BE1029964B1 - KIT FOR USE IN THE TREATMENT OF HUMAN SCARS - Google Patents

Abstract

The invention relates to a kit (1) for use in the treatment of human scars, comprising spatially separated components for use in assembling and attaching a scar treatment tape to one or more scars on human skin (2), wherein the components of the kit (1) comprise a first adhesive layer (3) for contacting one or more scars on which it is used and a second adhesive layer (4) configured to be overlaid on the first adhesive layer (3 ) so as to exceed the latter circumferentially during use.

Description

KIT FOR USE IN THE TREATMENT OF HUMAN SCARS

TECHNICAL AREA

The present invention relates to a kit for use in the treatment of human scars.

PRIOR ART

Scars that form during the healing of human skin wounds are often treated after healing is complete with cosmetics or surgical treatment. Cosmetic treatments are temporary solutions at best, and the need for subsequent surgery is both inconvenient and risky for the patient. It is therefore desirable to provide means for treating scars effectively, with optimum scar reduction, and with minimum effort and inconvenience to the human patient.

In this context, EP2931327A2 discloses a kit comprising non-crosslinked hyaluronic acid and crosslinked alginate both included in a hydrogel film; and a calcium chelator; wherein (a) the alginate is cross-linked with calcium, (b) the hydrogel film is flat and includes a width, a length and a thickness which is less than the width and the length, and (c) the hydrogel film is configured such that the resorbability of the hydrogel film increases in response to application of the calcium chelator to the hydrogel film. A membrane thus formed according to EP2931327A2 can be used to avoid undesirable scars after surgery.

The membrane of EP2931327A2 lacks potential for compression and scar contraction. Additionally, the EP2931327A2 membrane lacks sufficient potential for drainage of sweat and/or other bodily fluids formed on the skin beneath the membrane, requiring early membrane replacements during treatment. As a result, such a membrane must be replaced regularly, which complicates ongoing scar treatment with this tape, leading to suboptimal scar reduction.

The present invention aims to find a solution to at least some of the problems mentioned above.

SUMMARY OF THE INVENTION

The invention provides a kit for use in the treatment of human scars, according to claim 1. Preferred arrangements of the kit are described in claims 2 to 15.

BRIEF DESCRIPTION OF FIGURES

Fig. 1 and 2 are schematic presentations of a kit for use in the treatment of human scars, according to the preferred arrangements of the invention.

DETAILED DESCRIPTION OF THE INVENTION

The enumeration of numeric scales by endpoints includes all numbers and fractions included in that scale, along with the endpoints shown.

The term "hot melt adhesive" generally refers to a class of adhesives which are supplied in solid form at room temperature and flow when warmed to allow application to one or more substrates. On cooling, the adhesive returns to a solid form and the humidity decreases to stick to the substrate.

The term "polyolefin compounds" means any polymerized olefin, which may be linear, branched, cyclic, aliphatic, aromatic, substituted or unsubstituted. More specifically, the term "polyolefin compounds" includes olefin homopolymers, olefin copolymers, copolymers of an olefin and a non-olefin comonomer copolymerizable with the olefin, such as vinyl monomers, resulting polymers, and the like. Specific examples include polyethylene homopolymer, polypropylene homopolymer, polybutene homopolymer, ethylene alpha-olefin copolymer, propylene alpha-olefin copolymer, butene alpha-olefin copolymer, ethylene unsaturated ester, ethylene unsaturated acid copolymer, (for example, ethylene ethyl acrylate copolymer, ethylene-butyl acrylate copolymer, ethylene-methyl acrylate copolymer, ethylene-acrylic acid copolymer and ethylene-methacrylic acid copolymer), ethylene-vinyl acetate copolymer, ionomer resin, polymethylpentene, etc.

The term "silicone" refers to any viscous composition having polymerized siloxane or polysiloxane. Polysiloxanes have a silicon-oxygen structure (Si-

O-Si-O-Si-O-) and an organic group (such as methyl, ethyl or phenyl) attached.

The silicone may for example be a linear silicone oil of the non-crosslinked polydimethylsiloxane type. Alternatively, the silicone may for example be of the crosslinked organosiloxane type. The silicone can be in the form of an emulsion. Suitable emulsions include, but are not limited to, water-in-silicone emulsions, oil-in-water emulsions, and silicone-in-water emulsions. Combinations of one or more types of silicones with another component are also possible, such as mixtures of one or more types of silicone with polytetrafluoroethylene.

