BE1028265B1 - SCANNING MICROSCOPE MECHANISM AND PROCEDURE FOR LOADING PREPARATIONS - Google Patents

Abstract

This scanning microscope contains a simple and fast loading system for small specimens, such as for example with COVID19, where the time for handling the specimens and the time for creating a vacuum in the scan chamber are minimized. The loading system contains a sliding block that permanently closes the scanning chamber airtight and in which the specimen holder is placed, which is moved by means of the sliding block to the location of the scanning. During a specimen change or maintenance, the sample chamber can also be divided into a gun chamber and a small sample chamber by closing the scanning opening airtight with a valve, which benefits both the protection of the particle gun and the operator as well as a much shorter time to clear the sample chamber. back to vacuum. Finally, all or part of the movements, actions, controls, regulations, specimen identification, data processing and diagnosis can be performed automatically, so that the return is optimized.

Description

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18/66/2821 18:48 Krefel KEU HIirijk 938205855 HEE 3605 1 , a ; BE2020/5542 Momentesl there are different manlaren am sen pregaraat {4} In san sample room {1} of ; To place a scanning microscope with the existing octrocien Di, DA, DS and DA mauv :

5. lean on this new trot, a. | _ Cetrool DA contains a member that also covers the vacuum lock. _ whole traneporimachanism so with bat back vacuum making of this great fade precious time lost gest, 2 a a ; Olardel DE is the closest to this news cetroel since the preparasi holder has a sliding shift | 30 via one or more vacuumiboÏfers after the scanning site is shifted, Only the small space © above the proparasthobder can now be vacuumed, which means a great time-saving: The octranlan DS an 04 require time-consuming manipulations when loading vañhotprepargatzodstze … . rainder are suitable for maass production such as in a DOVIDIS pandemic. ; , / However, the existing patents do not contain a leak anywhere during the pre-yarn tube | 48 Dokcenentra san de vache of the stan operation is missing to the sample room ’ ; reduce and thus the time For pumping back vacuum to minimallserah, == © In this way precious time is lost, © . SOLUTION ; - == The invention describes a scanning microscopy with a mechanism to load preparations (4) into the sample chamber (43, where the wall of the housing (80) has its scanoperine {2} about the point ee ; where the axis of the scanstreal (5) the wall is buzzing, Against the atmospheric side of this soan opening (2) 'vis seals {7} and IB} a sliding block (14) is pressed in which a zen preparation {4} can be ; welded, Through the schlfblak {14} to shift Is the preparsat {4} transplanted from the ambient pressure near the sample car {4}, without the sample chamber {1} losing vacuum, this because Uiders san Short stopover of fat schlfblok {14} the small space 142} Lovers the preparation (4) first sufficient vacutim is pumped with sen VachimApom {Ba} (le ouk FIGE, STEP 2}. The 2° mechanism further allows the use of a preparast holder (100) of pale preparations (1023 an - simultaneously In the moneter chamber ( 4) can bring, for example more than a hundred preparsten 12024 something like that then s can be scanned in quick succession, ; - ; Sample chamber {1} is divided into a kenonkemer (201) and a small sample chamber {2083} where sen kiep (200) the sesnopenine [2 or 202} each time airtight sfeluit at zen nraperasteissel | (205), This improvement has several advantages: | 2° 5 == BR = the vaculm In the canoe rider {2037 is always edged so that the strasikanon 120} BC can work continuously without Lance on Damage; ... - The sample chamber (208) can be made very small during the preparation by the same valve {200), which reduces the time for the return Vacuum pump of the sample chamber (2051 very a | starkreduteurt ; 2 = den (200) à also san good security against damage by the scanstran (2) mengericht _ when there is no preparsat holder {5} or schlfbiok (14) for the scanoperine {2} would stsan, eg during san maintenance or at men!pulatis by less shocked * staff, ee : . " , BRIEF DESCRIPTION DRAWINGS - 200 KG, 1 wont a schematic representation of the scanning microscope; a. - FIG, 2 shows the principle of differential pumping; ; Hg 5 shows the princios of scanning I fastervorg ; ; ; 89 Ei, éfoonthe hhadmochanisrme In porpaétlef uppereary 101 RG, 5shows the loading mechanism In perspective osdarsen;u Fi.& shows the iandmachanism In purpentive sideway; the VE different phases of the charging cycle . ; ; ; FIG. 8 shows a small amount of proparasthousoids In perpactive above; ; . FG, 10 shows a multiple preparation container In bottom perspective; ! Fr, 44 shows the principle of the tilt (200) with additional scan opening (202); -

