BE2011C027I2 - - Google Patents

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Publication number
BE2011C027I2
BE2011C027I2 BE2011C027C BE2011C027C BE2011C027I2 BE 2011C027 I2 BE2011C027 I2 BE 2011C027I2 BE 2011C027 C BE2011C027 C BE 2011C027C BE 2011C027 C BE2011C027 C BE 2011C027C BE 2011C027 I2 BE2011C027 I2 BE 2011C027I2
Authority
BE
Belgium
Prior art keywords
aqueous liquid
liquid preparation
rhinitis
preservative
useful
Prior art date
Application number
BE2011C027C
Other languages
French (fr)
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32767329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2011C027(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Publication of BE2011C027I2 publication Critical patent/BE2011C027I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation. Also, the aqueous liquid preparation of the present invention in the form of a nasal drop is useful for the treatment of allergic rhinitis and inflammatory rhinitis (e.g. chronic rhinitis, hypertrophic rhinitis, nasal polyp, etc.).
BE2011C027C 2003-01-21 2011-08-30 BE2011C027I2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003012427 2003-01-21

Publications (1)

Publication Number Publication Date
BE2011C027I2 true BE2011C027I2 (en) 2023-03-07

Family

ID=32767329

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2011C027C BE2011C027I2 (en) 2003-01-21 2011-08-30

Country Status (15)

Country Link
US (9) US8129431B2 (en)
EP (1) EP1586316B1 (en)
JP (1) JP4500261B2 (en)
KR (1) KR101059711B1 (en)
CN (1) CN100341498C (en)
AT (1) ATE393627T1 (en)
BE (1) BE2011C027I2 (en)
CA (2) CA3043910A1 (en)
DE (2) DE602004013420T2 (en)
ES (1) ES2301964T3 (en)
HK (1) HK1083468A1 (en)
HU (1) HUS1100022I1 (en)
MX (1) MX2016014404A (en)
PT (1) PT1586316E (en)
WO (2) WO2004064828A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552020B1 (en) * 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
DE602004013420T2 (en) * 2003-01-21 2009-06-04 Senju Pharmaceutical Co., Ltd. AQUEOUS LIQUID PREPARATION WITH 2-AMINO-3- (4-BROMOBENZOYL) PHENYL ACETIC ACID
ES2369089T3 (en) * 2004-11-05 2011-11-25 Senju Pharmaceutical Co., Ltd. WATERY OPTICAL DROPS WITH ACCELERATED INTRAOCULAR MIGRATION.
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations
US20100130580A1 (en) * 2006-01-25 2010-05-27 Aciex Therapeutics, Inc. Formulations and Methods for Treating Dry Eye
WO2007087609A2 (en) * 2006-01-25 2007-08-02 Aciex, Inc. Formulations and methods for treating dry eye
MX2009009207A (en) * 2007-02-28 2010-02-12 Aciex Therapeutics Inc Methods and compositions for normalizing meibomian gland secretions.
MX2009012645A (en) * 2007-05-24 2010-03-08 Aciex Therapeutics Inc Formulations and methods for treating dry eye.
CN101313899B (en) * 2007-06-01 2012-02-29 北京德众万全药物技术开发有限公司 Medicament composition for eyes containing sodium bromfenac
CN101965183A (en) * 2008-02-21 2011-02-02 伊斯塔药品公司 Eye NSAID as adjuvant
RU2477631C2 (en) * 2008-03-17 2013-03-20 Алькон Рисерч, Лтд. Aqueous pharmaceutical compositions containing borate-polyol complexes
US8778999B2 (en) 2009-03-05 2014-07-15 Insite Vision Incorporated Non-steroidal anti-inflammatory ophthalmic compositions
TWI489997B (en) 2009-06-19 2015-07-01 Alcon Res Ltd Aqueous pharmaceutical compositions containing borate-polyol complexes
US8299295B2 (en) 2009-10-15 2012-10-30 Johnson Matthey Public Limited Company Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
GB2484843A (en) * 2009-10-15 2012-04-25 Johnson Matthey Plc Polymorphs of Bromfenac sodium
GB0919757D0 (en) * 2009-11-12 2009-12-30 Johnson Matthey Plc Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
WO2011058579A1 (en) * 2009-11-11 2011-05-19 Micro Labs Limited Pharmaceutical combination of prostaglandin compound and nsaid for the treatment of glaucoma and ocular hypertension
JPWO2012099142A1 (en) * 2011-01-18 2014-06-30 千寿製薬株式会社 Bromfenac aqueous liquid composition having storage efficacy
JP6012231B2 (en) * 2011-04-08 2016-10-25 ロート製薬株式会社 Bromfenac-containing composition
EP2701682A1 (en) 2011-04-29 2014-03-05 Allergan, Inc. Solvent cast film sustained release latanoprost implant
US20130023575A1 (en) * 2011-07-22 2013-01-24 Kamran Hosseini Compositions and methods for the treatment of ocular surface allergies
CA2852995C (en) 2011-10-12 2016-03-29 Bausch & Lomb Incorporated Ocular composition containing bromfenac with increased bioavailability
US20130165419A1 (en) * 2011-12-21 2013-06-27 Insite Vision Incorporated Combination anti-inflammatory ophthalmic compositions
US20130217657A1 (en) * 2011-12-21 2013-08-22 Insite Vision Incorporated Combination anti-inflammatory ophthalmic compositions
WO2014050301A1 (en) * 2012-09-27 2014-04-03 千寿製薬株式会社 Aqueous liquid medicine
JP6161500B2 (en) * 2012-10-05 2017-07-12 ロート製薬株式会社 Bromfenac-containing composition
EP2919755B1 (en) * 2012-11-19 2018-02-21 Bausch & Lomb Incorporated Aqueous liquid composition containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
US20150366966A1 (en) * 2013-01-31 2015-12-24 Senju Pharmaceutical Co., Ltd. Stable Aqueous Solution
WO2014119643A1 (en) 2013-01-31 2014-08-07 千寿製薬株式会社 Clear aqueous solution
WO2014120293A1 (en) * 2013-01-31 2014-08-07 Sentiss Pharma Pvt.Ltd. Ophthalmic formulations
EA201591910A1 (en) * 2013-06-19 2016-05-31 Сентисс Рисерч Центр STABLE BROMFENAKA SOLUTION
CN105451731B (en) * 2013-09-26 2019-01-18 参天制药株式会社 Water-based composition containing stabilized 2- amino -3- (4- benzoyl bromide) phenylacetic acid
WO2015087267A2 (en) 2013-12-12 2015-06-18 Sentiss Pharma Private Limited Stable bromfenac ophthalmic solution
CN104151182B (en) * 2014-06-16 2016-03-30 广东众生药业股份有限公司 The preparation method of a kind of Bromfenac sodium times semihydrate
US11452732B2 (en) 2015-09-05 2022-09-27 Randal Davis Homogeneous ophthalmic composition
US10130639B1 (en) 2015-09-05 2018-11-20 Randal Davis Homogeneous ophthalmic composition
CN106404952B (en) * 2016-08-31 2019-06-11 辰欣佛都药业（汶上）有限公司 A kind of measuring method of the sodium bromophenolate eye drops in relation to substance