By the term “spatially separated”, it is meant that the components of the kit according to the invention exist separately from each other in the disconnected state. By purchasing said kit, for example, from a doctor or patient, the doctor or patient can orient, assemble and attach the individual components as desired, for practical application to human skin of the multilayer tape thus formed for treating scars.

This allows an ideal application of the tape and at the same time allows a good storage of the individual components.

“Hydrocolloid material” means compounds commonly used in the art, known for their ability to absorb hydrophilic liquids, in particular water, and to transport them rapidly. Non-limiting examples of suitable hydrocolloid materials are one or more compounds of the following classes: organic, natural materials, such as, for example, agar agar, carrageenan, tragacanth, gum arabic, guar gum, locust bean gum, karaya gum, alginates, pectins, polysaccharides, guar flour, locust bean flour, starches, dextrins, gelatins and casein; modified organic natural materials such as, for example, carboxymethylcellulose and other cellulose ethers, hydroxyethylcellulose, hydroxypropylcellulose, microcrystalline cellulose and the like; all alkali metal salts, such as sodium or calcium, of the above compounds; and inorganic materials, for example, polysilicic acids, clay minerals such as montmorillonites, zeolites and silicas. These hydrocolloid materials can be used alone or in combination.

The term "polyurethane" refers to polymeric or oligomeric materials comprising urethane groups, urea groups, or both. It should be understood that the term "polyurethane" as used herein is not limited to polymers which include only urethane or polyurethane linkages. It is well understood in the art of polyurethane preparation that polyurethane polymers may also include allophanate, carbodiimide, uretidinedione and other linkages in addition to urethane linkages.

The term "film material" refers to a thin-film plastic material. Non-limiting examples of plastic materials that can act as a film material are polyolefins such as polypropylene and polyethylene; polyesters; polyamides; polyurethanes; polyvinyl halides such as polyvinyl chloride; acetates; biopolymers, including cellulose and cellulose derivatives, polylactic acid and polyhydroxy acid; and compatible combinations, blends or copolymers of at least two of them.

The term "UV blocking agents" refers to agents that block UV rays or UV radiation. UV blockers are preferably inorganic, organic or metallic. Examples of such agents include, but are not limited to; muscovite, phlogopite, biotite, sericite, fushtite, margarite, synthetic mica, metal oxide coated mica, colored pigment coated mica, talc, benzotriazole, e.g. chlorobenzotriazoles, acid para-aminobenzoic acid, metal oxides, metal hydroxides, mixed metal oxides and hydroxides, metal and mixed metal silicates and aluminosilicates, transition metal oxides and hydroxides, TiO2, ZrO2, Fe20;3, natural clay, metallic — sulphides, non-metallic elements, ionic salts and covalent salts, powdered ceramics, organic polymers, natural polymers, soluble organic materials and biomaterials, in particular UV-absorbing molecules, l aluminium, copper, copper-bronze, bronze-gold, silver and collagen. In preferred arrangements, these UV blockers comprise one or more particles.

The term "plane vector", as used in this text, refers to a direction according to the plane formed by a considerably to completely flat or plane object.

The invention provides a kit for use in the treatment of human scars, according to claim 1.

The second adhesive layer is thus configured to press the first adhesive layer towards the scar or scars. In use, the first adhesive layer of the kit is placed on a portion of human skin that has one or more scars. Subsequently, the second adhesive layer is placed over the first adhesive layer while at the same time outer portions of the second adhesive layer are placed on the skin, in order to press the first adhesive layer towards the scar(s). In this way, a multi-layered scar treatment tape is formed on the skin for scar treatment. Preferably, the second adhesive layer has self-adhesive properties to allow attachment to human skin. Alternatively, an additional adhesive layer can be applied to provide attachment between the second adhesive layer and the skin. Preferably, the first adhesive layer has self-adhesive properties to allow attachment to human skin. Alternatively, another additional adhesive layer may be applied to provide attachment between the first adhesive layer and the skin.

