BE1000730A5 - NOVEL TETRAHYDROCARBAZOLONES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION. - Google Patents

NOVEL TETRAHYDROCARBAZOLONES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION. Download PDF

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Publication number
BE1000730A5
BE1000730A5 BE8700814A BE8700814A BE1000730A5 BE 1000730 A5 BE1000730 A5 BE 1000730A5 BE 8700814 A BE8700814 A BE 8700814A BE 8700814 A BE8700814 A BE 8700814A BE 1000730 A5 BE1000730 A5 BE 1000730A5
Authority
BE
Belgium
Prior art keywords
tetrahydrocarbazolones
novel
preparation
pharmaceutical composition
composition containing
Prior art date
Application number
BE8700814A
Other languages
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of BE1000730A5 publication Critical patent/BE1000730A5/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

Tétrahydro-carbazolones de formule R1, R2, R3, R4, R5 représentent différents groupes chimiques, et leurs sels et produits de solvatation physiologiquement acceptables. Les composés sont des antagonistes puissants et sélectifs de l'effet de la 5-HT aux récepteurs à la 5-HT3 et sont utiles, par exemple, dans le traitement des maladies pshychotropes, de l'anxiété, et de la nausée et des vomissements.Tetrahydro-carbazolones of formula R1, R2, R3, R4, R5 represent different chemical groups, and their physiologically acceptable salts and solvates. The compounds are potent and selective antagonists of the effect of 5-HT at the 5-HT3 receptors and are useful, for example, in the treatment of pshychotropic diseases, anxiety, and nausea and vomiting .

BE8700814A 1986-07-23 1987-07-22 NOVEL TETRAHYDROCARBAZOLONES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION. BE1000730A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868617994A GB8617994D0 (en) 1986-07-23 1986-07-23 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
BE1000730A5 true BE1000730A5 (en) 1989-03-21

Family

ID=10601571

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700814A BE1000730A5 (en) 1986-07-23 1987-07-22 NOVEL TETRAHYDROCARBAZOLONES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.

Country Status (8)

Country Link
JP (1) JPS6335570A (en)
BE (1) BE1000730A5 (en)
CH (1) CH674008A5 (en)
DE (1) DE3724322A1 (en)
FR (1) FR2601951B1 (en)
GB (2) GB8617994D0 (en)
IT (1) IT1211667B (en)
NL (1) NL8701728A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
AU631632B2 (en) 1989-04-21 1992-12-03 Novartis Ag Therapeutic use of 5-ht3 receptor antagonists
EP0591434A4 (en) * 1991-06-26 1994-09-14 Sepracor Inc Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2153821A (en) * 1984-01-25 1985-08-29 Glaxo Group Ltd 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
EP0191562A2 (en) * 1985-01-23 1986-08-20 Glaxo Group Limited Tetrahydrocarbazolone derivatives
EP0210840A2 (en) * 1985-07-24 1987-02-04 Glaxo Group Limited Substituted imidazolylmethyltetrahydro-carbazolones
EP0219193A1 (en) * 1985-07-24 1987-04-22 Glaxo Group Limited Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0219929A1 (en) * 1985-07-24 1987-04-29 Glaxo Group Limited Process for the preparation of 3-imidazolylmethyltetrahydrocarbazolones
EP0221629A1 (en) * 1985-07-24 1987-05-13 Glaxo Group Limited Process for the preparation of 3-imidazolylmethyltetrahydrocarbazolones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2153821A (en) * 1984-01-25 1985-08-29 Glaxo Group Ltd 3-Imidazolylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives
EP0191562A2 (en) * 1985-01-23 1986-08-20 Glaxo Group Limited Tetrahydrocarbazolone derivatives
EP0210840A2 (en) * 1985-07-24 1987-02-04 Glaxo Group Limited Substituted imidazolylmethyltetrahydro-carbazolones
EP0219193A1 (en) * 1985-07-24 1987-04-22 Glaxo Group Limited Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0219929A1 (en) * 1985-07-24 1987-04-29 Glaxo Group Limited Process for the preparation of 3-imidazolylmethyltetrahydrocarbazolones
EP0221629A1 (en) * 1985-07-24 1987-05-13 Glaxo Group Limited Process for the preparation of 3-imidazolylmethyltetrahydrocarbazolones

Also Published As

Publication number Publication date
FR2601951B1 (en) 1991-04-26
FR2601951A1 (en) 1988-01-29
NL8701728A (en) 1988-02-16
CH674008A5 (en) 1990-04-30
JPS6335570A (en) 1988-02-16
GB8617994D0 (en) 1986-08-28
IT8748207A0 (en) 1987-07-22
DE3724322A1 (en) 1988-01-28
GB2192885B (en) 1990-02-07
GB8717353D0 (en) 1987-08-26
GB2192885A (en) 1988-01-27
IT1211667B (en) 1989-11-03

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RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19930731