BE542038A - - Google Patents

Info

Publication number

BE542038A

BE542038A BE542038DA BE542038A BE 542038 A BE542038 A BE 542038A BE 542038D A BE542038D A BE 542038DA BE 542038 A BE542038 A BE 542038A

Authority

BE

Belgium

Prior art keywords

neomycin

tetracycline

sep

weight

antibiotics

Prior art date

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 30
• 229930101283 tetracycline Natural products 0.000 claims description 25
• 229930193140 Neomycin Natural products 0.000 claims description 24
• 229960004927 neomycin Drugs 0.000 claims description 24
• 239000004098 Tetracycline Substances 0.000 claims description 22
• 229960002180 tetracycline Drugs 0.000 claims description 22
• 235000019364 tetracycline Nutrition 0.000 claims description 22
• 150000003522 tetracyclines Chemical class 0.000 claims description 22
• 238000000034 method Methods 0.000 claims description 7
• 239000004480 active ingredient Substances 0.000 claims description 6
• 230000001225 therapeutic effect Effects 0.000 claims description 4
• PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 3
• 229940053050 neomycin sulfate Drugs 0.000 claims description 3
• 239000011149 active material Substances 0.000 claims 4
• XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• 229960004989 tetracycline hydrochloride Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 description 15
• 229940088710 antibiotic agent Drugs 0.000 description 15
• 244000005700 microbiome Species 0.000 description 14
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
• 230000000694 effects Effects 0.000 description 7
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 6
• 210000001035 gastrointestinal tract Anatomy 0.000 description 5
• 230000002401 inhibitory effect Effects 0.000 description 5
• 230000003115 biocidal effect Effects 0.000 description 4
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
• NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 3
• 239000008187 granular material Substances 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 238000011282 treatment Methods 0.000 description 3
• 235000002767 Daucus carota Nutrition 0.000 description 2
• 244000000626 Daucus carota Species 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 235000019359 magnesium stearate Nutrition 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
• 241000588769 Proteus <enterobacteria> Species 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 230000000721 bacterilogical effect Effects 0.000 description 1
• 150000007514 bases Chemical class 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
• 239000011363 dried mixture Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 239000008240 homogeneous mixture Substances 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 239000000391 magnesium silicate Substances 0.000 description 1
• 229940099273 magnesium trisilicate Drugs 0.000 description 1
• 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
• 235000019793 magnesium trisilicate Nutrition 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 244000000010 microbial pathogen Species 0.000 description 1
• AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 150000004760 silicates Chemical class 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 229910001220 stainless steel Inorganic materials 0.000 description 1
• 239000010935 stainless steel Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 239000001043 yellow dye Substances 0.000 description 1