By pressing the first adhesive layer towards the scar(s) together with the mentioned second adhesive layer, compression and contraction of the scars is achieved by the thus formed and pressed scar treatment tape. Compression and contraction of — scars are the most effective physical operations for treating scars. The scar treatment tape thus pressed in particular exerts pressure on one or more scars present on the skin and also allows a rise in temperature on one or more scars. These two physical actions have a pronounced effect on the natural reorganization of the tissue of the scar(s): the activity of collagenase, a key enzyme in the remodeling process, is increased, the microcirculation in the scar(s) is activated and an improvement blood flow is impaired. As a result, the pressure and contraction performed reduces the collagen synthesis phase during scar healing and accelerates the maturation phase. In preferred arrangements, the second adhesive layer, optionally combined with said additional adhesive layer, is stretched while being applied to both the skin and the first adhesive layer. Preferably, the tape is applied along the length of the scars. Preferably, the tape assembled from a kit according to the invention is also applied continuously to human skin for a very long period, from more than 4 weeks up to 2-3 months or more, without being replaced.

By initially providing the scar treatment tape kit components as spatially separated components, the different components can be applied and combined just prior to use to assemble the tape, providing storage and efficient use of materials.

The preferred arrangements of the kit are described in claims 2 to 15.

The preferred arrangement of the kit according to claim 2 shows the advantage of the dimensioning of the second adhesive layer with respect to the first adhesive layer. Such dimensioning allows the second adhesive layer to be easily superimposed on the first adhesive layer so as to protrude circumferentially, and this independently of whether the second adhesive layer is stretched by being placed on the first adhesive layer used.

The preferred arrangement of the kit according to claim 3 shows that silicones have the advantage of whitening scars on contact. Preferably, the contact between the first adhesive layer comprising one or more silicones and the scar or scars on the skin must at least be maintained during the collagen synthesis phase and is also beneficial during the maturation phase, thus representing a period of 3 to 6 months. Silicones have the added advantage of being sticky materials. Consequently, good attachment between a first adhesive layer comprising one or more silicones with the scar(s) on the skin, and between said first adhesive layer with the second adhesive layer, is possible by the sticky nature of the silicone(s).

The preferred arrangement of the kit according to claim 4 shows the advantage of the perforations allowing water to pass through. Water on human skin can pass through the perforations in the first adhesive layer. This water is particularly sweat but can also come from other bodily fluids or can also be any water present on the skin before the application of the first adhesive layer. The perforations exert capillary forces. The transport of water away from the human skin is carried out by these capillary forces. By allowing wicking of skin perspiration while the first perforated adhesive layer is applied to human skin, frequent replacement of the tape is not necessary and the entire tape can be applied uninterrupted to human skin for a long time. period. As a result, only a few replacements are needed when treating the scar with the tape, and the treatment can be adhered to better. This results in more continuous contact of the tape with the scars, and therefore improved scar treatment. Thus, the tape assembled from a kit according to the invention can be applied continuously to human skin for a very long period, from more than 4 weeks up to 2-3 months or more without any side effects apart from a allergy that may occur. Normal scar compression/contraction treatment should last 3-6 months; if the tape does not have to be changed often or does not have to be changed at all, it is easier to use, and thus results in better treatment compliance.

The preferred arrangement of the kit according to claim 5 has the advantage that the percentages of perforations according to said range allow sufficient transfer of water, in particular in the form of sweat, away from the skin through the first adhesive layer while having a sufficient surface area and quantity of material available to carry out the treatment of the scars.

In a more preferred arrangement of the kit according to claim 5, 5% to 20%, and more preferably 10% to 20% of the surface of the first adhesive layer is perforated.

The preferred arrangement of the kit according to claim 6 has the advantage that the individual perforation areas are not dimensioned excessively large relative to the surface of the first adhesive layer. This is important because too much sizing would lead to insufficient structural stability of the first adhesive layer and could also lead to an insufficient layer of material at the scars, which could decrease scar treatment.

In addition, the relative dimensioning of the zones of the individual perforations makes it possible to have a capillary force exerted by the perforations. In a preferred arrangement of the kit according to claim 6, the area of the first adhesive layer relates to the area of a perforation in a ratio of at least 40:1, even more preferably at least 50:1, even more preferably more preferably at least 100:1, even more preferably at least 200:1, even more preferably at least 250:1, even more preferably at least 500:1 and most preferably at least 1000 :1.