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2880130A (en) 1956-12-24 1959-03-31 Upjohn Co Anti-inflammatory steroid solutions
US2880138A (en) 1956-12-24 1959-03-31 Upjohn Co Anti-inflammatory steroid solutions
SE400966B (en) 1975-08-13 1978-04-17 Robins Co Inc A H PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS
US4683242A (en) 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
GB8630273D0 (en) 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
IL87724A (en) * 1987-09-11 1992-01-15 Syntex Inc Ophthalmic compositions,their preparation and use
US5414011A (en) 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US4910225A (en) * 1988-01-27 1990-03-20 Senju Pharmaceutical Co., Ltd. Locally administrable therapeutic composition for inflammatory disease
JPH0283323A (en) * 1988-09-20 1990-03-23 Zeria Pharmaceut Co Ltd Stable aqueous solution of riboflavin butyrate
JPH02124819A (en) 1988-11-01 1990-05-14 Mitsubishi Kasei Corp Oral cholesterol lowering agent
JPH05223052A (en) 1992-02-06 1993-08-31 Kanematsu Eng Kk Current generator utilizing wave energy and hydrogen gas generator therewith
EP0656779B1 (en) 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
WO1994015597A1 (en) 1993-01-11 1994-07-21 Allergan, Inc. Ophthalmic compositions comprising benzyllauryldimethylammonium chloride
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
CN1091597C (en) 1994-03-15 2002-10-02 千寿制药株式会社 Method for stabilizing pranoprofen and stable liquid formulation of pranoprofen
ES2079320B1 (en) 1994-05-17 1996-10-16 Cusi Lab OPHTHALMIC DISSOLUTION BASED ON A DICLOFENACO AND TOBRAMYCIN AND ITS APPLICATIONS.
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
AU3609795A (en) 1994-10-10 1996-05-02 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US5558876A (en) * 1995-03-29 1996-09-24 Alcon Laboratories, Inc. Topical ophthalmic acidic drug formulations
US5750564A (en) * 1995-09-12 1998-05-12 Hellberg; Mark Anti-oxidant esters of non-steroidal anti-inflammatory agents
US6071904A (en) * 1996-12-11 2000-06-06 Alcon Laboratories, Inc. Process for manufacturing ophthalmic suspensions
US6274592B1 (en) * 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
TW546151B (en) 1997-07-23 2003-08-11 Senju Pharma Co Aqueous liquid pharmaceutical composition containing as main component benzopyran derivative
JPH11228404A (en) * 1997-12-11 1999-08-24 Senju Pharmaceut Co Ltd Stable aqueous eye drop
US6066671A (en) * 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6162393A (en) * 1998-08-06 2000-12-19 Ndt, Inc. Contact lens and ophthalmic solutions
US6319513B1 (en) * 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6369112B1 (en) * 1998-12-15 2002-04-09 Bausch & Lomb Incorporated Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
AU6917400A (en) 1999-08-31 2001-03-26 Alcon Laboratories, Inc. Use of 5-ht1b/1d agonists to treat otic pain
HUP0202745A2 (en) 1999-09-06 2003-01-28 Ono Pharmaceutical Co., Ltd. Preventive and therapeutic agents for treatment of eye diseases
AR030345A1 (en) 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
JP2002308764A (en) * 2001-02-09 2002-10-23 Taisho Pharmaceut Co Ltd Pharmaceutical composition for ophthalmic use
DE602004013420T2 (en) * 2003-01-21 2009-06-04 Senju Pharmaceutical Co., Ltd. AQUEOUS LIQUID PREPARATION WITH 2-AMINO-3- (4-BROMOBENZOYL) PHENYL ACETIC ACID
ATE552838T1 (en) * 2003-11-14 2012-04-15 Senju Pharma Co AQUEOUS SOLUTION WITH AMINOGLYCOSIDE ANTIBIOTIC AND BROMEFENAC
CA2852995C (en) * 2011-10-12 2016-03-29 Bausch & Lomb Incorporated Ocular composition containing bromfenac with increased bioavailability
EP2919755B1 (en) * 2012-11-19 2018-02-21 Bausch & Lomb Incorporated Aqueous liquid composition containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid

