797A
BE659797A BE659797DA BE659797A BE 659797 A BE659797 A BE 659797A BE 659797D A BE659797D A BE 659797DA BE 659797 A BE659797 A BE 659797A
Authority
BE
Belgium
Prior art keywords
ajmaline
phenyl
substituted
derivative
ethyl
Prior art date
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication of BE659797A publication Critical patent/BE659797A/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

       

   <Desc/Clms Page number 1> 
 



  Nouveau dérivé de l'ajmaline. 
 EMI1.1 
 '=.,i;; :l"   @   L'invention a pour objet un nouveau dérivé de   l'ajmaline   convenant comme régulateur du rythme cardiaque. Il représente le produit de salification de l'ajmaline avec un acide barbitu- rique substitué et correspond à la formule 
 EMI1.2 
 

 <Desc/Clms Page number 2> 

 dans laquelle R1 et R2 sont   différents   l'un   de .l'autre .et   représen- tent un radical aryle substitué ou non   substitué   ou un radical alcoyle pouvant comporter 1 à 3 atomes de carbone. 



   Lorsque R1 est un groupe phényle, R2 est avantageusement un groupe éthyle, 
Le phényl-éthyl-barbiturate   d'ajmaline   est une poudre blanche microcaristalline de saveur amère, soluble dansle chloro- forme, peu soluble dans l'alcool éthylique, non soluble dans   l'eau   fondant à 125 C et ayant un pouvoir rotatoire. 
 EMI2.1 
 f<L7D ' 83  (o l dans CIiCl3).

   i    REVENDICATIONS..   
 EMI2.2 
 'le- NoLau dérivé de 1$ajmaline, caractèrisé.on ce qu'il ' représente le produit de salification avec un acide barbiturique   substitué   et correspond à la formule 
 EMI2.3 
 dans laquelle R1 et R2 sont différents l'un de l'autre et   représen- .   tent un radical aryle portant ou ne portant pas de substituants, ou un radical alcoyle pouvant comporter 1 à 3   atomes*de   carbone.



   <Desc / Clms Page number 1>
 



  New derivative of ajmaline.
 EMI1.1
 '=., i ;; The subject of the invention is a novel adjmaline derivative suitable as a cardiac rhythm regulator. It represents the product of salification of ajmaline with a substituted barbitu- ric acid and corresponds to the formula
 EMI1.2
 

 <Desc / Clms Page number 2>

 in which R1 and R2 are different from each other and represent a substituted or unsubstituted aryl radical or an alkyl radical which may have 1 to 3 carbon atoms.



   When R1 is a phenyl group, R2 is advantageously an ethyl group,
Ajmaline phenyl-ethyl-barbiturate is a white microcaristalline powder with a bitter taste, soluble in chloroform, sparingly soluble in ethyl alcohol, insoluble in water, melting at 125 C and having an optical rotation.
 EMI2.1
 f <L7D '83 (o 1 in CIiCl3).

   i CLAIMS ..
 EMI2.2
 'the- NoLau derivative of 1 $ ajmaline, characterized by what it' represents the product of salification with a substituted barbituric acid and corresponds to the formula
 EMI2.3
 in which R1 and R2 are different from each other and represent. tent an aryl radical bearing or not bearing substituents, or an alkyl radical which may contain 1 to 3 carbon atoms.

Claims (1)

2. - Nouveau dérivé de l'aJmaline suivant la revendication 1, caractérisé en ce que R est un groupe phényle et R2 un groupe éthyle. 2. - New derivative of aJmaline according to claim 1, characterized in that R is a phenyl group and R2 an ethyl group. 3. - Régulateur du rythme cardiaque, caractérisé en ce qu'il comporte du phényl-éthylbarbiturate d'ajmaline. 3. - Heart rate regulator, characterized in that it includes ajmaline phenyl-ethylbarbiturate.
BE659797D 1965-02-16 BE659797A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE9045 1965-02-16

Publications (1)

Publication Number Publication Date
BE659797A true BE659797A (en)

Family

ID=3839808

Family Applications (1)

Application Number Title Priority Date Filing Date
BE659797D BE659797A (en) 1965-02-16

Country Status (2)

Country Link
BE (1) BE659797A (en)
FR (1) FR5174M (en)

Also Published As

Publication number Publication date
FR5174M (en) 1967-06-19

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