The preferred arrangement of the kit according to claim 7 shows the advantage of the dimensions of the perforations. These are large enough for the transfer of water away from the skin through the first adhesive layer, and also small enough to allow the capillary forces to be active on the one hand and to ensure sufficient coverage on the other hand. scars on the skin by the material of the first adhesive layer. In a more preferred arrangement of the kit according to claim 7, the first adhesive layer comprises perforations with dimensions from 2 µm to 4000 µm, preferably from 4 µm to 3500 µm, more preferably from 6 µm to 3000 µm, even more preferably from 8 µm to 2500 µm, and more preferably still 10 µm to 2000 µm.

The preferred arrangement of the kit according to claim 8 shows that a uniform distribution of the perforations allows a uniform transfer of water away from the skin through the perforations of the first adhesive layer. This effect has the advantage that there is a small risk of water, particularly in the form of sweat, accumulating in a certain area of the skin, which would lead to skin irritation and may require early replacement of the tape. treatment of scars on the skin.

In a preferred arrangement of the kit according to the invention, the perforations are of regular shape. The preferred arrangement of such a regular shape is a circle. Regularly shaped perforations, and preferably round perforations, have the advantage of allowing even transfer of water, particularly in the form of sweat, away from the skin through the perforations.

In a preferred arrangement of the kit according to the invention, the first adhesive layer has a thickness of between 10 μm and 250 μm and preferably between 10 μm and 50 μm. This so-called privileged thickness of the first adhesive layer allows the first adhesive layer to follow the curvatures and/or the movements of the skin while being thick enough to ensure easy handling. Also, in combination with the small dimensions of the perforations, said preferred thicknesses of the first adhesive layer are ideally suited to give sufficient capillary force to the perforations of this first adhesive layer, allowing the transport of water, in particular in the form of sweat, away from the skin.

In a preferred arrangement of the kit according to the invention, the second adhesive layer is configured to evacuate water vapour. The heat produced by the human body vaporizes the water which is transported away from the human skin through the perforations of the first adhesive layer. The second adhesive layer is preferably configured to release water vapor by having sufficient water vapor permeability that allows transport of water vapor away from the first adhesive layer and through the second adhesive layer. Thanks to this, water is prevented from being trapped between the first and the second adhesive layers, thus facilitating prolonged use of the tape. … The preferred arrangement of the kit according to claim 9 shows that said water vapor permeabilities, measured according to the ISO 2528 standard, and according to this same scale, are perfectly suited to allow water vapor to be transported of the first adhesive layer through the second adhesive layer. In an even more ideal preferred arrangement of the kit according to claim 9, the second adhesive layer has a — water vapor permeability (ISO 2528) of 300 g/(m2 x 24 h) to 1500 g/(m2 x 24 h).

The preferred arrangement of the kit according to claim 10 shows the advantage that these compounds are known to have good flexibility properties, which is desired for such close contact between the scar treatment tape and the skin of a being. human. Preferably, the second adhesive layer comprising one or more of said compounds is stretchable to a sufficient extent, so that a scar treatment tape assembled from a kit according to the invention can be easily and correctly applied to skin. human.

The preferred arrangement of the kit according to claim 11 shows the advantage of polyurethane which is known to have great flexibility and good water vapor permeability, which is beneficial for the healing process of one or more scars. with the use of a scar treatment tape assembled from the kit according to the invention. Preferably, a second adhesive layer comprising polyurethane has a water vapor permeability (ISO 25 2528) of 300 g / (m2 x 24 h) to 400 g / (m2 x 24 h), which allows excellent drainage of water from the first adhesive layer through the second adhesive layer. In addition, polyurethane has good UV filtering properties and thus protects sensitive scar tissue against UV rays.

Further, a second adhesive layer comprising polyurethane exhibits high skin conformability such that no unwanted gaps are left between the skin and the tape when the latter is applied to human skin.

Polyurethane has the additional advantage of being able to be produced in a very thin but very resistant layer. Due to the thinness and strength of such a polyurethane layer as a second adhesive layer, it is very suitable to apply the tape continuously to human skin for long periods of time. The thinness prevents the edges from curling if lateral force is applied. Polyurethane has the other advantage of being a translucent material, and thus offers great visibility of the materials behind it. A second adhesive layer formed of a thin layer of polyurethane thus takes on the color of the underlying skin. If it is discreet, compliance with the treatment is better. Polyurethane has the advantage that a second adhesive layer comprising polyurethane or made from polyurethane has perfect elasticity with respect to the traction necessary to obtain a continuous compression/contraction couple. Also, the adaptability of a polyurethane layer to any anatomical area is worth mentioning. As it is flexible, polyurethane can be stuck to any part of the human body. Another advantage of polyurethane is that it is waterproof; it can be kept in water, so there is no need to change the tape if the person wearing the tape comes into contact with water, such as walking in the rain, swimming, taking a bath or while taking a shower.