1R/08/2821 19:43 Krefol HEE Hirijk 38206088 Hey sai 2086 | ; BE2020/5542 . 3 . Fi, 12 shows the principle of the bep (200) distributed scanning openings (2 and 202} airtight afeitit, FIR, 18 shows the principle of the tip {2001 which only seals the opening {2} airtight; | ; WERNE . ; in the sample chamber (1) is the scahapening (2) on the ploats wear the scanstreat (3) come | ; 16 during scanning and therefore also the preparsat LA) is soaped On the hump side (almosfaerkent] of the scan opening {2} is located a glioppervisk 16} whereof ... : seal (71 applied, randomly the scenspening (2), The sliding block {14} can move in ; ; gélaiders (13) and is also pressed by these guides {18) tagen diehting 17} so that the vaoutm ; mansterkamer (1) is separated from the olmgewngsdhhuk : | 45 between the elifopervial {8} and the schulfbik (143) there is still a second larger seal 18} and the first seal 17), Between these two seals there is a zen little vacuum chamber af slutskoiie (12) with In this lock chamber (12) a veculm opening (10) through which ngs the hold above the pransrant {4} vacuum can be pumped, before the preparation {4} enters the sean opening {2} of ; the sample chamber {1} is brought and the preparsat (4) is also slightly recessed in the og schuhi: (14) because here the preparsat holder (5) leans against its kleins edge {27, so that it is prepared {4} during the plasticize the seals {7} and {8} ranit and thus not be damaged or soiled by the seals (73 or {84 N Cycle course {HG 8 Stop Tue 7 ; The proparast holder (5) with praparast {4} is placed in the opening 1453 of the shelter block (14).

Seal {8} ensures that the preparation holder (5) is vacuum sealed and is held firmly. If necessary, the preparation holder 15) can also be sealed by placing a vacuum cap on the 29 seal {14}, still hi de omgeingsleht, | Stan a: ; Flap (200) is slid in front of the scan opening (2 or 202} for safety.

SigpB: ; me Moved with schlfblak (14) so that the preparation (4) came completely into the zhaiskoik (12) : stean, which is subsequently vacuum pumped via Vaculm Opening 146} vacuum islding 111} and the vacuum pump (32). ; Step a: ; I The schlfbiok (14) is displaced until the preparation (4) crosses the seal {7} so that the gully chamber 132} 40 of the human chamber [when the small space above the preparation {16} are bandages, the sample chamber {à or 208) still manure vaculim garmsakt via vacvin opening (10%, vacuimielding {11} “on the vaculim pump (22) | Stan 5: - == ; The peeling varnish {143 is then further glossed as the preparation (4) in the middle of the : scanopenine {2} comes to stare.

A Stay Si I Te is that the desired vacuum has been obtained in the (reduced) sample chamber [1 or 208}, the blow (200) can be removed from the scene operation {2 or 202}. ; Step 7: ; #5 The vaculm sample chamber [L or 208) is completely closed by the seal {7} and the slide biox 114) with the preger set holder {5}, The scanning can start, Step: | After the scanovclus, the preparsat holder (5) is moved back in the reverse direction, Om this ; ta daan without vacılım verilas mon can for example In vacuOmlelding {13} also sen ; © 89 onertehungavential (83) urinate after the lock chamber 112) and also the sample chamber(s of 205) : stay by far when the sample {4} rustles the seal 17}. ; ; VERSIONS

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18/86/2001 1243 Erefel MALE AFFE 9335358881 : 00,581 3098 ; | ; . BE2020/5542 ; | automatic screening of the wanted virus patterns. In the scanned image by means of simme, homologeside software, this scanning microscope can also be operated by less discriminated personnel and the test speed and the efficiency of the scanning microscope are optimized, as well as a man per 50,000 inhabitants such a scanning microscope can be used, S then one can test the full population's chsaras moisture on san wael time and detect all infected persons and contact tracing with COVID+19 painting became superfluous.

Moreover, this scanning microscope does not have to cost a fortune so that it can also be used in poorer areas.

Up to slat man can vie senvoudies Internet always updates the traceable patterns up ts date . to hold. ;

Claims (1)

DISSE] 1: Brofel JE Mili IEEE 80.501 1608 ; N ; . BE2020/5542 . _ 6 | a CONCLUSIONS = | 4. A scanning microscope containing a scan line {3} with charged deatils covering a sample {4}: a sliding plate {93 that closes the vacuum scanning chamber permanently in an airtight manner and where the prepargathouider is placed which is placed through the scale plate to the gutter of the a ” sécanstraa!(5) is moved; eon Map (200) whose sample chamber {1} divides into a small sample chamber (208) an zen gun tamer (2021 ; 3, Mechanism according to claim 1 wherein all or san part of the movements, operations, controls, arrangements, preparation identifications, data processing can be performed automatically on the dagnose,