Also Published As

Publication number Publication date
WO2004064828A1 (en) 2004-08-05
US8754131B2 (en) 2014-06-17
EP1586316A1 (en) 2005-10-19
EP1586316B1 (en) 2008-04-30
CN100341498C (en) 2007-10-10
ATE393627T1 (en) 2008-05-15
MX2016014404A (en) 2017-10-27
US9144609B2 (en) 2015-09-29
US20140142183A1 (en) 2014-05-22
US8669290B2 (en) 2014-03-11
US20070287749A1 (en) 2007-12-13
DE602004013420D1 (en) 2008-06-12
HK1083468A1 (en) 2006-07-07
DE122011100019I1 (en) 2011-11-03
DE602004013420T2 (en) 2009-06-04
US8129431B2 (en) 2012-03-06
CA3043910A1 (en) 2015-11-12
CN1700913A (en) 2005-11-23
PT1586316E (en) 2008-05-28
KR20050092691A (en) 2005-09-22
CA2944832C (en) 2019-10-08
US20150011634A1 (en) 2015-01-08
CA2944832A1 (en) 2015-11-12
ES2301964T3 (en) 2008-07-01
US9561277B2 (en) 2017-02-07
US8497304B2 (en) 2013-07-30
JP4500261B2 (en) 2010-07-14
US20120115957A1 (en) 2012-05-10
US8871813B2 (en) 2014-10-28
US8927606B1 (en) 2015-01-06
US20140243413A1 (en) 2014-08-28
US20150025149A1 (en) 2015-01-22
JPWO2004064828A1 (en) 2006-05-18
US20050239895A1 (en) 2005-10-27
HUS1100022I1 (en) 2017-04-28
KR101059711B1 (en) 2011-08-29
US20140235721A1 (en) 2014-08-21
WO2015170177A1 (en) 2015-11-12
US20130090384A1 (en) 2013-04-11
EP1586316A4 (en) 2007-06-27

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