Another particular advantage of polyurethane is its self-adhesive property, which avoids the need for an additional application of an adhesive layer on the second adhesive layer to fix the latter to the skin.

In a preferred arrangement of the kit according to the invention, the second adhesive layer has a thickness of between 5 μm and 1100 μm, more preferably between 10 μm and 500 μm, even more preferably between 12 μm and 200 μm, and even more preferably between 14 um and 100 um and more preferably between 15 um and 50 um. The thickness of the second adhesive layer in these ideal dimensions allows the second adhesive layer to follow the curvatures and/or movements of the skin while the second adhesive layer is thick enough to ensure easy manipulation of the layer.

The preferred arrangement of the kit according to claim 12 shows the advantage that the UV blocking agent(s) blocks UV rays. This addition of UV blocking agents can be used to fine tune the degree of UV blocking achieved by the tape. … The preferred arrangement of the kit according to claim 13 shows the advantage of the water absorption function that the absorbent layer performs. In use, the water-absorbent layer is placed, preferably in advance, adjacent to the first adhesive layer, and is so used opposite human skin. Then the second adhesive layer will be placed over the combination of the first adhesive layer and the water absorbing layer. During perspiration, the sweat and therefore the water formed on the skin passes through the perforations of the first adhesive layer and is then absorbed by the water-absorbing layer. As a result, the surface of the skin remains dry, which helps to avoid skin maceration and irritation. The water absorbing layer swells due to water absorption. Preferably, the second adhesive layer is configured to wick away water vapor. The heat produced by the human body will vaporize the water present in the water-absorbing layer, after which the water vapor formed can be discharged through this second adhesive layer. This evaporation and transport of water prevents the water-absorbing layer from becoming oversaturated, facilitating prolonged use of the scar treatment tape formed by a kit according to the invention.

In a preferred arrangement of the kit according to the invention, the water-absorbing layer has a thickness comprised between 10 μm and 250 μm or, preferably, a thickness between 10 μm and 50 μm. The preferred thickness of the water-absorbing layer is large enough to provide the layer with sufficient water-absorbing capacity.

The preferred arrangement of the kit according to claim 14 has the advantage that hydrocolloid materials are ideal components for the water-absorbent layer because they are known for their ability to absorb hydrophilic liquids, in particular water, and to transport quickly. In addition to this functionality, hydrocolloid materials are also known to block UV rays, thereby shielding scars from UV rays when a scar treatment tape assembled from a kit according to the invention is applied to human skin. . As a result, the unwanted redness and pigmentation that (young) scars suffer from after exposure to UV radiation is avoided.

The preferred arrangement of the kit according to claim 15 shows the advantage that the distribution of the layers in the upper assembly and the lower assembly is ideally suited to assemble and fix the scar treatment tape correctly and hygienically on the human skin. . The so-called peel-off liners, the additional peel-off liner, and the protective layer protect the individual layers of the kit before use. Accordingly, it allows good and long storage of the layers of the kit. The provision of the kit as a combination of an upper mount and a lower mount allows for intuitive use and guides the user through correct application of the scar treatment tape using the kit components. The bottom assembly should be used first. Therefore, the additional release liner and, when present, the protective layer, are first removed after which the first adhesive layer is applied to an area of one or more scars on human skin. In a next step, the top assembly should be used. Therefore, the two release liners are first removed, after which the second adhesive layer, or alternatively when present, the additional adhesive layer, is pressed against the water absorbing layer and the skin. In preferred arrangements, the second adhesive layer, and when present, the additional adhesive layer, are stretched while being so applied.

In a preferred arrangement of the kit according to the invention, the detachable liners and/or the other detachable liner comprise a paper or a film material. These material choices have the advantage of providing strippable liners and/or other strippable liners that are ideally suited to protect adjacent layers of the kit from the environment. Preferably, said paper or filmic material is siliconed. In the current text, the term "silicone" is also understood in its conventional meaning of providing a material with a silicone coating.

In a preferred arrangement of the kit according to the invention, the additional adhesive layer comprises a pressure-sensitive adhesive based on rubber or acrylic.

