BE430582A - - Google Patents

Info

Publication number

BE430582A

BE430582A BE430582DA BE430582A BE 430582 A BE430582 A BE 430582A BE 430582D A BE430582D A BE 430582DA BE 430582 A BE430582 A BE 430582A

Authority

BE

Belgium

Prior art keywords

hormone

water

solution

milligrams

blood

Prior art date

Links

• Espacenet
• Global Dossier
• Discuss

• 229940088597 hormone Drugs 0.000 claims description 15
• 239000005556 hormone Substances 0.000 claims description 15
• 239000008280 blood Substances 0.000 claims description 10
• 210000004369 blood Anatomy 0.000 claims description 10
• 238000000034 method Methods 0.000 claims description 10
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
• 150000007530 organic bases Chemical class 0.000 claims description 5
• 210000000496 pancreas Anatomy 0.000 claims description 4
• 238000002360 preparation method Methods 0.000 claims description 3
• 239000012736 aqueous medium Substances 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 239000007795 chemical reaction product Substances 0.000 claims 2
• 239000008267 milk Substances 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
• 150000001875 compounds Chemical class 0.000 description 5
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 5
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 4
• 102000052651 Pancreatic hormone Human genes 0.000 description 3
• 101800001268 Pancreatic hormone Proteins 0.000 description 3
• 229940125396 insulin Drugs 0.000 description 3
• 239000004025 pancreas hormone Substances 0.000 description 3
• 229940032957 pancreatic hormone Drugs 0.000 description 3
• 102000004877 Insulin Human genes 0.000 description 2
• 108090001061 Insulin Proteins 0.000 description 2
• UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
• 206010062767 Hypophysitis Diseases 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• DZBUGLKDJFMEHC-UHFFFAOYSA-O acridine;hydron Chemical compound C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-O 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 229940050176 methyl chloride Drugs 0.000 description 1
• 210000003635 pituitary gland Anatomy 0.000 description 1
• 230000001376 precipitating effect Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 229940070353 protamines Drugs 0.000 description 1
• 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 239000005526 vasoconstrictor agent Substances 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1
• NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
• 235000009529 zinc sulphate Nutrition 0.000 description 1
• 239000011686 zinc sulphate Substances 0.000 description 1