BE518171A - - Google Patents

Info

Publication number

BE518171A

BE518171A BE518171DA BE518171A BE 518171 A BE518171 A BE 518171A BE 518171D A BE518171D A BE 518171DA BE 518171 A BE518171 A BE 518171A

Authority

BE

Belgium

Prior art keywords

formaldehyde

hydrazide

isonicotinic acid

condensation product

isonicotin

Prior art date

Links

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• WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 57
• QRXWMOHMRWLFEY-UHFFFAOYSA-N Isoniazid Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims description 22
• 239000007859 condensation product Substances 0.000 claims description 12
• TWBYWOBDOCUKOW-UHFFFAOYSA-N Isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 11
• 150000001875 compounds Chemical class 0.000 claims description 11
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
• 238000000034 method Methods 0.000 claims description 8
• 239000000203 mixture Substances 0.000 claims description 5
• 125000000217 alkyl group Chemical group 0.000 claims description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
• 229920002866 paraformaldehyde Polymers 0.000 claims description 4
• XHPATTUCUMRIEX-UHFFFAOYSA-N 2-methylpyridine-4-carbohydrazide Chemical compound CC1=CC(C(=O)NN)=CC=N1 XHPATTUCUMRIEX-UHFFFAOYSA-N 0.000 claims description 3
• ONQAABHBBACQBI-UHFFFAOYSA-N 2-ethylpyridine-4-carbohydrazide Chemical compound CCC1=CC(C(=O)NN)=CC=N1 ONQAABHBBACQBI-UHFFFAOYSA-N 0.000 claims description 2
• PMDHIMMPXRSDML-UHFFFAOYSA-N 2-methylpyridine-4-carboxylic acid Chemical compound CC1=CC(C(O)=O)=CC=N1 PMDHIMMPXRSDML-UHFFFAOYSA-N 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 230000001476 alcoholic Effects 0.000 claims 1
• 239000000047 product Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 239000002244 precipitate Substances 0.000 description 8
• 210000004940 Nucleus Anatomy 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• 238000002360 preparation method Methods 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• 229940042795 Hydrazides for tuberculosis treatment Drugs 0.000 description 2
• 238000001816 cooling Methods 0.000 description 2
• YRCQSPCQYCXBJK-UHFFFAOYSA-N 2-ethylisonicotinic acid Chemical compound CCC1=CC(C(O)=O)=CC=N1 YRCQSPCQYCXBJK-UHFFFAOYSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 230000000973 chemotherapeutic Effects 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• -1 for example Chemical compound 0.000 description 1
• 239000008098 formaldehyde solution Substances 0.000 description 1
• 239000000155 melt Substances 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 201000008827 tuberculosis Diseases 0.000 description 1