This hot melt rubber or acrylic based pressure sensitive adhesive has several properties that can help to compress and contract one or more scars: a) It increases the hydration of the stratum corneum and thus facilitates the regulation of the production fibroblasts and reduced collagen production. This results in a softer, flatter scar. It allows the skin to "breathe". b) It protects scar tissue from bacterial invasion and prevents bacteria-induced excess collagen production in scar tissue. c) It modulates the expression of growth factors, fibroblast growth factor B (FGF B) and tumor growth factor B (TGF B). TGF B stimulates fibroblasts to synthesize collagen and fibronectin. FGF B normalizes collagen synthesis in an abnormal scar and increases collagenase levels which break down excess collagen. The balance of fibrogenesis and fibrolysis is finally restored. d) It reduces itching and discomfort associated with scarring.

Such a rubber or acrylic based pressure sensitive adhesive can be easily attached to human skin by the simple application of pressure, obviating the need for solvent, water or heat for activation of the adhesive. 'adhesive. This both facilitates attachment of the assembled tape and improves standard hygienic use. The choice of a rubber or acrylic based pressure sensitive adhesive for said tie layer should not be taken for granted by a person skilled in the art, as that person would instead choose a more conventional approach comprising the using an adhesive that requires solvent, water or heat for adhesive activation. In more preferred arrangements, the pressure-sensitive adhesive is a solvent-based acrylic adhesive, since these adhesives exert strong adhesion.

Strong adhesion of the additional adhesive layer is necessary to ensure adequate adhesion to skin since the second adhesive layer and the additional adhesive layer will preferably be stretched upon application to skin. Furthermore, the strong adhesion property ensures that the additional adhesive layer adheres adequately to multiple skin types and that the adhesive strength of the tie layer resists any memory effect of the second adhesive layer as a result of stretching of this second adhesive layer. In this way, the second adhesive layer can maximally maintain its stretched configuration, which is beneficial for said pressure and temperature effect which is exerted on one or more scars on a skin. In the preferred arrangements, the pressure sensitive adhesive further has approved cytotoxicity. In other arrangements, polyacrylate-based, polyisobutylene-based and/or silicone-based pressure-sensitive adhesives can be chosen as the material for said additional adhesive layer.

In yet other arrangements, said additional adhesive layer comprises cyanoacrylate. Preferably, the adhesive selected for the additional adhesive layer has approved cytotoxicity. In the preferred arrangements, said additional adhesive layer has a thickness of between 5 μm and 300 μm, more preferably between 10 μm and 200 μm and even more preferably between 20 μm and 100 μm. In the preferred arrangements, said additional adhesive layer comprises one or more adhesives, i.e. a total amount of 20 g/m: to 60 g/m, more preferably 30 g/m: to 50 g/m: and even more preferably 35 g/m:at 45 g/m. Said thicknesses of said additional adhesive layer and/or said amounts of one or more adhesives in said additional adhesive layer ensure a good balance between adhesion and cohesion, and thus guarantee good adhesive properties. Said thicknesses of the additional adhesive layer also make it possible to have a certain humidity and/or temperature regulation around one or more scars. Furthermore, said thicknesses are sufficient to allow the sides of the second adhesive layer that protrude from the surface of the first adhesive layer to be oriented at a sufficiently large angle with respect to a skin surface, so that sufficient pressure can be applied to one or more scars on the skin.

In a preferred arrangement of the kit according to the invention, the protective layer comprises a paper or a film material. Said material choices have the advantage of having a protective layer which is perfectly suited to protect one side of the water-absorbing layer from the environment. Preferably, said paper or filmic material is siliconed.

In another arrangement of the kit according to the invention, the kit further comprises one or more edge sealing tapes.

Said edge sealing tapes are particularly desired if the dimensions of the second adhesive layer in all plane vectors are only slightly larger than the dimensions of the first adhesive layer and the water-absorbing layer. Said edge sealing tapes are suitable for sealing the edges of the second adhesive layer when a scar treatment tape assembled from the kit according to the invention is applied to human skin. In the preferred arrangements, two edge sealing tapes, preferably with parallel orientation to each other, are applied to two opposite edges of the tape, in order to completely avoid the mere possibility of detachment of the tape from the skin on which it is applied. In other preferred arrangements, two pairs of parallel oriented edge seal tapes are applied, both pairs oriented substantially perpendicular to each other and each pair is applied to two opposite edges of the tape. In preferred arrangements, said edge sealing tapes comprise a film layer, which film layer preferably comprises polyurethane, and an adhesive-containing layer, which adhesive-containing layer comprises a rubber-based pressure sensitive adhesive or acrylic, preferably a solvent based acrylic based pressure sensitive adhesive.

The invention is further described by the following non-limiting examples which further illustrate the invention, and are not intended to, nor should they be construed as, limiting the scope of the invention.

EXAMPLES

For the advantages and technical effects of the elements described below in the examples, reference is made to the advantages and technical effects of the corresponding elements described above in the detailed description.

Example 1

Example 1 relates to a kit for use in the treatment of human scars, according to the arrangements of the invention.

The kit according to this example includes spatially separated components for use in assembling and securing a scar treatment tape to one or more scars on human skin. The individual components of the kit according to Example 1 are shown below in Table 1. Please note that the row order of the table in which a component is shown corresponds to the relative position of a component in an attached assembled tape. to a human skin, in which a lower row indicates a position closer to a human skin.

Table 1 Composition of a kit for use in the treatment of human scars, according to example 1

Second layer Transparent self-adhesive polyurethane layer; 40 - 60 gsm adhesive:; layer thickness of 15 - 50 µm; water vapor permeability (ISO 2528) from 300 g / (m: x 24 h) to 400 g / (m: x 24 h)

Water absorbing layer Layer comprising hydrocolloids; 10-50um

First adhesive layer | Perforated layer comprising silicone; 10-50um perforated

Table 2 shows the specific properties related to the perforations of the first perforated adhesive layer.

Table 2 Perforation-related properties of the first perforated adhesive layer

Number of perforations in the first layer 10-20% adhesive

Ratio of the area of the first adhesive layer 500:1-1500:1 perforated to the area of a perforation

Puncture size 10 um to 2000 um

Diagram 1A gives a schematic representation of the kit according to example 1. The second adhesive layer 4 defines an area which is larger in all planar vectors than the individual areas defined by the first adhesive layer 3 and the water absorbing layer. 6. The first adhesive layer 3 and the water absorbing layer 6 have the same size.

During the use of the kit 1, for example by a patient or a doctor, the first adhesive layer 3 comprising perforations 5 of dimension D1 is first applied to an area of one or more scars on human skin 2 ( Figure 1B). The water-absorbent layer 6 is applied on top and on the side of the first perforated adhesive layer 3 (FIG. 1C). In practice, it may be useful to apply the water-absorbing layer 6 beforehand to the first perforated adhesive layer 3. After having applied the first perforated adhesive layer 3 and the water-absorbing layer 6, the second adhesive layer 4 is placed on the first adhesive layer 3 and the water-absorbent layer 6, while at the same time the outer parts of the second adhesive layer 4 protruding from the surfaces of the other layers 3, 6 are placed on the skin 2, in order to press the first perforated adhesive layer 3 towards the scar(s) (Fig. 1D). Preferably, the second adhesive layer 4 is stretched while being so applied. Accordingly, a scar treatment tape 14 is applied to the skin 2, which scar treatment tape 14 is capable of effecting scar healing for up to 2-3 months or more without having to be replaced.

Example 2

Example 2 relates to a kit for use in the treatment of human scars, according to the arrangements of the invention.

The kit according to this example includes spatially separated components for use in assembling and securing a scar treatment tape to one or more scars on human skin. The various components of the kit according to example 2 are presented below in table 3.

Table 3 Composition of a kit intended for use in the treatment of human scars, according to example 2

Second layer Transparent self-adhesive adhesive polyurethane layer; 40 - 60 g/M’; layer thickness of 15 - 50 µm; water vapor permeability (ISO 2528) from 300 g / (m: x 24 h) to 400 g / (m: x 24 h)

Bottom assembly Protective layer

Water absorbing layer Layer comprising hydrocolloids; 10-50um

First adhesive layer Perforated layer comprising perforated silicone; 10-50um

Removable liner Additional silicone paper

For the specific properties related to the perforations of the first perforated adhesive layer, reference is made to Table 2.

Diagram 2A gives a schematic representation of the kit according to example 2. The second adhesive layer 4 defines an area which is larger in all planar vectors than the individual areas defined by the first adhesive layer 3 and the water absorbing layer. 6. The first adhesive layer 3 and the water absorbing layer 6 have the same size.

When using the kit 1, for example by a patient or a doctor, the additional peel-off liner 12 and the protective layer 13 are first peeled off from the lower assembly 11. The remaining double layer configuration of the first perforated adhesive layer 3 and water-absorbent layer 6 is then applied to an area of one or more scars on human skin 2, with the first perforated adhesive layer 3 coming into contact with the skin 2 (Fig. 2B). . In a further step, the detachable liners 9, 10 are peeled off from the upper assembly 7. The remaining second adhesive layer 4 is then placed on both the first adhesive layer 3 and the water-absorbent layer 6, same time the outer parts of the second adhesive layer

4 protruding from the surfaces of the other layers 3, 6 are placed on the skin 2, in order to press the first perforated adhesive layer 3 towards the scar(s) (Fig. 2C). Preferably, the second adhesive layer 4 is stretched while being so applied.

Accordingly, a scar treatment tape 14 is applied to the skin 2, which scar treatment tape 14 is capable of effecting scar healing for up to 2-3 months or more without having to be replaced.

Claims (15)

A kit (1) for use in the treatment of human scars, comprising spatially separated components for use in assembling and securing a scar treatment tape to one or more scars on human skin (2), characterized such that that the components of the kit (1) comprise a first adhesive layer (3) to come into contact with the scar(s) on which it is used and a second adhesive layer (4) configured to be superposed on the first adhesive layer ( 3) in a manner exceeding circumferentially during use. 2. Kit (1) according to claim 1, wherein the second adhesive layer (4) defines an area which is greater in all planar vectors than an area defined by the first adhesive layer (3). 3. Kit (1) according to claim 1 or 2, wherein the first adhesive layer (3) comprises one or more silicones. 4. Kit (1) according to any one of claims 1 to 3, wherein the first adhesive layer (3) comprises perforations (5) which allow the transport of water away from the skin (2). 5. Kit (1) according to claim 4, in which 2% to 20% of an area defined by the first adhesive layer (3) is perforated. 6. Kit (1) according to claim 4 or 5, in which each of the perforations (5) defines an area, and in which the surface of the first adhesive layer (3) relates to the area of a perforation (5) in a ratio of at least 40:1. 7. Kit (1) according to any one of claims 4 to 6, in which the perforations (5) have dimensions (D1) of 1 μm to 5000 μm. 8. Kit (1) according to any one of claims 4 to 7, wherein the perforations (5) are uniformly distributed over the surface of the first adhesive layer (3). 9. Kit (1) according to any one of claims 1 to 8, in which the second adhesive layer (4) has a water vapor permeability (ISO 2528) of 100 g / (m:x 24 h) to 5000 g / (Mr x 24 hrs). 10. Kit (1) according to any one of claims 1 to 9, wherein the second adhesive layer (4) comprises one or more compounds selected from the group comprising one or more polyolefin compounds, polyamide, polyester, nylon, polychloride of vinyl, polyvinylidene chloride, polyethylene terephthalate and polyurethane. 11. Kit (1) according to claim 10, in which the second adhesive layer (4) comprises polyurethane. 12. Kit (1) according to any one of claims 1 to 11, wherein the second adhesive layer (4) comprises one or more UV blocking agents. 13. Kit (1) according to any one of claims 1 to 12, wherein the kit (1) comprises, as an additional component, a water-absorbent layer (6) intended to be placed between the first adhesive layer (3) and the second adhesive layer (4) in use. 14. Kit (1) according to claim 13, wherein said water-absorbing layer (6) comprises one or more hydrocolloid materials. 15. Kit (1) according to claim 13 or 14, wherein the second adhesive layer (4) is provided in an upper assembly (7), the upper assembly (7) further comprising two removable liners (9, 10) sandwiching the second adhesive layer (4) in the middle and optionally comprising an additional adhesive layer between one of the release liners (9, 10) and the second adhesive layer (4), and wherein the first adhesive layer (3) and the water-absorbent layer (6) are arranged adjacent to each other in a lower assembly (11), the lower assembly (11) further comprising another detachable liner (12) adjacent to the first layer adhesive layer (3) and opposite the water-absorbent layer (6)), and optionally comprising a protective layer (13) adjacent to the water-absorbent layer (6) and opposite the first adhesive layer (3).